Therapeutic Treatment of Resveratrol on Alzheimer’s Disease
with CL2006
Bradford Greaves
NeedFigure 1
Figure 2
http://uscnews2.usc.edu/Publication_JPGS/HSCWeekly/2003/HSCW2665p1.jpghttp://www.omh.state.ny.us/omhweb/Statewideplan/2005/images/figure4.2.gif
Alzheimer’s Disease
http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf
Figure 1 Figure 2
Figure 3
Figure 1
Alzheimer’s Disease cont.
http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf
Oxidative Damage
http://www.nia.nih.gov/NR/rdonlyres/A294D332-71A2-4866-BDD7-A0DF216DAAA4/0/Alzheimers_Disease_Unraveling_the_Mystery.pdf
The APP Processing
Senile Plaques
Modified from Laurén et al., Nature (2009)
Figure 1
Resveratrol Promotes Clearance of Alzheimer’s Disease Amyloid- Peptides, Marambaud 2005
The β amyloid peptide can act as a modular aggregation domain, Link 2008
Figure 2
Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans, Gutierrez-Zepeda 2005
Transgenic C. elegans as a Model in Alzheimer’s Research, Wu 2005
Purpose
To preventatively and therapeutically treat Alzheimer’s Disease with resveratrol using CL2006 and CL4176 C. elegan models
Hypothesis
Alternate Hypothesis: Both preventive and therapeutic treatment of resveratrol on CL2006 will lead to a decrease in amyloid beta production and for CL4176 there will be a delay of the onset of paralysis.
Null Hypothesis: There will be no change in amyloid beta production nor paralysis with the addition of resveratrol.
Resveratrol’s Coloration With Alzheimer’s Disease
http://www.resveratrol.org.uk/resveratrol.gif
Resveratrol’s Role
http://www.chiro.org/nutrition/ABSTRACTS/Resveratrol_in_Prevention_and_Treatment.pdf
Do Ability
• CL2006 and CL4176: Staining and Paralysis• Control food and Resveratrol available• Fluorescent Microscope at school
• Prism not known (GFP)
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