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Top Takeaways: #285 How Antibiotics Kill Off Your Mitochondria and The Latest In Mitochondrial Medicine and Clinical Trials with Dr. Michael Kucera

1. Dr. Kucera for the past 30 years has been a pioneer in Mitochondrial Medicine and has

worked with the Russian Space Agency and Mars 500 project for the past 20 years. Dr Kucera is responsible for the health and wellbeing of the cosmonauts. During this research in Russian Space Medicine, he evaluated and compared the amount mitochondrial damage caused by intense stressors of space travel with the mitochondrial damage caused by normal environmental stressors impacting the general population.

2. With the results from this Russian Space Medicine Research, Dr. Kucera began to develop nutritional formulations that were designed to repair, power, and protect mitochondria, which would help to prevent and even reversing disease.

3. One of the major discoveries during the Mars 500 Project was that cosmonauts would have to endure severe mitochondrial and receptor damage due to the intense cosmic radiation of space. On a 2 year journey to Mars and back the cosmonauts would age on the average of 16 to 20 years because of intense cosmic radiation.

4. Dr. Kucera and his team developed nutritional formulations that that could be used by the cosmonauts, and the normal population, to massively repair mitochondrial and receptor damage in the body.

5. Dr. Kucera will perform heart rate variability HRV tests in his patients to test their mitochondrial power and if there is sufficient mitochondrial power to adapt to stress. Dr Kucera uses this test as a baseline to measure how the mitochondria are functioning.

6. After using the HRV test as a baseline, Dr. Kucera will provide his patients with the Mitochondrial RX formulations that are designed to Repair, Power Up and Protect existing mitochondria. Dr Kucera then will retest the patient at the 30 and/or 60 day mark using a heart rate variability HRV testing to quantify the results. The results are always remarkable increases in mitochondrial functioning.

7. One of the biggest hurtles to over come with the development of these formulations was making sure there was enough mitochondrial energy to support the repairing benefits provided by carnosine in the cell.

8. Dr. Kucera’s Mitochondrial Nutrition System consists of 3 Mitochondrial RX formulations that are to be used together, which includes REPAIR (main ingredient is carnosine), POWER (main ingredient is Coenzyme Q10), and CALM (main ingredient is a flavonoids).

9. These three formulations work synergistically together to provide each of their primary

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functions. 10. Dr Kucera’s proprietary process developed in over 15 years of research, potentizes the

carnosine, CoQ10, flavonoids and other ingredients, providing maximum absorptions, efficacy, and benefits to the highest level. Something that regular off the shelf brands cannot provide.

11. The proprietary process for increasing the potency of carnosine and other ingredients in the formulas is what sets these supplements apart from those that you can find at any generic pharmacy.

12. This patented formula has proprietary potency that makes it very effective and why it was used for the Mars 500 project and Russian cosmonauts.

13. The longer you use the supplements the better the regenerating, healing, and antiaging benefits become, where in 2 years of use, it will turn your biological clocks back 10 – 15 years.

14. The carnosine in the supplements has had a great impact on children with autism, with even a case of a 14 year old boy who was unable to speak, starting to speak normally after a year of supplementation.

15. 85 to 90% of autistic children who used Dr. Kucera’s supplements have seen positive improvements.

16. The Mitochondria RX formulations improve the process that repairs mutations in cells back to healthy cells, as well as improving immune system function, both helping to prevent cancer as well as fights it during cancer treatments.

17. Another preventative measure of the supplements is preventing damage to healthy cells. When mitochondria don’t work in cancer cells, the cancer cell becomes immortal, but when there is mitochondria function, cancer cells can actually be killed off.

18. The succinate in the supplements are also able to prevent cancer cells from developing resistance to cancer treatments like chemotherapy.

19. Cancer patients using Mitochondria RX supplements have had a 75 to 80% remission rate.

20. Because the Mitochondrial RX Formulation provide maximum mitochondrial power to help the body to adapt to environmental stressor (instead of being overwhelmed by them) , provide proper regulation and balance of the autonomic nervous system between sympathetic to parasympathetic, as well as improve cellular energy, cellular repair, cellular protection, improved energy reserves, allowing for deeper restful and regenerating sleep, it is extremely efficient in helping people prevent and recover from disease and injury.

21. The Mitochondrial RX formulations are designed to repair receptor damage on all organs, glands, and systems. Because of the improved communication, Dr Kucera has seen a reversal in degenerative diseases such as hyper or hypothyroidism, adrenal fatigue, diabetes, hypoglycemia, autoimmune conditions, hormonal issues, infertility, the immune system, etc

22. The Mitochondria RX Formulations are also great at preventing and reversing heart disease and facilitating detoxification. Carnosine is one of the very best heavy metal binders.

23. To purchase Mitochondria RX Formulations, go to MitochondrialWellness.com

Wendy Myers: Welcome to the Myers detox podcast. My name is Wendy Myers, and on this show we explored topics related to heavy metal detoxification, detox protocols, and supplements. We also talk about bio-hacking techniques

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and supplements like today's show about mitochondrial supplements, specifically mitochondrial RX supplements that I've been taking for about six months, and they were developed by today's guest, Dr. Michael Kucera. And he spent 15 years doing research and trials to bring these supplements to market for the Mars 500 space project from the Russian cosmonauts and they were developed for Russian cosmonauts, who were you know, needing to recover from mitochondrial damage or radiation damage from spaceflight, and these revolutions supplements helped the space crew improve their performance, and their health, and recover from spaceflight. But they can help the average everyday person improve their body's functioning. And he has some amazing research, some amazing trials that have been done on fertility, on cancer, on autism with astounding results.

Wendy Myers: And just based on the way I feel those results speak for themselves. I'm just amazed at how much better I feel, how much my mood is improved, my energy levels, and I just feel like I'm functioning better on every level. And every client I've introduced these supplements to absolutely loves them, and they give people the energy they need, not only for healing, but also to detox. So really, really interesting concepts and information we're covering today on the show. Any of you listening are looking to detox heavy metals, or curious about learning about how to detox the best way to go about it. But I assure you, you do have heavy metals in your body affecting your brain functioning, affecting your energy levels, affecting your performance, and your moods. And this is my message on this show that I want to deliver to millions of people and I created a quiz. It's called the HeavyMetalsQuiz.com to look at some of your lifestyle factors, and based on that determine the levels of heavy metals that you may have in your body, and then give you some tips and tricks, and videos following taking the quiz about what the next steps are.

