Catalyzing Collaborations Outside NIH
Translation is a team sport
Requires tof performers with a wide variety of different expertise to work together to a common goal
Catalyzing Collaboration within NCATS
Across the Translational Spectrum
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Clinical and Translational Science Awards Led by NCATS Division of Clinical Innovation
CTSAs:
• Support a national consortium of medical research institutions
• Work together to improve the way clinical and translational research is conducted nationwide
Recent CTSA Awards Announcement
Examples of translational problems for
next-gen CTSA focus
• Data interoperability/governance
• Clinical trial networks
• EHRs for research
• IRB federation
• Patient recruitment
DHHS-NIH
ORDR/NCATS, NINDS,
NIAMS, NICHD, NHLBI,
NIDDK, NIDCR, NIAID, NCI
The Data Management and
Coordinating Center
Coalition of Patient
NCATS DPI Staff
• Drug: IT Cyclodextrin
• Collaborators
ü NIH
Tissue Chips for Drug Screening, a.k.a.: Microphysiological Systems (MPS) Program
• Goal ü Develop chip to screen for safe, effective drugs
Á Liver, heart, lung, other cell types
Á Designed for multiple different readouts
• NIH, DARPA contribute ~$70M 8ach over 5 y8ars ü NCATS and DARPA independently manage, fund separate
MPS Program Stem Cell Research and Therapy Special Issue
• Stem Cell Research and Therapy published a
supplement about Tissue Chip program on
December 20, 2013
• Introduction authored by Margaret Sutherland,
(NINDS), Dan Tagle, and Kristin Fabre (NCATS)
• 18 reviews authored by Tissue Chip grantees
• Freely available at:
http://stemcellres.com/supplements/4/S1.