![Page 1: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/1.jpg)
Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia
Abdul Mutalib
Center for Radioisotopes and Radiopharmaceuticals
National Atomic Energy Agency (BATAN)
![Page 2: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/2.jpg)
BATAN and PT Batantek
BATAN A Government R&D Institution
PT Batantek A Government owned Company
![Page 3: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/3.jpg)
BATAN has the following functions :
• To assess and prepare the national policy in the field of research,
development, and the beneficial uses of nuclear energy.
• To develop and utilize production technology of radioisotopes and radiopharmaceuticals for healthcare.
![Page 4: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/4.jpg)
Cyclotron CS30
Nuclear Reactor
Radioisotopes/Radionuclides
Sealed Sources)
Unsealed-Sources)
• Brachytherapy 125I, 103Pd, 192Ir, 198Au
• Radiotherapy 137Cs, 60Co
• Radiopharmaceuticals
• Radionuclide Generators
• Radioassay Kits
• Molecular Radiotracers
Technology of radioisotope production
![Page 5: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/5.jpg)
Brachytherapy Sources developed by BATAN
125I-seed brachytherapy
125I-thermosensitive polymer
198Au-Nanodevice brachytherapy
192Ir HDR/LDR brachytherapy
![Page 6: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/6.jpg)
Physical Characteristics of Brachytherapy Sources
Radionuclide Half-life E (KeV)Physical
Configuration Remarks
Gold-198
Iodine-125
Palladium-103
Iridium-192
2.7 d 412
60 d 35 Seeds Small size; less exposure to personnel
nanodevice Small size; higher dose rate
17 d 23 Seeds Small size; higher dose rate; less exposure to
personnelWire, seeds, cathethers
(afterloading)
74 d 136 – 1060 Wide variety of source strengths and sizes; usually afterloaded
![Page 7: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/7.jpg)
The BATAN’s Facility for Producing Radionuclide of 125I
![Page 8: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/8.jpg)
BATAN’s Laser Welder for preparing 125I and 103Pd seed and 192Ir
needle sealed-sources
![Page 9: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/9.jpg)
125I seed sealed-sources
Brachytherapy of Prostate
Cancer using 125I seeds
![Page 10: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/10.jpg)
Metalic
Radionuclide
Bifunctional
Chelating
Agent
Linker
(Pharmacokinetic Modifier)
Development of Target-Specific Radiopharmaceuticals
(Molecular Targeting Agents)
Non-Metalic
Radionuclide
Targeting Molecule
18F, 123I, 124I,11C, 131I, 211At
67Cu, 90Y, 99mTc, 188Re, 186Re, 166Ho, 177Lu
Targeting Molecule
![Page 11: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/11.jpg)
Requirements for target-specific radiopharmaceuticals
• Targeting molecule
with specific binding
to the target structure
(tumor, infection, etc)
Targeting Molecule
Targeting Molecule
• Suitable radionuclide
for imaging and therapy
with stable linkage to
the targeting molecule
Cancer Cell
Molecular Target
![Page 12: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/12.jpg)
GMP Based
Radiopharmaceutical
Production Facility
Cyclotron CS30
Nuclear Reactor
PET-CT
SPECT-CT
Hospitals
Radiopharmaceuticals for Molecular Imaging
18F,124I, 96Zr,123I, 111In, 64Cu
RPs of 18F,124I, 96Zr, 64Cu
RPs of 123I,111In, 99mTc, 131I
99mTc, 131I
RPs= Radiopharmaceuticals
![Page 13: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/13.jpg)
Radiopharmaceuticals developed by BATAN for
Nuclear Oncology:
• PET and SPECT radiopharmaceuticals, such as 18FDG, 18FLT, 123I-
MIBG, 99mTc-HYNIC Octreotide, 99mTc-HYNIC-Folate, etc.
• Therapeutic radiopharmaceuticals:
• 90Sr/90Y Therapeutic Generator
• PZC-Based 188W/188Re Therapeutic Generator
- 153Sm-EDTMP
- 186Re-HEDP
- 131I-MIBG
- 131I-Lipiodol
- 177Lu-DOTA-Nimotuzumab
- 177Lu-DOTA-TrastuzumabRadioimmunotherapy
![Page 14: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/14.jpg)
RIA Kits developed by BATAN for Nuclear Oncology:
• IRMA Kit CA 125 for in vitro diagnosis of
ovarium cancer
• IRMA Kit CA 15.3 for in vitro diagnosis of
breast cancer
![Page 15: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/15.jpg)
PACT Fundamentals
• National Cancer Control Programs:
• Radiation Medicine and the role of the BATAN and the IAEA
Prevention
Early Detection
Diagnosis and Treatment
Palliative Care
* Radiation Medicine includes both radiotherapy (or radiation
oncology) and diagnostic imaging involving the safe use of ionizing
radiation and nuclear medicine procedures.
![Page 16: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/16.jpg)
BATAN’s Role for PACT/Nuclear Oncology:
• Conducts R&D on radiopharmaceuticals, RIA/IRMA Kits, and
brachytherapy sealed sources for PACT
• Provides production technology packages of radioisotopes and
radiopharmaceuticals developed by BATAN to be implemented by
national companies, such as PT Kimia Farma, PT Batantek, for
fullfiling national needs.
![Page 17: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/17.jpg)
Program Action BATAN’s Contribution
• Early Detection • Develop RIA/IRMA Kits, PET and SPECT
radiopharmaceuticals as required by
Hospitals
• Diagnosis • Develop PET and SPECT
radiopharmaceuticals as required by
Hospitals
• Treatment or Therapy • Develop sealed sources (needle, seed) for
HDR and LDR Brachytherapy, CND
Brachytherapy, Targeted Therapeutic
Radiopharmaceuticals
• Palliative Care • Develop simple and targeted therapeutic
radiopharmaceuticals
![Page 18: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/18.jpg)
Summary
• BATAN will actively involve to support PACT through the R&D
programs.
• BATAN will encourage a close relationship and communication
between BATAN’s institutes with hospitals/medical doctors to
develop radiopharmaceuticals/RIA and IRMA Kits, brachytherapy
sealed sources for suitable for local condition.
![Page 19: Role of BATAN in Preparing Radioisotopes and Radiopharmaceuticals for Cancer Diagnosis and Treatment in Indonesia](https://reader033.vdocuments.us/reader033/viewer/2022051212/55720723497959fc0b8ba34e/html5/thumbnails/19.jpg)
Thank you