dr hugo lumbreras : ultimo viaje a huayopampa: huaral, … › images › 001… · la enfermedad...
TRANSCRIPT
![Page 1: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/1.jpg)
DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, 1985
![Page 2: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/2.jpg)
BARTONELLOSIS 2015 Introduction, History and epidemiology
CIRO MAGUIÑA, M.D. Research Vice-Rector, UPCH
Alexander von Humboldt Tropical Medicine Institute
FORMER DEAN OF THE PERUVIAN COLLEGE OF PHYSICIANS
Specialist in Infectious Diseases – Tropical Medicine - Dermatology
![Page 3: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/3.jpg)
BARTONELLOSIS 2015
Bartonella spp. ARE FASTIDIOUS HAEMOTROPIC Gram- negative bacteria which are mainly transmitted by vectors.
Since the last 23 years , the number of Bartonella species or subspecies identified from a wide range of mammals has considerably increased.
![Page 4: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/4.jpg)
Among the 13 species or subspecies known or suspected to be pathogenic for humans, FOUR have been isolated from CATS
DOMESTIC CATS ARE THE MAIN RESERVOIR FOR Bartonella henselae, the main agent of CSD. Also, Bartonella clarridgeiae has been suspected in a few cases of CSD and Bartonella koehlerae has been reported as a causative agent of endocarditis in humans and dogs
BARTONELLOSIS
![Page 5: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/5.jpg)
Bartonellosis Molecular Biology
Christoph Dehio, Infection-associated type IV secretion systems of Bartonella and their diverse roles in host cell interaction, Cellular Microbiology
(2008) 10 (8), 1591–1598
![Page 6: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/6.jpg)
Bartonellosis: Chomel BB, Kasten RW. Journal of aplllied Microbiology, 109 (20) 743-750, 2010
Recently, Bartonella quintana was isolated from a pet cat and its owner.
Domestic dogs have been shown to be infected with a broad range of Bartonellla species, such as B. vinsonii berkhoffii, B. Henselae, B. clarridgeiae, B. rochalimae, B. quintana, B. koehlerae, B. washoensis, and Bartonella elizabethae.
![Page 7: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/7.jpg)
Int J. Syst Evol Microbiology 2009
Bartonella rattaustraliani sp. nov.,
Bartonella queenslandensis sp. nov.
Bartonella coopersplainsensis sp. Nov.
Have been identified in Australian rats.
![Page 8: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/8.jpg)
Bartonella 2010
Bartonella japonica sp. nov.
Bartonella silvatica sp. nov., isolated from Apodemus mice.
Int J. Syst Evol Microbiology 2010 http://www.ncbi.nlm.nih.gov/pubmed/19656930#
![Page 9: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/9.jpg)
New Bartonellas:1993-2015
Bartonella weiss, Bartonella washoensis
Bartonella schoenbuchii,Bartonella birtlessi
Bartonella bovis, Bartonella capreoli
Bartonella rochalimae (Cusco, 2007)
![Page 10: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/10.jpg)
BACTEREMIA, FEVER, AND SPLENOMEGALY CAUSED BY A NEWLY RECOGNIZED BARTONELLA SPECIES JUNE 2007 Marina E. Eremeeva, M.D., Ph.D., Helen L. Gerns, B.A., Shari L. Lydy, Ph.D., Jeanna S. Goo, B.S., Edward T. Ryan, M.D., Smitha S. Mathew, B.S., Mary Jane Ferraro, Ph.D., Judith M. Holden, M.P.H., William L. Nicholson, Ph.D., Gregory A. Dasch, Ph.D., and Jane E. Koehler, M.D.
![Page 11: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/11.jpg)
![Page 12: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/12.jpg)
![Page 13: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/13.jpg)
B. rochalimae: Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 12, December 2009
Recently, B. rochalimae DNA was detected in a dog from Greece . High (43%) prevalence of bacteremia observed in gray foxes in California suggests that they might act as a wildlife reservoir for this newly identified species.
Furthermore, several B.clarridgeiae–like and
B. rochalimae genes have been detected in fleas collected from humans , rodents ,red foxes (Vulpes vulpes) , and the environment in the Democratic Republic of Congo (12) during a plague outbreak.
