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Virology 1
PM2 Pathophysiology
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Virus
• infectious particle• DNA or RNA as its
genetic material.• Needs to infect a
host cell for replication
• “toxic”, “poison”• virology
Tobacco mosaic virus
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Baltimore classification of viruses
• based on the mechanism of mRNA production. • I: dsDNA viruses
Adenoviruses, Herpesviruses, Poxviruses• II: ssDNA viruses (+)sense DNA
Parvoviruses • III: dsRNA viruses
Reoviruses • IV: (+)ssRNA viruses (+)sense RNA
Picornaviruses, Togaviruses • V: (-)ssRNA viruses (-)sense RNA
Orthomyxoviruses, Rhabdoviruses • VI: ssRNA-RT viruses (+)sense RNA :Retroviruses• VII: dsDNA-RT viruses :Hepadnaviruses
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Icosahedral
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Helical viruses
• not grouped in capsomeres
• ribbon-like structure
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Complex
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Start
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Forms of damage to the host cells
• 1. Cell lysis • 2. Production of toxic substances • 3. Cell transformation • 4. Induction of formation of substances • 5. Induction of structural alterations in the host cell ;
Nuclear (including chromosomal) or Cytoplasmic changes
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PRIONS
• Contain protein only• small, proteinaceous
particles • Kuru• Creutzfeldt-Jakob
disease syndrome
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DNA VIRUSES
• Herpes Virus
• Hepatitis B virus
• Adenovirus
• Parvovirus
• Polyomavirus
• Papillomavirus
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Herpesvirus
• herpes simplex virus type 1• herpes simplex virus type 2• varicella-zoster virus• Cytomegalovirus• Epstein-Barr virus• human herpesvirus 6• human herpesvirus 7• Kaposi's Sarcoma herpesvirus.
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HSV
• Causes encephalitis• DOC: Acyclovir
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Varicella (chickenpox)
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Herpes Zoster
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CMV: 3 types of infections
• 1. Congenital cytomegalovirus infection retinitispetechial/purpuric skin rashcentral nervous system defects
• 2. Mononucleosis syndromefever, malaise, atypical lymphocytosis,
pharyngitis• 3. immunocompromised individuals
life-threatening disease from either primary or reactivated infection
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EBV
• Epstein-Barr virus mononucleosis: most common that occurs in humans.
• Infectious mononucleosis
• Most cases: subclinical, (+) serology
• Main cause of malignant B-cell lymphoma in organ transplants
• PTLD:post-transplant lymphoproloferative disorder
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