Made by:Roshane Inlayo TanMarjorie Cabalse Cadaon_____________________BS-Pharmacy Students at Urdaneta City University

• OboiManufacturer

• Phil PharmawealthDistributor

• Epinephrine HClContents

ADRENIN•Cardi

ac stimulant in case of collapse, shock & anesth accidents.

•Hemostatic in hemorrhages.

• Prolongs action of infiltration anesth agent.

• Urticaria.

Indications

•IV Adult Severe anaphylactic shock 0.5 mL of 1:1000 soln in 10 mL saline.

•SC Bronchial asthma & bronchospasm 0.3-0.5 mL of 1:1000 dilution.

•Childn10 mcg/kg body wt or 300 mcg/m2 body surface up to 500 mcg/dose, repeated as necessary up to 6 times a day.

Dosage

•Cardiac arrhythmia

• tachycardia >140 bpm

• severe HTN•narrow-angle glaucoma

• anesth with halogenated hydrocarbon of cyclopropane

• with local anesth of finger or toe

• woman in labor•cardiac dilation & coronary insufficiency.

Contraindications

• CV disease• HTN• diabetes• hyperthyroidism & psychoneurosis• Allergy to Na metabisulfite• Pregnancy• Elderly

Special Precautions

• Diphenhydramine• d-chlorpheniramine• other antihistamines

Drug Interactions

• Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Pregnancy Category (US FDA)

•Cardiac Drugs

MIMS Class

•A01AD01 - epinephrine ; Belongs to the class of other agents for local oral treatment.

ATC Classification

•(amp) 1 mL x 100 × 1's

Adrenin inj 1 mg/mL

• MerckManufacturer

• MerckDistributor

• Tab 5 mg: Management of HTN & for prophylaxis of angina.

• Tab 10 mg: Treatment of HTN & myocardial ischemia.Indications

AFORBES

•HTN & angina Usual initial dose: 5 mg once daily. Max: 10 mg.

• Chronic stable/vasospastic angina 5-10 mg.

• Small, fragile, elderly or patients w/ hepatic impairment 2.5 mg once daily.

Dosage

•Known sensitivity to dihydropyridines.

Contraindications

•Patients w/ impaired hepatic & renal function, CHF. Pregnancy & lactation. Elderly.

Special Precautions

•May be taken with or without food.

Administration

• Headache• edema• fatigue• somnolence• nausea• abdominal pain• flushing• palpitation & dizziness.

Adverse Drug Reactions

• Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.Pregn

ancy Category (US FDA)

•Anti-Anginal Drugs

•Calcium Antagonists

MIMS Class

•C08CA01 - amlodipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects.

•Used in the treatment of cardiovascular diseases.

ATC Classification

•Rx

Regulatory Classification

• GlaxoSmithKlineManufacturer

• ZuelligDistributor

•Symptomatic treatment of seasonal•perennial allergic rhinitis including persistent allergic rhinitis•chronic idiopathic urticaria.Indicati

ons

XYZAL

•Adult & childn ≥6 yr 5 mg once daily (1 tab, 10 mL soln or 20 drops).Soln/drops.

• Childn 2-6 yr 2.5 mg (2.5 mL soln or 5 drops bid).

Dosage

•May be taken with or without food: The appropriate vol of oral soln should be measured w/ the syringe & poured in a spoon or diluted in another liqd eg in a glass of water/fruit juice. Diluted soln should be taken immediately.

Administration

•Hypersensitivity to levocetirizine & piperazine derivatives.

•Severe renal impairment (CrCl <10 mL/min).

Contraindications

•Alcohol intake. Predisposing factors of urinary retention (eg spinal cord lesion, prostatic hyperplasia).• Renal & hepatic impairment. May affect ability to drive or operate machinery. Pregnancy & lactation. Infant & childn <2 yr. Tab: Galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.• Childn <6 yr. Soln: Fructose intolerance. Soln/drops: Contains methyl & propyl parahydroxybenzoate causing allergic reactions.Speci

al Precautions

•Headache• somnolence• dry mouth• fatigue.• Soln/drops: Sleep disorders, diarrhea, constipation.Adver

se Drug Reactions

•Small decrease in clearance w/ theophylline. •Increased exposure w/ ritonavir. •CNS effects w/ alcohol & other CNS depressants.Drug I

nteractions

•Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Pregnancy Category (US FDA)

•Antihistamines

•Antiallergics

MIMS Class

•R06AE09 - levocetirizine ; Belongs to the class of piperazine derivatives used as systemic antihistamines.