![Page 14: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/14.jpg)
Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 15, No. 12, December 2009
Conclusions : We report the isolation or detection of
B. rochalimae from red foxes, raccoons, and coyotes from North America, Europe, and the Middle East.
Sequence analysis of 4 genes identified small variations in B. rochalimae isolates from these different geographic regions.
A relatively high percentage (26%) of raccoons had B. rochalimae bacteremia compared with only 9.5% (2/21) coyotes.
![Page 15: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/15.jpg)
B. tamiae (Thailand) J Clin Microbiol. 2008 February; 46 (2): 772–775.
Bartonella tamiae sp. nov., a newly recognized pathogen isolated from three human patients from Thailand. Kosov, et al. J Clin Microbiol. 2008 February; 46 (2): 772–775. Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, 3150 Rampart Road, Fort Collins, CO 80521, USA. [email protected]
![Page 16: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/16.jpg)
(10) Heller R, Kubina M, Mariet P, Riegel P,Delacour G, Dehio C, et al.Bartonella al-saticasp. nov., a new Bartonella species isolated from the blood of wild rabbits. Int J Syst Bacteriol. 1999;49:283–8
Bartonella spp. are zoonotic agents that infect erythrocytes of mammals in which they cause chronic bacteremia .
B. alsatica was first identified in 1999 in Alsace, France, as an agent of bacteremia in healthy wild rabbits (Heller 10).
However, in 2006, interest in B. alsatica increased when it was considered to be a human pathogen because it caused blood-culture–negative endocarditis in a patient who had contacts with rabbits (5).
The present case confirms that B. alsatica could be a human pathogen, especially in persons who live in contact with rabbits and should also be considered as a cause of lymphadenopathy
![Page 17: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/17.jpg)
Bartonella alsatica: Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 14, No. 12, December 2008
Human Case of Bartonella alsatica lymphadenitis
![Page 18: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/18.jpg)
New species: Bartonella ancashi, July 2013. Emergent Infectious Diseases
![Page 19: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/19.jpg)
![Page 20: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/20.jpg)
This strain was an unknown species .
This CO20 strain underwent genotyping (using rrs, gltA, and rpoB sequences).
It was compared with the genetic bank of Bartonella species.
The sequence 1351-bp from the rrs fragment was very similar to 99.0% of rrs from B. bacilliformis.
Fragments 312 and bp 589, as well as gltA and rpoB fragments , respectively, were similar to some parts of Bartonella bovis : 89.4% (gltA), and 85.9% (rpoB),
![Page 21: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/21.jpg)
![Page 22: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/22.jpg)
Diseases caused by Bartonella species in humans
B. bacilliformis : Carrion’ s disease (acute Oroya fever) and Peruvian warts B. quintana BA, endocarditis, trench fever chronic bacteremia B. henselae CSD, BA, peliosis hepatis endocarditis, bacteremia, neuroretinitis B. clarridgeaie CSD ( serology)
B. elizabethae Endocarditis
B. grahammi Neuroretinis
B. vinsonii
B. rochalimae Bacteremia
![Page 23: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/23.jpg)
Bacillary Angiomatosis (B. henselae and B.
quintana)
CUTANEOUS BARTONELLOSIS
![Page 24: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/24.jpg)
CONTRIBUTION TO STUDIES ON CARRION’S DISEASE AND OTHER
Bartonella spp.
![Page 25: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/25.jpg)
![Page 26: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/26.jpg)
Pre-Columbian Phase
Mochica
pottery
![Page 27: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/27.jpg)
CARRION’S DISEASE: Chronic phase
Krumdieck CF. La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina
1949; 32 (4): 227-306.
![Page 28: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/28.jpg)
History of Carrion’s Disease
Between 1870-1890, 7,000 Andean railroad workers died
They were building the highest railroad in the world (Oroya’s railroad 3,800 meters above sea level)
![Page 29: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/29.jpg)
![Page 30: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/30.jpg)
Bartonellosis: History
Mortality rates for the acute febrile phase varied around 40-90% in the pre-antibiotic era.