Wendy Myers: So take two seconds to take this quiz at heavymetalsquiz.com. Yesterday... Dr. Michael Kucera MD is an internationally renowned medical doctor who specializes in mitochondrial and anti-aging medicine, the only check MD, who has worked at NASA to train astronauts for flights to Mars. Dr. Kucera is dedicated to detecting, improving, and restoring the state of the health of the human body. He aims to improve the function of the autonomic nervous system in order to maintain an ideal internal environment and improve individual capacity to respond, and adapt to internal and external stressors of all kinds. Dr. Kucera uses mitochondrial medicine to improve loss or reduced autonomic nervous system regulatory ability and performance, his pioneering work has effectively improved the health status of patients with various chronic degenerative diseases associated with the aging process, which include cardiovascular disease, type 2 diabetes, joint and spine degeneration, Alzheimer's disease, Parkinson's disease, cataracts, glaucoma and more. And you can learn more about Dr. Michael Kucera and his revolutionary mitochondrial RX supplements at my... Dr. Kucera, thank you so much for coming on the show.

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Dr. Kucera: Yeah, thank you. Thank you. I'm very happy with it.

Wendy Myers: So you are one of the world's foremost experts on mitochondrial medicine, and in your opinion, Dr. Kucera what do you think is the number one contributing factor to people's health issues today and disease, and why so many people that are ill are not getting better?

Dr. Kucera: This is something that is necessary to see in big complex, it is a great complex of problems, which are negatively influencing our lives and on the base of research in space medicine it was the program Mars 500. But it's not only concerning this program, it's not concerning only the space crew and this very well known experiment where it was around more than 500 days they were closed in the capsule imitating the flight to Mars, but in parallel it was development, and Professor Baevsky was the leader of this, but it's project Mars parallel, and it was the same research on the normal population how is influencing stress situations to the population? How negative stress is influencing the development of health issues, aging processes, etc etc, and these results were compared together with the results from the space crew experiment project Mars 500.

Dr. Kucera: And the goal was to compare the normal life of the normal population working, living, and... I don't know what in normal life comparing with extreme stress in the space crew, and one of the goal was to compare how high the stress is influencing the space crew and how high the stress is influencing the normal population. And one of the goals was the results should be used in the modern medicine especially in prevention of diseases, and this is something that is an absolutely new view to health, and how to keep healthy. It has nothing to do with aging, aging is normal process, but we are accelerating the aging process, and this is opening doors for diseases development.

Wendy Myers: Yeah, so it's causing... A lot of people's lifestyles, and bad diet, environmental stressors, emf is causing mitochondrial damage and dysfunction, and then reduce energy production-

Dr. Kucera: Absolutely, absolutely.

Wendy Myers: Yeah, it was so amazing you worked on the Russian cosmonauts, Mars 500 project and you found that they had mitochondrial damage, mitochondrial receptor damage, and so what did you do, you developed a supplement product to help repair this mitochondrial damage that resulted from spaceflight.

Dr. Kucera: Right. Right. But the mitochondrial medicine does not concern the cell. Cellular level is one level, it's very well known, and it's possible to read many publications, and books speaking about mitochondria. But on the cellular level it's another program, it's not only the energy production and function, but it's also to keep the protein structures enzymes, DNA, and other protein, globulin et cetera, et cetera, many proteins to keep them... keeping structure of these proteins intact. So it means fully functional

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because one protein is losing the structure, is still the same protein, but losing the function for instance gamma globulin is still gamma globulin, but when the structure is slightly damaged after that it's losing the function, is not able to fulfil the function of immune system processes and this is the problem because we have no possibility to check it to, examine. We can examine is gamma globulin, okay, gamma globulin levels concentrations are okay, so why is the immune system is not working properly?

Dr. Kucera: So this is the second problem on cellular level, and another problem is problem of stress. So, it means systemic problem, and this is the parallelly with cellular mitochondrial systemic, and this is the problem of stress, because you know stress, everybody can imagine what is stress. Everybody knows the emotional stress, work stress, I don't know sports stress and so everything, but it's not so, because stress is necessary to define. And we have new definition developed for stress, stress is individual reaction to every change of inner or outer environment, and this is something that we can see. The stress is for somebody at the age of 70, the same like for well-trained and in good condition or good shape the person is the same like 50-year-old, but we can see that 30-year-olds are the same like 50 or 60-year-olds. So, it means here is the individual, so it was necessary to develop the only one possibility, which is how to cope with stress and this is adaptation, because after that any kind of my reaction when I have good adaptation capabilities after that the stress cannot negatively influence my health, and this is very important.

Dr. Kucera: To check the stress, individual stress, was developed this and patented is the Russian heart rate variability analysis and this is together with mitochondrial medicine its cellular level, and also the level is systemic control and regulation of body, because you are sitting on the processes responsible for adaptation. And now when we can say that it is every individual reaction to change of outer environment or inner environment, so it means this is stress, it's changing in our environment, but we have also chemical stress, pollution, chemicals in the food... I don't know, we have the physical atmospheric changes of atmospheric pressure and so on. So, we can see that it is a very global influence with permanent changes of the outer or inner environment, so it means we are under permanent stress. And some, for instance, detox is a one adaptation processes, the adaptation to changes of atmosphere is adaptation that after these changes in atmospheric pressure are not influencing, electromagnetic waves, smoke, electro smog, I can speak one hour about and maybe more one day.

Dr. Kucera: And this is principal of this mitochondrial and bio-regulatory medicine, so it means it is something, and for this it is result of research about project Mars... We can say new research, but the research began 20, 30 years ago, the project Mars. And that is why we are using the Russian software because the Russian software is highly sophisticated, is patented in Russia, and this is heart rate variability analysis, we can control the lot of

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the bodies, stress of the body individually for every body different, and we can see how we have the reserve for adaptation capabilities.