ATC Classification

Form

Xyzal film-coated tab 5 mg

Xyzal oral drops 5 mg/mL

Xyzal soln 0.5 mg/mL

Photo Packing/Price

30's (P734.20/pack)

10 mL x 1's (P222.40/bottle)

75mL x 1's (P242.60/bottle)

• Management of HTN.Indications

• Adult Initially 250 mg bid-tid for 2 days. Max: 3 g daily. Maintenance: 500 mg-2 g daily.

• Elderly Initially 125 mg bid, may be increased gradually but not >2 g daily.

Dosage•May be taken with or without food.

Administration

•Vamsler

Manufacturer

•Vamsler

Distributor

•Methyldopa sesquihydrate

Contents

DOPARINE

• Active liver disease or depression.Contraindica

tions• Impaired renal or hepatic function; history of hemolytic

anemia; not recommended for pheochromocytoma; +ve direct Coombs' test. May impair ability to drive or operate machinery.

Special Precautions

• Drowsiness; dizziness & lightheadedness associated w/ postural hypotension; fluid retention & edema; bradycardia, syncope, prolonged carotid sinus hypersensitivity. Impaired conc & memory, mild psychoses, depression, disturbed sleep & nightmares, paresthesias, Bell's palsy, involuntary choreoathetotic movements & parkinsonism. GI disturbances eg nausea & vomiting, diarrhea, constipation. Black/sore tongue, inflammation of salivary glands, dry mouth.

Adverse Drug Reactions

•Diuretics, other antihypertensives, drugs w/ hypotensive effects; TCAs, antipsychotics, β-blockers; sympathomimetics, MAOIs, entacapone, general anesth.

Drug Interactions

•Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Pregnancy Category (US FDA)

•Other Antihypertensives

MIMS Class

• C02AB01 - methyldopa (levorotatory) ; Belongs to the class of methyldopa, centrally-acting antiadrenergic agents. Used in the treatment of hypertension.

ATC Classification

• RxRegulatory Classification

Form Photo Packing/Price

Doparine film-coated tab 250 mg

100's

Presentation/Packing

•EnduranceManufacturer

•VispomedDistributor•AmbicaMarketer

•Celecoxib

Contents

•OA 200 mg daily as single or in 2 divided doses. If necessary, may be increased to 200 mg bid. RA 100-200 mg bid. Ankylosing spondylitis Initially 200 mg daily as single or in 2 divided doses. May be increased to 400 mg daily after 6 wk. Pain & dysmenorrhea Initially 400 mg followed by 200 mg if necessary on the 1st day & 200 mg bid thereafter. Adjunctive treatment of adenomatous colorectal polyps 400 mg bid.

Dosage

•May be taken with or without food: Dose for OA/RA may be given w/ or w/o meals, but doses for FAP must be given w/ meals.

Administration

Vicoxiv

• Allergy to NSAIDs. Asthma, CABG surgery.

Contraindications

• History of ischemic heart disease or cerebrovascular disease; significant risk factors for CV or peripheral arterial disease; dehydration. Increased risk of GI adverse events including bleeding, ulceration & perforation of the stomach or intestines. Discontinue use if skin rash & signs of hypersensitivity occur.

Special Precautions

• GI disturbances esp diarrhea. Skin reactions eg exfoliative dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis.

Adverse Drug Reactions

•Decreased absorption w/ antacids or H2-receptor antagonists. Reduced renal excretion w/ probenecid.

Drug Interactions

•Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Pregnancy Category (US FDA)

•Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)

MIMS Class

•DuncanManufacturer

•ZuelligDistributor•GlaxoSmithKlineMarketer

•Cefuroxime axetil

Contents

•Tab Adult Most infections 250 mg bid. UTI 125 mg bid. Mild to moderate lower resp tract infections 250 mg bid. More severe lower resp tract infections or if pneumonia is suspected 500 mg bid. Pyelonephritis 250 mg bid. Uncomplicated gonorrhea 1 g as single dose. Lyme disease Adult & childn >12 yr 500 mg bid for 20 days. Childn Most infections 125 mg bid. Max: 250 mg daily. ≥2 yr w/ otitis media or severe infections 250 mg bid. Max: 500 mg daily. Susp Recommended dose: 10 mg/kg bid. Max: 250 mg daily. Childn 2-12 yr 125 mg bid, 6 mth-2 yr 60-120 mg bid, 3-6 mth 40-60 mg bid. Otitis media/severe infections Recommended dose: 15 mg/kg bid. Max: 500 mg daily. Childn 2-12 yr 180-250 mg bid, 16 mth-2 yr 90-180 mg bid, 3-6 mth 60-90 mg bid.

