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The specific pairing we have postulated
immediately suggests a possible copying
mechanism for the genetic material Problemas:
-afinidade entre as fitas e entrelaçamento requer helicase e ATPases. - desenrolar das fitas cria enrolamento excessivo à frente, requerendo topoisomerase.- processo deve ser catalisado (é rápido)[4.8 milhões de pb em 40 min]- pareamento não é tão seletivo, é preciso mecanismo de “edição” – polimerase.- e a direção? que é exigência do fornecedor de energia? (o nucleotídeo tri-fosfato)
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Mudança conformacional de conferência
Verificação lateral, pela fenda menor
Par correto
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Par incorreto
Atividade exonucleolítica 3’-5’ = EDITORIAL
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OriC E. coli
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gene gene
ODP = origin definition point
TRDP = time of replication definition point
TRDPODP
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