Wendy Myers: Yeah, let me paraphrase this for a second. So you use a Vericard heart rate variability test, and you can test the mitochondrial power that somebody has, and you'll use this as a baseline for people to see how their mitochondria are functioning, and a lot of other factors, a lot of other test points also. And then people will take your Mitochondrial RX formulations, it's a three supplement kit, they'll take that, and people can test at like 30-day marks, and you see remarkable increase in the functioning of the mitochondrial power and energy output. And people have remarkable recoveries from illness, and you've done all types of trials, I mean you developed these for the Russian cosmonauts to help them recover, and function better during spaceflight, and recover afterwards. But for the everyday average layperson, these are amazing for people that want to increase their energy production.

Wendy Myers: I've been taking them for about five months, and I am just... Actually, six months now, and I'm just amazed at how much better I feel. I mean, I thought I felt really good before, but I really feel good now. I really wake up feeling really good, and you know, if I don't get enough sleep one day, it's okay, I feel like I'm adapting better to stressors in my environment.

Dr. Kucera: I agree with you. This is something necessary to notice that we are... it's not working like doping. Yes, it's only optimizing capabilities of energy production, but also regeneration processes. But not only structural regeneration, but also regeneration and setting up the energy reserves to have this reserves for eventually fight or flight and stress reactions, but it is fight or flight also, for instance, in detox and to improve the diseases it's only science that we are doing, it's only scientific. We are only optimizing the body capabilities, which is extremely powerful and every health issue, every small, big, from cancer to headache every time it is united with two levels with cellular function decrease and decrease of some function of this control system. Yes, losing control of blood pressure, you have high, losing control of sugar, you have diabetes, losing control of immune system you have allergies, auto-immune diseases, cancer, and every health issue we can recognize also as union with some lost or reduced capability to control something.

Wendy Myers: Yeah, and these are just maladaptations to stress when you're... like for instance, someone they develop a food sensitivity, that's just a maladaptation of the immune system the body is trying to cope with this issue in some way, cope with the stressor instead of responding to it in the way that you want, it responds to it by developing an immune system reaction to it. But when your body has enough energy, it is able to adapt and respond to stressors in a positive way.

Dr. Kucera: Yeah, that's right. And with carnosine this is something what is absolutely necessary to notice, that carnosine is built by the cells themselves, they are producing carnosine for their own use. And carnosine is very key,

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very dynamical, it's not only that it's sitting in cells and paying attention to something, it's moving from one protein to DNA, here it is an antioxidant, here it is repairing protein structure, here it is... So it means it's a very dynamic process and this process also needs energy support from the mitochondria, so that’s why mitochondria, energy is the basis, but the functions of proteins and so on, it's the carnosine's work. Yeah.

Wendy Myers: Okay. Yeah. So let's talk about the formulations, the mitochondrial RX formulations.

Dr. Kucera: So, first problem was to find how the carnosine was going to go into the cell because normally, carnosine is intercellular product, so it means that there is no existing natural transporting system. So, it is very well recognized by research also in the States, that if you want to see the effect of carnosine you need to give minimally 300 to 500 milligrams per kilogram of bodyweight to see the function of carnosine in some way, for instance, like cardiotonic function and this effect is persisting only one hour. So it means for clinical use this kind of carnosine is absolutely useless.

Wendy Myers: Yes. So you're talking about like any old carnosine you get off the shelf.

Dr. Kucera: Yes, it was the first problem. The second problem was that when we are supporting carnosine we needed to also optimize the energy production to support the carnosine function. Yeah. So it means that it was necessary to develop the combination, which will be able to optimize mitochondrial energy together with support of energy for the carnosine function. So this was first problem because it was 15 years of mistake, failures, animal experiments, to volunteers and so, in vitro it was working absolutely perfect, in vitro.

Wendy Myers: Yeah, in the test tube.

Dr. Kucera: The living organisms, absolutely not. So it was necessary to develop something what would be able to... So, first we developed the mix of working composition of substances working in vitro, but it was not working in animals, and of course, we tried to find out why that was, and it was necessary to recognize that it must be very special technology, which will prepare this substances to be united in some physio chemical compound, which is working also in powder, of course, not necessary to be in a capsule, but the technology is very difficult and it is taking a few days until the powder, or the capsule is working, and it's persisting eight to 12 hours, and not necessarily desired dosages of 300 milligrams per kilogram. But it was really very difficult also from the financial problem, because to research, to do the study on a diet supplement nobody was paid. It is not backed by pharma yeah, so it means that it was money from volunteers, from our own support, financial support and it was...

Dr. Kucera: You know, and believe me in 15 years we were without money very quickly.

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Wendy Myers: Yes. Yeah. I mean, you took 15 years to develop these formulations.

Dr. Kucera: It was unbelievable problem, but success came after... you know, in Russia, it was around 15 years, I was there participating because the formula is mine, I am developer for that, and success came around 12 - 13 years ago, and we started to bring it for the people, to the people, for the people, as prevention of diseases and the so called not [don't-know-sological't diagnostics, this is Professor Baevsky's term for the state of the body’s health without symptoms, but already with reducing capabilities to control losing energy, mitochondrial energy, but still functioning without any symptoms of a disease. Don't-know-sological means before symptoms and after that are coming the period of symptomatic diseases which is the domain of conventional medicine.

Wendy Myers: Yes, yes, yes. And so let's talk a little bit about the three Mitochondrial RX formulations. So there's three of them in this kit to get the mitochondrial function, so there's the repair, which is the carnosine, there's the power, which is the Coenzyme Q10 formulation, and a there's the calm, which is the flavonoid formulation. So we talked about carnosine, so let's talk about the CoQ10 formulation and how this is a completely different animal from any CoQ10 or ubiquinol you find on the supplement shelf.

