Download - SPINTRONIC NANOSENSORS for MEDICINE Prof. Riccardo Bertacco Centro LNESS Politecnico di Milano
SPINTRONIC NANOSENSORS for MEDICINEProf. Riccardo Bertacco
Centro LNESS Politecnico di Milano
Via Anzani 42, 22100 Como
Riccardo Bertacco
2Spintronic biosensors for molecular recognition
R
R’
No background
No bleaching
High stability
Molecule handling
High biological sensitivity
Tayloring the dinamic range
Lab on chip
Advantages
Disadvantages Not label free Impact of beads on the chemical affinity ?
biotin
streptavidin
target
probe
Riccardo Bertacco
SpinNanoMed FP7: NMP-2008-1.1-1 Converging sciences and technologies (nano, bio, info and/or cognitive)
3
End usersAntibody Microarrays C. Borrabaeck, Create
(Sweden)
User Interface, Data correlation and knowledge discovery
Database and Web Group – Bioinformatics Lab
P. Fraternali, S. Ceri, M. MasseroliPolitecnico di Milano (Italy)
Signal de-noising and data analysis
Digital Signal Processing Group- ISP Lab
M. TagliasacchiPolitecnico di Milano (Italy)
Signal read-out and LabOnChip electronics
Microfluidic transportInstitut fur Mikrotechnok Mainz GmbH
K. S. Drese (Germany)
Surface functionalization ICRM M. ChiariCNR (Italy)
Microfabrication of lab on chip micro arrays of spintronic biosensors
Spintronic group at LNESS
nanoGune
MIC - Copenhagen
R. Bertacco Politecnico di Milano (Italy)A. Berger, P. Vavassori (Spain)
M. F. Hansen (Denmark)
SPINTRONIC NANOSORS for MEDICINEPreventive medicine and diagnosis (in vitro diagnostic tests)Specific application:
Early detection of breast cancer via proteome profiling on the serum of patients
Lab on chip approach for point of care applications.
Riccardo Bertacco
Read out electronics (ASIC)
System layout
substrateInsulating layer
SiO2 + polymer
Microfluidics
AD conversion
DSP
Data mining
End user interface
Biomedical
validation
Riccardo Bertacco
Electronics
An ASIC, to be placed around the sensor chip, must be designed and realized with these functionalities:• front end electronics for the signal read out• analogical signal processing (filtering, amplification, ...)
A second external circuit will make the analog to digital conversion and provide suitable signal to an external PC for data acquisition and analysis.