The Gut-Brain Matrix,

Reprogramming

Health for Kids,

Moms, and Other

Superheroes

Zach Bush, MD

Internal Medicine, Endocrinology and Metabolism

Founder, Director of Clinical Affairs

Revolution Health Center

Charlottesville, VA

Founder, CEO

Biomic Sciences

Disclosure

• I am founder of Biomic Sciences, which has brought to

market RESTORE, the first carbon-based redox

supplement

• I am the founder and President of Revolution Health

Center, Charlottesville, VA.

• My clinical practice, basic science operations,

discoveries, and experience that I share with you today

produce all of my income

• I am not paid by any third-party companies or

organizations for my presentations or educational efforts

US Ranks 49th in Health Outcomes

1st World Epidemics

• Autism 1:45

• Attention Deficit 1:10 (70% medicated)

• Asthma 1:10

• Allergy 1:4

• Diabetes 1:4

• Obesity 1:3

• Major Depression 1:2

• Cancer 1:2

• Dementia 1:1

1st World Epidemics –

With Gut/Brain Source• Autism 1:45

• Attention Deficit 1:10 (70% are medicated)

• Asthma 1:10

• Allergy 1:4

• Diabetes 1:4

• Obesity 1:3

• Major Depression 1:3

• Cancer 1:2

• Dementia 1:1

Root Cause of Disease?Root Cause of Aging and Disease

Inflammation is the root of all

chronic disorder and disease

Autism

Depression

Oxidative Stress

• Acute inflammation can save our lives

– Injury Repair

– Infection control

• Chronic inflammation

– Oxidative stress = positive charge/acid

– Shutdown/overwhelm of the antioxidant system

chronic inflammation = loss of communication

Neurologic Inflammation

Brain Fog – Anxiety –Depression

– Fatigue – Chronic Pain

An adult spectrum disorder continuum

• Repeated/chronic stress leads to loss of volume

in the hippocampal formation –

– Hippocampus – memory processing

– Amygdala – Intense emotion processing

The Brain and Chronic Inflammations

Hypothalamic Stress

- immune (oxidative)

- hormonal

- neural/muscular

- psychological/emotional

--

Amygdala

What has changed??

• Did you have these same symptoms 10

years ago?

• Did your parents have the same problems

you do when they were your age?

– 1900, Major Depression 1:100

– 2000, USA Major depression prevalence 1:3

– 2015, USA Major depression prevalence 1:2

What Is the

Root Cause of Inflammation?Root Cause of Aging and Disease

Ecosystem News

• Bacterial population patterns in the human gut

predict occurrence of chronic inflammatory disease

– Obesity/Diabetes

– Asthma

– Autoimmunity

– Cancers

– Dementia

– Autism

Intercellular Tight Junctions

Firewalls of Defense

The GALT

• Gastrointestinal-Associated Lymphoid Tissue

GALT: 80% of the

antibodies in your

body are made here

Gut Inflammation

Food Sensitivity

Asthma/Eczema

Allergy

Autoimmune

Gut/Brain Axis

• Gut injury: Gluten, Glyphosate,

Lipopolysaccharides

• Zonulin goes systemic

• Tight junction injury– Gut

– Blood/brain barrier

– Vascular system

– Kidney tubules

Blood/Brain Barrier Leak

CNS inflammation

• Leaky Brain

– Interleukin inflammatory cytokines

– Neurotransmitter dysregulation

– Neurohormonal stress

What Is the

Root Cause of Population

Gut/Brain Injury?Root Cause of Aging and Disease

A Catastrophic Vulnerability

Bacteria

Unprotected

Membranes

Tight Junction Toxins

Bacteria

Bacterial Metabolites:

Carbon-Based Redox System• Each bacterial species (30,000 species) creates a unique

subset of carbon metabolites during the digestive process

• These function as an interspecies molecular communication network that allows for coordinated cell protection, injury response, and repair

Carbon Redox

www.restore4life.com

What are your bacteria saying?

• Dysbiosis: broken ecosystem– Monoculture

Antibiotics, pesticides, chemicals, processed foods• Weeds grow up: E.coli, Klebsiella, Pseudomonas, Candida

Probiotics – 3 - 24 species, $30 Billion monoculture

Monoculture = limited vocabulary = limited defense

• Optimal bowel ecology = 20,000 species

Biodiversity = fluid communication = strong defense

Functional Gut Barrier

www.restore4life.com

Gliadin (Gluten)

Tight Junction ImagingCONTROL Gliadin in 1 slice of pizza

www.restore4life.com

Glyphosate

Tight Junction ImagingCONTROL GLYPHOSATE 10 PPM

www.restore4life.com

Bacterial communication impacts

tight junction functionT

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www.restore4life.com

CONTROL GLIADIN

GLIADIAN and RESTORE RESTORE ww

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CONTROL GLYPHOSATE

GLYPHOSATE and RESTORE RESTORE

GLUTENToxic Peptides

CXCR3

InflammationZONULIN

ENZ

TJ breakdown

Leaky Gut/Brain Leak GutGLYPHOSATE

BACTERIAL/YEAST

OVERGROWTH

Enzymes

Chronic Inflammation

Leaky Gut/Brain

Leaky Gut - Leaky Brain

Inflammation Cascade from birth to death

Colic

Sensory-Processing Defects

Attention Deficit

Anxiety Disorders

Major Depression

Disordered Sleep

Insulin Resistance

Infertility

Diabetes

Vascular Disease

Cancer

Dementia

US Ranks 49th in Health Outcomes

www.restore4life.com

Gut/Brain Injury

What can we do about it?

