Download - Proteins: structure and functions
PROTEINS: STRUCTURE
AND FUNCTIONS
Claudia Hernández Troncoso
Medicine student
III semester
Faculty of medicine
School of health sciences
Universidad Pontificia Bolivariana
o
FOLDING
FOLDING 2
INTRODUCTION
macromolecules
formed by amino
acid chains joined for
peptides links they
have a big cellular
activity
each protein is a only
codified sequence
which can changes
as the different
structure levels, the
principal actions
inside and outside
cell
NEWS #1
Now the project is expanding into the HUPO, the Human
Proteome Organization
a number of proteins associated with
prostate cancer are controlled by
chromosome 19
MAPPING PROTEINS ON CHROMOSOME
19
HUPO
There are over 20 000
proteins coded by the
genome in the human body
Each protein has an unique
encoded structure
all functions depends of
variability sequence of
amino acid and the
different levels of
structures
CROMOSOME 19
MAPPING PROTEINS ON CHROMOSOME
19
CROMOSOME 19
SUPPORT 63 MILLONES
PARS OF BASES
CONTAINS BETWEEN 1,300 AND 1,700
GENS
IT HAS THE PSA: PROSTATE
SPECIFIC ANTIGEN
RELATIONSHIP BETWEEN THE PROTEINS AND
PROSTATE CANCER
PROSTATE CANCER• Is an adenocarcinoma more common in the peripheral zone
• may cause:
pain
Difficulty in urinating,
Problems during sexual intercourse,
Erectile dysfunction
• PSA is a tumor markers to determine the
origin of malignant cells that have metastasized
MAPPING PROTEINS ON CHROMOSOME
19
MAPPING PROTEINS ON CHROMOSOME
19
Medicine for the current is critical analysis
of the components of the human genome
and the evolution through the same, which
may generate some type of disease, therefor
e believe that the
proteins is a structural model of analysis and
set up to oriented to XXI century needs to
develop technologies that can fight
cancers, besides the use of new drugs.
NEWS # 2
Interactions between
proteins are of
fundamental
importance for a
number of processes in
virtually every living cell
In the process of protein folding one of the
partner don’t have the active configuration but it was purchased at the
union time
MYSTERY ABOUT RECOGNITION OF UNFOLDED
PROTEINS SOLVED: THE LOCK SHAPES THE KEY
FOLDING
the process by which a protein reaches its structur
e tridimension
The biological function of a protein depends on
its correct folding.
unions between protein-protein are due
to the hydrogen bonds and van der waals forces
to form the basis of three-dimensional structures
beta sheets and alpha helices
STRUCTURE LEVELS
MYSTERY ABOUT RECOGNITION OF UNFOLDED
PROTEINS SOLVED: THE LOCK SHAPES THE KEY
Primarystructure
• Lineal position of amino acid
• Covalents links between aminoacids
Secundarystructure
• Structure tridimentional form
• beta sheets and alpha helices
tertiarystructure
• Folding between beta sheets and alpha helices
• Interactions no covalent links as hydrogen bonds and van der waals force
quaternary structure
• Union between many peptide chains
• Globular forms
ENZYME RIBONUCLEASE S
in its active form comprises
the S-protein and an α-helical
S-peptide
S-protein has a defined three-dimensional shape, the S-peptide on its own is initially
unfolded
the S-protein recognizes the unstructured S-
peptide or a small fraction of peptide molecules in their
helical conformation
Protein-protein recognition in this case takes place via hydrophobic
interaction of the S-protein with two
spatially clearly defined areas of the unstructured
S-peptide.
MYSTERY ABOUT RECOGNITION OF UNFOLDED
PROTEINS SOLVED: THE LOCK SHAPES THE KEY
MYSTERY ABOUT RECOGNITION OF UNFOLDED
PROTEINS SOLVED: THE LOCK SHAPES THE KEY
Knowledge of the structural
configurations of proteins is essential for the
analysis of the respective cellular functions
and thus be able not only to understand its
complexity if not interact with
them to reach between protein folding thus pr
ovide an opportunity for science to modulate
their
activities and functions thus leading to greate
r scientific breakthrough.
MEDICAL UTILITY
MEDICAL UTILITY
A single amino acid, wrong folding, and wrong hydrogen bonds-may cause a clinical issue with disastrous consequences for the patient
Studies about them are important not only because their damage implications in clinical areas
MEDICAL UTILITY
Proteins areimportant for thedevelopment andresearch of newmedicaments andtherapies
MEDICAL UTILITY
BIBLIOGRAPHY
• MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 2. ed. Medellín: UPB. Fac. de Medicina, 2006. 105 p.
• COOPER,GM.. La célula. 2ed. Madrid :Marban, 2002. 76-79 p
• LODISH, h. Biología celular y molecular. 5ª edición. Buenos Aires: Medica Panamericana, 2004. 355 p
• “mapping protein in the chromosome 19” onsciencedaily.com
• “mystery about recofnition of unfoulded pro teinssolved: the lock shapes the key” onsciencedaily,com
THANKS YOU!!