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Receptors and Signal transduction
Min‐Chuan Huang
mchuang@ntu edu [email protected]
1Molecular Cell Biology 6th ed. Lodish et al.
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I ll l i li hIntracellular signaling pathways
• Kinases and phsphatases
GTP f il• GTPase superfamily
• Second messengers• Second messengers
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Kinases vs. phosphatases
Journal of Cell Science 121, 551-559 (2008)
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GTPase superfamilyp y
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Second messengers
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cAMPPKA‐AKAP‐Effector
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Eight major classes of cell surface receptors
TNFαTNFαreceptors
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G-protein-coupled receptor (GPCR) signaling
Internalization
Scaffold proteins signaling
RGS
GRKPKAPKC
RGS
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Modified from TRENDS in Pharmacological Sciences Vol.22 No.7 July 2001, 368-376
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TGFβ and TGFβ receptors
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Activated TGFβ receptors phosphorylate Smadtranscription factorstranscription factors
R‐Smads: receptor‐regulated Smads(Smad2, Smad3, Smad1, Smad5, Smad8/9)( , , , , / )
Co‐Smads: common‐mediated Smads(Smad4)
I Smads: inhibitory SmadsI‐Smads: inhibitory Smads(Smad6, Smad7)
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Downregulation of Smad transcription activationfunction(Ski d S )(Ski and Sno)
19Ski, Sno, and I‐Smads are negative regulators in TGFβ signaling
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Cytokine Receptors and the JAK/STAT Pathway
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Activation of Cytokine Receptors
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Activation of STAT proteins
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Termination of EpoR signaling
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Receptor Tyrosine Kinases
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Ligand‐induced dimerization of HER1
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The HER family of receptors and their ligands
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Activation of Ras
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Ras/MAP kinase pathway
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MAP kinase regulates the activity of transcription factors controlling early‐response genesfactors controlling early response genes
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The canonical Wnt signalling pathwayThe canonical Wnt signalling pathway
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Nat Rev Mol Cell Biol. 2010 Jun;11(6):404-13.
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Hedgehog (Hh) signalling pathwayHedgehog (Hh) signalling pathway
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TNF‐α/NF‐κB signalling pathway
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Notch signalling pathway
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