editors-in-chief scientific editors...craig b. thompson nicholas c. turner david a. tuveson robert...

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CANCER DISCOVERY FEBRUARY 2021 CANCER DISCOVERY EDITORIAL OFFICE: Cancer Discovery [ISSN 2159-8274 (Print); ISSN 2159-8290 (Online)] is published monthly, one volume per year, by the American Association for Cancer Research, Inc., 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404. Periodicals postage paid at Philadelphia, PA, and additional mailing offices. POSTMASTER: Send address changes to Cancer Discovery, AACR Member Services, 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404 or E-mail: [email protected]. Copyright 2021 by the American Association for Cancer Research, Inc. The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper). Robert T. Abraham Ash A. Alizadeh James P. Allison Carlos L. Arteaga Alan Ashworth Alberto Bardelli David Barrett Himisha Beltran René Bernards Elizabeth H. Blackburn John Blenis Paolo Boffetta Joan S. Brugge John C. Byrd Andrea Califano Hannah Carter Arul Chinnaiyan Heather R. Christofk Karen Cichowski Ryan B. Corcoran Sara A. Courtneidge Lisa Coussens Christina Curtis Alan D. D’Andrea Ralph J. DeBerardinis Johann S. de Bono David G. DeNardo Ronald A. DePinho Maximilian Diehn Susan M. Domchek Olivier Elemento Matthew J. Ellis Jeffrey A. Engelman Douglas T. Fearon Howard A. Fine Silvia C. Formenti Lori Friedman Stephen Frye Dmitry I. Gabrilovich Jennifer R. Grandis Nathanael S. Gray Daniel A. Haber William C. Hahn Kevin M. Haigis Douglas Hanahan Matthew D. Hellmann Helen E. Heslop Manuel Hidalgo Patrick Hwu David M. Hyman Tyler Jacks Elizabeth M. Jaffee William G. Kaelin Alec C. Kimmelman Theodore S. Lawrence Jonathan D. Licht Christine M. Lovly Douglas R. Lowy Ravindra Majeti Tak W. Mak Sami N. Malek Richard M. Marais Elaine R. Mardis John M. Maris Joan Massagué Frank McCormick Ignacio Melero Ingo K. Mellinghoff Ari M. Melnick Gordon B. Mills Sean J. Morrison Yael Mosse Benjamin G. Neel Olufunmilayo I. Olopade Pier Paolo Pandolfi William Pao Nickolas Papadopoulos D. Williams Parsons David R. Piwnica-Worms Helen M. Piwnica-Worms Kornelia Polyak Carol Prives Antoni Ribas Jeremy N. Rich Charles W.M. Roberts Jeffrey M. Rosen Mark A. Rubin Yardena Samuels Charles L. Sawyers Alice T. Shaw Margaret A. Shipp Kevan M. Shokat M. Celeste Simon Lillian L. Siu Mark J. Smyth David B. Solit Jean-Charles Soria Laura Soucek Kimberly Stegmaier Charles Swanton Josep Tabernero Craig B. Thompson Nicholas C. Turner David A. Tuveson Robert H. Vonderheide Karen H. Vousden Jennifer A. Wargo Ashani T. Weeraratna Kathryn E. Wellen E. John Wherry Eileen White Monte M. Winslow Timothy A. Yap SCIENTIFIC EDITORS Luis A. Diaz EDITORIAL STAFF SENIOR EXECUTIVE EDITOR Robert Kruger EXECUTIVE EDITOR Elizabeth S. McKenna SENIOR EDITORS Michele M. Hartsough I-Mei Siu ASSOCIATE EDITOR Avital Lev SENIOR EDITOR, SCIENCE AND MEDICAL NEWS Suzanne L. Rose WRITER/REPORTER, SCIENCE AND MEDICAL NEWS Catherine C. Caruso SCIENCE WRITER Nicole Haloupek SENIOR EDITORIAL ASSOCIATE Ingrid Lin SENIOR PRODUCTION PROJECT EDITOR Julie Ehlers Lewis C. Cantley EDITORS-IN-CHIEF

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Page 1: editors-in-chief scientific editors...Craig B. Thompson Nicholas C. Turner David A. Tuveson Robert H. Vonderheide Karen H. Vousden Jennifer A. Wargo Ashani T. Weeraratna Kathryn E

