Aims

Effect of initial application of PAP therapy on daily arterial partial pressure of oxygen in OSA patients

Andreja Šajnić1, Sandra Karabatić1, Vida John1, Miroslav Samaržija1

andreja.sajnic@gmail.com1University Hospital Center, Clinic for Pulmonary Diseases Jordanovac, Zagreb, Croatia.

Methods PAP is the most effective therapy in OSA patients, but whether it is successful in improving the daily arterial partial pressure of oxygen in these patients. Aims of the research were to determine: 1) The distribution of patients by categories of OSA according to measured value of AHI, 2) OSA in interaction with other medical diagnoses, 3) Demonstration of the difference between the daily arterial partial pressure of oxygen and the initial implementation of PAP therapy.

Results

Conclusion

These are the results for the year 2008 to 2010. The target group were all patients who came to the OSA treatment (N=277), and whose findings were AHI≥10 (therapy group). In each patient, we recorded the AHI, BMI, age, sex, comorbidities, ABG analysis and initial implementation of PAP therapy. AHI is a result of polysomnography (PSG). All patients made a complete full night PSG (ALICE IV or LE 5 Respironics).

TABLE 1. The distribution of patients by categories of OSA according to measured value of AHI. (N=277)

TABLE 2. The distribution female and male OSA patients with AHI≥10 and certain medical conditions (N=158)

TABLE 1. There was noted a large number 57% of patients with AHI≥10 (therapy group). This can be explained by the fact that it is still a large number of patients who have not been diagnosed in the previous years.

TABLE 3. There was noted 57% of patients with; AHI≥10, daily ABG PaO2<80mmHg and with successfull application of initial PAP therapy had improvement in PaO2 after just one night of PAP application. (N=80).

TABLE 2. A review of the distribution frequency of certain medical conditions (daily ABG PaO2<80mmHg, BMI≥30, Arterial hypertension), we observed a high prevalence mentioned above and similar representation in percentages both in men and women

TABLE 3. The distribution of patients according to the differences of PaO2 after the initial application of PAP device (N=80)

In this study we have demonstrated that PAP therapy is effective in improving the daily arterial partial pressure of oxygen in OSA patients. Given that a large number of patients has decreased daily PaO2<80mmHg, we consider that these data provide encouraging results for future work with patients suffering from OSA.

26%

17%

57%

N=277

65%

88%

77%69%83%

77%

F MDaily ABG PaO2<80mmHg

≤0mmHg

1-4mmHg

5-9mmHg

10-14mmHg

15-19mmHg

≥20mmHg

0% 5% 10% 15% 20% 25% 30% 35% 40% 45%

42%

14%

12%

13%

11%

8%

BMI≥30 Arterial hypertension