Dr. Kucera: This CoQ10 is nothing special by technology, a CoQ10 complex is not very special, it is only a very clever formula because of the mitochondrial oxidative phosphorylation, that means the first step of the energy production is oxygen giving free radicals to the Kreb cycle, from the Krebs cycle is coming out the succinate, and succinate is starting the complex one, two, three, and so on. Q10 is complex three, yes? It was very necessary when we... To increase the energy we need to add also something that is the step before, and step before is succinate, but how does... because succinate is an intercellular product, how to bring the succinate into the cell. So, after that we bound succinate to vitamin E, because vitamin E a is membrane vitamin, yes, liposoluble, lipo-active. So the vitamin is bringing the succinate into the cell, and into the mitochondria, vitamin E is blocked in the membrane and succinate is entering mitochondria and starting this... so after that following Q10 and for Q10 and vitamin it's transport system is carnitine, that is why that L-carnitine is also in this composition.

Dr. Kucera: And carnitine is playing very important role because L-carnitine is bringing Q10 and succinate into the mitochondria, and bringing back the waste. So it's cleaning, detoxifying the cell from the waste, bringing it back because L-carnitine is product of the liver, so L-carnitine is going back to liver, and this waste is going to detoxify by bile, and go to stool, and so it's some circle, which was... So that is why you have these four compounds there to have one complex only for mitochondrial function, in the carnosine we have Q10 also there, but we have Q10 also for energy for carnosine function, and this is for mitochondrial cellular function. So, it means that we have these three basic compounds, and we don't need anything more. Sometimes we are giving cortisol some multivitamin, and [so what is

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generally very well known, but most of the effect for a good body function, for adaptation, for fighting stress are these three basic substances.

Wendy Myers: Okay, can you go more into the Calm formula, which has the flavonoid, what are the benefits of the flavonoids, and why are they in the formula?

Dr. Kucera: This is combination again, which is responsible for many functions especially in detox and immune system. Chlorophyll is very well known, chlorophyll is very well known for healing, for... I don't know working up for vessels also for the blood coagulation, optimizing, and so on. Beta-glucans are very well known Immunol moderators. Yes, this is true and we gave them something that is typical for aging processes so it need it. In men prostate cancer, lutein is there, eye problems, yes, presbyopia, and so on, lutein. For the retina, and for obesity this is very well known. So this combination was done, we are giving also this flavonoid also to the basic substance to carnosine formula, to Q10 formula and so why?

Dr. Kucera: Because, for instance carnosine is very good antioxidant, so if we are giving carnosine... so after that, because free radicals are very dangerous, and body knows it. So, first the carnosine is used as an antioxidant, and cannot enter the cell to do the jobs in protein. And so, it means that we need the flavonoids, which are very powerful antioxidants, more so they never become free radicals because they are working with two electrons. So, it means they are never becoming free radical with one unpaired electron. So, it means that it is like cover and that is why also the technology is very difficult for carnosine, because when they are these antioxidants carnosine is covered also, but technology should be prepared, not together to mix it because when you mix it after that the reaction is inside the capsule, or inside the powder, when mixing and after that it is in fire.

Wendy Myers: Okay, we don't want that. Yeah, we want the fire in our mitochondria, not in the capsule. So if anyone that wants to try these groundbreaking revolutionary supplements, this is something that I recommend to all the clients that I personally work with, go to mitochondrialwellness.com, and you can purchase the Repair, the Calm, and the Power, it's a three supplement kit. And they're something that I take every single day. I take it twice a day. And so the challenge in repairing the mitochondria is really getting enough of the carnosine, the form of CoQ10, and the flavonoids that you have in your formula, and so you created this process to potentize or to increase the potency of the carnosine and the other ingredients in the formula, which makes it totally different from the ingredients, say the CoQ10 or carnosine you just get on the shelf at GNC or other formulas.

Wendy Myers: That it's not comparable even though the names may be the same, your formula has a proprietary potency way that its patented that you make it, which makes it so effective, and why it was used with a Russian cosmonauts with the Mars 500 project. And took you 15 years to figure this out, so it's not the same thing.

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Dr. Kucera: From anybody, by the experiments that we did so that's right that when you are using the effectiveness of this carnosine it is not only increasing with the dosage, it's increasing also with the time of use, so the longer you are using it the better the effect, so it’s always improving. And when somebody is using it around one to two years, biologically the age is going down 15 years but not more, up to 15 years biological years. We have had problems with some ladies because they started with this formulation during menopause. They were without periods, and without monthly bleeding, and they started to have normal function of the ovaries after using the supplements.

Wendy Myers: Wow.

Dr. Kucera: And it is very interesting to say German ladies they were angry at me that I made this happen.

Wendy Myers: Their period came back.

Dr. Kucera: We were happy without these problems every month and now we need to... And English ladies, they were so happy that for them it was symptom of youth, that they were back younger. So they were hammering me and saying thank you for that, but it's good also for prevention of cancer because when you are... the risk of cancer is lower.

Wendy Myers: Yeah, let's talk about the trials that you've done. You have done trials with cancer, with autism, with fertility. Can you talk about some of these things and how had the profound results?

Dr. Kucera: With autism, yes, I have... My register is 1,300 autistic children, so from our view on this it's only, I must say it's not only our truth, because Autism is very complex problem, and its needs are complex, and they teamwork. Yes, education, social, and... But from our view the typical failure of adaptation is why they are not communicating, they are not socializing because it is total failure of adaptation. So, here the carnosine is really helpful, really helpful. We have children they were not speaking until the age of 12, and I must say one very, very, I can say sensitive case when the boy, which was 14 year old and until 14 years was isolated in his family with his mother, with no relation, no emotions, only living in his own world, typical autistic symptoms with the angry aggressive attacks, and so on.

Dr. Kucera: And after around one year of using carnosine from day to day, the mother told me when they went to check-up, he woke up, prepared breakfast, brought it to mother's bed, and said I love you mom.

Wendy Myers: Wow.

Dr. Kucera: And she was crying because it was his first word after 14 or something years of living together, so it means that sometimes it is like miracle, but I

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can say more than 85 - 90 percent of autistic children are effected positively by the supplements. With cancer, it's something else.

