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26/07/2017

DRUG STABILITY RESEARCH GROUP 1996 - 2017

PUBLICATIONS NATIONALES ET INTERNATIONALES : 49 POSTERS : 75 ORAL COMMUNICATIONS : 16 PRIX ET NOMINATIONS : : 5

Hecq JD1,2, M Godet1,3, Jamart J1,4, Bihin B 1,4, Galanti L1,3

1Drug Stability Research Group 2Pharmacie hospitalière

3Laboratoire de Chimie Médicale 4Unité de Support Scientifique

CHU UCL Namur - site de Godinne

Avenue Therasse, 1 5530 Yvoir

jean-danie l.hecq@uclouvain.be

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Détail des publications nationales et internationales A Température ambiante : 9 A 5 ± 3 °C : 14 Congélation et décongélation par micro-ondes : 24 Collyres : 1 Solutions orales : 1

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PUBLICATIONS Galanti L., Hecq J.-D., Vanbeckbergen D., Jamart J. Long term stability of cefuroxime and cefazolin sodium in intravenous infusion J. Clin Phar Ther 1996 21 185-189 Galanti L.M., Hecq J.-D., Vanbeckbergen D., Jamart J. Long term stability of vancomycin HCl in intravenous infusions J. Clin Phar Ther 1997 22 353 – 356 Galanti L.M. – Hecq J.-D. – Jeuniau P. – Vanbeckbergen D. – Jamart J. Assessment of the stability of teicoplanin in intravenous infusions Int J Pharm Compound 2001 5 397 – 400 Schlesser V - Hecq J.-D. – Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of cefepime in 5% dextrose infusion P.V.C. bags Int J Pharm Compound 2002 6 391 – 394 Berlage V - Hecq J.-D., Vanbeckbergen D., Jamart J., Galanti L. Long term stability of procaine hydrochloride in cardioplegic infusion p.v.c. bags at 4 C. Pharmakon 2003 35 3 3 – 8 Lebrun J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of tramadol in 5% dextrose infusion P.V.C. bags . Int J Pharm Compound 2004;2:156-159 Hecq JD, Boitquin L, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L. Long term stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion pvc bags at 4°c Pharmakon 2004 36 1 8-14 Boitquin L. - Hecq J.-D. – Evrard J.-M. -Vanbeckbergen D – Jamart J – Galanti L. Long term stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion pvc bags at 4°c J Pain Symptom Manage 2004 28 4 - 6 Boitquin L, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. Stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion after microwave freeze-thaw treatment Ann Pharmacother 2004 38 1836 - 1839

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10 Hecq JD, Berlage V, Vanbeckbergen D, Jamart J, Galanti L. Effects of freezing, long-term storage, and microwave thawing on the stability of piperacillin plus tazobactam in 5 % dextrose for infusion Can J Hosp Pharm 2004;5:276 – 282 Hecq JD – Schlesser V - Vanbeckbergen D – Jamart J – Galanti L Effects of freezing, long-term storage, and microwave thawing on the stability of cefuroxime sodium in 5 % dextrose infusion polyvinyl chloride bags Eur J Hosp Pharm - Science 2005 ;1:23 - 25 Hecq JD - Boitquin LP - Vanbeckbergen DF - Jamart J - Galanti LM. Effect of the Freezing Conditions and Microwave Thawing Power on the Stability of Cefuroxime in Dextrose 5% Infusion Polyolefin Bags at 4 {degrees}C (July/August). Ann Pharmacother. 2005 Jul-Aug;39(7-8):1244-8 Hecq JD - Boitquin LP - Vanbeckbergen DF - Jamart J - Galanti LM. Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Ketorolac Tromethamine Ann Pharmacother 2005;39:1654-1658. DOI 10.1345/aph.1G194 Rodenbach MP, Hecq JD, Vanbeckbergen D, Jamart J, Galanti G . Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Vancomycine Hydrochloride in 5% dextrose infusions Eur J Hosp Pharm - Science 2005 ;11:111-113 Rodenbach MP, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Stability of cefuroxime infusion : the brand-name versus a generic product Eur J Hosp Pharm - Science 2006 ;12 : 16 – 18 Hecq JD, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L Effect of freezing, long term storage and microwave thawing on the stability of ceftriaxone sodium in 5 % dextrose infusion polyolefin bags at 2-8°C Eur J Hosp Pharm - Science 2006 ; 12 : 52 - 56 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of Voriconazole 4 mg/ml in dextrose 5 % polyvinyl chloride bags at 4 °C. Eur J Hosp Pharm - Science 2006 ; 12 : 57 – 59 Hecq JD, Boitquin L, Lebrun C, VanbeckbergenD, Evrard JM, Jamart J, Galanti L Freeze thaw treatment of ketorolac tromethamine in 5% dextrose infusion polyolefine bags: effect of drug concentration and microwave power on the final long-term stability at 4°c Eur J Hosp Pharm - Science 2006 ; 12 : 72 – 75 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of sodium folinate in dextrose 5% polyolefin bags at 4°C J Oncol Pharm Pract 2007 ; 13 : 99 – 103

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20 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J,Galanti L Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate in dextrose 5 % polyolefin bags. EJHP-S 2009 ; 15 (1) : 15- 19 Galanti L, Lebitasy MP, Hecq JD, Vanbeckbergen D, Jamart J Long-term stability of 5-Fluorouracil in 0.9 % sodium chloride after freezing, microwave thawing and refrigeration Can J Hosp Pharm 2009 ; 62 (1) : 34-38 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J,Galanti L Stability of 5-fluorouracil and sodium folinate admixtures in two types of ambulatory infusion system. HPE 2009, 42 :30 – 31 Lebitasy M, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of tramadol hydrochloride and droperidol mixture in 5% dextrose infusion polyolefin bags at 5 ± 3°C Annales Pharmaceutiques Françaises 2009 ;67 : 272 – 277 Lebitasy M, Hecq JD, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, microwave thawing, and long-term storage on the stability of calcium levofolinate in 5% dextrose infusion polyolefin bags J CLIN PHAR THER 2009 ; 34 : 423 – 428 DOI: 10.1111/j.1365-2710.2009.01043.x Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of a tramadol chlorhydrate and alizapride hydrochloride mixture stored in dextrose 5% polyolefin bags at 5 +/- 3°C J Oncol Pharm Pract 2009; 15:195-200

