Download - zPiyix IL-2
-
7/24/2019 zPiyix IL-2
1/32
1
THE EFFECT OF CATERPILLAR FUNGUS(Cordyceps sinensis [Berk.] Sacc.)
TOWARDS IL-2 LEEL INPARACETA!OL-INDUCED !ICE
(Mus musculusL.)
"OHANES IRSAND"#$%#%#$
FACULT" OF !EDICINE!ARANATHA CHRISTIAN UNIERSIT"
BANDUNG2##&
-
7/24/2019 zPiyix IL-2
2/32
2
BAC'GROUND
Paracea*+ A,a+e/c0 A,/1/re/c0 a,
A,//,3+aa/*,
S/e e33ec 4e1a**5/c/6
L*, er 7ae *3 1aracea*+ a6
ca7e +/8er aae
-
7/24/2019 zPiyix IL-2
3/32
3
BAC'GROUND c*,Paracea*+
N-acetyl-p-N-acetyl-p-benzoquinonebenzoquinone
imine (NAPQI)imine (NAPQI)
Biotransformation
Cytochrom P450(Van de straat et al.,
1987)
Very reactive &
Toic s!"stance
#i$id Peroidationreaction(%anson, 199)
Free radicalsFree radicals
LI!" #A$A%!
&' cells &' cells
IL- IL- IL-* IFN- &NF- '#4 '#5 '# '#10 '#1*
-
7/24/2019 zPiyix IL-2
4/32
4
BAC'GROUND c*,
Cordyceps sinensis/ *,e *3 a ra//*,a+4er9a+ e/c/,e0 :4/c4 4a 9ee, :/e+6 7e96 4e a,c/e, c4/,ee
Cordyceps sinensis(&%;0&2 )
Cordyceps sinensis7e a a+er,a/8e 4era163*r a,6 k/, *3 /eae (!a,*,0 %&&2)
-
7/24/2019 zPiyix IL-2
5/32
5
PROBLE!S
D*e Cordyceps sinensisecreaeer7 IL-2 +e8e+ /, 1aracea*+-/,7ce/ce
-
7/24/2019 zPiyix IL-2
6/32
6
OB?ECTIE
E5a/,e 4e e33ec *3 Cordyceps
sinensisaa/, er7 IL-2 +e8e+ /,1aracea*+-/,7ce /ce
-
7/24/2019 zPiyix IL-2
7/32
7
RESEARCH BENEFICIALS
Acae/c 9e,e3/c/a+@ * e51a, 4ek,*:+ee a9*7 4er9a+ e/c/,e01ar/c7+ar+6 Cordyceps sinensis
Prac/ca+ 9e,e3/c/a+@ * e51+*rec/e,/3/c a11+/ca/*, 3*r Cordycepssinensisa 4e1a*1r*ec*r
-
7/24/2019 zPiyix IL-2
8/32
8
FRA!E OF WOR'SParacea*+
er7IL-2 +e8e+
er7IL-2 +e8e+
L/8er Daae
Cordyceps sinensis
-
7/24/2019 zPiyix IL-2
9/32
9
H"POTHESIS
Cordyceps sinensisecreae er7 IL-2+e8e+ /, 1aracea*+-/,7ce /ce
-
7/24/2019 zPiyix IL-2
10/32
10
EPERI!ENTAL DESIGN
C*1ara/8e 1r*1ec/8e +a9*ra*r6e51er/e, :/4 c*1+ee ra,*/e e/,
!ea7ree, *3 er7 IL-2 +e8e+ ELISAe4*
Daa O,e-Wa6 ANOA = T7ke6 HSD
-
7/24/2019 zPiyix IL-2
11/32
11
TI!E AND PLACE
T/e @ ?7,e 2##> ?a,7ar6 2##&
P+ace @ P7a Pe,e+//a, I+7 'e*kera, (PPI')0
Fac7+6 *3 !e/c/,e-!ara,a4a C4r//a,U,/8er/60 Ba,7,
-
7/24/2019 zPiyix IL-2
12/32
12
!ACROSCOPIC OF LIER
-
7/24/2019 zPiyix IL-2
13/32
13
!ICROSCOPIC OF LIER
Ce,ra+8e/,
S/,7*/
S1a/7
D/e
Ter/,a++/3a/c
L/3a/c 8e/,
L/8er ce++
