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SMAD 4/ DPC4and Colon Cancer
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Morphological and molecular analyses of Smad4-/- embryos (Right) and their littermate controls (Left).
Yang X et al. PNAS 1998;95:3667-3672
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References• Beretta G, Braud F, Kildani B, et. al. (2010) Colon Cancer.
Oncology/Hematology 74(2), 106- 133• Deng C, Li C, Xu X, Yanh X. (1998) The tumor suppressor SMAD4/DPC4 is
essential for epiblast proliferation and mesoderm induction in mice. PNAS. 95(7) 3667-3672
• Fleming N, Jorissen R, Mouradov D, et. al. (2012) SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer. The Journal of Cancer Research 73. 725-735
• Li X, Liu B, Ma J, Xiao J, Zhang Y. (2011) Roles of VEGF-C and SMAD4 in the Lymphangiogenesis, Lymphatic Metastasis, and Prognosis in Colon Cancer. Journal of Gastrointestinal Surgery 15(11), 2001-2010
• Malkoski S, Wang X. (2012) Two sides of the story? SMAD4 loss in pancreatic cancer versus head and neck cancer. FEBSLetters. 586
• Xiao D, Wen J, Li J, et. al. (2006) Effect of DPC4 Gene Invasion and Metastasis of Colorectal Carcinoma Cells. ABBS. 38(12) 883-892