François J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of a Mixture of Diclofenac and Sodium Bicarbonate in Glucose 5% Polyolefin Bags Annales Pharmaceutiques Françaises 2009 ;67 :427-432 Lebitasy M, Ampe E, Hecq JD, Karmani L A, Hanspeler N, Galanti L Ability of deferasirox to bind iron during mesurement of iron Clin Chem Lab Med 2010;48(3):427-429 Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of the hydrochlorides of tramadol and alizapride in dextrose 5% polyolefin bags at 5 +/- 3°C Annales Pharmaceutiques Françaises 2010 ;68 :157 - 162 Rollin C, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Effects of freezing and microwave thawing on the stability an ondansetron / dexamethasone mixture stored in dextrose 5% polyolefin bags. Annals of Pharmacotherapy 2011;45:130 – 131

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30 Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Physico-chemical analysis of several injectable drug in ready-to-use infusion after microwave freeze-thaw treatment and final storage at 5 ± 3 ̊C Annales Pharmaceutiques Françaises 2011 ;69: 270-276 Rolin C, Hecq JD, Vanbeckbergen P, Galanti L Mise au point du dosage de la témocilline par HPLC pour l’étude de la stabilité de poches de perfusions Immunoanalyse et Biologie spécialisée 2011 ;26 :101 Rolin C, Hecq JD, Tulkens P, Vanbeckbergen P, Jamart J, Galanti L Long-term stability of temocillin in dextrose 5% and in sodium chloride 0.9% polyolefin bags at 5 ± 3 °C after freeze-thaw treatment Annales Pharmaceutiques Françaises 2011;69:296-301 Hecq JD, Jamart J, Galanti L Microwave freeze-thaw treatment of dose-banded cytotoxics injectable drugs: A review of the literature from 1980 to 2011 Annales Pharmaceutiques Françaises 2012;70:227-235 Hecq JD, Lewis AL, Vanbeckbergen D, Athanosopoulos A, Galanti L, Jamart J, Czuczman P, Chung T Doxorubicin-loaded drug-eluting beads (DC Bead®) for use in transarterial chemoembolization: A stability assessment J Oncol Pharm Pract 1078155212452765, first published on July 16, 2012 as doi:10.1177/1078155212452765 J-D. Hecq, M. Godet, P. Gillet, J. Jamart, L. Galanti Long-term stability of morphine Hydrochoride in 0.9 % NaCl infusion polyolefin bags after freeze-thaw treatment and in polypropylene syringes at 5°C ± 3°C International Journal of Pharmaceutical compounding 2014 2014;18:78-82

Anrys P, Magnette A, Jamart J, Galanti L, Hecq JD Compatibilité physique d’un mélange d’alizapride et de clorazépate dans des poches souples de 100 ml glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2014 ;96 :38-39 Dewulf J, Galanti L, Godet M, Gillet P, Jamart J, Hecq JD. Long-term stability of acyclovir in 0.9 % NaCl infusion polyolefin bags at 5°C ± 3°C after freeze-thaw treatment: a generic product versus the brand name Annales Pharmaceutiques Françaises 2015 ; 73 : 108 - 113

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Huvelle S, Godet M, Gillet P, Jamart J, Galanti l, Hecq JD Compatibilité physique d’un mélange d’alizapride et de dexamethasone dans des poches souples de 100 ml glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2015 97:38-39 Dewulf J, Hecq JD, Huvelle S, Godet M, Gillet P,Jamart J, Galanti L Long-term Stability of Cocaine Hydrochloride Aqueous Solution 50 mg/mL (5%) at Room Temperature and at 5°C ± 3°C in Glass Bottles. Int J Pharm Compound 2015;19: 268-270 40 Hecq JD, Godet M, Jamart J, Bihin B, Galanti L. Etude systématique de la stabilité chimique à long terme de solutions de médications injectables prêtes à l’emploi produites par une Unité Centrale de Reconstitution d’Injectables Journal de Pharmacie de Belgique 2015 ;97 (3) :36-44 Hecq JD, Godet M, Jamart J, Galanti L. Microwave freeze-thaw technique of injectable drugs.A review from 1980 to 2014. Annales Pharmaceutiques Francaises 2015;73(6): 436 - 441 Hecq JD, Rolin C, Godet M, Gillet P, Jamart J, Galanti LM Long term stability of esomeprazole in 5% dextrose infusion polyolefin bags at 5°C ± 3°C after microwave freeze-thaw treatment Int J Pharm Compound 2015;19(6): 521 – 524 Simar J, Delcave C, Godet M, Decoster C, Gillet P, Bihin B, Jamart J, Galanti LM, Hecq JD Stabilité physique du chlorhydrate d’amiodarone dans des seringues de glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2016 ;98 (1) : 24-25 Huvelle S, Godet M, Hecq JD, Gillet P, Bihin B, Jamart J, Galanti L. Long term stability of Ketamine hydrochloride 50mg/ml injection in 3 ml syringes. Annales Pharmaceutiques Francaises 2016 ;74 :283-287 Huvelle S, Godet M, Hecq JD, Gillet P, Jamart J, Galanti L Long term stability of vancomycin hydrochloride in oral solution: the brand name versus a generic product. Int J Pharm Compound 2016; 20:347-350 Huvelle S, Godet M, Hecq JD, Gillet P, Jamart J, Galanti L. Long term stability of vancomycin hydrochloride in glucose 5% polyolefin bag: the brand name versus a generic product. Int J Pharm Compound 2016; 20:416-420 Closset M, Hecq JD, Gonzalez E , Bihin B , Jamart J , Galanti L. Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes? Eur J Hosp Pharm 2016 doi:10.1136/ejhpharm-2016-00145

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Simar J, Godet M, Hecq JD, Closset M, Gillet P, Langhendries C, Bihin B, Jamart J, Galanti L. Long term stability of dexamethasone and alizapride or ondansetron in sodium chloride 0.9 % polyolefin bag at 5 ± 3°C. Annales Pharmaceutiques Francaises 2016 Doi : 10.1016/j.pharma.2016.07.004 49 Closset M, Hecq JD, Soumoy L, Simar J, Gonzalez E, Charlet L, Declave C, Gillet P, Galanti L. Physical stability of highly concentrated injectable drugs solutions used in intensive care units. Ann Pharm Fr. 2017 Feb 13. pii: S0003-4509(16)30055-4. doi: 10.1016/j.pharma.2016.12.004.

