Il parto nella donna con diabeteFederico Mecacci
Prenatal Medicine High Risk Pregnancy Unit
Careggi Universitary Hospital Newbornrsquos and Womens Health Department
0
1
2
3
4
5
6
7
madri obese
48
Del 20 delle madri obese dal 2008 al 2016Dati regione Toscana
57
Nascere in Toscana 2015
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
0
1
2
3
4
5
6
7
madri obese
48
Del 20 delle madri obese dal 2008 al 2016Dati regione Toscana
57
Nascere in Toscana 2015
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
MATERNAL AGE DELAYED CHILDBEARING AND METASBOLIC SYNDROME
2016
Prevalence of metabolic syndrome(NCEP ATP III) in the NHANES III survey Ford ES JAMA 2002 287356
Balkau B Diabet Metabol 2002
36 of Europeans were observed at the ageof 40-55 years with metabolic syndrome
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
Prevalence of hyperglycaemia in pregnancy by age
Global estimates of the prevalence of hyperglycaemia in pregnancy L Guariguata et al Diabettesresearch and clinical practice 2014
Global prevalence of hyperglycaemia in pregnancy 169
The prevalence of HIP increases sharply with age with a prevalenceof 392 in women40ndash44 and up to 479 in women 45ndash59 years
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
IN CHE MODO IL DIABETE INFLUENZAIL TIMING LA MODALITAgrave E LrsquoOUTCOME DEL
PARTO
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
THE EFFECTS OF HYPERGLYCEMIAMETABOLIC SYNDROME
FFA(fat mobilization)
Glucose
leptina
INSULIN RESISTANCE
OBESITY
GESTATIONAL DIABETES
IGF1
Adiponectina
insulin
FETAL NUTRIENT AVAILABILITY
PLACENTAL TRASPORT OF NUTRIENTS
mTOR+
ldquoadaptive regulationrdquo
FETAL OVERNUTRITION-MACROSOMIALGA
Romero Am J Obstet Gynecol 2017
Brett KE Int J Mol Sci 2014
MACROSOMIAL
MACROSOMIALG
DISTOCIA STILLBIRTH
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |
Macrosomia e rischio di distocia
Birth weight distribution in diabetic pregnancies
Persson et al Diab Care 2011341145-1149
ldquoDIABESITYrdquo and MACROSOMIA
MACROSOMIA ASIMMETRICA
OBESITY IS INDEPENDENTLY ASSOCIATED WITH FETAL HYPERINSULINEMIABIRTH WEIGHT AND NEWBORN ADIPOSITY
Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
Fetal growth profiles in diabetic pregnancies
08
085
09
095
1
105
11
115
12
125
13
100 120 140 160 180 200 220 240 260 280
Gestational age in days
Hea
d to
abd
omin
al c
ircu
mfe
renc
e ra
tio
(HC
AC
rati
o)
IDDM non-macrosomia
IDDM macrosomia
DM2 non-macrosomia
DM2 macrosomia
GDM non-macrosomia
GDM macrosomia
Birthweightgt90th
Type-1-diabetes LGA
Type-1 AGA
N Hammoud et al UOG 2012
Type-2-diabetes LGA
GDM LGA
Grafiek3
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
iddm gdm 977
IDDM
IDDM lt9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631103696580000000211212701600000001113882472000000011156360261173876780000000111913742812088527612263122200000001124375266000000011261174080000000112785764800000001129595986000000011313324220000000113306695613479958813653031799999999138259146000000021399860720000000114171109614343421800000002145155438146874755999999991485921720000000115030768600000002152021298153733008000000041554428159999999915715072200000003158856726000000011605608280000000116226302799999999163963326000000021656617221673582160000000316905280817074549800000003172436286174125172000000021758121559999999917749723800000001179180418180861696000000021825410719999999918421854600000003185894117999999991875677880000000118923955599999999190909422000000011925773860000000219424344800000003195907608000000011975698660000000219923022200000003200888676000000032025452280000000120419987800000001205852626000000012075034720000000220915241600000002210799458000000022124445980000000121408783600000001215729172000000012173686060000000321900613800000002220641768000000012222754962239073220000000222553724600000001227165268000000032287913880000000123041560600000003232037922000000012336583360000000223527684823689345800000001238508166000000022401209720000000224173187624334087824494797800000001246553176000000012481564720000000124975786600000001251357358252954948254550636256144422000000022577363060000000125932628799999998260914368000000022625005459999999926408482200000003265667195999999992672476680000000326882623799999999270402906000000032719776719999999827355053600000002275121497999999972766905580000000127825771600000002279822972000000052813863262829477780000000328450732799999997286064976287620722289174566000000032907265080000000229227654800000005293824685999999992953709220000000129691525629845768800000002299998218000000013015368460000000330307357200000001304608396000000033061413180000000130767233800000002309201456000000063107286720000000231225398631377739800000001315298908000000043168185160000000531833622199999996319852026000000023213659280000000532287792832438802599999997325896222000000023274025160000000532890690800000004330409398000000013319099863334086720000000233490545600000002336400337999999983378933180000000233938439600000004340873572000000023423608459999999834384621800000002IDDM =gt 9771191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631094598540000000211125305500000002113048962000000021148475750000000211664889400000003118452919000000021202596500000000212206908700000002123881230000000021256960790000000312751363400000002129333895000000011311568620000000213298253500000001134810914000000031366419990000000313847579000000002140312287000000031421514900000000214399339900000001145838014000000021476853350000000114953536200000002151388095000000021532435340000000115510167900000002156962530000000021588260870000000316069235000000003162561319000000031644329940000000416630737500000004168184462000000021700642550000000317194675400000003173831959000000011757198700000000117761048700000003179503810000000021813998390000000118329857400000003185200015000000041871041620000000318901101500000001190920574000000021928328390000000419474781000000002196665487000000011985858700000000320050895900000003202434754000000032043632550000000120629446200000001208228375000000032101649940000000421210431900000003214046350000000022159910870000000221793853000000001219888679000000022218415340000000222379709500000001225755362000000022277163350000000222968001400000003231646399000000032336154900000000223558728700000003237561790000000032395389990000000224151891400000002243501535000000022454868620000000324747489500000003249465634000000022514590790000000325345523000000003255454087000000022574556499999999925945991900000001261466893999999972634765749999999726548896200000001267504054999999992695218540000000227154235899999998273565569999999982755914869999999727762011000000001279651438999999982816854742837222150000000128576166228780381499999999289848674000000022918962389999999829394650999999999295999486999999992980551699999999830011355900000001302174653999999983042384549999999930630496199999999308374174999999983104460940000000231252071899999999314598053166780873187608332084627899999998322934434000000013250252949999999732711886199999998329215134999999983313141140000000233341579899999999335520190000000013376272870000000233973709000000002341849599000000013439648139999999934608273500000001348203361999999973503266949999999735245273400000002354581479356712929999999973588470869999999936098394999999999363123518999999993652657939999999736741077536955846200000002371708854999999973738619539999999737601775900000001378176269999999993803374870000000138250141000000002384668039000000023868373740000000138900941499999999391184162000000013933616149999999739554177399999998
Gestational age in days
Fetal abdominal circumference (mm)
GDM
GDM lt97711912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311821037200000001119969022999999991217245379999999812347691712522615999999999126972266999999991287152381304550730000000313219177200000001133925334999999991356557620000000113738305299999999139107207999999991408282271425461114426085699999999145972468000000021476809429999999814938628199999999151088484999999991527875520000000115448348299999998156176278157865937000000031595524616123584700000001162916098000000011645932129999999916626719199999999167938035000000011696057419999999917127031299999999172931748174590047176245209999999991778972370000000217954612799999998181191882999999991828345019999999918447398500000003186110332187743542999999991893736180000000219100055700000001192624361942450270000000219586255800000001197476952999999981990882122006963352023013222039031730000000120550188800000001207097467000000022086899121027921699999999211865388213448422999999992150283222166050852181787119999999921974920300000002221316558000000012228807769999999922444186000000002225999807227554617999999982291062929999999923065483223220023500000002233742502235281633236817628000000012383504869999999923988021000000001241406797000000012429302480000000124445056300000002245967742000000022474817852489926920000000125050046325200509799999998253506597255004959999999982565001869999999825799227825948123300000003260967051999999972624497349999999826392928226540569299999999266878967999999992683491072698161100000000427127997699999997272740707999999982741983029999999527565276227710408527855227200000002279997322999999992814392379999999928287801728431365999999997285746167000000012871755380000000228860177300000004290024872000000022914448350000000129286166199999997294275353295685907999999982970933270000000429849761000000001299898756999999993012967679999999930269164330408338200000003305471985000000023068574520000000230823978299999999309618978000000033109950369999999731236795999999998313737747000000013151043980000000631646791300000001317828292000000033191855349999999632053964200000001321890613000000033232384480000000132458314732592471327263137000000033285984279999999632993058300000001331259602000000033325854850000000633390823233522784300000001336544317999999983378576570000000233916786000000002GDM =gt 977119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120182679000000011216229731230675110000000112451629300000002125969319127426589000000011288881031303538609999999913182386300000002133298109000000011347765991362593330000000313774631100000002139237533000000011407329990000000114223270914373666299999999145244861000000011467573030000000114827398914979491899999999151320092999999991528495109999999815438317315592107899999999157463229000000011590096231605602611621151430000000216367426900000001165237639166805253000000021683771110000000116995321300000003171533559000000031731181489999999917470698300000001176300061177897383000000021794989490000000118110475918271481300000002184329110999999981859476531875704389999999918919746899999998190828743192464260999999991941040230000000119574802919739627900000002199048773000000012007055112023664930000000220403171900000001205701189207374902999999992090528610000000121073506321242150900000001214112199215807133000000022175063110000000121920973300000003220917399000000022226293090000000122434546322606586100000001227790503229519389000000022312525190000000123298989300000002234731511000000012364773730000000323822747900000002239981829000000032417404229999999924350326100000001245270343247041669000000012488172392505970530000000225238111125416941300000002255961959000000012577587489999999725955978299999998261365060999999972631745829999999826498834900000003266806358999999992686286130000000327045511099999999272285853000000032741208389999999927596006900000003277803543000000052796512610000000328150322300000005283359429000000032852198790000000528708457300000003288953510999999992908266930000000329270411899999999294585788999999982964717029999999929836186099999998300256262999999993021549089999999830405779899999999305964933000000033078763109999999930979193300000003311711798999999983136359090000000331556426300000004317496861000000023194337030000000432137478900000002323320119000000033252696929999999632722351100000003329181572999999963311438790000000333311042900000001335081223000000023370562610000000133903554300000002341019069343006839000000013449988533469951110000000134899561299999999351000359353009348999999993550225833570400610000000435906178299999999361087749000000033631179590000000436515241300000002367191110999999983692340530000000237128123899999997
Gestational age in days
Fetal abdominal circumference (mm)
FAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311463706227116228381219117819700168119411019117000011210023380660000112259365701500001124184975964125776294913127367613862128958932811000011305502517600000113214157070900001133732889658135324208607136915527556138506846505140098165454141689484402999991432808033520000214487212230099999146463441250000021480547601989999914964607914800001151237398096999981528287170460000115442003599500001156011354944157602673893159193992842160785311791162376630741639679496889999916555926863799999167150587587000021687419065359999917033322548500001171924544433999981735158633830000117510718233200001176698501281000011782898202317988113917918147245812818306377707718465509602618624641497499999187837733923999991894290528729999919102037182200002192611690770999991942030097200000119579432866900001197385647618000011989769665670000120056828551620215960446520375092341420534224236320693356131199999208524880260999992101161992099999921170751815899999213298837107999992148901560570000121648147500600001218072793955000012196641129040000122125543185322284675080222443806975122602938872276207076492292120265979999923080334554699999232394664495999992339859834449999923557730239399999237168621342999982387599402920000124035125924100001241942578190000012435338971392451252160882467165350372483078539862498991729352514904918839999925308181083299999254673129781999992562644487310000225785576767999999259447086629000012610384055779999826262972452700001264221043475999982658123624252674036813739999726899500032327058631927199997272177638221273768957170000022753602761189999927695159506800002278542914016999992801342329660000128172555191499998283316870864000012849081898129999828649950876228809082771099997289682146662912734656090000329286478455829445610350699997296047422455999992976387414050000229923006035399999300821379303000013024126982519999830400401720100001305595336149999983071866550990000130877797404799998310369292997311960611945999973135519308953151432498440000231673456879299999318325887741999963199172066909999932150852564000002323099844588999993246911635380000132628248248699998327873801436000013294651203849999833105643933433264775828299997334239077232335830396180999973374217151333901303407900002340604353027999993421956719769999634378699092599999IDDM macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631131321413511492848268500001116724824021185211653550000112031750669122113848025000011239101893612570653069512750287203000001129299213365000011310955547000000113289189603513468823737000002136484578704999991382809200400000114007726137500001141873602711436699440450000214546628537999999147262626715000011490589680515085530938515265165072000002154447992054999991562443333900000115804067472515983701606161633357395000021634296987300000116522604006500001167022381416881872273499999170615064070000021724114054050000117420774674176004088075177800429409999991795967707450000118139311208000001183189453415184985794750000031867821360850000218857847742000001190374818755000011921711600919396750142500002195763842760000021975601840950000119935652543201152866765202949208100000022047455494350000220654189077000001208338232105210134573442119309147750000221372725611000001215523597445000012173199387821911628011500002220912621450000022227089627850000122450530412000001226301645455000032280979867900000222989432812500002231690669460000012334870107952352833521300000323707969346500002238876034800000012406723761350000124246871747244265058805000022460614001400000224785774147500001249654082810000012514504241452532467654800000225504310681500002256839448150000012586357894850000326043213082262228472155000022640248134900000426582115482500001267617496160000032694138374952712101788300000227300652016500004274802861500000012765992028350000327839554416999999280191885505000022819882268400000428378456817528558090951000003287377250845000052891735921800000129096993351500004292766274852945626161850000229635895751999999298155298855000012999516401900000330174798152530354432286000002305340664195000043071370055300000130893334686500003310729688200000063125260295350000231432237086999999316118712205000013179150535400000331971139487532150773621000002323304077545000043251004188800000132689676021500003328693101550000053304894428850000233228578422000004334082125555335878466890000033376748082249999933947114956000001341267490895000043430638322334486017356500003346656514900000053484528562350000135024919757000004352045538905000063538418802400000235563822157499999357434562910000013592309042450000336102724558362823586915000023646199282500000436641626958500001368212610920000033700089522550000537180529359000002DM2 non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263117561169644999991191476615939999812073415354299999122320645491999981239071374409999912549362938999998127080121338999991286666132880000113025310523713183959718599999133426089134999981350125810839999813659907303299997138185564981999991397720569309999814135854888142945040828999991445315327779999814611802472699998147704516675999971492910086249999915087750057399998152463992523154050484471999991556369764209999915722346836999998158809960318999971603964522679999916198294421699998163569436166165155928114999991667424200639999916832891201299998169915403961999971715018959109999917308838785999998174674879809176261371758177847863706999991794343556559999818102084760499997182607339553999991841938315029999818578032345218736681540118895330734999999190539799298999981921262912479999719371278319699999195299275145999991968857670949999819847225904420005875099299999201645242941999982032317348909999720481822683999999206404718788999992079912107379999820957770268721116419463599999212750686584999982143371785339999721592367048321751016243199999219096654380999982206831463322226963827899999223856130227999982254426221769999822702911412622861560607499999230202098023999982317885899732333750819219999923496157387099998236548065819999982381345577692397210497179999924130754166699998242894033616244480525564999992460670175139999924765350946299998249240001412250826493360999992524129853099999825399947725925558596920799999257172461156999992587589531059999826034544505499997261931937004000022635184289530000126510492090226669141285126827790479999999269864396748999982714508886979999727303738064699996274623872596000012762103645452777968564942793833484429999928096984039199998282556332340999972841428242899999628572931623900001287315808188000012889023001372904887920859999929207528403499998293661775983999972952482679329999729683475988199996