Dosage

•Should be taken with food: Take immediately after food.

Administration

ZINNAT

• Hypersensitivity to cephalosporins.Contraindica

tions• Hypersensitivity to penicillins & other β-lactams.

Pseudomembranous colitis. Jarisch-Herxheimer reaction. Diabetics & phenylketonurics. Prolonged use. May impair the ability to drive or operate machinery. Pregnancy & lactation.

Special Precautions

• GI disturbances eg diarrhea, nausea, abdominal pain, hypersensitivity reactions. Eosinophilia. Headache & dizziness. Transient increases of hepatic enzyme levels eg ALT (SGPT), AST SGOT), LDH.

Adverse Drug Reactions

•Antacids, OCs.

Drug Interactions

•Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Pregnancy Category (US FDA)

•Cephalosporins

MIMS Class

Form Photo Packing/Price

Zinnat film-coated tab 250 mg

24's (P902.60/box)

Zinnat film-coated tab 500 mg 24's (P1509.09/box)

Zinnat granules for oral susp 125 mg/5 mL

50 mL x 1's (P366.30/bottle)

70 mL x 1's (P453.90/bottle

Zinnat granules for oral susp 250 mg/5 mL

50 mL x 1's (P554.00/bottle)

Presentation/Packing

•PascualManufacturer

•ZuelligDistributor•ADP PharmaMarketer

ANTAMIN•C

hlorphenamine maleate

Contents

•Tab 1 tab 4-6 hrly as needed. Max: 24 mg daily. Syr

• Adult 2 tsp tid.

•Childn >12 yr 1 tsp tid. Inj 1

/3-1 mL IM or SC daily.

Dosage

•May be taken with or without food.

Administration

• Lower resp tract disease. Newborn or premature infants.

Contraindications

• Hypersensitivity. Open- & closed-angle glaucoma. Prostatic enlargement. CV diseases, cardiac arrhythmias, HTN, hyperthyroidism, pheochromocytoma, diabetes. Allergic reactions. Avoid operating vehicles or machinery.

Special Precautions

• Sedation, lassitude, elation or depression, irritability, paranoid psychosis, delusion, hallucination. Muscular weakness, incoordination. GIT disturbances. Headache, tinnitus. Difficulty in micturition. CV effects. Allergic reactions.

Adverse Drug Reactions

•Alcohol, CNS depressants, anticholinergic drugs, MAOIs.

Drug Interactions

•PO: B

Pregnancy Category (US FDA)

•Antihistamines & Antiallergics

MIMS Class

• Packing/PriceForm• (amp) 1 mL x 10 × 1's (P415.00/box)

• (vial) 10 mL x 1's (P269.00/vial)Antamin inj 10 mg/mL

• 60 mL x 1's (P93.00/bottle)Antamin syr 2 mg/5 mL

•100's (P491.00/pack)

Antamin tab 4 mg

Presentation/Packing

•LloydManufacturer

•The Generics PharmacyDistributor•GAMOT PhilsMarketer

•Metformin HCl

Contents

•850-mg tab Initially 500 mg bid-tid or 850 mg once or bid, gradually increased to max of 2 or 3 g daily. 1-g tab 1 tab bid, gradually increased to max of 3 g daily.

Dosage

•Should be taken with food: Take w/ or after meals.

Administration

Glucotin

• IDDM (type 1). Diabetic coma, ketoacidosis, renal impairment, chronic liver disease, heart failure, recent MI, acute or chronic alcoholism, tissue hypoxia lactic acidosis, severe infections, trauma, surgery, dehydration or any other condition likely to predispose to lactic acidosis.

Contraindications

• A10BA02 - metformin ; Belongs to the class of biguanides. Used in the treatment of diabetes.

ATC Classification

• GI disturbances eg anorexia, nausea & vomiting; impaired absorption of various substances including vit B12; metallic taste; lactic acidosis.

Adverse Drug Reactions

•Increased hypoglycemic effects w/ other drugs that lower blood-glucose conc & alcohol. Increased risk of lactic acidosis w/ alcohol.