![Page 31: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/31.jpg)
LIMA-LA OROYA RAILROAD: 3,800 m above sea level
![Page 32: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/32.jpg)
Verrugas bridge (Km 61)
![Page 33: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/33.jpg)
![Page 34: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/34.jpg)
Henry MEIGGS (USA)
highest railroad in the world
(Oroya’s railroad 3,800 meters
above sea level)
(1870-1885)
![Page 35: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/35.jpg)
Carrion’s disease, 2015
![Page 36: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/36.jpg)
´`
![Page 37: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/37.jpg)
A Peruvian medical student, Daniel A. Carrión, self-inoculated fluid obtained from a verruga lesion
Days later he developed the acute phase of the disease with severe anemia and eventually died (Oct 5, 1885)
![Page 38: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/38.jpg)
Chilean soldier with ‘mullar’ lesions. He
probably became infected in the Rimac valley during the South Pacific war
Garcia, U. Historiografia de la Enfermedad de Carrion. Ideas e Imágenes en la enfermedad de Carrión. Análisis Historiográfico
de la Iconografia de la Bartonellosis Humana. Parte II. Folia Dermatológica Peruana 1999; 10 (1): 57-63.
Patient with ‘mullar’ lesions
![Page 39: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/39.jpg)
In 1905, Dr. Alberto Barton discovered the agent of Oroya fever and named it ‘endoglobular body’.
![Page 40: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/40.jpg)
In 1913, Townsend discovered the vector of the disease
(“Titira”-Phlebotomus) (Today, Lutzomyia) (sandfly)
![Page 41: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/41.jpg)
Colombia has reported
in the last 60 years only
two cases of Carrion’s
disease
It is not a public health
issue in Colombia
![Page 42: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/42.jpg)
Ecuador has
reported cases in
the coast at 150 m
above sea level
Alexander B. A review of bartonellosis in Ecuador and Colombia Am J Trop Med
Hyg 1995; 52: 354-359.
![Page 43: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/43.jpg)
In Peru, the disease is endemic at an altitude between 500-3,200 meters above sea level.
Cases have been reported from Andean valleys and the high rain forest.
Bartonellosis (Carrion`s disease):
Epidemiology
![Page 44: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/44.jpg)
0.00
4.00
8.00
12.00
16.00
20.00
24.00
28.00
32.00
36.00
1945
1947
1949
1951
1953
1955
1957
1959
1961
1963
1965
1967
1969
1971
1973
1975
1977
1979
1981
1983
1985
1987
1989
1991
1993
1995
1997
1999
2001
2003
2005
Años
Tasa x
100 0
00 h
ab.
Bartonelosis en el Perú 1945 – 2005*(SE08)
Tasa de Incidencia - Curva Histórica
Fuente: Ministerio de Salud – ESN-Metaxenicas - DGSP
Año 2004:
Casos : 8,883 (A+V+P)
T.I. : 32 x 100,000hab.
T.M. : 0.18 x 100,000 hab.
![Page 45: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/45.jpg)
Case distribution: January – June
2012
![Page 46: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/46.jpg)
Deaths caused by Carrion’s disease according to Departments and Regional Health Directions, Peru
(2002-2012 June)
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012* Total %
Ancash 2 8 8 9 2 1 1 1 0 0 1 33 13.5
Cajamarca 22 11 40 12 4 5 2 0 1 6 4 107 43.7
Cajamarca 2 0 0 0 1 0 0 0 0 0 0 3
Chota 0 0 1 1 0 0 0 0 0 0 0 2
Cutervo 3 1 9 3 1 2 0 0 0 1 1 21
Jaén 17 10 30 8 2 3 2 0 1 5 3 81
La Libertad 3 1 2 0 4 3 0 0 1 0 0 14 5.7
Amazonas 4 12 10 0 2 2 0 0 1 0 1 32 13.1
Piura Piura 2 12 3 2 1 2 5 2 0 1 1 31 12.7
Cusco 1 0 2 2 1 0 5 1 0 0 0 12 4.9
Lima Lima Norte 0 0 0 0 1 0 0 0 0 0 0 1 0.4
Huánuco 0 0 0 4 1 0 0 0 0 0 0 5 2.0
Ayacucho 0 0 0 0 3 0 0 0 0 0 0 3 1.2
Lambayeque 1 0 0 0 1 3 0 0 0 0 5 2.0
San Martín 0 1 0 0 0 0 0 0 0 0 0 1 0.4
Loreto 0 0 0 0 0 1 0 0 0 0 0 1 0.4
Total 35 45 65 29 20 14 16 4 3 7 7 245 100.0
Fuente: DGE-RENACE. (*) = Datos hasta junio de 2012.