298421251831000013000077437830159423572899999303180727677999983047672196269999730635371157600002307940203525000023095266954740000131111318742331269967937199999314286171320999983158726632699999831745915521899997319045647167999963206321391170000132221863106632380512301499999325391614963999983269781069129999832856459886199997330151090811000023317375827600000133332407470933491056665799999336497058606999993380835505559999833967004250499997341256534453999963428430264029999534442951835234601601030099999DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631149421065111672301552711850392454412028483356112206574257812384665159512562756061212740846962912918937864599999130970287662999991327511966799999913453210569699999136313014713999991380939237309999913987483274799999141655741765000021434366507820000214521755979900001146998468816000011487793778330000115056028685000001152341195867000011541221048840000115590301390100001157683922918000011594648319350000116124574095200001163026649969164807558986166588468003168369377021701502860371719311950541737121040711754930130881772739221051790548311221808357401389999918261664915599999184397558172999991861784671899999918795937620699999189740285223999991915211942409999919330210325799999195083012274999991968639212919999919864483030899999200425739325999982022066483429999820398755735999998205768466376999982075493753939999820933028441099998211111193427999982128921024449999821467301146199998216453920479218234829496220015738513221796647532235775565472253584655642271393745812289202835982307011926152324821016322342630106489999923604391966599999237824828682999992396057376999999924138664671699999243167555733999992449484647509999924672937376799999248510282784999992502911918019999925207210081899998253853009835999982556339188529999825741482787000001259195736887000012609766459040000126275755492100001264538463938000012663193729550000126810028197226988119098927166210000627344300902327522391804277004827057278785736074280566645091282347554108284128463125285909372142287690281158999992894711901759999929125209919299999293033008209999992948139172269999929659482624399999298375735260999993001566442779999930193755329499999303718462311999993054993713289999830728028034599998309061189362999983108420983799999831262300739699998314403916413999983161848254309999831796573444799998319746643464999983215275524819999832330846149899997325089370515999973268702795329999732865118854999997330432097566999973322130065839999733399391560099997335774824617999973375557336349999733933664265200002341117551669000023428984606860000234467936970300002346460278720000023482411877370000235002209675400002351803005771000023535839147880000235536482380500001357145732822000013589266418390000136070755085600001362488459873000013642693688900000136605027790700001367831186924000013696120959410000137139300495800001GDM non-macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263119123845098120706214957000011222885848160000112387095467500001125453324534000021270356943930000112861806425200001130200434110999991317828039713336517382900001134947543688136529913547000011381122834060000213969465326514127702312400001142859392983000021444417628421460241327010000114760650256000002149188872419000011507712422780000215235361213700003153935981996000011555183518549999915710072171415868309157300001160265461432161847831291000011634302011500000216501257100916659494086800001168177310727000021697596805861713420504450000117292442030400002174506790163000011760891600220000217767152988100003179253899740000011808362695989999918241863945818400100931700001185583379175999991871657490351887481188940000219033048875319191285861200001193495228471000021950775983319665996818900001198242338048000021998247079072014070777660000120298944762520457181748400001206154187343000022077365572022093189270610000121090129691999999212483666779214066036638000012156484064972172307763560000121881314621500002220395516074221977885933000012235602557920000222514262565122672499551000001228307365369229889735228000012314721050870000223305447494623463684480500001236219214663999992378015845232393839543820000124096632424124254869410000001244131063959000022457134338182472958036770000124887817353600002250460543395252042913254000012536252831129999925520765297200001256790022830999992583723926900000325995476254900001261537132407999992631195022670000326470187212600001266284241984999992678666118439999826944898170300002271031351562272613721421000042741960912800000227577846113927736083099799998278943200857000022805255707162821079405749999928369031043400003285272680293000012868550501519999928843742001099997290019789870000012916021597289999929318452958800003294766899447000012963492693062979