Wendy Myers: Okay, just one second. Let me paraphrase for a second, so you did this trial with over 1,300 autistic children, and they were taking your Mitochondrial RX supplements, and you said 85 to 90 percent of children had some form of improvement after taking the supplements for how long?

Dr. Kucera: First signs of improvement after six months, three to six months. And somebody after two years, two-three years or so. The longer the time the more improvement, but in some ways we can say that improvement is almost by all of that, around 10 to 15 percent because this trial is only in... we are working on and there is not much time to work on it because also who will pay it? Yeah, this is absolutely not interesting... Nobody is interested in it, nobody, only the mothers and they are crying because it's not very cheap, and they're giving good money to bring the baby to a better condition, but when there is some positive results like that…

Wendy Myers: And that is statistically huge. I mean when you have a large sample size like this of over 1,300 children, and there's an 85 percent I mean, that's absolutely unheard of, to have an 85 percent improvement that's massively statistically significant. Let's talk about cancer, so this is something a lot of people have a concern about. We all know or have a loved one that has cancer. My father died from oesophageal cancer, it's a big fear for a lot of people. And there's so many toxins in our environment, and so many people getting sick, and that makes people that have low energy levels, and lots of toxins, they're more susceptible to cancer. So let's talk about that, and how the mitochondrial RX formulations can help to reverse a cancer diagnosis and improve it and prevent cancer.

Dr. Kucera: Yeah, it's necessary to say, we are not able to treat cancer disease with this method with mitochondrial medicine, absolutely, it's nonsense. But what we are hoping is that this combination has a very positive effect on some processes, which are together with cancer, so first, they're improving intercellular communication, so it means they are improving the prevention of cancer, they are improving... The first step to get cancer is that you have mutation, so this combination is improving the processes, which are repairing mutations back to healthy cell, so this is first big success in this. Yeah. Second when you already have cancer, so treatment is on oncologists. Of course, we have some patients they refuse the oncological treatment, and the results with this is 50/50. So it means that 50 percent positive results with remission and 50 have died. But with the combination, they are some levels, or some processes, which are very important while treating cancer. Chemotherapy is attacking immune system. This is first what we are doing that our combination is improving immune system capabilities, so it's helping chemotherapy to fight cancer.

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Dr. Kucera: Second, the influence of our supplements is directly targeted to cancer but preventing damage of healthy cells because it's improving repair and due to the different metabolism of cancer cells, after that we are able to target, for instance, to start the mitochondrial apoptosis and cancer will kill itself by the apoptosis because normal cancer cells are switching off mitochondria. Mitochondria are not working in cancer, so that is why it is immortal, never die, a cancer cell never dies, but we are making immortal to mortal.

Wendy Myers: Yes.

Dr. Kucera: We're switching on mitochondria, so we are, we can say provoking suicide of cancer cell. It's a process slow, but very effective. And second, our supplements are reducing side effects of chemotherapy, so this is true, and one of the substances it's vitamin is succinate, I think it’s very important by chemotherapy very important influence because the cancer cells are very clever like bacteria, they are developing like bacteria resistance to chemotherapy. So after that, that is why very often we can see that chemotherapy from beginning it's starting to work, but suddenly the effect is losing, reducing, and we need to give another chemotherapy because cancer cells are developing resistance, like bacteria resistance to antibiotics. And vitamins in succinate are negatively influencing the development so cancer cell with supplementation with our supplements are not able to develop resistance.

Dr. Kucera: So mitochondria starting apoptosis, and second, no chemotherapy resistance, that is why we use them together with chemotherapy, and our supplementation that's why we are increasing the successful rate to 75 80 percent. So it is huge improvement.

Wendy Myers: So you're saying that when cancer patients are working with their oncologist and taking the Mitochondrial RX supplements they have a 75%... Did you say 85% percent success rate, where they live and go into remission? That's massive.

Dr. Kucera: This is true and more when using permanently or regularly after this remission, we can keep them in remission in this sense, so this is also important. But we need to wait until the oncologist will understand us.

Wendy Myers: Yes, yeah. That's why they do these studies in Europe, not in the United States.

Dr. Kucera: Our supplementation is increasing the efficiency of radiotherapy sensitivity of only the cancer cells, only cancer cells, but preventing damage of healthy cells, so efficiency of radiotherapy is much more powerful without side effects.

Wendy Myers: Yes, because you develop the flavonoid complex to help protect the cosmonauts from the radiation, the cosmic radiation in space.

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Dr. Kucera: And more every time is good to improve efficiency of immune system because immune system normally is ignoring cancer, because cancer is my own body cell. So, normal immune system is ignoring it, but when the cancer cell is destroyed some way the fragments are already immuno competent, and immune system is able to fight. And when fighting fragments, fighting the cancer tumor, and metastases, so after that it's very good to support the immune system. But cancer cells should be somewhat destroyed by chemotherapy or by radiation.

Wendy Myers: Yeah, so let's talk a little bit about people that are ill, that are sick, they need energy to recover. This is one of the reasons why a lot of people don't recover. They just don't have enough energy to regenerate their bodies, they don't have enough energy to sleep to recover, which is a very highly energy intensive recovery process. And they stay stuck in this cycle, this downward spiral of illness because it takes a lot of energy to get well, leaving many to remain ill for years and even decades. And so can you comment on how the body needs this mitochondrial power to fully recover from disease or injury, and how your formulations give people hope to get well?

Dr. Kucera: Absolutely. So first, disease means stress. Disease is stress changing in our environment and my reaction on that is stress reaction, so it means we need adaptation, so it's needs shift from sympathetic, destroying metabolism to anabolic to regenerative, parasympathetic. And this shift is possible already with increases and development of adaptation. Adaptation means shift from sympathetic to parasympathetic, and so it means that our supplements are doing it, our supplements with improving energy, improving repairs, and shifting from sympathetic to parasympathetic. So from catabolic to anabolic metabolisms, it means regeneration, repair, recover, energy reserves, building, and so on. And also sleeping because sleeping is normal biorhythm, and we are with our supplemental, we are normalizing biorhythms.