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Détail des publications nationales et internationales A Température ambiante Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J,Galanti L Stability of 5-fluorouracil and sodium folinate admixtures in two types of ambulatory infusion system. HPE 2009, 42 :30 – 31 Lebitasy M, Ampe E, Hecq JD, Karmani L A, Hanspeler N, Galanti L Ability of deferasirox to bind iron during mesurement of iron Clin Chem Lab Med 2010;48(3):427-429 Hecq JD, Lewis AL, Vanbeckbergen D, Athanosopoulos A, Galanti L, Jamart J, Czuczman P, Chung T Doxorubicin-loaded drug-eluting beads (DC Bead®) for use in transarterial chemoembolization: A stability assessment J Oncol Pharm Pract 1078155212452765, first published on July 16, 2012 as doi:10.1177/1078155212452765 Anrys P, Magnette A, Jamart J, Galanti L, Hecq JD Compatibilité physique d’un mélange d’alizapride et de clorazépate dans des poches souples de 100 ml glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2014 ;96 :38-39 Huvelle S, Godet M, Gillet P, Jamart J, Galanti l, Hecq JD Compatibilité physique d’un mélange d’alizapride et de dexamethasone dans des poches souples de 100 ml glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2015 97:38-39 Simar J, Delcave C, Godet M, Decoster C, Gillet P, Bihin B, Jamart J, Galanti LM, Hecq JD Stabilité physique du chlorhydrate d’amiodarone dans des seringues de glucose 5 % pour perfusion Journal de Pharmacie de Belgique 2016 ;98 (1) : 24-25 Huvelle S, Godet M, Hecq JD, Gillet P, Bihin B, Jamart J, Galanti L. Long term stability of Ketamine hydrochloride 50mg/ml injection in 3 ml syringes. Annales Pharmaceutiques Francaises 2016 ;74 :283-287 Closset M, Hecq JD, Gonzalez E , Bihin B , Jamart J , Galanti L. Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes? Eur J Hosp Pharm 2016 doi:10.1136/ejhpharm-2016-00145

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9 Closset M, Hecq JD, Soumoy L, Simar J, Gonzalez E, Charlet L, Declave C, Gillet P, Galanti L. Physical stability of highly concentrated injectable drugs solutions used in intensive care units. Ann Pharm Fr. 2017 Feb 13. pii: S0003-4509(16)30055-4. doi: 10.1016/j.pharma.2016.12.004. [Epub ahead of print]

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A 5±3 °C Galanti L., Hecq J.-D., Vanbeckbergen D., Jamart J. Long term stability of cefuroxime and cefazolin sodium in intravenous infusion J. Clin Phar Ther 1996 21 185-189 Galanti L.M., Hecq J.-D., Vanbeckbergen D., Jamart J. Long term stability of vancomycin HCl in intravenous infusions J. Clin Phar Ther 1997 22 353 – 356 Galanti L.M. – Hecq J.-D. – Jeuniau P. – Vanbeckbergen D. – Jamart J. Assessment of the stability of teicoplanin in intravenous infusions Int J Pharm Compound 2001 5 397 – 400 Berlage V - Hecq J.-D., Vanbeckbergen D., Jamart J., Galanti L. Long term stability of procaine hydrochloride in cardioplegic infusion p.v.c. bags at 4 C. Pharmakon 2003 35 3 3 – 8 Hecq JD, Boitquin L, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L. Long term stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion pvc bags at 4°c Pharmakon 2004 36 1 8-14 Boitquin L. - Hecq J.-D. – Evrard J.-M. -Vanbeckbergen D – Jamart J – Galanti L. Long term stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion pvc bags at 4°c J Pain Symptom Manage 2004 28 4 - 6 Rodenbach MP, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Stability of cefuroxime infusion : the brand-name versus a generic product Eur J Hosp Pharm - Science 2006 ;12 : 16 – 18 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of Voriconazole 4 mg/ml in dextrose 5 % polyvinyl chloride bags at 4 °C. Eur J Hosp Pharm - Science 2006 ; 12 : 57 – 59 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of sodium folinate in dextrose 5% polyolefin bags at 4°C J Oncol Pharm Pract 2007 ; 13 : 99 – 103

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10 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J,Galanti L Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate in dextrose 5 % polyolefin bags. EJHP-S 2009 ; 15 (1) : 15- 19 Lebitasy M, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of tramadol hydrochloride and droperidol mixture in 5% dextrose infusion polyolefin bags at 5 ± 3°C Annales Pharmaceutiques Françaises 2009 ;67 : 272 – 277 Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of a tramadol chlorhydrate and alizapride hydrochloride mixture stored in dextrose 5% polyolefin bags at 5 +/- 3°C J Oncol Pharm Pract 2009; 15:195-200

Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of the hydrochlorides of tramadol and alizapride in dextrose 5% polyolefin bags at 5 +/- 3°C Annales Pharmaceutiques Françaises 2010 ;68 :157 - 162 14 Simar J, Godet M, Hecq JD, Closset M, Gillet P, Langhendries C, Bihin B, Jamart J, Galanti L. Long term stability of dexamethasone and alizapride or ondansetron in sodium chloride 0.9 % polyolefin bag at 5 ± 3°C. Annales Pharmaceutiques Francaises 2016 Doi : 10.1016/j.pharma.2016.07.004

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Congélation et décongélation par micro-ondes Schlesser V - Hecq J.-D. – Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of cefepime in 5% dextrose infusion P.V.C. bags Int J Pharm Compound 2002 6 391 – 394 Lebrun J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of tramadol in 5% dextrose infusion P.V.C. bags . Int J Pharm Compound 2004;2:156-159 Boitquin L, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L. Stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion after microwave freeze-thaw treatment Ann Pharmacother 2004 38 1836 - 1839 Hecq JD, Berlage V, Vanbeckbergen D, Jamart J, Galanti L. Effects of freezing, long-term storage, and microwave thawing on the stability of piperacillin plus tazobactam in 5 % dextrose for infusion Can J Hosp Pharm 2004;5:276 – 282 Hecq JD – Schlesser V - Vanbeckbergen D – Jamart J – Galanti L Effects of freezing, long-term storage, and microwave thawing on the stability of cefuroxime sodium in 5 % dextrose infusion polyvinyl chloride bags Eur J Hosp Pharm - Science 2005 ;1:23 - 25 Hecq JD - Boitquin LP - Vanbeckbergen DF - Jamart J - Galanti LM. Effect of the Freezing Conditions and Microwave Thawing Power on the Stability of Cefuroxime in Dextrose 5% Infusion Polyolefin Bags at 4 {degrees}C (July/August). Ann Pharmacother. 2005 Jul-Aug;39(7-8):1244-8 Hecq JD - Boitquin LP - Vanbeckbergen DF - Jamart J - Galanti LM. Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Ketorolac Tromethamine Ann Pharmacother 2005;39:1654-1658. DOI 10.1345/aph.1G194 Rodenbach MP, Hecq JD, Vanbeckbergen D, Jamart J, Galanti G . Effect of Freezing, Long-Term Storage, and Microwave Thawing on the Stability of Vancomycine Hydrochloride in 5% dextrose infusions Eur J Hosp Pharm - Science 2005 ;11:111-113 Hecq JD, Evrard JM, Vanbeckbergen D, Jamart J, Galanti L Effect of freezing, long term storage and microwave thawing on the stability of ceftriaxone sodium in 5 % dextrose infusion polyolefin bags at 2-8°C Eur J Hosp Pharm - Science 2006 ; 12 : 52 - 56