Departamento DISA
Año
![Page 47: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/47.jpg)
![Page 48: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/48.jpg)
![Page 49: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/49.jpg)
![Page 50: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/50.jpg)
Bartonellosis –Carrion’s disease: Microbiology
The agent is Bartonella bacilliformis.
A pleomorphic Gram negative bacilli. Blood smears with Giemsa and Wright stains are useful for the diagnosis.
Special culture media containing hemoglobin, alanine and tryptophan are required for its isolation.
It grows at temperatures ranging from 25 to 28º C
The bacterium has a single pollar flagelum on electronic microscopic evaluation
![Page 51: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/51.jpg)
R. J. Birtles, Norman K. F, P. Ventosilla, A. G. Cáceres,E. Sánchez, H Vizcarra, & D Raoult. Identification of Bartonella bacilliformis Genotypes and
Their Relevance to Epidemiological Investigations of Human Bartonellosis. J Clin Microb. 2002; 40: 3606–3612
Genotypes and Epidemiology
![Page 52: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/52.jpg)
DISTRIBUTION OF THE SIX GENOTYPES OF B.
bacilliformis IN PERU, 1994-1999.
![Page 53: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/53.jpg)
Natives with severe acute forms
![Page 54: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/54.jpg)
BARTONELLOSIS (CARRION'S DISEASE) IN THE MODERN ERA 2001.
Bartonellosis remains a major problem in Peru, but many contemporary aspects of this disease have not been adequately described. We examined the cases of 145 symptomatic patients in Lima, Peru, in whom bartonellosis was diagnosed from 1969 through 1992, including 68 patients in the acute (hematic) phase and 77 patients in the eruptive (verruga) phase. In modern Peru, symptomatic patients who have acute-phase bartonellosis typically present with a febrile illness and systemic symptoms caused by profound anemia; most patients respond successfully to treatment with chloramphenicol. Patients who have eruptive-phase bartonellosis most often present with cutaneous verrugas but may have less specific symptoms, such as fever and arthralgias; diagnosis can be confirmed in such patients by Western immunoblotting, and most patients appear to respond to treatment with rifampin. PMID: 11512081 [PubMed - indexed for MEDLINE]
Maguiña C, García PJ, Gotuzzo E, Cordero L, Spach D
Alexander von Humboldt Tropical Medical Institute, Cayetano
Heredia University of Peru, Lima, Peru.
![Page 55: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/55.jpg)
CLASSIC CONCEPTS FOR CARRION’S DISEASE (old
paradigms)
Oroya fever (acute phase)
‘Intercalar’ phase – asymptomatic
Peruvian ‘verruga (warts) – chronic form
Asymptomatic carriers
![Page 56: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/56.jpg)
![Page 57: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/57.jpg)
Carrion’s disease: Signs and symptoms
Pallor 66 (97%) Hepatomegaly 56 (82%) T > 38 °C 53 (78%) Cardiac murmur 53 (78%) Jaundice 48 (71%) Lymphadenopathy 47 (69%)
Tachycardia 38 (56%)
Splenomegaly 20 (29% )
Anasarca 6 (9%)
Maguina et al. Bartonellosis (Carrion!s Disease) in the Modern Times: Clinical features of 68 patients with acute phase. CID 33:772-9 2001
![Page 59: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/59.jpg)
Many clinical patterns are present in Carrion’s disease (NEW!!)
Asymptomatic
Mild febrile illness
Moderate, acute and non complicated febrile illness
Classis acute febrile illness with common complications
Classic acute febrile illness with new features (multiorgan failure)
Recurrent acute febrile illness
Acute febrile illness and then the eruptive phase
No acute febrile illness, just the eruptive phase
Eruptive phase and then acute deterioration
Recurrent eruptive phase
Rheumatoid syndrome reumatoide ??
