![Page 1: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/1.jpg)
Autogenous Vaccines in Principle and PracticeAn opportunity in Asia?
Tim Wallis BSc PhD
Ridgeway Biologicals Ltd, Units 1-3 Old Station Business Park, Compton, Berkshire, U.K.
www.ridgewaybiologicals.co.uk
![Page 2: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/2.jpg)
Why do we need autogenous vaccines?
• Bacteria are continuously evolving– emergence of new variants– resulting in conventional vaccine breakdowns
• Changes in farming practices create newly susceptible populations– emergence of “new pathogens”– new fully licensed products take 5yrs to develop
• Fully licenced vaccines – not always available
• Autogenous vaccines can provide a rapid solution– reduce dependence on antibiotics
![Page 3: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/3.jpg)
Autogenous (emergency) vaccines- definitions
• Derived from pathogens isolated from the target farm/production system
• Inactivated vaccines• Used where fully licensed products have proved ineffective or
are unavailable• Have to be manufactured in premises licenced by regulatory
authorities– Using QA assured manufacturing/QC processes
• Used under the supervision of veterinary surgeon
![Page 4: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/4.jpg)
High specification manufacturing facilityResourced with committed team
Strong Customer focusHighly skilled workforceResponsive vaccine manufacturing processesAdaptable production schedulingRobust Quality Assurance
“near cGMP”Strong R&D ethos
![Page 5: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/5.jpg)
Pathogen submission/strain analysis
Isolation of pathogens pre- and post-saleGood liaison: Veterinary surgeon Expert local diagnostic laboratory
BacteriologyMolecular biologyCell cultureVirology
Vaccine manufacturer
![Page 6: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/6.jpg)
Autogenous vaccine products: poultry
• Pasteurella sp• Riemerella anatipestifer• Erysipelothrix rhusiopathiae • Salmonella sp • Mycoplasma gallisepticum• Mycoplasma synoviae• Gallibacterium anatis• Ornithobacter rhinotrachealis• E.coli• Avian Influenza• Newcastle disease
LayersBroiler breedersTurkeysDucksGeeseGame birds
Multivalent vaccines can simplify vaccination programs
Vaccines adjuvated with oil or alhydrogel
![Page 7: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/7.jpg)
Autogenous Vaccine products: Pigs
Actinobacillus pleuropnumoniaHaemophilus parasuisSalmonella speciesStreptococcus suisBrachyspira hyodysenteriaeMycoplasma hyosynoviae/hyorhinis/hyopneumoniaePRRSSwine flu
![Page 8: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/8.jpg)
Autogenous vaccine products: aquatic species
Vibrio speciesTenacibaculum maritimus Flavobacterium psychrophilumYersinia ruckeriPseudomonas anguillosepticumPhotobacterium damseliaeAeromonas salmonicidaStreptococcus speciesNodavirusViral Haemorrhagic Septicaemia
Atlantic Cod SalmonTroutSea BassTilapiaOlive flounderCleaner fishDisplay fish
![Page 9: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/9.jpg)
Understanding route to Asian market
Better understand: Veterinary medicines regulations State Veterinary health service provisionIdentify lead: Veterinary Diagnostic LaboratoriesUnderstand disease issues of main: Poultry broiler breeders Table egg producers Commercial duck producers Pig integrators Aquaculture sectorsTarget market prioritiesDevelop the supply chain Logistically possible?
![Page 10: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/10.jpg)
Autogenous vaccines: Summary (1)
• Fully licenced vaccines are not always available for the diseases of minor species
• Microbial pathogens are continuously evolving leading to the emergence of new strains
• Conventional vaccines are not always able to provide cross-protection against all variants of pathogens
• Autogenous vaccines are derived from farm-specific pathogens and can control new outbreak strains
• High quality products manufactured in regulated premises with defined and controlled processes
![Page 11: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/11.jpg)
Autogenous vaccines: Summary (2)
• Formulated to the specific requirements of each client – planning is required as they are bespoke products
• Rapid, adaptable response to new emerging infections
• Valuable resource for controlling infectious disease– can help reduce dependence on antibiotics
• Not an alternative to good management, good nutrition and other prophylactic measures
![Page 12: Tim Wallis, Founder and Managing Director, Ridgeway Biologicals Ltd](https://reader036.vdocuments.us/reader036/viewer/2022070511/58a279541a28ab94628b77cb/html5/thumbnails/12.jpg)
Thanks for listening