down's syndrome: is gluten/alpha-gliadin sensitivity/coeliac disease the cause?

8/6/2019 Down's Syndrome: Is Gluten/Alpha-gliadin Sensitivity/Coeliac Disease the Cause?

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The lnternatiOnal Journal of Biosocial ResearchPublication Oftice: P.O. Box 1174, Tacoma, WA 98401 U.S.A.Published semi-annually. Reproduction without permission is prohibited.

DOWN'S SYNDROME: lS GLUTEN/ALPHA.G LIADI N SENSITIVITY/COELIACDISEASE THE CAUSE?christopher t"l;11?:;P;* i Y,t;;?;l;;lt;* o N z c P'


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Copyright @ 1984 Biosocial Publications. All rights reserued

ORIGINAL RESEARCHDOWN'S SYNDROME: lS GLUTEN/ALP HA.G LIADI N SENSITIVITY/COELIACDISEASE TH E CAUSE?

Christopher M. Reading, B.Sc., M.B., 8.S., M.R.A.N.Z.C.P.'AbstractA recent examination of Down's syndrome subjects with alphagliodin sensitiuity with or without celiocdiseose ocquired t'rom the parent suggests o model t'or ocquisition of the disorder. A genetic model ondmetabolic pothways are presented. (lnt J Biosociol Reseorch, 6(1):62-65' 1984.)INTRODUCTION

Recently Sheehan and Hillary of Dublin, Ireland, described an unusual cluster ofbabies with bown's syndrome OS) bom to former pupils of an Irish boardin_g s.chool.'This suggested an infective cause as had been suggested by Collman and Stoller2 one*pos,trZlo radiation or both. Howel et al3 reports a Down's syndrome patient that liv'ed to 71, had oesophageal cancer and coeliac disease and stated "the association ofDown's syndrome ind ioeliac disease has been reported once-previously." aWe list here the similaries between coeliac disease and Down's syndrome pro-viding findings in 26 Down's syndrome patients. Gluten antibodies were seen in47%and ilpha gliadin antibodies in 43% of patients' reticulin antibodies 78%, parietal cellantibodies 58% and, thyroid antibodies 35%.OFanelly et al of Dublin, Ireland, described the importance of alpha-gliadin an-tibodies as a serological test for coeliac disease,s supporting the concept that im-munological sensitivity to alpha-gliadin is specific to coeliac disase6.7, however, theycan occur where typical biopsy changes diagnostic of coeliac disease are not present(probably "latent coeliacs").Thui another explanation of Sheehan and Hillary's finding could be that the- mothers, being lrish, had coeliac disease or gluten/ alpha-gliadin sensitivity (and latentcoeliac disease if bowel biopsy is normal) as the cause of the meiotic non-dysjunctionas a alpha-gliadin sensitivity/coeliac disease is not uncommon in lreland'Recommendations for Research what now needs to be done to strongly supportthe above is:(1) Identifu a group of male and female Down's syndrome patients with alpha-gliadin/gluten sensitivity + coeliac disease on bowel biopsy.(2)-Study the parents for alpha-gliadin/gluten sensitivity + coeliac disease onbowel biopsy.(3) Idiniify those parents clearly with -gliadin/gluten sensitivity etc . . . and thosethat do not have the above, and finallyCorrespondence address:Pacific Medical CentreA.P.O. Box 587Dee Why 2033, AustraliaReceived Mach 21, 1984 Accepted Apnl 10' 1984.,Presented at th 13th Annual McCanison Sciety Meeting, St. Hugh's College, Oxford Univrsity, England, September 24, 1983.


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Links between Down's Syndrome, Lymphoma/Leukemia, Alzhelmer's Disease and Older Mothers and Fathers.)

aoOlder Motherand Risk forCoeliac Disease(or Latent)

Older MotherAbnormal Oocytic Maturation(1)lcAMP due to low 81, biotin, Ca and PGE,(2) +PGE, due to low PGE, due to low Vit C, 86, 83,Zn, Mn, Mg + suppression of PGErby gluten, -gliadin, other prolaminfractions or exorphins with opiateactivity.(1) & (2) ? results in meiotic non-disjunction and Trisomy 21t

.r+ L1 nnp r,o-+ / Le- k'ae*'c'

High Risk for Alzheimer's DiseaseMissed Coeliac-*Low 81, 83, 812, folate, zincPreferentialAbsorption of Cd, ,A1, Pb, Hg -ue to low 81, 86 and food allergiesToxic effect per SE of Gluten, -Gliadin, Exorphinsor other prolamin fractionsRisJ-{or Hypothyroidism, SLE, Diabetes{rlio A.rd. guclr rr L-1i1pl.pt'or'"

