ecg changes and sle
TRANSCRIPT
Dr Fariz Yahya
Rheumatology Unit
UMMC
Case Report
Miss RP 13 yr old with underlying SLE SLE diagnosed 2009 Eldest of 3 siblings Father taxi driver, mother factory worker
Case Report
Initially presented with systemic symptoms 10/2009
Fever Arthralgia Bicytopenia
Hb 5.5, WBC 6.3, plt 96
AIHA: Coombs positive with evidence of haemolysis
Case Report ESR 140 Low C3 (14),C4 (<10) Raised IgG Anticardiolipin – 21 Lupus anticoagulant: + ANA 1:1280, dsDNA 692 Serositis : bilateral pleural effusions and
ascites UFEME: NAD ECHO: normal
Initial ECG in 2009
Case Report
BMAT no evidence of malignancy received IVI Methylprednisolone
4mg/kg/day responded to steroids discharged with oral steroids
tapering doses
started Azathioprine 11/2009 added Hydroxychloroquine 2/2010
Case Report
However, ESR remained high considered for Rituximab Appeared Cushingoid BMD in 06/2011 - osteoporotic for her
age
ESR trend
Recent admission
Presented again on 07/2011 with AIHA Hb was 5.7, Plt 296, ESR 140, CRP 3.6 dsDNA 237 Hapto 59, se iron 3.5, ferritin 1252 Raised LDH 314 and Retics 14.9% IVI Methylprednisolone given Hb improved to 7.3 Azathioprine changed to Mycophenolate
Recent admission
Developed left sided chest pain after discharge
Atypical, tender left chest wall No fever ECG: Q waves and inverted T in II, III,
aVF, V5-V6Dynamic changes
Trop I was 8.36,Trop T 0.46, CK 464, CKMB 4
ECGs
ECGs
ECGs
ECGs
Case Report
ECHO: Normal LVEF 63%, no RWMA, LA size normalPASP 38mmHgNo pericardial effusionNo pericarditis
Multi slice CT coronary angiogram: normal
CTPA: No Pulmonary Embolism
Further follow up
Treated as Myocarditis Given NSAIDs, aspirin Symptoms improve No further chest pain
Latest ECG
Discussion
Possible differential diagnosis?
Differential diagnosis
Myocarditis Pericarditis Valvular disorders Coronary artery disease Costochondritis Anaemia induced Pulmonary embolism
Differential diagnosis
Small vessel vasculitis Pleurisy Drug induced: eg prednisolone
Myocarditis
Not common: 3-14% of patients can develop myocarditis (Routray et al 2004)
Chest pain, palpitations or SOB Resting tachycardia Can have either minimal symptoms or
CCF if severe
Myocarditis
Non-specific ST/T wave changes on ECG Conduction disturbances and heart block Common Echo findings include decreased
LV ejection fraction and segmental wall motion abnormalities (Law et al, 2005) or diffuse hypokinesia
Myocarditis
Endomyocardial biopsy remains technique of choice for diagnosis (Tincani et al, 2006)Invasive and subject to sampling error
Patients improve with cardiac support, steroids and immunosupression eg Azathioprine, Cyclophosphamide, or IVIG
Improve in symptoms and LVEF
Pericarditits
Most common cardiac abnormality in SLE: 6 – 45%
Left shoulder pain precipitated by lying down, relieved by sitting up
Consider any cause: unknown, infection, radiation, trauma, drugs, metabolic, malignancy, IBD
Any 2: chest pain, ECG changes, pericardial friction rub, pericardial effusion
ECG in pericarditis
ECG in pericarditis ECG showing diffuse upsloping ST segment
elevations seen best here in leads II, III, aVF, and V2 to V6. There is also subtle PR segment deviation (positive in aVR, negative in most other leads). ST segment elevation is due to a ventricular current of injury associated with epicardial inflammation; similarly, the PR segment changes are due to an atrial current of injury which, in pericarditis, typically displaces the PR segment upward in lead aVR and downward in most other leads.
Courtesy of Ary Goldberger, MD.
Pericarditis
Treat with aspirin and NSAIDS Some studies suggest use of colchicine
or prednisolone
Valvular disease Systolic murmur in 16-44% of pts Mitral valve involvement is most common
(Mitral regurg) May occur at any time and unrelated to
disease activity Vegetation or thickening more related to
APLS in SLE: Anti-cardiolipin antibody
Libman Sacks endocarditis Libman-sacks endocarditis
Verrucous endocarditis of valve leaflet, papillary muscles and mural endocardium
The verrucae are near the edge of the valve
Consists of immune complexes, mononuclear cells, haematoxylin bodies, fibrin and platelet thrombi
Healing leads to fibrosis, scarring or calcification
Verrucous endocarditis with valvular vegetations (arrows) in a 52-year-old woman with systemic lupus erythematosus who died of pneumonia and chronic interstitial pneumonitis. The vegetations had not been observed by echocardiography, although a cardiac murmur had been heard by auscultation.
Libman Sacks endocarditis Usually aymptomatic If lesions are extensive: can produce
valve deformity – MR/AR Verrucae can fragment and produce
emboli – leading to IE
Coronay artery disease
Role of autoimmunity in atherosclerosis Increase cardiac and cerebrovascular
events in pts with autoimmune diseases (Salmon et al, 2001)
Risk of developing CAD is 4-8 times higher in SLE pts
Consider risk factors
Summary
Generally cardiopulmonary problems associated with SLE respond to treatment
Treatment must be tailored to each patient and problem