The NIH Roadmapfor Medical Research
nihroadmap.nih.gov
Evolving Health Challenges
Acute to Chronic Conditions
Health Disparities
Emerging Diseases
Aging Population
Biodefense
Why was there a need for a Roadmap?
Position NIH to address evolving public health challenges
Accelerate the pace of discoveries Develop more rapid translation from
laboratories to patients and back
NIH Roadmap Goals..
Accelerate basic research discoveries and speed translation of those discoveries into clinical practice
Explicitly address roadblocks that slow the pace of medical research in improving the health of the American people
NIH opportunities and challenges…
Revolutionary and rapid changes in science Increasing breadth and growth of NIH mission NIH is a complex organization made up of 27
institutes and centers, as well as multiple program offices, structured by Disease, Organ, Life stage, Discipline ….
Rapid convergence of science Multi- and interdisciplinary research
Multi- and Interdisciplinary Research will be Required to Solve the “Puzzle” of Complex Diseases and Conditions
GenesBehaviorDiet/NutritionInfectious agentsEnvironment Society???
How was the Roadmap developed?
Extensive consultations with stakeholders, scientists, health care providers
Discussions addressed: What are today’s scientific challenges? What are the roadblocks to progress? What do we need to do to overcome roadblocks? What can’t be accomplished by any single Institute
but is the responsibility of NIH as a whole?
What is the NIH Roadmap? A framework of priorities that the NIH
as a whole must address in order to optimize its entire research portfolio.
A set of initiatives that are central to extending the quality of healthy life for people in this country and around the world.
A vision for a more efficient and productive system of biomedical and behavioral research.
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Roadblocksto technology transfer
Three themes emerged….
New Pathwaysto Discovery
Re-engineering theClinical Research
Enterprise
Research Teamsof the Future
NIH
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New Pathways to Discovery
Building Blocks, Biological Pathways, & Biological NetworksMolecular Libraries & Molecular ImagingBioinformatics & Computational BiologyStructural BiologyNanomedicine
nihroadmap.nih.gov/newpathways/index.asp
New Pathways to Discovery
Grasping the emerging complexity of biology Understanding biological systems Accessing biological data, technologies, and other
scientific resources Promoting Multi-and Interdisciplinary research
Initiatives within this theme address Initiatives within this theme address technologies and approaches necessary to technologies and approaches necessary to meet contemporary research challenges.meet contemporary research challenges.
Bioinformatics and Computational Biology: National Centers for Biomedical Computing Partnerships of:
Computer scientists Biomedical computational scientists Experimental and clinical biomedical and behavioral
researchers Focused on software rather than hardware Each National Center to have Driving Biological
Projects Programs in preparation for partnerships between
individual investigators and National Centers
www.bisti.nih.gov/ncbc/index.cfm?
The FY-2004 NIH Roadmap -National Centers for Biomedical Computing: Physics-based Simulation of Biological Structures
Russ Altman, M.D., Ph.D. Stanford University
National Alliance for Medical Imaging ComputingRon Kikinis, M.D.Brigham and Women's Hospital
Informatics for Integrating Biology and the BedsideIsaac Kohane, M.D., Ph.D.Brigham and Women's Hospital
Center for Computational BiologyArthur Toga, Ph.D. University of California at Los Angeles
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Interdisciplinary Research TeamsPioneer Award
Public-Private Partnerships
Research Teams of the Future
Building Blocks, Biological Pathways, & Biological NetworksMolecular Libraries & Molecular ImagingBioinformatics & Computational BiologyStructural BiologyNanomedicine
nihroadmap.nih.gov/researchteams/index.asp
Research Teams of the Future
Encouraging Multi- and Interdisciplinary teams Supporting larger, coordinated, resource sharing teams Preserving investigator-initiated strategy Promoting investigators to take creative, unexplored
avenues of research
Initiatives within this theme provides Initiatives within this theme provides mechanisms for interdisciplinary research, mechanisms for interdisciplinary research, high-risk strategies and public-private high-risk strategies and public-private partnerships.partnerships.
NIH Director’s Pioneer Award New program to support individuals with
untested, potentially groundbreaking ideas!
Encourages innovation, high risk taking
Totally new application and peer review process
Expected to be highly competitive
Expanded eligibility – (not only traditional biomedical investigators)
Provides $500,000 per year for 5 years
nihroadmap.nih.gov/pioneer/
NIH Director’s Pioneer Award Laurence F. Abbott, Ph.D., Brandeis University, Waltham, MA
George Q. Daley, M.D., Ph.D., Children's Hospital, Boston, MA
Homme W. Hellinga, Ph.D., Duke University Medical Center, Durham, NC
Joseph McCune, M.D., Ph.D., J. David Gladstone Institutes, San Francisco, CA Steven L. McKnight, Ph.D., UT Southwestern Medical Center, Dallas, TX
Chad Mirkin, Ph.D., Northwestern University, Evanston, IL
Rob Phillips, Ph.D., California Institute of Technology, Pasadena, CA
Steven R. Quake, Ph.D., California Institute of Technology, Pasadena, CA
Sunney Xie, Ph.D.. Harvard University, Cambridge, MA
nihroadmap.nih.gov/pioneer/Recipients04.aspx
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Clinical Research Networks, & NECTARDynamic Assessment of Patient-Reported Chronic Disease OutcomesClinical Research Policy Analysis & CoordinationClinical Research Workforce TrainingTranslational Research
Interdisciplinary Research TeamsPioneer Award Public-Private Partnerships
Re-engineering the Clinical Research Enterprise
Building Blocks, Biological Pathways & Biological NetworksMolecular Libraries & Molecular ImagingBioinformatics & Computational BiologyStructural BiologyNanomedicine
nihroadmap.nih.gov/clinicalresearch/index.asp
Reengineering the Clinical Research Enterprise
Promoting better integration of existing clinical research networks, including the National Electronics Clinical Trials and Research (NECTAR) network
Supporting translational research Encouraging the development of technologies to improve
the assessment of clinical outcomes Harmonizing regulatory processes Enhancing training for clinical researchers
Initiatives within this theme address the need Initiatives within this theme address the need for developing new strategies to enhance the for developing new strategies to enhance the infrastructure and capacity for clinical research infrastructure and capacity for clinical research and reenergize the clinical research workforce.and reenergize the clinical research workforce.
NIH RoadmapPercent of Total NIH Budget – FY-2004
FY-2005 Request = $28,757 Million
Non-Roadmap99.2%
($28,520 Million)
Roadmap0.8%
($237 Million)
“How does the NIH Roadmap benefit research funded by NIH ICs?” Speeding removal of major and fundamental
roadblocks common to all diseases
Institutes working together to solve issues
This is a common trans-NIH pool of transforming investments open to all disease areas and all investigators for competition
The NIH Roadmap:A Work in Progress
nihroadmap.nih.gov