Older Fatherwith missed Coeliac Diseaseor Gluten/ -Gliadin SensitivityDisturbed Hypothalamo-Pituitary Regulation of/ GonadalLUpsets {t\/\/\

/\AMP I-(DS).(1) OlderMothers(2) Sibs withDS andLymphom

+++++

+++++

ExcessLH\\Depletion c{ cAMP

Down's Syndrome(with Pathology o{Coeliac Disease)

Preleukaemia)Wfor Lymphomav)o0)

h(,-n9_ B paFg REs,-cl, e.E g H''^.9 g 6!9 o-A _^!9:L!! -uJ ^ 6 ? = -2'6 Eo !T; sEfi ! P f ;E E F,t: E ,i*Qe IE g I',;oef 3-E'.E o.o.9E E_+_]9* a(n -o ,; ::F Eb!.9 -PE -'c'| u.=6 -'bE0 F3= bd*E IFE' 65.oc'p-q.0< 3 eiE s !pEEfislF.9ooots-

= oq o o oq !E q;EEES'a JJO-o.O..Jtrq)o0O0)H

=ozu- z.

q)oGq)GbpEU -LIG rr5 00P = 33d + + + + + j + j j +

.sSsEn Ht 3o=.:o o Y^r=fi-.-xOa tEEEpi FOo i:E c=:.1- X {tr; =E;6 L* V q)9, i.9_*O


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lnt J Biosocial Reseqrch Vol.6 (7):62-65,1984(a) Normal Meiosis. PGE' Series

Adequate 86, 83Vit C, Mg, Mn,ZincPGE,

(b) Abnormal Meiosis.'(1) IPGE' Series due toexorphins of wheat/grains, dairy products.(2) IPGE' Series due tolow Vit C, 83, 86, Mg, I pGE, S"ri",Mn & Zinc (as incoeliacdisease).

/ \+ PGE,

LH

/\, /cAMP

LH

^*1''\:r

/Meiosis\Normal

\/AbnormalMeiosisTrisomy 21(DS)

If 81 is low,made worse bylow calcium.Low PGEt canMAKE cAMP low.? Opioidpeptides(exorphins)can depressPGE, andthus cAMP.

' lf the mther or father of a DS child has celiac disase, they could haw low 81, 83, 86, Vit C., Mg, Mn, zinc upsefting @genesis in the rcthqor spmatogmesis in the faths md resuit in Down s Syndrome.

REFERENCESShehan, P.M.E., Hillary, I.B. An Unusual Cluster of Babies With Down's Syndrome Bom to Fomer Pupils of an lrish Berding Schol. BrMd J, 287, 1428-29, 7983.Collman, R.D., Stoller, A., Notes on the Epidmiology of Mongolism in Victoria, Australia from 7942 lo 7957 . Praeedings of the Con-ference on Science and Mental Deficiency, 7, 517 , 7962.Hwel, S.J.L., Foster, K.J., Rckless, J., Protracted Survival in Patients With D@n's Syndrcme. Br. Med J, 287, 1429.30, 1983.Bendey, D. A Case of Drun's Slmdrcme Complicated by Retinoblastoma and Celiac Disase. Pediatrics, 56, 131 3, 1975.OTarelly, C., Kelly, J., Henkkens, W., Bradley, 8., Thompson, A., Feighery, C., Weir, D.G., Alpha-Gliadin Antibody Lwels: A Serologi@lTest fq Celiac Direase. Br Med J, 286, 2007 10, 1983.Haeney, M.R., Asquith, D., Inhibition of Leucdy'te Migration by Alpha Gliadin in Patients With Gastr@ntestimal Diseasq lt's Spci{icityWith Resp4t to C@liac Disase and Alpha'Gliadin. In: McNicholl, B., McCarthy, C.F., Fottrell, P.F., Perspectives in celiac disease. Lan-caster, MTP Press,229, 1978.O'Fuelly, C., Feighay, C., Greally, J., Weir, D.G., Cellula Respose toAlphaGliadin inUntreatedCoeliacDisease. Guq23,8387,7982.Rading, C.M., Relwane of Cytotoxic Test to Detect F@d Allagieslntolaance/Hypasdsitivity in Psychiatric Patients. Addrcss toSchizophrenia Assciation of Great Britian Coference, Recnt Trends in Biological Psychiatry, Apnl 22, L98l.Radlng, C.M., Dwn's Syndrome: Nutritional Interuention. Address to the 13th Annual Conferene: The McCanison Saiety 24thSeptoba 1983. Nutrition ild Mental Health: The Unks Between Fod and Behaviour Nutr Health 3, (ln Press).

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down's syndrome: is gluten/alpha-gliadin sensitivity/coeliac disease the cause?

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