dr. salwa tayel, dr. a. almazam , dr afzal mahmood
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Dr. Salwa Tayel, Dr. A. Almazam , Dr Afzal Mahmood KSU, Department of Family & Community Medicine (November, 2013). TUTORIAL SCREENING . Calculating sensitivity and specificity of a screening test . Calculating sensitivity and specificity of a screening test . Sensitivity = 95% - PowerPoint PPT PresentationTRANSCRIPT
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Dr. Salwa Tayel, Dr. A. Almazam, Dr Afzal MahmoodKSU, Department of Family & Community Medicine
(November, 2013)
TUTORIALSCREENING
November 26, 2013 1
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2November 26, 2013
Calculating sensitivity and specificity of a screening test
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Sensitivity = 95%
Specificity =95%
November 26, 2013
Calculating sensitivity and specificity of a screening test
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Calculating sensitivity and specificity of a screening test
November 26, 2013
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Sensitivity = [a/(a+c)] X 100 = 95%What is the meaning of this result?
Specificity = [d/(b+d)] X 100 = 95%What is the meaning of this result?
Calculating sensitivity and specificity of a screening test
November 26, 2013
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Sensitivity: a / (a + c)Sensitivity = 95%
i.e. Screening test will correctly identify 95% of all true cases.
Specificity: d / (b + d)Specificity = 95%
i.e. Screening test will correctly classify 95% of all non-cases as being disease free.
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How to interpret results
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7November 26, 2013
Calculating PPV and NPV
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P.P.V. = a/(a+b) = 19/(19+99) =16%What is the meaning of this result?
N.P.V. = d/(c+d) = 1881/(1881+1)=99.99%What is the meaning of this result?
8November 26, 2013
Calculating PPV and NPV
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How to interpret results
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• P.P.V. = a/(a+b) = 19/(19+99) =16%• Among persons who screen positive, 16% are found
to have the disease.
• N.P.V. = d/(c+d) = 1881/(1881+1)=99.99%• Among persons who screen negative, 99.9% are
found to be disease free.
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10November 26, 2013
Calculating the PPV/NPV of a screening test
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P.P.V. = 57/59=96.6%
N.P.V. = 38/41=93%11November 26, 2013
Calculating the PPV/NPV of a screening test
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Comparison of mammography results with findings from surgical excisional biopsies in women without palpable breast masses
TotalGold standard
)Surgical biopsy( Screening test (Mammography)No cancer Cancer
65 49 16 Positive
935 931 4Negative
1000 980 20 Total
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Comparison of mammography results with findings from surgical excisional biopsies in women without palpable breast masses
TotalGold standard
)Surgical biopsy( Screening test (Mammography)No cancer Cancer
TP+FP65
FP49
TP16
Positive
FN+TN935
TN931
FN4
Negative
1000 FP+TN980
TP+FN20
Total
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November 26, 2013 14
Calculate:• Sensitivity • Specificity • Positive Predictive Value • Negative Predictive Value • False Positive rate • False Negative rate • Disease prevalence
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Following is a diagram that may help you to remember how to calculate sensitivity, specificity and the predictive values.
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Calculations:
• Sensitivity: 16/20*100 = 80%• Specificity: 931/980*100 = 95%• PPV: 16/65*100 = 24.6%• PNV: 931/935*100 = 99.6%• False Positive rate = 49/980*100 = 5%• False Negative rate = 4/20*100=20%• Disease prevalence 20/1000*100=2%
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• Effectiveness of the Screening Program
• DISCUSS: The factors that influence effectiveness of Screening and Screening Programs
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DISCUSSION
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factors that influence effectiveness of Screening and Screening Programs1. Accurate2. Simple easy to implement Screening3. Inexpensive4. Acceptable to those who agree to be tested5. Safe
6. The disease is of public health significance1. High Prevalence (see the next slide for relationship
between prevalence and predictive value of screening)2. Significant in terms of morbidity, mortality, disability,
cost to the community
7. Availability of effective treatment 8. Health system capable of providing services to allNovember 26, 2013 18
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Prevalence (%) Sensitivity Specificity PPV
0.1 90% 95% 1.8%
1.0 90% 95% 15.4%
5.0 90% 95% 48.6%
50.0 90% 95% 94.7%
Factors affecting the PPV/NPV of a screening test
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