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10 Hecq JD, Boitquin L, Lebrun C, VanbeckbergenD, Evrard JM, Jamart J, Galanti L Freeze thaw treatment of ketorolac tromethamine in 5% dextrose infusion polyolefine bags: effect of drug concentration and microwave power on the final long-term stability at 4°c Eur J Hosp Pharm - Science 2006 ; 12 : 72 – 75 Cadrobbi J, Hecq JD, Vanbeckbergen D, Jamart J,Galanti L Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate in dextrose 5 % polyolefin bags. EJHP-S 2009 ; 15 (1) : 15- 19 Galanti L, Lebitasy MP, Hecq JD, Vanbeckbergen D, Jamart J Long-term stability of 5-Fluorouracil in 0.9 % sodium chloride after freezing, microwave thawing and refrigeration Can J Hosp Pharm 2009 ; 62 (1) : 34-38 Lebitasy M, Hecq JD, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, microwave thawing, and long-term storage on the stability of calcium levofolinate in 5% dextrose infusion polyolefin bags J CLIN PHAR THER 2009 ; 34 : 423 – 428 DOI: 10.1111/j.1365-2710.2009.01043.x François J, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of a Mixture of Diclofenac and Sodium Bicarbonate in Glucose 5% Polyolefin Bags Annales Pharmaceutiques Françaises 2009 ;67 :427-432 Rollin C, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Effects of freezing and microwave thawing on the stability an ondansetron / dexamethasone mixture stored in dextrose 5% polyolefin bags. Annals of Pharmacotherapy 2011;45:130 – 131 Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Physico-chemical analysis of several injectable drug in ready-to-use infusion after microwave freeze-thaw treatment and final storage at 5 ± 3 ̊C Annales Pharmaceutiques Françaises 2011 ;69: 270-276 Rolin C, Hecq JD, Vanbeckbergen P, Galanti L Mise au point du dosage de la témocilline par HPLC pour l’étude de la stabilité de poches de perfusions Immunoanalyse et Biologie spécialisée 2011 ;26 :101 Rolin C, Hecq JD, Tulkens P, Vanbeckbergen P, Jamart J, Galanti L Long-term stability of temocillin in dextrose 5% and in sodium chloride 0.9% polyolefin bags at 5 ± 3 °C after freeze-thaw treatment Annales Pharmaceutiques Françaises 2011;69:296-301

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Hecq JD, Jamart J, Galanti L Microwave freeze-thaw treatment of dose-banded cytotoxics injectable drugs: A review of the literature from 1980 to 2011 Annales Pharmaceutiques Françaises 2012;70:227-235 20 J-D. Hecq, M. Godet, P. Gillet, J. Jamart, L. Galanti Long-term stability of morphine Hydrochoride in 0.9 % NaCl infusion polyolefin bags after freeze-thaw treatment and in polypropylene syringes at 5°C ± 3°C International Journal of Pharmaceutical compounding 2014 2014;18:78-82

Dewulf J, Galanti L, Godet M, Gillet P, Jamart J, Hecq JD. Long-term stability of acyclovir in 0.9 % NaCl infusion polyolefin bags at 5°C ± 3°C after freeze-thaw treatment: a generic product versus the brand name Annales Pharmaceutiques Françaises 2015 ; 73 : 108 - 113 Hecq JD, Godet M, Jamart J, Bihin B, Galanti L. Etude systématique de la stabilité chimique à long terme de solutions de médications injectables prêtes à l’emploi produites par une Unité Centrale de Reconstitution d’Injectables Journal de Pharmacie de Belgique 2015 ;97 (3) :36-44 Hecq JD, Godet M, Jamart J, Galanti L. Microwave freeze-thaw technique of injectable drugs.A review from 1980 to 2014. Annales Pharmaceutiques Francaises 2015;73(6): 436 - 441 24 Hecq JD, Rolin C, Godet M, Gillet P, Jamart J, Galanti LM Long term stability of esomeprazole in 5% dextrose infusion polyolefin bags at 5°C ± 3°C after microwave freeze-thaw treatment Int J Pharm Compound 2015;19(6): 521 – 524

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Solutions orales Huvelle S, Godet M, Hecq JD, Gillet P, Jamart J, Galanti L Long term stability of vancomycin hydrochloride in oral solution: the brand name versus a generic product. Int J Pharm Compound 2016; 20:347-350

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Collyres Dewulf J, Hecq JD, Huvelle S, Godet M, Gillet P,Jamart J, Galanti L Long-term Stability of Cocaine Hydrochloride Aqueous Solution 50 mg/mL (5%) at Room Temperature and at 5°C ± 3°C in Glass Bottles. Int J Pharm Compound 2015;19: 268-270

