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Synthetic BiologyPresentation by Brown iGEM Team
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Building Biotechnology
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Bacterial Photography
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E. Coli that smell!
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Biofuels
GreenFuel Company
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Invade Cancer Cells
1. Aerobic Conditio
ns
2. Low Oxygen Detected!
3. INVASION!
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How do we build these?
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Parts
Devices
Systems
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DNA:
AATGAATATCCAGATCG
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Biological Part:
PromoterPromoter
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Biological parts are building blocks made of
genetic material
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---
Different Parts connect together
PromoterPromoter--- ---GeneGene ---TerminaTerminatortor
This is a device
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MIT Parts Registry
A database with standardized genes for easy assembly and reusability.
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MIT Parts Registry
From about 100 parts in 2004
to about 2000 parts in 2007
But still a lot of work to be done!
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Characterization
•How does this part work?
•What does it do?
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Recap
•A set of tools and parts to engineer biology
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What is iGEM?•Internationally Genetically Engineered Machines Competition
•Brown’s Team: 7 undergraduate students
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Our Projects
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Lead Sensor
•Lead contamination is health problem
•Expensive to sense lead
•We need cheap solution that doesn’t take long
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Lead Sensor
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Tri-Stable Switch
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Tri-Stable SwitchTurn on/off three different proteins in cell
Differentiation of stem cells
Tissue Engineering
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Synthetic Biology at Brown
University•Synthetic Biological SystemsProfessor Wessel
•BiomechanicsProfessor Richardson
•BiomaterialsProfessor Webster
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