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International Myeloma Foundation Brian GM Durie
Saturday June 10, 2017
Paris Seminar for Patients & CaregiversWhat Causes Myeloma: Current Understanding
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International Myeloma Foundation
➢Underlying tendency➢Can be in families (5 – 7%)
➢Multiple possible trigger factors
➢DNA damage from toxic exposures
Causes of Myeloma
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International Myeloma Foundation
➢Immune defect➢Abnormal immune response
➢Overreaction of immune system
➢Unable to break down toxic chemicals
➢Unable to repair DNA damage
Underlying Tendencies
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International Myeloma Foundation
Increase number and growth of plasma cells which could be or become damaged
Trigger Factors
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➢ Inflammation➢ Infection➢ Obesity➢ Implant surgery
• Metal pins/hip/knee• Breast silicone• Dental
➢ Trauma: accidents/tissue injury
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International Myeloma Foundation
Toxic chemicals
Causes of DNA Damage
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➢ Benzene; solvents➢ Farm chemicals➢ Fire retardants➢ Agent Orange/Vietnam➢ Processed food/drink chemicals
Radiation➢ Atomic ➢ Diagnostic/therapy
Other➢ Severe tissue damage: lightening strike
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International Myeloma Foundation
Jobs
Exposure Situations
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➢ Industry: benzene/solvents/etc➢ Farming: spray chemicals➢ Fireman: fire retardants/flammable chemicals➢ Military operations
Social Activities➢ Schools: weed/building sprays➢ Parks/golf courses
Home
➢ Pest spraying➢ Personal use chemicals➢ Electronics
Food➢ GMO products➢ Processed foods/drinks
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International Myeloma Foundation
Prevention Strategies
• Screening for MGUS
• Lifestyle changes
• Healthy diet
• Exposure precautions/treatment
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