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POSTERS Hecq J.-D. – Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of cefepime in 5% dextrose infusion P.V.C. bags 6th Congres of the European Association of Hospital Pharmacists, Amsterdam, 21 – 23/03/2001 Hecq J.-D. – Schlesser V. - Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of cefuroxime in 5% dextrose infusion P.V.C. bags 30th Congrès of the European Society of Clinical Pharmacy, Anvers, 10 – 13/10/2001 Hecq J.-D. – Schlesser V. - Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of piperacillin plus tazobactam in 5% dextrose infusion P.V.C. bags 30th Congrès of the European Society of Clinical Pharmacy , Anvers, 10 – 13/10/2001 Schlesser V. - Hecq J.-D. - Vanbeckbergen D – Jamart J – Galanti L. Implication of the laboratory in stability assessment of drugs in intravenous solution study of three cephalosporins 24th National symposium of the BVBK-SBBC( Société Belge de Biologie Clinique) / BVKV-SBCC ( Société Belge de Chimie Clinique) , Bruxelles, 21/10/2001 Schlesser V. - Hecq J.-D. - Vanbeckbergen D – Jamart J – Galanti L. Interest of stability studies of three cephalosporins in intravenous solution by HPLC 18eme Colloque de la CORATA ( Commission de radioanalyse et techniques associées), Nantes, 24 – 26/10/2001 Hecq J.-D. – Schlesser V. - Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of piperacillin plus tazobactam in 5% dextrose infusion P.V.C. bags 36TH ASHP Midyear Clinical Meeting, New-Orleans, 2 – 6/12/2001 Hecq J.-D. – Lebrun J. - Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of ketorolac tromethamine and tramadol HCl in 5% dextrose infusion 7th Congres of the European Association of Hospital Pharmacists, Vienna 20 – 22/03/2002 Lebrun J. - Hecq J.-D. - Vanbeckbergen D – Jamart J – Galanti L. Effect of freezing, long-term storage and microwave thawing on the stability of ketorolac tromethamine and tramadol HCl in 5% dextrose infusion 54th annual meeting of the American Society of Clinical Chemistry, Orlando, 28/07 – 1808/2002 Hecq J.-D. – Lebrun J. - Vanbeckbergen D – Evrard J.-M. - Jamart J – Galanti L. Long term stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion pvc bags at 4°c 31th Congrès of the European Society of Clinical Pharmacy , Florence, 30/10 – 2/11/2002

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10 Hecq J.-D. – Berlage V - Vanbeckbergen D - Jamart J - Evrard J.-M. - Galanti L. Stability of sufentanil citrate with levobupivacaine HCl in 0,9 % sodium chloride infusion after microwave freeze-thaw treatment 8th Congres of the European Association of Hospital Pharmacists, Florence, 26 – 28/02/2003 Hecq J.-D. – Gillet P. – Bary S – Jacquet S. – Evrard J.-M Ten years of centralised intravenous admixture service ( civas) at the hospital pharmacy of the university hospital of Mont-Godinne 50eme Anniversaire de l’Association Belge des Pharmaciens Hospitaliers, Bruxelles, 10/05/2003 Hecq J.-D. – Berlage V – Vanbeckbergen D. – Jamart J – Galanti L. Utilisation of the freeze-thaw treatment by micro-wave in the development of a centralised intravenous admixture service in an hospital pharmacy 50eme Anniversaire de l’Association Belge des Pharmaciens Hospitaliers, Bruxelles, 10/05/2003 Hecq J.-D., Vanbeckbergen D., Evrard J.-M., Jamart J., Galanti L. Long term stability of procaine hydrochloride in cardioplegic infusion p.v.c. bags at 4 C. 32th Congrès of the European Society of Clinical Pharmacy , Lisbonne, 14 – 16/05/ 2003 Hecq J.-D., Evrard J.-M. , Vanbeckbergen D., Jamart J., Galanti L. Effect of freezing, long term storage and microwave thawing on the stability of ceftriaxone sodium in 5% dextrose infusion 9th Congres of the European Association of Hospital Pharmacists, Séville , 17 - 19/03/2004. Hecq J.-D., Evrard J.-M. , Vanbeckbergen D., Jamart J., Galanti L. Utilisation of the freeze-thaw treatment by microwave in the development of the Centralised IntraVenous Admixture Service of the University Hospital of Mont-Godinne 2nd ACCP - ESCP International Congres on Clinical Pharmacy, Paris, 28 – 30/04/ 2004 Hecq J.-D. Système congélation – décongélation par four à micro-ondes : revue de la littérature 1980 - 2003 Première journée des doctorants en Sciences Pharmaceutiques – Faculté de Médecine – Louvain-en-Woluwe, 24/09/2004 Hecq J.-D., Evrard J.-M. , Vanbeckbergen D., Jamart J., Galanti L. Utilisation of the freeze-thaw treatment by microwave in the development of the Centralised IntraVenous Admixture Service of the University Hospital of Mont-Godinne Première journée des doctorants en Sciences Pharmaceutiques – Faculté de Médecine – Louvain-en-Woluwe, 24/09/2004 Hecq J.-D., Boitquin L. , Vanbeckbergen D., Evrard J.-M. , Jamart J., Galanti L. Effect of the conditions of freezing and the power of microwave thawing on the stability a 4°C of cefuroxime in 5% dextrose infusion polyolefine bags 39th ASHP Midyear Clinical Meeting, Orlando, 5 – 9/12/2004

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J.-D. Hecq, L. Boitquin, C. Lebrun, D.Vanbeckbergen, J.-M. Evrard, J. Jamart, L.Galanti. Freeze thaw treatment of ketorolac tromethamine in 5% dextrose infusion polyolefine bags : effect of drug concentration and microwave power on the final long-term stability at 4°c 10th Congres of the European Association of Hospital Pharmacists, Lisbonne, 16 - 18/03/2005. 20 Hecq J.-D., Gillet P., Lebrun C., Vanbeckbergen D., Jamart J., Galanti L. Long term stability of voriconazole 4 mg/ml in dextrose 5% polyvinyl bags at 4°C. 40th ASHP Midyear Clinical Meeting, Las vegas, 4 – 8/12/2005 Hecq JD, Rodenbach MP, Vanbeckbergen D, Jamart J, Galanti L Long term stability of cefuroxime 1.5 g/100 ml in dextrose 5% polyolefine bags at 4°C: the brand-name drug versus a generic compound. 40th ASHP Midyear Clinical Meeting, Las Vegas, 4 – 8/12/2005 Rodenbach MP, Hecq JD, Jamart J, Galanti L Does freezing followed by microwave-thawing have an impact on water permeation through polyvinylchloride and polyolefin bags ? 11th Congres of the European Association of Hospital Pharmacists, Geneva, Switzerland, 22 - 24/03/2006. Rodenbach MP, Hecq JD, Jamart J, Galanti L Stability of ionic solutions used in hydration schemes of anti-cancer therapy. 11th Congres of the European Association of Hospital Pharmacists, Geneva, Switzerland, 22 - 24/03/2006. Hecq JD, Cadrobbi J, Léonard N, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of sodium folinate in dextrose 5 % polyolefin bags at 4 °C. 41th ASHP Midyear Clinical Meeting, Anaheim, 3 – 7/12/2006 Hecq JD, Evrard JM, Leonard N, Remy G, Pirlot C, Gillet P Système congélation – décongélation par four à micro-ondes : Revue de la littérature 1980 – 2006 . 18eme Journée de l’AFPHB, Jodoigne, 27/02/2007 Prix de l’AFPHB 2007 Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Collaboration between Hospital Pharmacy, Medical Laboratory and Centre of Biostatistics in stability assessment of drugs in intravenous solutions – a ten years experience. 12th Congres of the European Association of Hospital Pharmacists, Bordeaux, France, 21 – 23/03/2007. Hecq JD, Cadrobbi J, Vanbeckbergen D, Jamart J, Galanti L Effect of freezing, long-term storage and microwave thawing on the stability of sodium folinate in dextrose 5 % polyolefin bags. 12th Congres of the European Association of Hospital Pharmacists, Bordeaux, France, 21 – 23/03/2007. Hecq JD, Cadrobbi J, Gillet P, Leonard N, Vanbeckbergen D, Jamart J, Galanti L Stability of 5-fluorouracil and sodium folinate solutions in ambulatory infusion systems. 7TH ESCP Spring conference on Clinical Pharmacy, Edinburgh, UK, 16 – 19/05/2007

