dr barry sears nfl retired players
DESCRIPTION
Dr. Barry Sears discusses inflammation and its direct relationship to concussions. His labs have developed a test for the detection of inflammation and related symptoms of concussionTRANSCRIPT
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Underlying Cause of Chronic Illness
• Increased Inflammation
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What is Inflammation?
• Ancient Greeks– Internal Fire
• Ancient Romans– Heat– Pain– Swelling– Redness
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What is Inflammation?
• Complex orchestration of pro-inflammatory and anti-inflammatory events
• Usually associated with pain• Mediated by eicosanoids• Treated by drugs that alter eicosanoids
– Aspirin– NSAID’s– COX-2 inhibitors– Steroids
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Events That Turn On Inflammatory Responses
• Microbial invasion
• Injuries
• Diet
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Two Types of Inflammation
• Screaming Pain– Organ or joint damage
• Silent Pain– Cellular inflammation
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Measuring Cellular Inflammation
• High sensitivity C-reactive protein– Non-specific– Highly variable due to infection
• AA/EPA Ratio– Most precise marker of eicosanoid
precursors at cellular level– Highly reliable
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Typical AA/EPA Ratios
1.5Japanese
15Americans
20Depression
25ADHD
40Brain Trauma
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Diseases Associated With Cellular Inflammation• Obesity• Type 2 Diabetes• Heart Disease• Cancer• Alzheimer’s• ADHD• Asthma• Allergies• Inflammatory conditions (“itis”)
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Typical Chronic Conditions In Retired NFL Players
• Obesity• Diabetes• Heart Disease• Arthritic Pain• Depression• ADHD• Dementia
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My Early Days With The NFL
• Marv Marinovitch
• Garrett Giemont
• Jon Kolb
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Improvement of Performance Of NFL Players
• LA Rams– Doug Smith– Lucious Smith
• Pittsburgh Steelers– Steve Courson
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Current NFL Teams We Work With
• Green Bay Packers• New York Jets• San Diego Chargers• Oakland Raiders
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My Early Days with Dr. Dan Amen
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Cerebral Blood Flow Can Be Altered By Zone Diet and High Dose Fish Oil
Before
After
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Effect of High-Dose Fish Oil on ADHD• Improvement
is rapid• Must be
continued to maintain benefits
AA/EPA Ratio
0
5
10
15
20
25
30
35
aaepa_1 aaepa2 aaepa3
101
102
103
104
106
107
108
109
110
Clinical Global Impression
0
1
2
3
4
5
6
psoi mglob_im fglob
101
102
103
104
106
107
108
109
110
Sorgi et al Nutrition J 6:16 (2007)
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Linear Regression with95.00% Mean Prediction Interval
- 80.00 - 60.00 - 40.00 - 20.00
AA/ EPA ratio % change pre- final
- 40.00
- 20.00
0.00
20.00
SEVEREITY OF ILLNESS % CHANGE PRE-FINAL
WW
W
W
W
W
W
W
SEVEREITY OF ILLNESS % CHANGE PRE- FINAL = 4.38 + 0.45 * aa.e.pfR-Square = 0.73
ADHD Improvement Is Correlated with AA/EPA
p =.007
Sorgi et al Nutrition J 6:16 (2007)
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SPECT Scan 12-09
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Traumatic Brain Injury
• Leading cause of death and lifelong disability among children and young adults in the United States
• 1.5 million Americans survive a traumatic brain injury, among whom approximately 230,000 are hospitalized
• 50,000 Americans die each year following traumatic brain injury
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Protocol
• EPA/DHA concentrate (2:1)
• 15 grams of EPA and DHA per day
• Measure AA/EPA ratio in the isolated plasma phospholipids weekly to ensure AA/EPA ratio >1.5
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Medical Miracle or High-Dose Fish Oil?
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Results to Date
26 M WV Coal miner CO Coma Recovered
40 M TX Firefighter CO Coma Recovered
12 M NY Baseball player Commotio cordis
ComaCardiac arrest
Recovered
40 M KY Firefighter CO Coma Recovered
29 M WV Logger CHI Coma Recovered
43 F NY Childbirth Anoxia Coma Recovered
55 F FL Stroke Ischemia Coma Recovered
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Is There a Blood Test for Predicting Future Dementia?
Group Relative IncreaseIn The AA/EPA Ratio
Normal (n = 19) 1.0Alzheimer’s (n = 19) 1.9Other dementias (n = 10) 1.8Cognitively impaired (n = 36) 1.7
Conquer et al. Lipids 35: 1305 (2000)
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AA/EPA Ratio Can Change Rapidly In Brain Trauma Patients
• Pre-Treatment (11-23-10)– AA/EPA ratio = 41
• Post-Treatment (1-20-11)– AA/EPA ratio =3
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Other Neurological Conditions Treated By
High-Dose Fish Oil
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Bipolar Depression Can Be Treated with High-Dose Fish Oil
• 9.6 grams of n-3 per day
• 500% greater remission in 3 months
Stoll et al Arch Gen Psychiatry 56: 407 (1999)
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AA/EPA
Disability Status
6
2.2
1.5
1.6*
Start 2 Year
Multiple Sclerosis Disability Can Be Reversed
* p < 0.005
Nordvik et al Acta Neurol Scand 102:143 (2000)
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My Most Well Known Parkinson’s Patient
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Animal Studies
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• Weight drop onto steel helmet affixed to skull
• Produces reliable and reproducible injury
• High yield of traumatically injured axons in white matter tracts
Impact Acceleration Injury
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Omega-3 Blood Levels
-10%
10%
30%
no supplement
10mg/kg/day
40mg/kg/day
% Change in omega 3 levels from baseline
Miles et al. J Neurosurgery 114: 77 (2011)
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AA/EPA Ratio
0%
50%
100% no supplement
10mg/kg/day
40mg/kg/day
% Change in AA/EPA ratio from baseline
Miles et al. J Neurosurgery 114: 77 (2011)
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Amyloid Precursor Protein
Accumulation in retraction bulbs of morphologically injured axons
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Immunohistochemistry
Animals subjected to impact acceleration injury demonstrate APP positive axons with retraction bulb morphology at 30 days
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Immunohistochemistry
Animals subjected to impact acceleration injury and supplemented with 40 mg/kg/day EPA:DHA demonstrate fewer APP positive axons with retraction bulb morphology at 30 days
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APP positive axonsA
xon
s p
er h
igh
po
wer
fie
ld
NoSupplement
Sham10 mg/kg/d
40mg/kg/d
9.64
0.216 0.410.330
5
10
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Chronic Disease – What’s Below the Surface
Autoimmune
Cancer
Heart diseaseAging
Neurological
Cellular Inflammation
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Summary
• Cellular inflammation is the underlying cause of neurological disease
• It can be reversed by high-dose fish oil• Test, don’t guess about how much fish
oil you need• No one is going to help you rebuild
your brain except yourself