Download - The CHEST trial - HES in the ICU
![Page 1: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/1.jpg)
Colloids - The end of the end for starches in the critically ill ??
Dr Andrew FergusonConsultant in Anaesthetics and Intensive Care Medicine, Craigavon Area Hospital
Myburgh JA, et al. Hydroxyethyl Starch or Saline for Fluid Resuscitation in Intensive Care. NEJM 2012; 367:1901-1911
The CHEST Study
![Page 2: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/2.jpg)
Philosophical Disclosures
• I’ve used HES, and I quite liked it
• I like albumin• I believe all iv fluids are potentially harmful
• No other conflicts to declare
Confessions
![Page 3: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/3.jpg)
How this Piggy got to Market
• Approval based on small clinical studies– Underpowered
– Limited clinical settings
– Limited follow-up duration
– Limited comparators – better than ancestors
• Approval based on what came before– Previously approved colloids/HES
– Assumption of “a HES is a HES is a HES”
![Page 4: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/4.jpg)
What happened when Piggy got there?
• Novelty• Marketing• Reinforcement by small positive trials• Usage outside original study settings• Impression of benefit => clinical bias• Increased usage• Positive poor-quality reviews
![Page 5: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/5.jpg)
The CHEST trial
Maize-based
![Page 6: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/6.jpg)
Who was in?• Consent obtained (pro-or retrospectively)• Fluid resuscitation required based on at least one of:
• HR > 90 bpm
• SBP <100 mmHg or MAP < 75 mmHg or 40% fall from baseline
• CVP < 10 mmHg
• PCWP < 12 mmHg
• SPV/MAPV > 5 mmHg
• Capillary refill time > 1 second
• U/O < 0.5 ml/kg for 1 hour
• Clinician content that HES and saline equally suited
![Page 7: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/7.jpg)
Who was out?
![Page 8: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/8.jpg)
Screening
![Page 9: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/9.jpg)
Fate of randomised patients
![Page 10: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/10.jpg)
Intervention• 6% HES 130/0.4/9:1 in 0.9% NaCl v 0.9% NaCl (saline)• Identical 500-ml Freeflex bags, composition checks• Staff blinded to allocation
• Used for all fluid resuscitation in ICU during the first 90 days following randomisation or until death
• Maximum daily dose 50 ml/kg/day • If upper limit exceeded during 24-hrs, open-label 0.9% NaCl
used until 24-h period lapsed, following which patient resumes allocated study fluid.
![Page 11: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/11.jpg)
Data collection
RIFLE up to day 7, SOFA to day 28, RRT in ICU
![Page 12: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/12.jpg)
Sample size (7000 patients)• Based on 90-day mortality of 26% in saline group
– Actual 90-day mortality 17%
• 90% power to detect absolute difference of > 3.5% in mortality with 5% loss to follow-up
• 90% power to detect an increase in the RR for renal failure by factor of 1.5 from expected 6% (saline group)
– Actual incidence 9.2% of RIFLE-F
– Actual incidence RRT 5.8%
![Page 13: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/13.jpg)
Statistical analysis• Binary outcomes– Relative risk (95% CI) & Chi-square
• Continuous outcomes– Mean difference and unpaired t-tests
• Adjusted analysis– Baseline covariates trauma, age, admission source,
APACHE II, baseline creatinine– Binary outcomes - robust Poisson regression– Continuous outcomes - robust linear regression
• Survival times– Log rank presented as Kaplan-Meier curves
![Page 14: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/14.jpg)
Primary Outcome – Death @ 90d
NO significant difference
![Page 15: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/15.jpg)
Secondary Outcomes
More RRT, significantly less RIFLE-R and -ILower incidence of new CVS failureMore hyperbilirubinaemia
![Page 16: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/16.jpg)
The piggy goes “wee….wee….wee”
![Page 17: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/17.jpg)
Tertiary outcomes
No significant difference
![Page 18: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/18.jpg)
Treatment related adverse effects
Effectively all cutaneous
![Page 19: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/19.jpg)
Subgroup Analyses – Death @ 90d
Based on urine output
![Page 20: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/20.jpg)
Fluid Intake
More fluid in Saline group
More blood in
HES group
![Page 21: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/21.jpg)
Author’s conclusions
• No difference in 90 day mortality overall or sub-groups• 21% relative increase in RRT• Less new CVS failure
• No evidence of clinical benefit with HES
![Page 22: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/22.jpg)
Criticisms put forward
• “All-comers” study - dilution of benefit and harm
• Indications for administration of fluid
• Use of a colloid in patients post-resuscitation phase
• Lack of goal-directed approach
• Lack of renal data past day 7 and no control of RRT
• No assessment of harm effect of PRBC transfusion
• No control of transfusion trigger
![Page 23: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/23.jpg)
The bottom line for the patientYou’ll be less likely to need pressors, BUT
You’re just as likely to dieYou won’t get off the vent or out of ICU quickerYour creatinine is more likely to go upYou’re more likely to need “dialysis”You’re more likely to get a blood transfusionYou’re more likely to go a bit yellowYou’re more likely to get a rashYou’re more likely to get an itch and it may not go away
![Page 24: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/24.jpg)
Where next?
