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Development & Remodeling
The Skeletal System
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Bone Formation & Maintenance
Ossification (osteogenesis)
Stages
Bone formation
Begins in the 2nd month of development
Postnatal bone growth
Until early adulthood
Bone remodeling and repair
Lifelong
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Types of Ossification
1. Endochondral ossification
Bone forms by replacing hyaline cartilage
Forms most of the skeleton
2. Intramembranous ossification
Bone develops from fibrous membrane
Forms flat bones
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Endochondral Ossification
Uses hyaline cartilage models
Requires breakdown of hyaline cartilage prior to ossification
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Copyright © 2010 Pearson Education, Inc. Figure 6.9
Bone collar
forms around
hyaline cartilage
model.
Cartilage in the
center of the
diaphysis calcifies
and then develops
cavities.
The periosteal
bud inavades the
internal cavities
and spongy bone
begins to form.
The diaphysis elongates
and a medullary cavity
forms as ossification
continues. Secondary
ossification centers appear
in the epiphyses in
preparation for stage 5.
The epiphyses
ossify. When
completed, hyaline
cartilage remains only
in the epiphyseal
plates and articular
cartilages.
Hyaline
cartilage
Area of
deteriorating
cartilage matrix
Epiphyseal
blood vessel
Spongy
bone
formation
Epiphyseal
plate
cartilage
Secondary
ossification
center
Blood
vessel of
periosteal
bud
Medullary
cavity
Articular
cartilage
Childhood to
adolescence
Birth Week 9 Month 3
Spongy
bone
Bone
collar Primary
ossification
center
1 2 3 4 5
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Copyright © 2010 Pearson Education, Inc. Figure 6.10
Calcified cartilage
spicule
Osseous tissue
(bone) covering
cartilage spicules
Resting zone
Osteoblast depositing
bone matrix
Proliferation zone
Cartilage cells undergo
mitosis.
Hypertrophic zone
Older cartilage cells
enlarge.
Ossification zone
New bone formation is
occurring.
Calcification zone
Matrix becomes calcified;
cartilage cells die; matrix
begins deteriorating.
1
2
3
4
Epiphyseal
growth plates
continue to
produce
cartilaginous
elongation as long
as bones are
increasing in length
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Intramembranous Ossification
Forms flat bones
Skull roof, lower jaw, clavicles
Uses a fibrous membrane model formed from mesenchymal
cells
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Figure 6.8, (1 of 4)
Mesenchymal
cell
Collagen
fiber Ossification
center
Osteoid
Osteoblast
Ossification centers appear in the fibrous
connective tissue membrane.
• Selected centrally located mesenchymal cells cluster
and differentiate into osteoblasts, forming an ossification center.
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Figure 6.8, (2 of 4)
Osteoid
Osteocyte
Newly calcified
bone matrix
Osteoblast
Bone matrix (osteoid) is secreted within the
fibrous membrane and calcifies.
•Osteoblasts begin to secrete osteoid, which is calcified
within a few days.
•Trapped osteoblasts become osteocytes.
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Bone Maintenance
Bone is dynamic throughout human lifespan
Remodeling has several functions
Replacement and repair
Release of calcium
Response to stress (modification of density)
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Bone Remodeling
Deposit
Where bone is injured or
added strength is required
Osteoblasts
Resorption
Releases minerals from
bone
Osteoclasts
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Control of Remodeling
Hormones
Growth Hormone (GH)
Calcitonin
Parathyroid Hormone (PTH)
Sex hormones
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Hormonal Control of Blood Ca2+
Blood Ca2+ levels
Parathyroid glands release PTH
PTH stimulates osteoclasts to degrade bone matrix and release Ca2+
Blood Ca2+ levels
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Figure 6.12
Osteoclasts
degrade bone
matrix and
release Ca2+
into blood.
Parathyroid
glands
Thyroid
gland
Parathyroid
glands release
parathyroid
hormone (PTH).
Stimulus
Falling blood
Ca2+
levels
PTH
Calcium homeostasis of blood: 9–11 mg/100 ml
BALANCE BALANCE
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Bone Maintenance
Bone deposition
Occurs where bone is injured or added strength is needed
Development requires proper nutrition
Vitamins C, D, and A
Calcium and phosphorus