'7133er ce++
B/++/ar/ ca,a+/c7+/
P*ra+ 8e/,
He1a/c arer6
B/++/ar/ D7c
-
7/24/2019 zPiyix IL-2
14/32
14
1. Metabolic function
2. Haematologic function
3. Bile secetion
LIER FUNCTION
-
7/24/2019 zPiyix IL-2
15/32
15
1. !egeneation an" accumulation intacellula
2. #ecosis an" a$o$tosis
3. %nflammation
4. &egeneation
5. 'ibosis
6. (i)osis
LIER PATHOLOG"
-
7/24/2019 zPiyix IL-2
16/32
16
PARACETA!OL(Ace4a/,*14e,)
-
7/24/2019 zPiyix IL-2
17/32
17
INTERLEU'IN 2 (IL-2)
9+a*e,/c 3ac*r0 T ce++ r*:4 3ac*r0+614*c6e 1r*+/3era/, 3ac*r
'unction* T ce++ r*:4 3ac*r
S/7+ae N' ce++ = L/3*/ B 1r*+/3era/*,
N' ce++ /33ere,/a/*,
/,creae N'ce++ k/++/, e33ec
-
7/24/2019 zPiyix IL-2
18/32
18
BIOLOGIC ACTIIT"
-
7/24/2019 zPiyix IL-2
19/32
19
CATERPILLAR FUNGUS+Cordyceps sinensis ,Be-. /acc.
!iisio * 'ungi
/ub"iisio * scomcota
(lass * /o"aiomcetes "o * H$oceales
'amili * (laici$itaceae
enus * (o"ce$s /$ecies * Cordyceps sinensis +Be-. /acc.
(H*+/a6 a, C+ea8er0 2##)
-
7/24/2019 zPiyix IL-2
20/32
20
(% (M:#!/
; co"ce$in +3
-
7/24/2019 zPiyix IL-2
21/32
21
(o"ce$in +3
-
7/24/2019 zPiyix IL-2
22/32
22
!ATERIAL = !ETHODS
DD" /ce0 2#-2$ ra0 > :eek *+
A++ /ce :ere aa1e 3*r ; a6
-
7/24/2019 zPiyix IL-2
23/32
23
Gr*71@%. C!C % (#0L
-
7/24/2019 zPiyix IL-2
24/32
24
-
7/24/2019 zPiyix IL-2
25/32
25
A8erae *3 Ser7 IL-2 Le8e+ a*, Gr*71Treae,
Groups erum IL-
Le.el
#ay / #ay
Negative Control 0 1,296
Paracetamol 19,515 40,979
Cordyceps sinensis 0,986 3,819
Paracetamol +Cordyceps sinensis
22,367 3,681
-
7/24/2019 zPiyix IL-2
26/32
26
Paracea*+ /,creae er7 IL-2 +e8e+ a Da6 $
#
2#
#
#
>#
C*,r*+ Paracea*+ CS Paracea*+ J
CS
D-$
IL-2Le8e+(1
-
7/24/2019 zPiyix IL-2
27/32
27
Cordyceps sinensis ecreae er7 IL-2 +e8e+ a Da6 %2
KK P #0### KK P #0###
KK P #0###
#
2#
#
#
>#
'*,r*+ Paraea*+ CS Paraea*+ J
CS
D-%2
IL-2Le8e+(1
-
7/24/2019 zPiyix IL-2
28/32
28
DISCUSSION
I, 1aracea*+-/,7ce /ce IL-2+e8e+ /,creae /,/3/ca,+6
Cordyceps sinensis (&%;
-
7/24/2019 zPiyix IL-2
29/32
29
DISCUSSION c*,
I,3+aa/*,
N' ce++
IL-2
CS
TNF-M
LIER DA!AGE
Paracea*+
-
7/24/2019 zPiyix IL-2
30/32
30
C*,c+7/*,
Cordyceps sinensis4a a, a9/+/6 *ecreae er7 IL-2 +e8e+in
$aracea*+-/,7ce /ce
-
7/24/2019 zPiyix IL-2
31/32
31
THAN' "OU
-
7/24/2019 zPiyix IL-2
32/32