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Athanasopoulos A, Hecq JD, Vanbeckbergen D, Jamart J, Galanti L HPLC study of stability metoclopramide-tramadol mixture for infusion at 4°C 31st International Symposium on High Performance Liquid Phase Separations and Related Techniques, Ghent, Belgium, 17 – 21 june 2007. 30 Hecq JD, Athanasopoulos , Vanbeckbergen D, Jamar J, Galanti L Long-term stability of a tramadol chlorhydrate and metoclopramide hydrochloride mixture stored in dextrose 5% polyolefin bags at 4°C. 42th ASHP Midyear Clinical Meeting, Las Vegas, USA, 2-6/12/2007 Hecq JD, Galanti L Microwave freeze-thaw treatment of injectable drugs : a review of the literature from 1980 to 2007. 13th Congres of the European Association of Hospital Pharmacists, Maastricht, The Netherlands, 27 – 29/02/2008 Hecq JD, Gillet P, Bary M ,Léonard N, Pirlot C, Evrard JM Fifteen Years of Centralised Intravenous Admixture Service (CIVAS) at the Hospital Pharmacy of the University Hospital of Mont-Godinne 13th Congres of the European Association of Hospital Pharmacists, Maastricht, The Netherlands, 27 – 29/02/2008 Hecq JD, Lebitasy MP, Cadrobbi J, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L Stability of frozen thawed 5-FU solutions stored 28 days at 4°C for dose banding purposes ESCP International Workshop, The oncological patient and the clinical pharmacist, Leuven, Belgium, 26 – 28/05/2008 Hecq JD, Lebitasy P, Vanbeckbergen D, Jamart J, Galanti L Etude de la stabilité à long terme de médications injectables : bilan de 12 ans de collaboration entre la Pharmacie Hospitalière, le Laboratoire de chimie médicale et le centre de biostatistique. 20eme Journée de l’AFPHB, Genval, 03/2009 Hecq JD, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of tramadol chlorhydrate perfusion in combination with anti-nausea drugs stored in dextrose 5% polyolefin bags at 5 ±3°C 20eme Journée de l’AFPHB, Genval, 03/2009 Hecq JD,Athanasopoulos A, Vanbeckbergen D, Jamart J, Galanti. L Long-term stability of a tramadol chlorhydrate and alizapride hydrochloride mixture stored in dextrose 5% polyolefin bags at 5 +/- 3°C. 14th EAHP Congress – Barcelona, Spain - 25 - 27 March 2009 Hecq JD, Lebitasy P, Vanbeckbergen D, Jamart J, Galanti L Long-term stability of a tramadol hydrochoride and droperidol mixture stored in dextrose 5% polyolefin bags at 5 +/- 3°C. 14th EAHP Congress – Barcelona, Spain - 25 - 27 March 2009

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Hecq JD, Lebitasy P, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, microwave thawing, and long-term storage on the stability of calcium levofolinate in 5% dextrose infusion polyolefin bags 14th EAHP Congress – Barcelona, Spain - 25 - 27 March 2009 Hecq JD, François J, Vanbeckbergen D, Jamart J, Galanti L Effect of Freezing, Long-Term Storage and Microwave Thawing on the Stability of a Mixture of Diclofenac and Sodium Bicarbonate in Glucose 5% Polyolefin Bags 44th ASHP Midyear Clinical Meeting, Las Vegas, USA, 6-10/12/2009 40 J.-D. Hecq, D. Vanbeckbergen, J. Jamart, L Galanti Multidisciplinary collaboration between hospital and university departments in stability assessment of drugs in intravenous solutions 15th EAHP Congress – Nice, France - March 2010 J.-D. Hecq, D. Vanbeckbergen, J. Jamart, L Galanti Effects of freezing and microwave thawing on the stability an ondansetron / dexamethasone mixture stored in dextrose 5% polyolefin bags. 15th EAHP Congress – Nice, France - March 2010 Multidisciplinary collaboration between hospital and university departments in stability assessment of drugs in intravenous solutions Hecq JD, Vanbeckbergen D, Jamart J, Galanti L 22eme Journée de l’AFPHB, La Hulpe (Bruxelles), 26/02/2011 JD Hecq, C Rollin, D Vanbeckbergen, J Jamart, L Galanti Long-term stability of esomeprazole in dextrose 5% polyolefin bags at 5 ± 3°C after freeze thaw treatment 16th EAHP Congress – Vienna, Austria - March 2011 JD Hecq, C Rollin, D Vanbeckbergen, J Jamart, L Galanti Long-term stability of temocillin in dextrose 5% and in sodium chloride 0.9% polyolefin bags at 5±3°C after freeze thaw treatment. 16th EAHP Congress – Vienna, Austria - March 2011 J.-D. Hecq , J Jamart, L Galanti Microwave freeze-thaw treatment of cytotoxic and hazardous injectable drugs: a review of the literature from 1980 to 2011 17th EAHP Congress – Milano, Italy - March 2012 JD Hecq, M Godet, J Jamart, L Galanti Long-term stability of morphine in 0.9% NaCl infusion 17th EAHP Congress – Milano, Italy - March 2012 Anrys P, Magnette A, Jamart J, Galanti L, Hecq JD Evaluation of the physical stability of a mixture of clorazepate and alizapride in dextrose 5 % polyolefin bag at room temperature : 24eme Journée de l’AFPHB, La Hulpe (Bruxelles), 02/03/2013

