![Page 1: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/1.jpg)
Principles of ImmunologyCells of the Immune System 1/26/06
“Those who have health, have hope. Those who have hope have everything.”
Arabian proverb
![Page 2: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/2.jpg)
Word List Apoptosis Granulocyte Hematopoiesis Homeostasis Kupffer cells Necrosis Pluripotent
![Page 3: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/3.jpg)
Hematopoiesis
Formation and development of blood cells Begins in yolk sac Moves to liver and spleen Moves to bone marrow
![Page 4: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/4.jpg)
![Page 5: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/5.jpg)
PLuripotent Stem Cells
Able to renew at constant rate
Have capacity to differentiate into myeloid or lymphoid progenitor cells
![Page 6: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/6.jpg)
![Page 7: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/7.jpg)
![Page 8: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/8.jpg)
Myeloid Lineage
Granulocytes Eosinophils Basophils Megakaryocytes Erythrocytes Dendritic cells
![Page 9: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/9.jpg)
Lymphoid Lineage
T Lymphocytes B Lymphocytes Natural Killer Cells
![Page 10: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/10.jpg)
Neutrophils 60-70% of WBCs Multi-lobed nucleus Granulated cytoplasm Life span is 2-3days Prominent in inflammatory response Leukocytosis is marker for infectious
process Actively phagocytic
![Page 11: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/11.jpg)
![Page 12: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/12.jpg)
Eosinophils ~2% of WBCs Bi-lobed nucleus Granulated cytoplasm Stains with acid dye (eosin) Prominent in response to parasitic
infections Phagocytic
![Page 13: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/13.jpg)
![Page 14: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/14.jpg)
Basophils <1% of WBCs Lobed nucleus Heavily granulated cytoplasm Stains with basic dye Prominent in allergic responses Non-phagocytic
![Page 15: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/15.jpg)
![Page 16: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/16.jpg)
Monocytes and Macrophages Large WBCs Monocytes are circulating precursors Macrophages
Phagocytic “Fixed” throughout the body, e.g. Liver (Kupffer) Activated by cytokines and gamma interferon APC Secretes numerous immune response factors
![Page 17: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/17.jpg)
![Page 18: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/18.jpg)
![Page 19: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/19.jpg)
![Page 20: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/20.jpg)
Mast Cells
Found in many different tissues Contains granules which release
histamine Play role in allergic reactions
![Page 21: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/21.jpg)
Dendritic Cells
Have long “dendrites” Major role as APC Stimulated by innate response Have co-stimulatory molecules
constitutively Have constitutive MHC II expression Phagocytic and endocytic
![Page 22: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/22.jpg)
Lymphocytes
~30-40% of WBCs
T Lymphocytes Mature in thymus Have TCRs Recognize Ag on cells only Two subpopulations
![Page 23: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/23.jpg)
Lymphocytes
B Lymphocytes Mature in bone marrow Have membrane-bound Ab(~10,000 per
cell) Go from “naive” to activated. Plasma cells are Ab secretors
~1-2 week life span
![Page 24: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/24.jpg)
Natural Killer Cells
Detected for anti-tumor activity Lack T and B cell markers Lack Ag receptors Involved with Ab-dependent cell-
mediated cytotoxicity
![Page 25: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/25.jpg)
Homeostasis Apoptosis vs. Necrosis
Apoptosis Programmed cell death Genetically controlled Macrophages engulf apoptotic bodies
Necrosis Results from cell injury Cell contents released Can trigger inflammation Genetically controlled Macrophages engulf apoptotic bodies
![Page 26: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/26.jpg)
![Page 27: Principles of Immunology Cells of the Immune System 1/26/06](https://reader035.vdocuments.us/reader035/viewer/2022062310/568167a7550346895ddcf414/html5/thumbnails/27.jpg)