Download - Seminar (Drug Absorption)
![Page 1: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/1.jpg)
DRUG ABSORPTION
Prepared By:Abhishek Mishra
Chemical Technology(III-year)Pharmaceutical Technology
![Page 2: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/2.jpg)
OutlinePharmacokinetics.Determinants of Drug activity.What is Drug Absorption ?? & its Mechanism..!!!Factor affecting Drug Absorption. Fick’s Law of Diffusion
![Page 3: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/3.jpg)
Pharmacokinetics
Absorption
DistributionMetabolism(Bio-transformation)
Excretion
![Page 4: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/4.jpg)
Determinants of Drug Activity
![Page 5: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/5.jpg)
![Page 6: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/6.jpg)
Drug Absorption
The translocation(transfer) of drug from the site of administration into the blood-stream
Must be described BOTH in terms of rate and extent
![Page 7: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/7.jpg)
Mechanisms of Drug Absorption
All drug absorption requires crossing of bio membranes
Passive non-ionic diffusion Facilitated diffusion or carrier-mediated
transport Active transport Pinocytosis, endocytosis, phagocytosis
![Page 8: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/8.jpg)
![Page 9: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/9.jpg)
Factors Determining the Rate and Extent of Drug
Absorption Physicochemical properties of the drug
– Stereo chemical properties– Solubility
Molecular size Dosage form and delivery system Vehicles Dose
![Page 10: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/10.jpg)
Cont’d
Route and site of administration Contact time with absorptive
surface pH at site of absorption Integrity of the membrane Vascularization and blood flow at
absorptive site
![Page 11: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/11.jpg)
Fick’s Law of Diffusion
Rateof
Penetration
PartitionCoefficient
MembraneThickness
DiffusionCoefficient[ [] ]x
[ ]= x SurfaceArea[ ] Concen-
trationGradient[ ]x
Solutions> Emulsions> Suspensions> Capsules> Tablets> Coated Tablets> Enteric Coated Tablet> Sustain Release Tablet
Order of Drug Absorption
![Page 12: Seminar (Drug Absorption)](https://reader035.vdocuments.us/reader035/viewer/2022062522/588395a21a28ab2b568b4dc1/html5/thumbnails/12.jpg)
Thank You