Drug Interactions

•Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Pregnancy Category (US FDA)

•Antidiabetic Agents

MIMS Class

•ActavisManufacturer

•ZuelligDistributor•PascualMarketer

PACTAL

•Paclitaxel

Contents

•Premed Dexamethasone 20 mg orally 12 & 6 hr before Pactal; diphenhydramine 50 mg or chlorpheniramine 10 mg IV; cimetidine 300 mg or ranitidine 50 mg IV 30-60 min before Pactal. IV infusion Ovarian cancer 1st line: 175 mg/m2 over 3 hr or 135 mg/m2 over 24 hr, doses followed by cisplatin 75 mg/m2 w/ a 3-wk interval between cures. 2nd line: 175 mg/m2over 3 hr w/ a 3-wk interval between cycles. Breast cancer 1st line: When associated w/ trastuzumab, 175 mg/m2 over 3 hr w/ a 3-wk interval between cures, starting on the day following 1st dose of or immediately after 2nd trastuzumab dose. 2nd line: 175 mg/m2 over 3 hr w/ a 3-wk interval between cures. Advanced non-small cell lung carcinoma 175 mg/m2 over 3 hr followed by cisplatin 80 mg/m2 w/ a 3-wk interval between cures.

Dosage

•In combination w/ cisplatin or carboplatin for the treatment of primary ovarian cancer, advanced or metastatic breast cancer & non-small cell lung cancer.

Indications

• Hypersensitivity to paclitaxel or macrogolglycerol 35 ricinoleate (Cremophor EL). Neutrophil count <1,500/mm3 & thrombocyte count <100,000/mm3. Pregnancy & lactation.

Contraindications

• L01CD01 - paclitaxel ; Belongs to the class of plant alkaloids and other natural products, taxanes. Used in the treatment of cancer.

ATC Classification

• Bone marrow suppression; severe neutropenia, thrombocytopenia, anemia; arterial hypotension, bradycardia; alopecia; nausea/vomiting, diarrhea, stomatitis; arthralgia/myalgia; neurotoxicity, hypersensitivity reactions.

Adverse Drug Reactions

•CYP3A4 inhibitors or substrates.

Drug Interactions

•Category D: There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk (e.g., if the drug is needed in a life-threatening situation or for a serious disease for which safer drugs cannot be used or are ineffective).

Pregnancy Category (US FDA)

•Cytotoxic Chemotherapy

MIMS Class

SANDOSTATIN

•Novartis HealthcareManufacturer

•ZuelligDistributor

•Octreotide acetate

Contents

•Acromegaly & gastro-entero-pancreatic endocrine tumors Initially 0.05-0.1 mg SC once or bid; increase gradually up to 0.1-0.2 mg tid, if necessary. AIDS-related refractory diarrhea Initially 0.1 mg SC tid, increasing gradually up to 0.25 mg tid if necessary. Complications following pancreatic surgery 0.1 mg SC tid for 7 consecutive days, starting on the day of op, at least 1 hr before laparotomy. Bleeding gastroesophageal varices 25 mcg/hr for 5 days by continuous IV infusion. Can be used in dilution w/ physiological saline. The soln should reach room temp before SC inj.

Dosage

•Acromegaly in patients inadequately controlled by surgery or radiotherapy or unsuitable for such procedures; in the interim period until radiotherapy becomes fully effective. Relief of symptoms associated w/ functional gastro-entero-pancreatic endocrine tumors eg carcinoid tumors w/ features of carcinoid syndrome, VIPomas, glucagonomas, gastrinomas or Zollinger-Ellison syndrome, insulinomas, GRFomas. Control of refractory diarrhea associated w/ AIDS. Prevention of complications following pancreatic surgery. Emergency management of bleeding of gastroesophageal varices in patients w/ cirrhosis.Click to view Sandostatin detailed prescribing infomation

Indications

• H01CB02 - octreotide ; Belongs to the class of antigrowth hormone. Used in hypothalamic hormone preparations.

ATC Classificati

on

• Crampy abdominal pain, diarrhea, flatulence, constipation, inj site reaction & discomfort at the site of SC inj (pain, rarely, swelling & irritation).

Adverse Drug

Reactions

•Impaired intestinal absorption of ciclosporin, cimetidine; increased bioavailability of bromocriptine. Caution w/ concomitant use of drugs mainly metabolized by CYP3A4 (eg terfenadine) & which have a low therapeutic index.

Drug Interactions

•Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1sttrimester (and there is no evidence of a risk in later trimesters).

Pregnancy Category (US FDA)

•Trophic Hormones & Related Synthetic Drugs / Other Gastrointestinal Drugs

MIMS Class

Form Photo Packing/Price

Sandostatin inj 0.1 mg/mL

(amp) 1 mL x 5 × 1's (P4673.25/box)

Sandostatin inj 0.5 mg/mL

1 mL x 5 × 1's (P20325.05/box)

PresentationPacking

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