effects of zernike wavefront aberrations on visual acuity...
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Effects of Effects of ZernikeZernike WavefrontWavefrontAberrations on Visual AcuityAberrations on Visual Acuity
measured using Electromagneticmeasured using ElectromagneticAdaptive Optics TechnologyAdaptive Optics Technology
KarolinneKarolinne Maia Rocha, Maia Rocha, MDMDLaurent Laurent VabreVabre, , PhDPhD
Jean-LucJean-Luc NguyenNguyen KhoaKhoa, MD, MDNicolas Nicolas ChateauChateau, , PhDPhD
Ronald Ronald KruegerKrueger, , MDMD
PurposePurpose
To measure the changes in visualacuity induced by various amounts of singleZernike aberrations
MethodsMethods
crx1 Adaptive Optics Visual Simulator
(Imagine Eyes, Orsay, France)
software kit:
• irx3 aberrometer software• SVAO wavefront builder
• CSO adaptive optics software
• wavefront stroke 50µm
MethodsMethods
• 10 eyes (10 subjects);
• 1 eye excluded;
• initial measurement of the total ocularaberrations;
• static compensation for wavefront error;
• application of pure Zernike aberrations;
MethodsMethods
Pupiltracker
Badalsystem
Deformablemirror
Wavefrontsensor
IRdiodes
Microdisplay
Wavefrontmeasurement
MethodsMethods
Pupiltracker
Badalsystem
Deformablemirror
Wavefrontsensor
IRdiodes
Microdisplay
Static correctionand Zernikegeneration
MethodsMethods
Pupiltracker
Badalsystem
Deformablemirror
Wavefrontsensor
IRdiodes
Microdisplay
Visual stimulation
MethodsMethods
Visual Acuity:
Freiburg Acuity Test
• Landolt C
• 8 directions
• 18 presentations
50 cd/m2
MethodsMethods
Simulator pupil diameter: adjusted to 5mm
Applied aberrations:
• none (uncorrected)
• sph/cyl correction
• full correction (2nd to 5th orders)
• full correction + single Zernike modes
ResultsResults
FH LV NC EL XL SB KM CP GC
SPHERO-CYL FULL
Correction
-0.3
-0.2
-0.1
0.0
0.1
0.2
0.3
VA
(LogMA
R)
Comparison between best sphero-cyland full AO correction
ResultsResults
Mean ±SE ±SD
SPHERO-CYLFULL
Correction
-0.3
-0.2
-0.1
0.0
0.1
0.2
0.3
VA
(LogMA
R)
Comparison between best sphero-cyland full AO correction
ResultsResults
-0.20
-0.15
-0.10
-0.05
0.000.0 0.5 1.0 1.5
Preexisting HOA RMS (µm)
Full
corr
ecte
d VA
- sp
hero
cyl
VA (L
ogM
AR
)
Is the improvement in VA with full AOcorrection related to the preexistingamount of HOAs ?
MethodsMethods
Zernike generation:
RMS 0.1 µm, 0.3 µm, 0.9 µm
• defocus Z(2,0)
• astigmatism Z(2,2)
• coma Z(3,1)
• trefoil Z(3,3)
• spherical aberration Z(4,0)
ResultsResults
Defocus Z(2,0)
Mean ±SE ±SD 0.1 0.3 0.9
RMS aberration (µm)
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Astigmatism Z(2,-2)
Mean ±SE ±SD 0.1 0.3 0.9
RMS aberration (µm)
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Coma Z(3,-1)
Mean ±SE ±SD 0.1 0.3 0.9
RMS aberration (µm)
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Trefoil Z(3,-3)
Mean ±SE ±SD 0.1 0.3 0.9
RMS aberration (µm)
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Spherical aberration Z(4,0)
Mean ±SE ±SD 0.1 0.3 0.9
RMS aberration (µm)
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Coefficient 0.1 µm
Mean ±SE ±SD
DefocAsti
ComaTrefoil
S.A.
Aberration mode
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Coefficient 0.3 µm
Mean ±SE ±SD
DefocAsti
ComaTrefoil
S.A.
Aberration mode
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
ResultsResults
Coefficient 0.9 µm
Mean ±SE ±SD
DefocAsti
ComaTrefoil
S.A.
Aberration mode
-0.2
0.0
0.2
0.4
0.6
0.8
1.0
Change in V
A (LogM
AR
)
Conclusion• The static correction of HOA improved visual acuity
by one line in average, compared to sphero-cylindercorrection.
• The generation of different Zernike aberrations ofequal RMS resulted in different changes in VA.
• The more central aberrations in the Zernike pyramid,e.g. defocus and spherical aberration, had moredetrimental effect on VA.
• Neural Adaptation could impact the difference invisual improvement with HOA compensationbetween subjects.