Transcript
![Page 1: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/1.jpg)
Trusted evidence.Informed decisions.Better health.
![Page 2: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/2.jpg)
![Page 3: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/3.jpg)
➢
➢
➢
![Page 4: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/4.jpg)
![Page 5: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/5.jpg)
•
•
•
![Page 6: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/6.jpg)
Review Section Guiding Question
![Page 7: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/7.jpg)
![Page 8: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/8.jpg)
![Page 9: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/9.jpg)
![Page 10: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/10.jpg)
![Page 11: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/11.jpg)
![Page 12: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/12.jpg)
![Page 13: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/13.jpg)
![Page 14: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/14.jpg)
![Page 15: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/15.jpg)
![Page 16: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/16.jpg)
![Page 17: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/17.jpg)
• Specific statistical model to fit NMA: Bayesian vs. frequentist setting;
• Fixed or random effects; • Multivariate meta-analysis vs. hierarchical
model.
• Account for correlated nature of multi arm studies?
• Assumptions about the heterogeneity variance and the method for estimating it should be reported
![Page 18: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/18.jpg)
![Page 19: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/19.jpg)
![Page 20: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/20.jpg)
![Page 21: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/21.jpg)
![Page 22: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/22.jpg)
![Page 23: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/23.jpg)
➢
![Page 24: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/24.jpg)
➢
![Page 25: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/25.jpg)
![Page 26: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/26.jpg)
➢
.
![Page 27: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/27.jpg)
![Page 28: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/28.jpg)
![Page 30: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/30.jpg)
•
•
![Page 31: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/31.jpg)
![Page 32: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/32.jpg)
![Page 33: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/33.jpg)
![Page 34: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/34.jpg)
![Page 35: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/35.jpg)
➢
➢
![Page 36: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/36.jpg)
•
•
•
•
![Page 37: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/37.jpg)
•
•
•
•
![Page 38: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/38.jpg)
![Page 40: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/40.jpg)
‘rank’ if applicable)
![Page 41: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/41.jpg)
![Page 42: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/42.jpg)
➢
➢
![Page 43: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/43.jpg)
•
•
![Page 44: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/44.jpg)
❖
❖
❖
❖
❖
![Page 45: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/45.jpg)
❖
❖
❖
❖
❖
![Page 46: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/46.jpg)
![Page 47: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/47.jpg)
•
•
•
•
![Page 48: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/48.jpg)
•
•
![Page 49: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/49.jpg)
•
•
•
•
![Page 50: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/50.jpg)
![Page 52: Trusted evidence. Informed decisions. Better health. · Such pairwise meta-analyses can only compare two agents that have been compared directly in head-to-head trials (direct evidence)](https://reader035.vdocuments.us/reader035/viewer/2022071107/5fe1eea9de416e3ac65f4d0b/html5/thumbnails/52.jpg)
•
•