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Hecq JD, Godet M, Jamart J, Galanti M Results of a systematic long-term stability study for ready-to-use injectable drugs produced by a Centralized intravenous Admixture Service. 18th EAHP Congress – Paris, France – 13 – 15 March 2013 50 Hecq J.-D, Dewulf J. Godet M., Gillet P., Jamart J., Galanti L. Long term stability of acyclovir infusion: the brand name versus a generic product. 44th ASHP Midyear Clinical Meeting, Orlando, USA, 8-12/12/2013 Hecq JD, Huvelle S, Godet M, Gillet P, Jamart J, Galanti L

Etude de la stabilité à long terme de perfusions de vancomycine : générique versus princeps Hopipharm, 1er congrès francophone de pharmacie hospitalière, La Rochelle, 14 – 16 mai 2014 Hecq JD, Huvelle S, Godet M, Gillet P, Jamart J, Galanti L Etude de la stabilité à long terme de solutions orales de vancomycine : générique versus princeps Hopipharm, 1er congrès francophone de pharmacie hospitalière, La Rochelle, 14 – 16 mai 2014 Huvelle S, Godet M, Galanti L Validation of a novel UPLC method for a rapid quantification of Ketamine hydrochloride in solutions for injection 30th International Symposium on Chromatography in Salzburg from 14th - 18th September 2014. Huvelle S, Godet M, Hecq JD, Gillet P, Jamart J, Galanti L Long term stability of Ketamine hydrochloride injection in 1ml syringes 30th International Symposium on Chromatography in Salzburg from 14th - 18th September 2014. Dewulf J, Galanti L , Godet M, Gillet P, Jamart J, Hecq JD. Long-term stability of acyclovir in 0.9 % NaCl infusion polyolefin bags at 5°C ± 3°C after freeze-thaw treatment : a generic product versus the brand name 26eme Journée de l’AFPHB, La Hulpe (Bruxelles), 7/03/2015 Hecq JD, Huvelle S,Godet M, Jamart J, Galanti L Results of a systematic long-term stability study for ready-to-use injectable drugs produced by a Centralized intravenous Admixture Service. 26eme Journée de l’AFPHB, La Hulpe (Bruxelles), 7/03/2015 Huvelle S, Godet M, Gillet P, Jamart J, Galanti, Hecq JD. Evaluation of the physical stability of a mixture of dexamethasone and alizapride in 0.9% NaCl polyolefin bag at room temperature. 26eme Journée de l’AFPHB, La Hulpe (Bruxelles), 7/03/2015

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Hecq JD, Closset M, Soumoy L, Gonzalez E, Tondu A, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of isosorbide dinitrate in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Closset M, Soumoy L, Gonzalez E, Matagne L, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of noradrenalin (0.120mg/ml) in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 60 Hecq JD, Closset M, Soumoy L, Gonzalez E, Matagne L, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of noradrenalin (0.240mg/ml) in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Closset M, Soumoy L, Gonzalez E, Tondu A, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of lorazepam in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Closset M, Soumoy L, Gonzalez E, Charlet L, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of sodium valproate in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Closset M, Soumoy L, Gonzalez E, Tondu A, Gillet P, Bihin B, Jamart J, Galanti L. Evaluation of the physical stability of salbultamol in 0.9% sodium chloride polypropylene syringes at room temperature 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Simar J, Godet M, Jamart J, Bihin B, Galanti L. Results of a systematic long-term stability study for ready-to-use injectable drugs produced by a Centralized intravenous Admixture Service. 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Simar J, Godet M, Bihin B, Jamart J, Gillet P, Langhendries Cl, Galanti L. Long term stability of dexamethasone and alizapride in sodium chloride 0.9% polyolefin bag at 5 ± 3°C. 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Simar J, Godet M, Bihin B, Jamart J, Gillet P, Langhendries Cl, Galanti LM. Long term stability of dexamethasone and ondansetron in sodium chloride 0.9% polyolefin bag at 5 ± 3°C 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016

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Hecq JD , Closset M, Gonzalez E , Bihin B, Jamart J, Galanti L. Does an interaction exist between ketamine hydrochloride and Becton Dickinson syringes? 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Godet M, Simar J , Braibant M, Soumoy L, Gillet P, Jamart J, Bihin B, Galanti L Stability of concentrated solution of vancomycine hydrochloride in syringes for ICU 27eme Journée de l’AFPHB, La Hulpe (Bruxelles), 5/03/2016 Hecq JD, Simar J, Delcave Ch , Godet M, Decoster C , Gillet P, Bihin B, Jamart J, Galanti L. The physical stability of injectable drugs must be proved to ensure patient’s safety. 21th EAHP Congress Vienna 16 – 18 March 2016 70 Godet M, Huvelle S, Galanti L , Bihin B, Jamart J, Hecq JD. Long-term stability of a generic product of Piperacilline / Tazobactam in glucose 5% infusion polyolefin bags at 5°C ± 3°C after microwave freeze-thaw treatment. 21th EAHP Congress Vienna 16 – 18 March 2016 J-D. Hecq1,4J Simar2, M. Godet2,4, P. Gillet1, Langhendries Cl1, B. Bihin3 J. Jamart3, L. Galanti Stabilité à long terme de la dexamethasone en association avec de l’alizapride ou de l’ondansetron dans une solution de chlorure de sodium 0,9 % conservée dans une poche de polyoléfine à 5 ± 3 °C. Hopipharm 2016, Mai 2016, Clermont-Ferrand Hecq JD, Closset M, Simar J, Godet M, Gonzalez E, Delcave C, Soumoy L, Gillet P, Bihin B, Jamart J, Galanti L Evaluation préalable de la stabilité physique de principes actifs en solutions concentrées pour utilisation en unités de soins intensifs Hopipharm 2016, Mai 2016, Clermont-Ferrand Hecq JD, Closset M, Onorati S, Bihin B, Decoster C, Docquier M , Gillet P, Galanti L Long-term stability of 5-Fluorouracil at standardized rounded doses in sodium chloride infusion polyolefin bags, stored at room temperature. 22th EAHP Congress Cannes 22 - 24 March 2017 & 28eme Journée de l’AFPHB, Mons, 18/02/2017 Hecq JD, Closset M, Onorati S, Bihin B, Decoster C, Gillet , P Gillard F, Tondu A, Galanti L Long-term stability of 5-Fluorouracile at standardized rounded doses (SRD) in two types of portable infusion devices. 22th EAHP Congress Cannes 22 - 24 March 2017 & 28eme Journée de l’AFPHB, Mons, 18/02/2017

