echocardiography in valvular heart disease, heart failure ... › sites › default › files ›...
TRANSCRIPT
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Echocardiography in Valvular Heart Disease, Heart Failure, and Cardiomyopathies
Asif Serajian, DO FACC
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Disclosures
Speaker for Zoll Lifevest
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Case
● 45 year old Columbian male who migrated to the US 5 years ago (let us assume you did
not get this history) comes in with shortness of breath on exertion
● On exam, patient has crackles and JVD
● CXR demonstrates pulmonary vascular congestion
● BNP 500
● Echo with EF 35%
Working diagnosis: Systolic congestive heart failure
● Ischemic
● Non-ischemic: Hypertensive? Idiopathic? Alcoholic?
You proceed with your usual workup… stress test? Cath? Look for clinical clues in history
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Systolic
● Ischemic
● Nonischemic ○ Hypertensive
○ Alcoholic
○ Metabolic
■ Hypothyroidism
■ Pheochromocytoma
○ Infiltrative
■ Amyloidosis
■ Diabetes
○ Peripartum
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Chagas Disease
Rhodnius prolixus is the principal vector in Colombia,
Venezuela, Guatemala, Honduras, and some parts of
Nicaragua and El Salvador
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American trypanosomiasis, is a tropical parasitic disease caused by the protozoa Trypanosoma cruzi
It is spread mostly by insects known as Triatominae
Early stage, symptoms are typically either not present or mild, and may include fever, swollen lymph nodes,
headaches, or local swelling at the site of the bite
30 to 40% of people develop further symptoms 10 to 30 years after the initial infection, including congestive
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● LV aneurysm (60-70% patients)
● Myocarditis
● Regional WMA (inferolateral wall)
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Case
● 55 y/o male with harsh systolic murmur that can be heard at the suprasternal notch but
not at the carotid arteries
● Murmur gets quieter with squatting and louder with standing
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Hypertrophic cardiomyopathy
● Small LV cavity
● Inappropriate LHV > 1.3 cm
● Classical form has LVOT
obstruction
● Apical pattern
● Papillary muscle
involvement
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● M-mode shows 1.3:1 septal to posterior wall hypertrophy
● Typically anterior septum is involved
● LVOT obstruction in 40%
● Mitral regurgitation is late peaking
● Systolic anterior motion of the mitral valve can also develop
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● Late peaking
● Dagger shape
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Valsalva
● Increase in gradient with valsalva
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Case
● 80 y/o male with sob on exertion
● Echo demonstrates severe LVH, restrictive diastolic pattern, and bi-atrial enlargement
● Patient has mild hypertension that has been well controlled for many years
● He brings his BP log from home showing well controlled BP
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Diagnosis..
Amyloidosis
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Restrictive cardiomyopathy
● Not a common cause of cardiomyopathy
however must be in the differential
● Findings○ Bi-atrial enlargement (due to both LV and RV
restriction) many times is only early finding
○ Restrictive inflow pattern E/A over 2 and short
decel time < 160 ms
○ Pericardial effusion
○ LVH
○ Blunted pulmonary vein systolic inflow
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Case
● 57 y/o female with exertional dyspnea, le edema and ascites
● History of radiotherapy 22 years ago with Co-60 after radical mastectomy for left breast
cancer
● EKG demonstrates low voltage
● CXR demonstrates pericardial calcification
Medicine (Baltimore). 2017 Feb; 96(5): e5932.
