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Supplementary Information
A Convenient Synthesis, Reactions and Biological Activity of Some New
6H-Pyrazolo[4’,3’:4,5]thieno[3,2-d][1,2,3]triazine Compounds as Antibacterial,
Anti-Fungal and Anti-Inflammatory Agents
Remon M. Zaki,*,a Adel M. Kamal El-Dean,
a Shaban M. Radwan
a and Ahmed F. Saber
a
aChemistry Department, Faculty of Science, Assiut University, 71516 Assiut, Egypt
Spectral analyses
Figure S1. FTIR spectrum (KBr) of amino thienopyrazolecarbonitrile compound 5.
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*e-mail: [email protected], [email protected]
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Figure S2. 1H NMR spectrum (300 MHz, DMSO-d6) of amino thienopyrazole carbonitrile compound 5.
Figure S3. 13
C NMR spectrum (300 MHz, DMSO-d6) of amino thienopyrazole carbonitrile compound 5.
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Figure S4. Mass spectrum of the o-amino carbonitrile compound 5.
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Figure S5. FTIR spectrum (KBr) of chlorotriazine compound compound 6.
Figure S6. 1H NMR spectrum (300 MHz, CDCl3) of chlorotriazinecompound 6.
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Figure S7. Mass spectrum of the chlorotriazine compound 6.
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Figure S8. FTIR spectrum (KBr) of the phenylaminotriazine compound 7a.
Figure S9. 1H NMR spectrum (300 MHz, CDCl3) of the phenylamino-triazine compound 7a.
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Figure S10. Mass spectrum of the phenylaminotriazine compound 7a.
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Figure S11. FTIR spectrum (KBr) of the p-tolylamino-triazine compound 7b.
Figure S12. 1H NMR spectrum (300 MHz, CDCl3) of the p-tolylamino-triazine compound 7b.
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Figure S13. FTIR spectrum (KBr) of the p-anisylamino-triazine compound 7c.
Figure S14. 1H NMR spectrum (300 MHz, CDCl3) of the p-anisylamino-triazine compound 7c.
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Figure S15. FTIR spectrum (KBr) of the piperidinylcompound 8a.
Figure S16. 1H NMR spectrum (400 MHz, CDCl3) of the piperidinyl compound 8a.
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Figure S17. FTIR spectrum (KBr) of the morpholinyl compound 8b.
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Figure S18. Mass spectrum of the morpholinyl compound 8b.
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Figure S19. FTIR spectrum (KBr) of the piperazinyl compound 8c.
Figure S20. FTIR spectrum (KBr) of thetriazinylaminobenzene sulfonamide derivative 9a.
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Figure S21. 1H NMR spectrum (300 MHz, CDCl3) of the triazinylaminobenzene sulfonamide 9a.
Figure S22. 13
C NMR spectrum (300 MHz, DMSO-d6) of triazinylaminobenzene sulfonamide compound
9a.
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Figure S23. FTIR spectrum (KBr) of the N-carbamimidoyl benzene sulfonamide 9b.
Figure S24. 1H NMR spectrum (300 MHz, DMSO-d6) of the N-carbamimidoyl benzene sulfonamide 9b.
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Figure S25. FTIR spectrum (KBr) of the N-thiazolyl benzene sulfonamide 9c.
Figure S26. 1H NMR spectrum (300 MHz, DMSO-d6) of the N-thiazolyl benzene sulfonamide 9c.
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Figure S27. 13
C NMR spectrum (300 MHz, DMSO-d6) spectrum the N-thiazolyl benzene sulfonamide 9c.
Figure S28. FTIR spectrum (KBr) of the hydrazinotriazine compound 10.
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Figure S29. 1H NMR spectrum (300 MHz, DMSO-d6) of the hydrazinotriazine compound 10.
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Figure S30. Mass spectrum of the hydrazinotriazine compound 10.
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Figure S31. FTIR spectrum (KBr) of the triazolotriazine compound 11.
Figure S32. 1H NMR spectrum (300 MHz, DMSO-d6) of the triazolotriazine compound 11.
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Figure S33. 1H NMR spectrum (300 MHz, DMSO-d6) of the triazolotriazinethione compound 12.
Figure S34. FTIR spectrum (KBr) of the dimethyl pyrazolyl compound 13.
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Figure S35. 1H NMR spectrum (300 MHz, CDCl3) of the dimethyl pyrazolyl compound 13.
Figure S36. 13
C NMR spectrum (300 MHz, CDCl3) of the dimethyl pyrazolyl compound 13.
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Figure S37. Mass spectrum of the dimethyl pyrazolyl compound 13.
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Figure S38. FTIR spectrum (KBr) of the benzylidenehydrazino compound 14.
Figure S39. 1H NMR spectrum (300 MHz, DMSO-d6) of the benzylidenehydrazino compound 14.
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Figure S40. 13
C NMR spectrum (300 MHz, DMSO-d6) of the benzylidenehydrazino compound 14.