Dr. Kucera: So, it means... and also, sleep cycle is biorhythm together with production of melatonin, who it's not only darkness, notice everything is in the hand of big conductor of our body orchestra is hypothalamus and this is leader of everything.

Wendy Myers: Okay, let me ask you this question. So, what role does the receptor damage, mitochondrial receptor damage, have in the occurrence of hypothyroidism, diabetes, hypoglycaemia, adrenal fatigue, hormonal issues, which extends to fertility with old injuries that won't heal, how does your Mitochondrial RX formulations help with this mitochondrial receptor damage to address these conditions?

Dr. Kucera: Improving sensitivity of receptors and improving production of energy generally, so it means that it doesn't matter if it is energy is for muscles, for liver, for the kidneys, for the hypothalamus, for the thyroid gland, for anything. And because all receptors are protein structures, and when we are improving protein structure, we are improving sensitivity, because lost

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structure of protein is losing function. So, this is very important, of course, to repair the structure and to improve the sensitivity of receptors to be able to react on the level of my estrogen, of melatonin, of anything. So, it means this is important so our supplementation is also participating in this circle, receptor information going to the center back and effector.

Dr. Kucera: So effector is also depending on sensitivity of receptor for this impulse, so it means that it is a circle, which we are on every level we are improving, that is why we are so successful. From information to effect.

Wendy Myers: Yeah, so let's talk about... and it's just amazing how just by improving mitochondrial functioning and mitochondrial receptor sensitivity, you can improve almost any imaginable symptom or health issue because it's really just... I mean, you have these mitochondria in every single cell of your body, and we have to power up the body energy wise in order to heal, so you can heal any imaginable health issue or dramatically improve it. And so let's talk about the mitochondria, so we are born with a number of mitochondria, and then they're almost like bacteria, they are... you know evolutionary wise they're considered bacteria, and behave the same way. And then they die off, our mitochondria slowly start to die as we get older, and we have less as we get older, and then we also have reduced sensitivity in the receptor sites. Can you talk a little bit about that like what causes the mitochondria to die off and lose sensitivity?

Dr. Kucera: So, first is necessary to say that, we are born with some count in every cell, and different counts in the heart, and in cartilage, and controls sites. But generally the sum is typical for the cell of some organ. Of course, mitochondria... what's going on in mitochondria, in mitochondria is transport of free radical, this is the problem with mitochondria. So when these enzymes, which are preventing the membrane of mitochondria preventing the electron so that it cannot go away from the chain transport reaction of oxidative phosphorylation. So, this is a problem when these enzymes are not working properly, so they are not catching these free radicals, and free radicals are able to destroy mitochondria, and once destroyed mitochondria will never again be repaired. Once lost they are lost forever. So, it means we are slowly, by normal aging, reducing the count of mitochondria in every cell.

Dr. Kucera: This is one but there are many influences because mitochondria are a rare bacteria evolutionary, so it means that every use of antibiotics is killing mitochondria that is why we have antibiotics cardiotoxic, hepatotoxic, nephrotoxic, and ototoxic, so some kind of antibiotics is able to kill mitochondria in some organ. Yes, that is my mitochondria they are bacteria, so antibiotics are against bacteria, so it means that the use of antibiotics are less as possible. Of course, we need to balance what is more profitable for the patient, and more profitable for the pharma, or something like that. So, hyper use of antibiotics is killing bacteria, so after that we have children, they have count of bacteria in age of 15 like in the age of 40. So that is why that we are aging much more quickly than

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before, I don't know 50 years ago. So, this is one thing with mitochondria, once destroy it's never...

Dr. Kucera: So it means we need to keep our count of mitochondria as high as possible, so to prevent damages, to keep super oxidized, and these enzymes, which are mitochondria enzymes, prevent having anti-oxidative effect against the free radicals, which are normally in mitochondria they are the first victim of my work, They are a victim of free radicals. So, it means that as I said to know this, so that is why to keep mitochondria count as much as possible and second, loss of energy production is slowly losing efficiency of this oxidative process with losing of Q10 production from liver... Of course, liver is producing Q10 for all body, for every cell, so it means that liver... but liver is also aging, so producing less Q10, and so it means at the age of 30 everybody should use Q10, and our supplements. This is the age when we need to start.

Wendy Myers: Yeah, and it's so sad when people are taking statin medications or cholesterol lowering medications they're poisoning their enzyme that makes CoQ10, and that makes the problem even worse, with interfering in energy production and mitochondrial functioning.

Dr. Kucera: Now, it is true that with carnosine now many studies are saying also we are cited in some literature is some studies, my work is cited that carnosine is becoming the unique medicine for us in conventional medicine. Yes, professor, Dr. [inaudible 00:56:45] in Melbourne University is the leader of the big group working on carnosine, how is working with diabetics second type because insulin receptor is receptor protein structure when we shall repair this structure insulin resistance is off, and diabetics is as well.

Wendy Myers: Yeah, that's amazing.

Dr. Kucera: So, this is something what is good, we can improve the blood pressure you know cardiovascular diseases everything is by stress, no adaptation for that, and so mitochondrial medicine can here to do very good job.

Wendy Myers: Well, why don't you list all the conditions that you think can be dramatically improved with taking the Mitochondrial RX supplements that improve the protein structures and improve energy production. Can you just go through a list of things that you've seen improve?

Dr. Kucera: Every degenerative disease, so it means Alzheimer's, Parkinson's, everything various degeneration because degeneration is a stress catabolic process when we are changing to anabolic to repair regeneration, of course, we are also improving the disease this is for second diabetic second type absolutely.

Wendy Myers: What about maybe thyroid receptor improvement?

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Dr. Kucera: Absolutely, thyroid almost all of my patients and I have around 30,000 registered people there is around, I don't know, 1,000 of thyroid supplement they used to thyroid gland... After using carnosine after six to one year, they don't need it because after that we repaired the function of thyroid and it's under control of our own body of hypothalamus pituitary axis, and so on. So TSH is normal to reacting to the needs of the thyroid gland to produce the thyroxine.