CANCER DISCOVERY

February 2021 CANCER DISCOVERY

EDITORIAL OFFICE: Cancer Discovery [ISSN 2159-8274 (Print); ISSN 2159-8290 (Online)] is published monthly, one volume per year, by the American Association for Cancer Research, Inc., 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404. Periodicals postage paid at Philadelphia, PA, and additional mailing offices. POSTMASTER: Send address changes to Cancer Discovery, AACR Member Services, 615 Chestnut Street, 17th Floor, Philadelphia, PA 19106-4404 or E-mail: [email protected]. Copyright 2021 by the American Association for Cancer Research, Inc. The paper used in this publication meets the requirements of ANSI/NISO Z39.48-1992 (Permanence of Paper).

Robert T. Abraham

Ash A. Alizadeh

James P. Allison

Carlos L. Arteaga

Alan Ashworth

Alberto Bardelli

David Barrett

Himisha Beltran

René Bernards

Elizabeth H. Blackburn

John Blenis

Paolo Boffetta

Joan S. Brugge

John C. Byrd

Andrea Califano

Hannah Carter

Arul Chinnaiyan

Heather R. Christofk

Karen Cichowski

Ryan B. Corcoran

Sara A. Courtneidge

Lisa Coussens

Christina Curtis

Alan D. D’Andrea

Ralph J. DeBerardinis

Johann S. de Bono

David G. DeNardo

Ronald A. DePinho

Maximilian Diehn

Susan M. Domchek

Olivier Elemento

Matthew J. Ellis

Jeffrey A. Engelman

Douglas T. Fearon

Howard A. Fine

Silvia C. Formenti

Lori Friedman

Stephen Frye

Dmitry I. Gabrilovich

Jennifer R. Grandis

Nathanael S. Gray

Daniel A. Haber

William C. Hahn

Kevin M. Haigis

Douglas Hanahan

Matthew D. Hellmann

Helen E. Heslop

Manuel Hidalgo

Patrick Hwu

David M. Hyman

Tyler Jacks

Elizabeth M. Jaffee

William G. Kaelin

Alec C. Kimmelman

Theodore S. Lawrence

Jonathan D. Licht

Christine M. Lovly

Douglas R. Lowy

Ravindra Majeti

Tak W. Mak

Sami N. Malek

Richard M. Marais

Elaine R. Mardis

John M. Maris

Joan Massagué

Frank McCormick

Ignacio Melero

Ingo K. Mellinghoff

Ari M. Melnick

Gordon B. Mills

Sean J. Morrison

Yael Mosse

Benjamin G. Neel

Olufunmilayo I. Olopade

Pier Paolo Pandolfi

William Pao

Nickolas Papadopoulos

D. Williams Parsons

David R. Piwnica-Worms

Helen M. Piwnica-Worms

Kornelia Polyak

Carol Prives

Antoni Ribas

Jeremy N. Rich

Charles W.M. Roberts

Jeffrey M. Rosen

Mark A. Rubin

Yardena Samuels

Charles L. Sawyers

Alice T. Shaw

Margaret A. Shipp

Kevan M. Shokat

M. Celeste Simon

Lillian L. Siu

Mark J. Smyth

David B. Solit

Jean-Charles Soria

Laura Soucek

Kimberly Stegmaier

Charles Swanton

Josep Tabernero

Craig B. Thompson

Nicholas C. Turner

David A. Tuveson

Robert H. Vonderheide

Karen H. Vousden

Jennifer A. Wargo

Ashani T. Weeraratna

Kathryn E. Wellen

E. John Wherry

Eileen White

Monte M. Winslow

Timothy A. Yap

scientific editors

Luis A. Diaz

editoriAL stAff

SENIOR EXECUTIVE EDITOR

Robert Kruger

EXECUTIVE EDITOR

Elizabeth S. McKenna

SENIOR EDITORS

Michele M. Hartsough

I-Mei Siu

ASSOCIATE EDITOR

Avital Lev

SENIOR EDITOR, SCIENCE AND MEDICAL NEwS

Suzanne L. Rose

wRITER/REPORTER, SCIENCE AND MEDICAL NEwS

Catherine C. Caruso

SCIENCE wRITER

Nicole Haloupek

SENIOR EDITORIAL ASSOCIATE

Ingrid Lin

SENIOR PRODUCTION PROjECT EDITOR

Julie Ehlers

Lewis C. Cantley

editors-in-chief

Page 2: editors-in-chief scientific editors...Craig B. Thompson Nicholas C. Turner David A. Tuveson Robert H. Vonderheide Karen H. Vousden Jennifer A. Wargo Ashani T. Weeraratna Kathryn E

CANCER DISCOVERYISSN 2159-8274 (pRINt) ≠ ISSN 2159-8290 (ONLINE)

publishing information

CANCER DISCOVERY February 2021 AACRJournals.org

International print subscriptions include cost of surface mail. Expedited mailing is available. Contact the American Association for Cancer Research for rates.

