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The Space LaboratoryPast Experience and Future Perspectives
Jörn Rittweger
German Aerospace Center (DLR)
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STS-9
First SpaceLab Payload (28th Nov to 8th Dec 1983)
Preparing Spacelab 1 at KSC
So
urc
e:
ES
A/N
AS
A
So
urc
e:
NA
SA
Launch of STS-9
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Spacelab: German Astronauts
Ulf Merbold
Reinhard FurrerErnst Messerschmid
Ulrich WalterHans Schlegel
D1
D2
STS-9
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Life Science Experiments on STS-9
PI Experiment Discipline Country Publication
A Scano Ballistocardiography in weightlessness
Cardio-vascular Physiology
Italy
RJ von Baumgarten
Effects of Rectilinear Acceleration, Optokinetic and Caloric Stimulation on Human Vestibular Reactions and Sensations
Vestibular Physiology
Germany Science 225:208-12 (1984)
O Quadens Eye movements during sleep Neuroscience Belgium Science 225:221-222 (1984)
A Cogoli Effects of weightlessness on lymphocyte proliferation
Cell and Molecular Biology
Switzerland Science 225:228-230 (1984)
HE Ross Mass discrimination during weightlessness
Neuroscience United Kingdom
Science 225:219-221 (1984)
KA Kirsch Measurement of central venous pressure and hormones in blood serum during weightlessness
Cardio-vascular Physiology
Germany Science 225:218-219 (1984)
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Caloric Nystagmus:a standard test in medicine
• Warm fluid evokes typical sequence of
rapid and slow eye movements
• Explained by density-related fluid flow by
Robert Bárány (Nobel prize in 1915)
• However, caloric nystagmus can also be
elicited in the absence of gravity
• So, the mechanisms are still unclear….
after 100 years of research on Earth!
3D-ETDClarke & Scherer (1988)
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Salt & blood pressure:Space Medicine fosters Medicine on Earth
Excess sodium is stored in the skin!
Macrophages are salt-sensitive
Lymphatic vessel formation in response to salty diet
Machnik et al., Nature Medicine, 15:545-552 (2009)
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MARS500
- Renin- mineralocorticoids,- glucocorticoids- androgens, and - sodium excretion
can explain 80% of long-term blood pressure variance during confinement.
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Flight experiment SOLO:
SOdium LOad in Microgravity
PI: Petra Frings-Meuthen
Astro 1 Astro 224
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Low NaCl High NaCl
Bicarbonate mmol/L
Hypothesis
Salt Intake
Acidosis
Bone Loss
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Lessons learnt
Life Science in Space is possible and often fruitful
More experiments, and greater samples are
desirable
Solution: International Space Station
Complicated mechanisms often difficult to unravel
in Space
Solution: Ground based parallel research
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Gerzer Passing the Torch 110421 10
:envihabA new DLR facility for ground-based
parallel research into the human organism
Partners: Space Community+Acad. Industry Health Insurers Hospital Chains Military„Green Industry“ Outreach Stakeholders
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Folie 12Vortrag > Autor > Dokumentname > Datum
:enviGeneration – Matrix organisation
Genetics / omics
Gender
Age
Prevention & Rehabilitation
e.g.
Cen
trifu
ge T
rain
ing
e.g.
Pha
rmac
olog
ical
C
ount
erm
easu
res
e.g.
Eye
pro
blem
s in
ast
rona
uts
…
Musculoskeletal, cardiovascular, psychological well-being
Topics
The
mes
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Thank you for your attention !
:envihab - Current status (functional in 2013)