Wendy Myers: Yeah, because... I mean, so it's for repairing the thyroid function, and receptor site function, and restoring hormone production, so that after... so some people are taking thyroid prescription medication or glandular but if the receptor sites aren't able to accept it, that's not going to work or the medication isn't going to work even if you're taking it.

Dr. Kucera: And this is very... It's absolutely un-logical, I don't want to criticize because I am conventional doctor, I don't want to criticize this endocrinological, I don't know... if it is fashion or I don't know that everybody with higher TSH is using hydroxyzine, and some thyroxine hormone, but this is killing thyroid gland because it's killing... This is the same like principle of contraceptive pills, if I don't want to work my ovaries to produce hormones, and to produce egg ovum, so after that I shall start to take pills, and my ovaries will stop working. So, with the thyroid gland it is different, it is not the same. If I take thyroid hormones, my thyroid will stop the work, and when I'm taking five 10 years, it's forever. So, it means it's not very logical this treatment, it's not very logical because it is parallel limits, so every time when I use some hormone, my own gland will stop it. If I shall take my cortisol many diseases are on cortisol treatment, so my suprarenal gland will stop producing cortisol of course.

Wendy Myers: Yeah, yeah, and it's just natural, your body senses you have the hormone floating in your blood, not going to produce it that's how the body works. And so, what about other conditions like autoimmune conditions, what have you seen in that regard, improving with mitochondrial Rx?

Dr. Kucera: We have their combination of Immunol moderator, but I told you few minutes ago about globulins, globulins are proteins, when this protein is damaged by free radicals, by other [dehydration 01:01:31] and many other carbonylation, and so the structure is damaged, still gamma globulin or globulin it is, but without function, without immune function. Carnosine is able to repair structure, so after the globulin will start to work like it should, so this is first. Of course, this is not only a question of globulin, it is a question of white cells, white blood cells, because they need energy to function to [fungicide 01:02:07], to fight NK cells, they need to shoot the free radicals against bacteria, against cancer cell. And so it means that we are back in the energy. Yes, so energy immune modulation by beta-glucan, for instance and carnosine repair of structure.

Dr. Kucera: So this is general, and this is more we can say it's normalizing, so we are improving allergies very well, we are improving autoimmune diseases, because we are improving hypothalamus, and immune system problem is

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immune system of control as how the conductor is controlling that. So lost control, immune system is crazy at killing all cells in autoimmune diseases, it is allergy, and intolerance is the same its adaptation problem. So it means that is influencing physiologic of very powerful body efficiency.

Wendy Myers: Yeah. And let's talk about hormonal issues and fertility issue. This is a big problem for so many people, so many women, and men too, but so many women are going into their 30s and have the hormone levels of menopausal woman, and we know there's lots of toxins in our environment interfering in hormone production, xeno, estrogens, but let's talk about how mitochondrial RX can help improve hormone production.

Dr. Kucera: It's necessary to see first the reason why it is so, so 95 percent or maybe more were using birth control pills for many years five, 10, 15 years.

Wendy Myers: The pill.

Dr. Kucera: They are going to conceive in elder ages not like 30 - 40 years ago it was normal, that 20 year old girls were becoming pregnant. Today, it is 30, 35, maybe more, so it means that after these years their ovaries are sleeping. So this is first problem, second problem stress, work stress, career stress, partnership... So stress is possible to create adaptation, so first adaptation mitochondrial medicine does it, mitochondria medicine is regenerating sleeping ovary function when we are speaking fertility. And more is necessary to know when we are starting normally this function so I must say with mitochondria medicine, and it's without any side ideas and side thinking, I have around 100 infertile patients and only one pair didn't conceive, all of them went and all of them these pairs, they came to me after many IVF unsuccessful treatments. One of them I remember was treated seven times to conceive by an IVF method with no success. Once it was successful, but in three weeks of pregnancy it was aborted.

Dr. Kucera: And I have they used to say carnosine children because all of them are extremely intelligent, extremely clever, and absolutely healthy, no problems with vaccination, they have immune system like bull.

Wendy Myers: Yeah. Like a sewer rat.

Dr. Kucera: Until now the mothers, they are coming to show me how they are growing, the oldest is now around seven years, and the youngest is around two years. They used to say carnosine children or Kucera's children. So it's one of the most successful mitochondrial treatment we can say, absolutely, unbelievable.

Wendy Myers: Yeah, and that's amazing because, you know, we need hormones for so many things in our bodies, not just for fertility but just for, you know, making our menstrual cycle better, for having clearer thinking, for having a better mood, we need estrogen to make serotonin. I mean, we need

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serotonin to make melatonin. I mean, hormones have a huge impact on so many different functions in our bodies.

Dr. Kucera: Oxytocin, yes, there're many hormones. Today we know around 300 hormones, only around 60 hormones are only in digestive tract, it's terrible.

Wendy Myers: Yeah, and we talk about estrogen, progesterone, and testosterone, but it's more complex than that.

Dr. Kucera: Yeah, that is why we can let it to own hypothalamus to own body, but it knows how to handle this orchestra big Symphonic Orchestra of hormones, of organs, of systems, of processes know it's genial, we need only to learn from it, we cannot improve nature, nature is already totally improved.

Wendy Myers: But let's talk about the top chronic health conditions that are killing so many people, let's talk about heart disease. So can we talk... and we know the heart muscle has more mitochondria than any other organ in the body, so how does mitochondrial RX contribute to improving and preventing heart disease?

Dr. Kucera: But it is necessary to say heart also... comprising of the highest concentration, number one is the brain, and number two with concentration of carnosine is in the heart. So it means that the nature shows where the carnosine is most important, and this is something that is the heart, so it means carnosine... We were speaking about carnosine as the protein structure repair substance not only, carnosine has also a very special effect in brain like neuro peptide repairing function, synapsis, and also that is why we are successful in Alzheimer's, and Parkinson's, and other degenerative diseases, but also is cardiotonic is three times more effective than digoxin. So this means that it is the most effective substance to treat heart failure, so it means that carnosine is number one in helping in cardiovascular diseases, especially cardiomyopathy, also genetical cardiomyopathy we can improve them unbelievably. Just half a year ago was one of my patients in Barth Syndrome Foundation in America, he is my patient. He is now 20 years old, and 20 years ago, when he was two months old, this Barth syndrome, it is very genetic disease with very cerebral cardiomyopathy.

