Download - Program Goals
Program Goals
Overview of Following Talks
Major Outcomes in MS
Disease-Modifying Therapies
Interferon Beta:
Mechanisms of Action
Interferon Beta:
Pivotal Trials — CIS and RRMS
Trials of Interferon Beta in CIS
BENEFIT Trial: Interferon Beta-1b for CIS
REFLEX Trial: Interferon Beta-1aSC in Patients With CIS
Interferon Beta-1b in SPMS:
European and North American Trials
Mortality for Interferon Beta-1b vs Placebo
The Challenge of Choice
The Physician’s Role
DMT Choice Factors
Case 1: Dan
What Would You Tell This Patient?
What Is the Single Most Important Therapeutic Issue at This Point?
Is His History of Depression a Contraindication to Using an
Interferon-Beta?
What DMT Would You Recommend?
Reviewing Treatment Options
Interferon Beta and Depression
Interferon Beta and Depression (cont)
Interferon Beta: Positives
Interferon Beta: Concerns
Case 2: Dana
Is Interferon Beta a Good Choice for This Patient?
Interferon Beta Issues
Interferon Beta Issues (cont)
Summary
A Multitude of Factors Contributeto Optimal MS Management
Case Study 1: Lisa
Case Study 1: Lisa (cont)
Case Study 1: Lisa (cont)
Management of Adverse Therapeutic Effects
Management of Adverse Therapeutic Effects (cont)
Case Study 1: Lisa (cont)
Case Study 1: Lisa (cont)
Case Study 2: Bill
Case Study 2: Bill (cont)
What Would Your Recommendation
Be?
Case Study 2: Bill (cont)
What Are Your Next Steps?
Case Study 2: Bill (cont)
Case Study 2: Bill (cont)
How Do You Begin to Counsel Bill?
Case Study 2: Bill (cont)
What Are Your Next Steps?
Case Study 2: Bill (cont)
Case 1: MRI
Would You Consider a Change in Therapy for This Patient?
How Many Attacks Would You Allow a Patient to Have in a Given Year Before You Recommend a Change in Therapy?
How Likely Are You to Change Therapy for a Patient Who Has No Clinical Symptomatology or Exacerbations But With 1-2 New MRI Lesions?
Case 2
What Would You Do?
If You Make a Switch, What Would You Switch To?
MRI
Breakthrough Disease Facts
Why Ascertain Adherence?
Assessing Therapy — Factors to Consider
Risk Factors Contributing to "More Aggressive" Disease
Suboptimal Response: Clinical Criteria
Suboptimal Response: MRI Criteria
Therapeutic Response
Suboptimal Response: Proposed Criteria
Abbreviations
Abbreviations (cont)
Abbreviations (cont)
References
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)
References (cont)