Download - Red Wine and Human Health
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 1/19
Red Wine and
Human HealthWINESCI 705
Prasad Patil
1
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 2/19
FRENCH PARADOX Lippi G., F. M., Favalor E. T., Targher G.,
O French Paradox was coined by Dr. Serge Renaud in 1992 a scientist from
Bordeaux University in France.
O This Paradox described the low incidence of cardiovascular disease in
French population despite of having a high intake of saturated fats.
O The French population had lower incidence of atherosclerosis related deaths
than population from other countries due to moderate consumption of red
wine .
O Red wine produces beneficial effects that targets all phases of
atherosclerosis.
O Inhibits lipoproteins oxidation, macrophage cholesterol accumulation by the
help of resveratrol and polyphenols.
2
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 4/19
RESVERATROL
O Found in skin of the grapes that are used in the
fermentation of red wine.
O Found in plants as a defence system against disease.
Fig.: Resveratrol
4
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 5/19
Resveratrol content in wines
O Beverage Total resveratrol (mg/L)
O Muscadine Wines 14.1 - 40
O Red Wines (Global) 1.98 - 7.13
O Red Wines (Spanish) 1.92 - 12.59
O Red grape juice (Spanish) 1.14 - 8.69
O Rose Wines (Spanish) 0.43 - 3.52
O Pinot Noir 0.40 - 2.0
Source: http://www.worldofmolecules.com/antioxidants/resveratrol.htm
5
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 6/19
Health Benefits
O Atherosclerosis
O Diabetes
O Cancer
O Bones
O Dementia and Mental Function
O Vision
O Weight Management
6
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 7/19
Atherosclerosis
O Atherosclerosis is a condition in which fatty materials collect along
the arteries.
O The fatty material gets deposited and forms calcium deposits and
even block the arteries.O Formed by the multiple plaques in the arteries.
O Plaques makes the arteries narrower and less flexible and makes
harder to blood flow.
O This causes less blood flow towards the heart and may even lead
to stop the heartbeats.
O Symptoms due to atherosclerosis are chest pain, short breath andheart attack.
7
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 8/19
Developmental process of atherosclerosis
8
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 9/19
Effect of wine resveratrol in minimizingatherosclerosis
Das D., Ray D. 2010
O Inhibits platelet aggression.
O Platelets set into motion the process of vascular occlusion through
the activation process of thrombus formation and its aggregation.
O It is was observed that 0.15 and 0.25 micromole/l resveratrolinhibited collagen-induced platelet activation followed by Ca+2
immobilization, thromboxane A2 formation phosphoinositide
breakdown and protein kinase C (PKC) activation.
O Another study from the European Journal of Pharmacology showed
that the researchers used cell culture consisting human umbilical cells
from the inner lining of a vein.
O In this study it was shown that resveratrol kept LDL cholesterol under
control and inflammated and oxidized (LDL cells) free.
9
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 10/19
Diabetes
O A study presented to the American Diabetes Association in 2005
suggested that moderate consumption of red wine may lower the
risk of developing Type 2 diabetes.
10
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 11/19
Cancer
O In 2009 the medical journal of Gastroenterology suggested that
moderate wine consumption may reduce the risk of certain forms
of esophageal cancers such as esophageal adenocarcinoma and
the precancerous condition Barrett·s esophagus.O A study conducted by Kaiser Permanente in California, reported
drinking 1 glass of wine a day had 56% decrease in the risk for
developing Barret·s esophageal. These studies suggested that
antioxidants present in red wine may offer some benefits when
consumed in moderate amount.
O A research done at the University of Nebraska suggested that
resveratrol found in grapes had preventive benefits against breastcancer. In this study human breast cells were exposed to low doses
of resveratrol about a conc. Of 10 micromoles/l. A glass of red
wine has conc. In between 9-29 micromoles/l.
11
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 12/19
Bones
O A study from St. Thomas Hospital in London and the medical group
in France suggested that moderate wine consumption lead to
positive benefits to elderly women in retaining bone density and
reducing the risk of developing osteoporosis.O Consumption of more than three glasses of red wine a day showed
a result in reducing bone density.
O Another study showed that women who drank moderately 1 to 3
glasses of wine a day increases in bone density over two year study
period.
O It was observed that moderate wine drinkers were more likely to
live active lifestyles that included physical work that also benefited
bone density.
12
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 13/19
Dementia and Mental Function
O Studies have shown that moderate alcohol consumption lowers the
risk of developing Alzheimer·s and dementia.
O A research carried out by Wake Forest University School of Medicine in 2009 suggested that moderate alcohol drinking
helped healthy adults ward off the risks of developing dementia
but can accelerate declining memory for those already suffering
from cognitive impairment.
13
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 14/19
Vision
O A study published in the American Journal of Pathology has found
that the compound found in red wine resveratrol shows positive
benefit in slowing the effects of macular degeneration which
causes vision to decline as people age increases.
14
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 15/19
Weight Management
O Wine consumed with food offers some positive benefit for weight
management.
O Increases appetite
O Slower the stomach·s emptying time and decrease the amount of food consumed at the meal.
O As compared with other beverages red wine has moderate amount
of calories. 148ml of red wine contains approximately 106 calories
and 2.51g of carbohydrates.
15
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 16/19
Fig.: The diagram shows the relationship between wine drinking and risk for
death. ( A glass of red wine contains approximately 10g of alcohol.)
16
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 17/19
CONCLUSION
O Moderation is the key.
O Most healthy people who drink wine regularly and
moderately live longer.
17
8/6/2019 Red Wine and Human Health
http://slidepdf.com/reader/full/red-wine-and-human-health 18/19
REFERENCES
1. Lippi G., F. M., Favalor E. T., Targher G., Moderate red wine consumption and Cardiovascular diseaserisk : Beyond the French Paradox . 2006, 36(1), 59-70
2. Atherosclerosis; Hardening of the arteries; Plaque buildup-arteries 2010.http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001224/
3. Day, K. Red wine to the Rescue? More Health Benefits Discovered 2011.http://www.peakhealthadvocate.com/745/health-benefits-of -red wine, healthy heart and longevity.15 2010,467-477.
4. Robinson, J., The Oxford Companion to Wine 3rd ed.; 1194; p4335. Boyles, S. Research Shows Moderate Wine Drinkers May Have Less Risk of Barretts Esophagus
March2, 2009. http://www.webmd.com/cancer/news/20090302/wine-may-cut-risk-of-esophageal-cancer.
6. DeNoon, D. J. Resveratrol May Prevent Breast Cancer July 7, 2008. http://www.webmd.com/breast-cancer/news/20080707/resveratrol-may-prevent-breast-cancer.
7. Gaffney, J. Moderate Drinkng May Keep Womens Bones Stronger, Study Finds 2004http://www.winespectator.com/webfeature/show/id/Wine-May-Increase-Bone-Mass-in-Elderly- Women-Study-Finds-_20648
8. Gaffney, J. Wine May Increase Bone Mass in Elderly Women, Study Finds 2000http://www.winespectator.com/webfeature/show/id/Wine-May-Increase-Bone-Mass-in-Elderly- Women-Study-Finds-_20648
9. Laino, C. Study Shows Alcohol Has Potential Benefits in Preventing Dementia 2009.http://www.webmd.com/healthy-aging/news/20090713/moderate-drinking-may-cut-dementia-risk.10. Cooper, S. Red wine may protect vision 2010. http://www.drcutler.com/vision/red-wine-may-protect-
vision-19867601/.
11. . Calories and wine 2004. http://www.davidstuff.com/wine/calories.htm .
18