![Page 60: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/60.jpg)
Poor outcome, tachypnea, hypoxemia, hypotension, cardiac pump failure, myocarditis,
mechanical ventilation, inootropic and vasotropic support. Died after 48 hours post
admission in the ICU
Ig M and G for Toxoplasmosis: (+) AUTOPSY: Toxoplasma myocarditis and pneumonitis
![Page 61: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/61.jpg)
New Complications of Carrion’s disease: 2015
Neurobartonellosis: mental alteration, from somnolence to coma.
Cardiovascular involvement, multiorgan failure
Opportunistic infections
typhi and non-typhi Salmonella ( classic) , malaria, ameba
New conditions: Toxoplasmosis reactivation, TB
Disseminated histoplasmosis
Sepsis: Shigella, Staphylococcus, Enterobacter
P. jiroveci pneumonia
Tifus, Leptospirosis, etc.
![Page 62: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/62.jpg)
![Page 63: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/63.jpg)
![Page 64: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/64.jpg)
Superinfections associated with Human Bartonellosis (Acute Carrion’s Disease) among Inpatients in the Northern Peruvian Forest Pachas PE, Aranda M, Troyes L, Matos Arias J, Padilla C, Ventura G, Canelo A, Huatuco G, Chancafe JA, Suarez-Ognio L.
From 115 subjects enrolled, 75 were confirmed cases. The median age was 9 years old (3months-62 years),
and 61% were male. The main superinfections associated were: leptospirosis 54% (29/53), toxoplasmosis 8.3% (4/48), Chagas disease 1,7% (1/60), P. vivax 1.3% (1/75) and P. falciparum malaria 1.3%(1/75).
Abstracts ASTMH 56th Annual Meeting Philadelphia Marriott Downtown, Philadelphia, Pennsylvania USA, November 4-8, 2007.
![Page 65: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/65.jpg)
![Page 66: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/66.jpg)
New Cardiovascular Findings and Complications
Heart failure 62.5% Effusive pericarditis 56.5%(#) Acute pulmonary edema 40% Cardiac Tamponade 17.5% Cardiovascular shock 15% Myocarditis 2.5% Endocarditis ( 2004, first case)
(#) Ordaya, Maguiña , 2008 Acta Medica
Peruana: constrictive subacute Pericarditis
![Page 67: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/67.jpg)
![Page 68: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/68.jpg)
Oxford textbook of medicine, Vol. 1. Oxford, UK: Oxford University Press; 1996. p. 773. Llanos-Cuentas A,
Maguiña-Vargas C,
Bartonellosis. In: Warrell DA
![Page 69: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/69.jpg)
THE OLDEST PICTURE OF A PATIENT WITH CARRION’S DISEASE, BY Dr. SALAZAR
![Page 70: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/70.jpg)
Bartonellosis. Maguiña C, Guerra H, Ventosilla P. Clin
Dermatol. 2009 May-Jun; 27 (3): 271-80. Review.
![Page 71: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/71.jpg)
CARRION’S DISEASE: CHRONIC PHASE
Krumdieck CF. La Enfermedad de Carrion o Verruga Peruana en
el Niño. Anales de la Facultad de Medicina 1949; 32 (4): 227-306.
![Page 72: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/72.jpg)
![Page 73: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/73.jpg)
PLoS Negl Trop Dis. 2012;6(10):e1819.
doi: 10.1371/journal.pntd.0001819. Epub 2012 Oct 25.
Bartonella bacilliformis: a systematic review of
the literature to guide the research agenda for
elimination.
Sanchez Clemente N, Ugarte-Gil CA, Solórzano N,
Maguiña C, Pachas P, Blazes D, Bailey R,
Mabey D, Moore D.
![Page 74: DR HUGO LUMBRERAS : ULTIMO VIAJE A HUAYOPAMPA: Huaral, … › images › 001… · La Enfermedad de Carrion o Verruga Peruana en el Niño. Anales de la Facultad de Medicina ... In](https://reader034.vdocuments.us/reader034/viewer/2022042315/5f04267c7e708231d40c8f5e/html5/thumbnails/74.jpg)
BROTHERS, THERE IS STILL TOO MUCH TO DO… (DANIEL A. CARRION)
THANK YOU VERY MUCH!!