Transcript
Protein Localization
• Transport to the endoplasmic reticulum H2N-Met-Met-Ser-Phe-Val-Ser-Leu- Leu-Leu-Val-Gly-Ile-Leu-Phe- Trp-Ala-Thr-Glu-Ala-Glu-Gln- Leu-Thr-Lys-Cys-Glu-Val-Phe- Gln-
• Retention to the endoplasmic reticulum -Lys-Asp-Glu-Leu-COOH
Prion protein processing in the ER
Prion protein trafficking and the development of neurodegeneration
Ramanujan S. Hegde and Neena S. Rane
Things to Mimic
• ER conditions – Primary folding…
• Cytoplasmic conditions– Aggregation and amyloid formation– Intermediates