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75 Hecq JD, Closset M, Godet M, Jamart J, Bihin B, Galanti L Results of a systematic long-term stability study for ready-to-use injectable drugs produced by a Centralized intravenous Admixture Service. 28eme Journée de l’AFPHB, Mons, 18/02/2017

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ORAL COMMUNICATIONS Hecq JD, Cadrobbi J, Gillet P, Leonard N, Vanbeckbergen D, Jamart J, Galanti L Stability of 5-fluorouracil and sodium folinate solutions in ambulatory infusion systems. 7TH ESCP Spring conference on Clinical Pharmacy, Edinburgh, UK, 16 – 19/05/2007 Analyse physico-chimique de différentes molécules injectables en perfusion prêtes à l’emploi après congélation, décongélation par micro-ondes et stockage final à 5 ± 3 °C Académie Nationale de Pharmacie. 6 avril 2011.Paris, France Dewulf J, Galanti L , Godet M, Gillet P, Jamart J, Hecq JD. Long-term stability of acyclovir in 0.9 % NaCl infusion polyolefin bags at 5°C ± 3°C after freeze-thaw treatment : a generic product versus the brand name Hopipharm, 1er congrès francophone de pharmacie hospitalière, La Rochelle, 14 – 16 mai 2014 Godet M, Huvelle S, Hecq JD, Bihin B, Jamart J, Galanti LM Long-term stability of a generic product of Piperacilline / Tazobactam in dextrose 5% infusion polyolefin bags at 5°C ± 3°C after microwave freeze-thaw treatment. 18th Forum of Pharmaceutical Sciences, 28 may 2015, Blankenberge, Belgium Hecq JD 20 ans du DSRG Symposium « Vers une centralisation accrue de la préparation des injectables » CHU Dinant-Godinne, Yvoir, 09/10/2015 Galanti L, Godet M Quand le laboratoire de chimie rencontre la pharmacie Symposium « Vers une centralisation accrue de la préparation des injectables » CHU Dinant-Godinne, Yvoir, 09/10/2015 Jamart J, Bihin B . L’analyse statistique des études de stabilité des médicaments injectables Symposium « Vers une centralisation accrue de la préparation des injectables » CHU Dinant-Godinne, Yvoir, 09/10/2015 Hecq JD Reconstitution des injectables : du manuel à l’automatique Symposium « Vers une centralisation accrue de la préparation des injectables » CHU Dinant-Godinne, Yvoir, 09/10/2015 Hecq J-D, Godet M, Jamart J, Bihin B, Galanti L Etude systématique de la stabilité chimique à long terme de solutions de médications injectables prêtes à l’emploi produites par une Unité Centrale de Reconstitution d’Injectables Hopipharm 2016, Mai 2016, Clermont-Ferrand

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Hecq JD Préparations injectables en poches prêtes à l’emploi (congelées) Hopipharm 2016, 18 – 20 Mai 2016, Clermont-Ferrand Hecq JD Introduction Symposium «Vers une centralisation accrue et automatisée de la préparation des injectables» CHU UCL Namur, Yvoir, 14/10/2016 Galanti L Analyse chimique : UPLC vs HPLC Symposium «Vers une centralisation accrue et automatisée de la préparation des injectables» CHU UCL Namur, Yvoir, 14/10/2016 Bihin B Nouvelle définition statistique de la stabilité chimique adaptée aux injectables Symposium «Vers une centralisation accrue et automatisée de la préparation des injectables» CHU UCL Namur, Yvoir, 14/10/2016 Hecq JD Automatisation des reconstitutions : nouveaux automates. Symposium «Vers une centralisation accrue et automatisée de la préparation des injectables» CHU UCL Namur, Yvoir, 14/10/2016 Bihin B New statistical definition for stability studies of injectable drugs International symposium on infusion technologies. Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille, Droit et Santé, Lille (Fr), 10/11/2016 16 Hecq JD Technologies and infused stability International symposium on infusion technologies. Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille, Droit et Santé, Lille (Fr), 10/11/2016

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PRIX, NOMINATIONS

Prix AMGEN 2005 J.-D. Hecq Stabilité des médicaments injectables en perfusion édition 2005 16eme Journée de l’AFPHB ,Genval, 19/02/2005 Prix de l’AFPHB 2007 Hecq JD, Evrard JM, Leonard N, Remy G, Pirlot C, Gillet P Système congélation – décongélation par four à micro-ondes : Revue de la littérature 1980 – 2006 . 18eme Journée de l’AFPHB, Jodoigne, 27/02/2007 Prix de la Belgian Society of Clinical Biology 2008 Lebitassy M, Ampe E, Hecq JD, Karmani L, Hanspeter N, Galanti M Iron dosage and chelation therapy : the news about deferasirox. Belgian Society of Clinical Biology, 4th October 2008, Leuven, Belgium 2009 Third Prize Poster Award EAHP J.D. Hecq, M. Lebitasy, A. Athanassopoulos, D. Vanbeckbergen, J. Jamart, L. Galant2. Effect of Freezing, microwave thawing, and long-term storage on the stability of calcium levofolinate in 5% dextrose infusion polyolefin bags 14th EAHP Congress – Barcelona, Spain - 25 - 27 March 2009

Classement mondial et européen 2017 du Drug Stability Research Group Classement mondial, en terme de nombre de publications, des équipes de recherche se consacrant à la stabilité physico-chimique à long terme des injectables prêts à administrer en milieu hospitalier

• 6eme place, derrière 4 équipes américaines et une canadienne, au niveau mondial • 1er place au niveau européen, devant le Centre universitaire Gutenberg à Mayence et

l’Hôpital Mondor à Paris http://www.stabilis.org/EquipesRecherche.php?liste=1&sortBy=references&sortOrder=DESC Carte d’identité de notre équipe de recherche. http://www.stabilis.org/EquipesRecherche.php?idEquipe=38

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Collaborateurs temporaires

Ampe E

Anrys P

Athanasopoulos A

Bary M

Berlage V

Boitquin L

Cadrobbi J

Closset Mélanie

Dewulf J

Evrard JM

Francois J

Gillet P

Huvelle S

Jacquet S

Jeuniau P

Lebitassy MP

Lebrun C

Lebrun J

Leonard N

Magnette A

Pirlot C

Rodenbach MP

Rollin C

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Schlesser V

Simar J

Tulkens PM