Site Licenses For information about institutional site licenses, contact [email protected].

AACR Members AACR members may opt to receive either a print subscription with online access to content or an online-only subscription. Contact [email protected] or visit the membership page at https://aacr.org for more information.

Single Issue Sales/Claims Due to the impact of COVID-19, the AACR has discontinued single issue orders and fulfillment of claims through December 31, 2021.

ADVERTISING INFORMATIONFor information about advertising in AACR journals, contact The Walchli Tauber Group, Inc., 2225 Old Emmorton Road, Suite 201, Bel Air, MD 21015; 443-512-8899; [email protected]

COPYRIGhT AND PERMISSIONSContent printed in or disseminated by Cancer Discovery is protected by copyright. Authors who wish to publish material in Cancer Discovery must formally transfer copyright to the AACR. All authors must sign copyright transfer forms before the AACR can proceed with publication.

To read the complete AACR Copyright and Permissions Policy, visit https://aacrjournals.org/content/authors/copyright-permissions-and-access.

SCOPECancer Discovery publishes high-impact, peer-reviewed articles describing major advances in research and clinical trials. As the premier cancer information resource, the Journal also presents Review Articles,

AACR OFFICERSAntoni Ribas, PresidentDavid A. Tuveson, President-ElectElaine R. Mardis, Past PresidentWilliam N. Hait, TreasurerMargaret Foti, Chief Executive Officer

PUBLICATIONS COMMITTEEVictor E. Velculescu, ChairpersonDafna Bar-SagiMary Helen Barcellos-HoffMichael E. BerensJohn D. CarptenMaura L. GillisonRakesh K. JainPasi A. JänneGerrit A. MeijerGordon B. Mills Steffi OesterreichWilliam PaoGloria M. PetersenDavid R. Piwnica-WormsCharles W.M. RobertsAlice T. ShawLillian L. SiuSaraswati V. SukumarToshikazu Ushijima

PubLishing stAffPUBLIShERChristine BattleDIRECTOR, jOURNAL OPERATIONS AND SYSTEMSDaniel S. EvankoDIRECTOR, jOURNAL SALES AND MARkETINGNicola L. HillDIRECTOR, DIGITAL PUBLIShINGMark JacobsonASSOCIATE DIRECTOR, PRODUCTIONCharlene SquibbASSISTANT DIRECTOR, jOURNAL MARkETINGJoanna ArnoldASSISTANT DIRECTOR, INSTITUTIONAL SALES & OUTREAChKarola Rac

Per spectives and Commentaries, News stories, and Research Watch summa-ries of important journal articles to its readers to keep them informed about the latest findings in the field. Topics span the spectrum of cancer research and medicine from the laboratory to the clinic and epidemiologic studies.

Cancer Discovery is abstracted and/or indexed in Current Contents/Clinical Medicine, MEDLINE, Science Citation Index, Scopus, and Web of Science.

SUBMISSION OF MANUSCRIPTSManuscript submission is welcomed online at http://cd.msubmit.net. Before submitting a manuscript, please read the Instructions for Authors, which are available from the Journal’s home page at https://cancerdiscovery.aacrjournals.org.

PUBLICATION ChARGESArticles will be published with the understanding that the author(s) will pay both a publication fee plus a color figure handling fee. Please see the Publication Fees and Reprints page which is available at https://aacrjournals.org/content/authors/publication-fees-and-reprints.

SUBSCRIPTION INFORMATION Nonmember IndividualsSubscriptions include online access only. Contacts listed below are for nonmember individual subscriptions.

USA and Rest of World (excluding Japan)American Association for Cancer Research, 615 Chestnut Street, Philadelphia, PA 19106; 1-855-744-4667; [email protected]

Japan [email protected]; [email protected]; [email protected]