• Enough evidence to guide practice inside ICU• Calls for – focus on pre-ICU resuscitation phase– more perioperative trials– better crystalloids– ditch HES altogether outside RCT
• Regulatory review
![Page 25: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/25.jpg)
“It is a mistake to think you can solve any major problems just with potatoes”
Douglas Adams, Life, the Universe, and Everything
or maize!
![Page 26: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/26.jpg)
Parting thoughts – Challenge assumptions
If you have never changed your mind about some fundamental tenet of your belief, if you have never questioned the basics, and if you have no wish to do so, then you are likely ignorant.
Before it is too late, go out there and find someone who, in your opinion, believes, assumes, or considers certain things very strongly and very differently from you, and just have a basic honest conversation. It will do both of you good.”
Vera Nazarian, The Perpetual Calendar of Inspiration
![Page 27: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/27.jpg)
Not everyone agrees about efficacy• It works if you select the right end-point– What should that be? Haemodynamics? Volume?
Oedema?• It works in some conditions, not in others– Effects are disease-specific
• It works in some patients, not in others– Effects are patient-specific (for unknown reasons)
• It works if you don’t give too little or too much– Effects are dose-specific (dosing schedule unknown)
• It works if you give it at the right time– Effects are time-specific (best time-point unknown)
![Page 28: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/28.jpg)
Not everyone agrees about safety• It is safe in some conditions, is harmful in others– Any harm is disease-specific
• It is safe for some patients, is harmful to others– Any harm is patient-specific (but who?)
• It’s benign, if you choose the right one– Any harm is molecule & structure-specific
• It is benign, but the carrier is harmful– Any harm is formulation-specific (no evidence)
• It is safe unless overdosed– Harm is dose-specific
![Page 29: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/29.jpg)
Complex questions about HES
• Do we know when we should/shouldn’t use it?
• Do we know what we want it to do?
• Do we know how to measure/titrate its effect?
• Does it do what we want it to do?
– Even if it does, then:
• Is it as good as the alternatives?
• Is it as safe as the alternatives?
• Is it as cost-effective as the alternatives?
![Page 30: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/30.jpg)
Fluid-related background signals…
• Acid-base abnormalities• Impaired coagulation • Fluid overload• Osmolality and tonicity issues• Allergic reactions• Direct organ toxicity• Effects on inflammation
![Page 31: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/31.jpg)
Poor quality
Low event rates
Small patient numbers
Poor reporting of adverse events
![Page 32: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/32.jpg)
Physiological effects
![Page 33: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/33.jpg)
Outcome adjusted for age, APACHE, baseline creatinine trauma diagnosis
![Page 34: The CHEST trial - HES in the ICU](https://reader033.vdocuments.us/reader033/viewer/2022052822/554b036db4c90559058b553e/html5/thumbnails/34.jpg)
Remaining questionsMechanism? Are the issues secondary toa) Inappropriate use?b) Cumulative exposure?c) Dosing rate?d) Impact of endothelial glycocalyx disruption?e) Impact of blood product use?
Is HES still an option for EGDT in severe sepsis as a defined, time & volume limited therapy?