Ebola Hemorrhagic Fever

Viral Overview

http://yunus.hacettepe.edu.tr/~coner/VIR/2/Image65.gif

Geographic Range-Zaire Virus- Sudan Virus- Reston Virus- Cote’d Ivoire Virus- Bundibugyo Virus

http://www.topnews.in/files/Ebola%20Virus.jpg

Phylogeny

Outbreak Map

Outbreak HistoryYear Country Subtype Reported

Human CasesReported Deaths

1967 Zaire E. Zaire 318 280 (88%)

1976 Sudan E. Sudan 284 151 (53%)

1994 Gabon E. Zaire 52 31 (60%)

1995 Dem. Rep. of Congo

E. Zaire 315 250 (81%)

2000-2001 Uganda E. Sudan 425 234 (53%)

2002-2003 Dem. Rep. of Congo

E. Zaire 143 129 (89%)

2007 Dem. Rep. of Congo

E. Zaire 264 187 (71%)

Epidemiology

Possible Suspects and Viral Reservoirs

How Does it Infect?

How Does it Infect?

Viral Replication

http://virus.stanford.edu/filo/replication.gif

A little Closer

Immunological Avoidance

Immunological Avoidance

Possible Treatment

Prevention Is the Best Defense