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Echo findings: elevated E/A ratio however
● > 25% E wave variation with respiration
● E’ velocity is preserved
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Valvular heart disease case
● Cardiology fellow decides to do his own echocardiogram in training as his colleague
heard a systolic murmur
● Finds systolic doming of the aortic valve
● Eccentric aortic regurgitation jet
● Fish mouth appearance of the aortic valve
● Peak gradient is elevated moderately and mean gradient is elevated only mildly
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Pearls with AS and AI such as in bicuspid aortic valve
● 4V² is used for calculating aortic stenosis gradient
● In aortic insufficiency cannot ignore LVOT velocity 4 (V2² - V1²)
● LVOT diameter² *0.785*LVOT VTI is the stroke volume
● If stroke volume < 35 mL this is considered low flow
● Pressure recovery phenomenon○ Aortic stenosis peak gradient is lower in cath lab as jet decelerates downstream
○ Echocardiogram measures highest velocity along the path anywhere
○ Noted most in small aortic roots
○ Mean gradient correlates
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● AS and MR waveform can be “contaminated”
● Look for timing of the jet
● AS waveform has a delay compared to R wave
● MR waveform starts immediately after R wave
● AVA calculation by continuity equation
○ Not affected by AI
○ Not affected by LV function
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Aortic stenosis
Severe
● MG > 40 MMHG
● AVA < 1 cm2 or indexed AVA < 0.6 cm2
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Flow reserve
*low flow low gradient gradient severe if with DSE..
*SVI increases by 20%
*MG over 40
*jet over 4
*ava less than 1
*No reserve if DSE gradient less than 40 and ava less than 1 then do calcium score of AV
*If over 1200 woman and 2000 man severe by ESC
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Case
● 50 year male with uncontrolled hypertension
● Ripping chest pain radiating to the back
● Unequal pulses in the arms
● Stat echocardiogram performed
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Echo Findings
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Aortic insufficiency causes
● Aortic root dilation due to hypertension
● Bicuspid aortic valve aortopathy
● Dissection
● Syphilis
● Aortic valve endocarditis
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Severe aortic insufficiency
● Pressure half time < 250 mS
● Holodiastolic flow reversal in the descending aorta
● > 60% of LVOT height
● ERO > 0.3 cm2
● VCW > 0.6 cm
● Regurgitant volume > 60 mL
● Regurgitant fraction > 50%
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Acute aortic insufficiency causes?
● Dissection
● Endocarditis
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Diastolic MR
● Hallmark of severe AI
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Case
● 60 year old woman with new
onset cerebrovascular accident
has an echocardiogram
● Answer?
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● Echo tech asks you to come take a look at this
echocardiogram where he notes a systolic
“doming” of the mitral valve and he wants your
opinion
● You ask him to get a M-mode across the mitral
valve to assess further
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Mitral stenosis
● Rheumatic- most common cause
● Congenital○ Parachute mitral valve with one papillary muscle
○ Abnormal leaflet with chordae
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● Normal area 4-6 cm2
● mild > 1.5 cm2 gradient < 5
● mod 1-1.5 gradient 5-10
● severe < 1.0 gradient > 10
● Ef slope nl > 60
● Severe pasp > 50 mmHg
● Calculated with 220/PHT
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● Echo tech calls you into the room
because of a high peak mitral gradient
but the mean gradient is only mildly
elevated
● There is mitral annular calcification and
she cannot see the mitral regurgitation
jet
● Answer?
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Mitral regurgitation
● Leaflet problem
● Apparatus problem
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True mitral regurgitation
● Goes through systole (not just early)
● Has convergence of jet (vena contracta)
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Non-true MR
● 50 ms later no mitral regurgitation is noted
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Flail leaflet with severe mitral regurgitation
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Flail mitral valve CW signal with tissue signature
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MR due to cardiomyopathy
Apically displaced mitral valve due to dilated
left ventricle
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Tethering of the posterior mitral leaflet due to
posterior myocardial infarction and ipsilateral
severe jet
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Mitral regurgitation grading
● Severe vc > 0.7 volume > 60 rf > 50 ero > 0.4 ( for secondary mitral regurgitation the ero cut off is greater than 0.2)
● Mild vc < 0.3 volume < 30 rf < 30 ero < 0.2
● End systolic dimension > 40 ef < 60 class, I indication also pap > 50 or afib class iia
● 60 50 40 rule ef < 60 pap >50 esd >40
● MV REPLACEMENT is class iii in rheumatic mr if less than 50% posterior leaflet is involved. MV repair is
recommended
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Thank you