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Conclusion: The presence and development of allodynia is associat-ed with severity but not duration of migraine. This retrospectiveanalysis suggests that migraine severity is a significant factor incentral sensitization.Study supported by MAP Pharmaceuticals, Inc., a wholly ownedsubsidiary of Allergan, Inc.

doi:10.1016/j.jns.2013.07.1790

Abstract — WCN 2013No: 1411Topic: 8 — HeadacheElectrophysiological evaluation of headaches associated withtemporomandibular dysfunction

E.A. Kuznetsova. Neurology, Neurosurgery and Medical Genetics,Kazan State Medical University, Kazan, Russia

Objective: To study clinical and neurophysiological peculiarities ofheadaches associated with temporomandibular dysfunction (TMD)and to evaluate involvement of trigemino-cervical system inpathogenesis of TMD headaches.Methods: 30 patients aged 17–59 years old with headache com-plaints and TMD, confirmed by clinical and instrumental methods,were included into study. 30 healthy subjects aged 18–54 years oldpresented control group. Neurophysiological methods includedtrigeminal evoked potentials (TEP), blink reflex (BR) and EMG ofmasticatory muscles. Fisher exact test and correlation analysis withPearson criterion were used for statistical analysis.Results: The present study showed the trend to TEP latenciesdecrease, statistically significant latencies decrease of BR compo-nents R1 (p b 0.05) and R2 ipsi- and contralaterally (p b 0.001)compared with healthy controls. The analysis of the results ofstimulative EMG revealed M-response asymmetry with amplitudedecrease on the side of pain (p b 0.05).Correlation analysis showed strong direct correlation betweenlatencies of TEP and M-response of masticatory muscles (r = 0.83)and inverse correlation between latencies of R2 component of BRipsilaterally and M-response amplitudes (r =−0.91).Conclusion: The obtained results demonstrated increased reflexirritability of trigeminal system and brainstem structures in patientswith headaches associated with TMD. Functional state of trigemino-cervical system determines parameters of M-response of masticatorymuscles. Increased irritability of trigeminal system is accompaniedby increased muscle tone of masticatory muscles and leads toenhancing of pain syndrome. According to the obtained results,complex therapy of TMD headaches is recommended, includinganticonvulsants in case of trigeminal system involvement.

doi:10.1016/j.jns.2013.07.1791

Abstract — WCN 2013No: 653Topic: 8 — HeadacheThe role of plasm nitrites in diagnosing of migraine severityin children

O. Rakhmanina, E. Levitina. Tyumen Medical Academy, Tyumen, Russia

Objective: Studying of plasma concentration of steady nitrogen oxidemetabolite under migraine in children with regard to the type ofmigraine (with andw/o aura), frequency, rate and duration of a seizure.Methods: The Study group is comprised of 81 children with migraine(54 boys, 27 girls) at the age from 6 to 18 y.o. Control group is 20healthy children. Defining of nitrites in blood plasm was being

conducted in accordancewithmethodology by Karpyukwith co-author(2000). The accuracy of differences: t-criterion of Student at p b 0.05.Results: There's been diagnosed proven increase of plasm nitrite levelup to 3.2 ± 0.8 nM/l in the Study group against 2.2 ± 0.09 nM/l in theControl group. The group of patients with frequent seizures (≥2 timesper month) is comprised of 61 children with seizure frequency at therate of 3.3 ± 1.5 per month and pain rate per visual analogue scale is6.5 ± 2.0 points. The group of children with occasional seizures (b2times per month) — 20 children with seizure frequency at the rate of0.25 ± 0.2 permonth and pain rate at 7.4 ± 2.0. Frequent seizure groupappeared to have increase of nitrite plasm level up to 3.4 ± 0.9 nM/lagainst the group with occasional seizures (2.7 ± 0.9 nM/l). The studydidn't show any dependence of migraine type, pain rate and seizureduration on the level of nitrogen oxide.Conclusion: The level of plasm nitrites can serve as a laboratoryindicator of disease severity and depends on the frequency ofmigraine seizure.

doi:10.1016/j.jns.2013.07.1792

Abstract — WCN 2013No: 1110Topic: 8 — HeadacheThe primary headache subtypes in Nazareth city;co morbidity potential risk factors and disability rate

A. Mazaib. Clalit Health Services, Nazareth, Zarzir, Israel

Introduction: To investigate the primary headache subtype preva-lence and disability rate associated with mood disorders in low socioeconomic status (LSES) may underlie both diseases.Methods: I identified 276 headache sufferers, drawn from more than1254 individuals representative of heterogeneous community ofNazareth city, which were referred to our center by family physiciansfor various neurological disorders, were subdivided subsequently intension type headache (TTH) and migraine disorders according to IHScriteria and undergone complete work up profile with therapeuticstrategies, secondary headaches were excluded. The socioeconomicstatus (SES) for every individual was considered and meticulouslyexamined according employment, income and educational gradients.Verbal informed consent was obtained during the first round.Results: The vast majority of those individuals were belonging toLSES (57.3%) and subdivided according IHS and DSM-IV(for psychi-atric illnesses, mood disorders, depressive and anxiety disorders) in172 (62.3%)sufferers of TTH with 69.3% depressive disordersbackground and other psychiatric illnesses, 102 (36.96%)migraine(included with/without aura) with30.7% mood disorders,and finally, 2 (0.72%) sufferers of cluster headache.Conclusions: The main target of this observational study was toverify the relationship between primary headache disorders andpotential co morbidity risk factors. Psychiatric co morbidity wasassessed by DSM-IV criteria. The LSES was considered as remarkableco morbidity risk factor for both headache subtypes, migraine andtension type headache.

doi:10.1016/j.jns.2013.07.1793

Abstract — WCN 2013No: 894Topic: 8 — HeadacheCaMEO (Chronic Migraine Epidemiology & Outcomes) Study:Design, Methodology, and Baseline Cohort Characteristics

A.N. Manacka, M.L. Reedb, V. Marskeb, D. Serranob, K. Fanningb,C. Cunanana, D.C. Busec, R.B. Liptonc. aAllergan, Inc., Irvine, CA, USA;

Abstracts / Journal of the Neurological Sciences 333 (2013) e481–e518 e507