• Tight junction firewall up and running

• Direct toxin antidote – glyphosate, gluten, pharmacy

• Promote eco-diversity in the gut and beyond

• Increase enzyme breakdown of toxins

• Increase bio-availability of food nutrients

Maximize the Biome:

Get out in nature – breathe biodiversity

Grow your own food

Eat from the bottom of the food chain

Stop dairy (high glyphosate, highly acidic)

Wild Fermented foods:

miso soup, sauerkraut, etc.

Gut/Brain Communication Supplement:

What’s in Restore?• Raw ingredients include Carbon-based redox

molecules from fossil soil in the USA. This inert raw material is shipped to VA where we put the substrate through a redox process to achieve the safety and biologic efficacy of the finished product

• Trace micronutrients – minerals and amino acids with concentration profiles similar to that of a sweet potato skin.

• Unprecedented results in cellular safety studies– Gold-standard Renal Tubule Toxicity studies – No LD50,

extends life of cell lines at every concentration

– Even at 100% concentrations renal and hepatocyte studies show zero toxicity, instead at every concentration Restore increases longevity/decreases apoptosis rates

Restore Logistics

• For very sensitive individuals:

– 2-5 drops by mouth – plain or

with non-chlorinated water/juice

– Slowly increase to 1 TSP – 1 TBL three times/day

• Reduce or stop probiotics and digestive enzymes to

speed recovery of natural gut biome diversity and

healthy digestive processes

• No drug-drug interactions

Intelligent membranes,

What to expect• Bowel changes – formed stools, more bulk

to the stools, typically resulting in two large

soft, formed stools when at optimal use

• Nutritional changes – food absorption and

digestion improves, decreased dark circles

under eyes, better skin health

• Metabolic changes – growth recovery

• Neurologic changes – verbal changes,

attention/focus, visual processing

changes, gait and 3D processing changes

• appeite

Side effects of the

rehydration/refeeding syndrome• Constipation/Bloating

– Hydration

– Magnesium Calm powder twice to three times

daily

– Reduce to two drops or nasal use of Restore

if needed

• Diarrhea/cramping – this can indicate

parasite – discuss with your

pediatrician/consult usage guidelines

Side effects of the

rehydration/refeeding syndrome• Neurologic

– Mood changes

– Hyperactivity

– Sleep changes

• Wrapping/nurture techniques

• Knapping

• Brain Gym

• Nitric Oxide breathing exercises – buteyko

breathing

References1. Centers for Disease Control and Prevention (CDC), Key Findings: Trends in the

Parent-Report of Health Care Provider-Diagnosis and Medication Treatment for ADHD: United States, 2003-2011 the National Survey of Children's Health (NSCH)

2. Ellwood P, Williams H, Aït-Khaled N, Björkstén B, Robertson C, ISAAC Phase III Study Group. Translation of questions: The International Study of Asthma and Allergies in Childhood (ISAAC) experience. Int J Tuberc Lung Dis. September 2009; 13(9): 1174-1182

3. Massey JT, Moore TF, Parsons VL, Tadros W. Design and estimation for the National Health Interview Survey, 1985–1994. National Center for Health Statistics. Vital Health Stat 1989;2(110)

4. Botman SL, Moore TF, Moriarity CL, Parsons VL. Design and estimation for the National Health Interview Survey, 1995–2004. National Center for Health Statistics. Vital Health Stat 2000;2(130)

5. Centers for Disease Control and Prevention. National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States, 2014. Atlanta, GA: US Department of Health and Human Services; 2014

References6. Janeway, CA Jr.; et al. (2001). "The mucosal immune system". Immunobiology. New

York: Garland Science. 10-13

7. Salminen S, Bouley C, Boutron-Ruault MC, et al. (1998). "Functional food science and gastrointestinal physiology and function". British Journal of Nutrition 80 (S1): S147–S171

8. Moriame G; et al. Viral Suppression and Immune Restoration in the Gastrointestinal Mucosa of HIV Type 1-Infected Patients Initiating Therapy during Primary or Chronic Infection Journal of Virology, August 2006, p. 8236-8247, Vol. 80, No. 16

9. Abbas A.B.; Lichtman A.H. (2009). "Ch.2 Innate Immunity". In Saunders (Elsevier). Basic Immunology. Functions and disorders of the immune system (3rd ed.)

10. Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). "Inflammation in wound repair: molecular and cellular mechanisms". Journal of Investigative Dermatology 127 (3): 514–525

11. Van Dorpe, S; et al. (2012). "Brainpeps: The blood–brain barrier peptide database". Brain structure & function 217 (3): 687–718

12. Schneider, Stefan W.; et al. (March 2004). "Glioblastoma cells release factors that disrupt blood–brain barrier features". Acta Neuropathologica 107 (3): 272–276

References13. H Chen; EE Konofagou. Journal of Cerebral Blood Flow &

Metabolism (2014) 34, 1197–1204

14. H Matsui ; et al. (2011). The pathophysiology of non-steroidal anti-inflammatory drug (NSAID)-induced mucosal injuries in stomach and small intestine J Clin Biochem Nutr. 2011 Mar; 48(2): 107–111

15. Eadon MT; et al. Endotoxemia alters tight junction gene and protein expression in the kidney (2012). Am J Physiol Renal Physiol. 2012 Sep 15; 303(6): F821–F830

Bacterial Communication Induces

Differential

Mitochondrial ROS Activity

RO

S p

roduction

www.restore4life.com

ROS assay RT- PCR

1 3 5 10 60

Minutes

DAMAGED

(MCF-7)

HEALTHY

Bacterial Communication Impacts

Stem Cell Activation

Urine C

D133

www.restore4life.com

Urine CD133 Stem Cell Marker

before and two hours after Restore