Dr. Kucera: They told the parents prepare in three four weeks, this boy will die because it is only boys having Barth syndrome is united with chromosome X, and now he's 20 doing sports. Normally with Barth syndrome, they are very small, he is two meters eight, so it's unbelievable. So he was on a conference about foundation, he was speaking about how he is living, and everybody there they were surprised how it is possible with this diagnosis, so it means cardiotonic, unbelievable. So cardiovascular diseases 100 percent, yes it is so. It's preventing, of course, together with flavonoids it's preventing any atherosclerosis development because it's improving the inner epithelium,

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yes, is improving nitric oxide production so it means it is one of the best treatment for cardiovascular disease.

Wendy Myers: Yeah, that's fantastic. That's fantastic. And so let's also talk about detoxification. So my specialty and of this podcast also is talking about heavy metal and chemical detoxification. You touched on it earlier, can we talk about how the mitochondrial RX supplements can facilitate and hasten detoxification?

Dr. Kucera: Hypothalamus pituitary axis is responsible to run and control the processes of detoxification. This is the first level, we are improving it with our supplement but there is also again, some very special effect of the supplementation, chlorophyll is detoxifying, beta-glucan are detoxifying, and carnosine is chelating. So it means the chelating heavy metals is the only one natural substance what we know of, I don't know of any other, only medications and so on. But chelating agent is carnosine, so it means also we can remove heavy metals, it's not dramatic, it's a slow process because the body is clever, it's working on its own speed and everything, yes, we cannot... We can only optimize the body capabilities and efficiency nothing else, and let it to the body, body it knows how to.

Dr. Kucera: You know, the body has a powerful immune system, for instance, the best example is that in middle ages in Europe where the plaque or cholera or Spanish flu epidemic killing half the population of Europe, the second half without antibiotics, without knowledge of this, without anything to survive, which is possible because their immune system was able to fight it until we are not here because when plague is killing everybody, so we are not here. So, it means that immune system knows how to kill every bacteria only must... the function should be optimum. So, it means first to detect bacteria, second step to find out how to kill these bacteria. And after that to eliminate these bacteria from the body to kill and eliminate and repair what was damaged. So it means that this process by the development in centuries, we were killing slowly, we wanted to be more clever than the nature, and it was opposite, we need to relearn from how our immune system is doing it to recognize how the system is able to recognize these bacteria, and what will kill these bacteria, if it will be phagocytosis, if it will be free radical, if it will be another process.

Dr. Kucera: And so it means that we need to support this because how I said the body knows everything, only we need to support what it already knows.

Wendy Myers: Yeah. And so if anyone is interested in purchasing and starting the mitochondrial RX supplements that we talked about the Calm, Power and Repair, which is vital to take all three, go to mitochondrialwellness.com. Let's talk about the upcoming Mitochondrial Therapy Training event that's coming up in Orlando, Florida June 1st, 2nd, and 3rd. This is where they'll be training people about the supplements, and how they work and, you know, a lot of different things very, very interesting for any clinicians interested in using this in their practice. What will practitioners learn during this three-day training?

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Dr. Kuchea: This three-day training will be about mitochondria and how mitochondria is working, how to work with mitochondria, and in what way we can say and how it's working with... it's basic training. So, it means it will be something about history, about history in space, when the Russians started with this, and so on. So, it means that it will be a little bit history, it will be a little bit about the biochemistry, physiology and so on. And this is basic training is also with we can say with practical discussions, who is interested in what to know exactly and one day is training with heart rate variability analysis, yes, how to work that, what conditions is necessary, how to explain the parameters, and how to estimate the results, and one control examination, what we can expect with control checkups and so on.

Wendy Myers: Yeah, this is going to be a very interesting training because you start with learning about the dynamic heart rate variability system, testing your patients or clients, you know, getting a baseline, seeing what their mitochondrial power level is, and lots of other factors as well. And then once people start the mitochondrial RX supplements, then you can test the patient's every 30-day point or longer, and see how they're doing, and see how they're improving on the supplements essentially, is kind of what you're teaching.

Dr. Kucera: Yeah, because you know, for instance, it's necessary to know that the full effect is developing after starting using this supplements, effect on cellular level is after two hours already, but systemic, so it means the control of the regulatory system, the hypothalamic pituitary axis activity, and so it's three months. So it is activation, hormonal metabolic phase, stabilization, and so on. So it means that it's necessary to know because to understand this system of medicine, we can say medicine, so it’s something absolutely different from the conventional medicine, we don't repair anything. We only support what is damaged; we are trying to repair by our own power, by our own system.

Wendy Myers: And you're also going to be at the A4M conference in May as well.

Dr. Kucera: Yes.

Wendy Myers: You'll have a booth there with Robert Marking at the Mitochondrial RX, you know, supplements, mitochondrial supplements for anyone that's interested in going there, they can meet you guys in person. Dr. Kucera, thanks so much for coming on the show. That was such an interesting podcast because I truly believe that your mitochondria are the key to recovering your health and wellness, these are like the basic building blocks that we need to be addressing in order to heal, and in order to just feel better. Even if you're perfectly healthy, you still have to protect and improve mitochondrial functioning and receptor sensitivity, so thanks for coming on the show and just blessing us with your wealth of information.

Dr. Kucera: Thank you very much. It was great session with you. Thank you.

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Wendy Myers: And everyone, thanks so much for listening to the Myers detox podcast. Every week we have guests on to help educate you to give you those pieces of the puzzle that you need to get well. So it's my pleasure to serve you and helping you on your healing journey. Thanks so much for tuning in. And I'll speak to you guys very soon.