316391649999829951400902400002301096378883302678748742000043042611186010000230584348846307425858318999993090082281779999731059059803700001312172967895999993137553377550000331533770761400001316920077472999993185024473319999732008481719100001321667187053232495569090000332483192676800002326414296627327996666485999983295790363450000233116140620433274377606299998334326145922000023359085157810000133749088563999999339073255498999973406556253580000134223799521699999343820365076000033454027349350000134698510479399999GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263118366695550000021200538851470000212174107474400002123428264341000021251154539380000212680264353500002128489833132130177022729000021318642123260000313355140192300001135238591521369257811170000113861297071400003140300160311000011419873499081436745395050000114536172910200003147048918699000011487361082961504232978930000115211048749000003153797677087000011554848666841571720562810000115885924587800002160546435475000011622336250721639208146690000116560800426600002167295193863000011689823834599999917066957305700001172356762654000021740439522510000117573114184800002177418331445000011791055210420000218079271063900001182479900236000021841670898330000118585427943000002187541469027000011892286586240000219091584822119260303781800002194290227415195977417012000021976646066091993517962060000220103898580320272617540000002204413364997206100554594000022077877441912094749337880000221116212338521284931298200001214536502579216223692176000012179108817732195980713700000122128526096722297245056400001224659640161226346829758000012280340193552297212089520000123140839854923309558814600001234782777743236469967340000012381571569370000223984434653400001241531536131000022432187257280000124490591532500002246593104922000012482802945190000224996748411600001251654673713000022533418633100000125502905290700002256716242504000042584034321010000226009062169800001261777811294999992634650008920000326515219048900002266839380086000012685265696829999927021375928000003271900948877000022735881384742752753280709999927696251766800003278649707265000022803368968622820240864589999928371127605600003285398465653000022870856552528877284484699999290460034444000032921472240410000229383441363829552160323499999297208792832000032988959824290000130058317202630227036162299999303957551220000033056447408170000130733193041430901912001100004310706309608000033123934992050000131408068880231576787839899998317455067996000033191422575930000132082944719322516636787000043242038263840000232589101598100001327578205578329265395174999983309525847720000233263977436900001334326963965999993360141535630000433770134316000002339388532757000013410757223539999934276291195099998344450101548000023461372911450000134782448074199999349511670339000033511988599360000235288604953335457323912999999356260428726999983579476183240000235963480792136132199751799999
Gestational age in days
Fetal abdominal circumference (mm)
HC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM 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macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631482140156551496505480215108708038499998152523612749999981539601451149999915539667747999999156833209845158269742211597062745750000116114280694000001162579339305000021640158716716545240403516688893640000001168325468764999981697620011299999917119853349499999172635065861740715982251755081305900000117694466295500001178381195320000021798177276849999918125426005182690792415184127324779999981855638571449999918700038950999999188436921875189873454241913099866050000119274651897000001194183051335000021956195836999999919705611606519849264843199929180795000012013657131600000120280224552499999204238777889999992056753102552071118426220854837498500001209984907350000012114214397150000221285797208214294504445215731036810000012171675691750000121860410154000002220040633904999992214771662722291369863522435023100000001225786763365000012272232957300000222865982809499999230096360462315328928252329694251900000123440595755500001235842489920000022372790222852387155546524015208701500001241588619380000012430251517450000224446168411000002245898216475247334748842487712812050000125020781357000001251644345935000022530808782999999925451741066525595394303257390475395000012588270077600000126026354012500002261700072490000032631366048550000326457313722000004266009669584999982674462019499999926888273431499999270319266682717557990452731923314100000127462886377500001276065396140000022775019285050000227893846087000003280374993235000032818115255999999828324805796500004284684590329999992861211226952875576550628899418742500001290430719790000012918672521550000229330378452000002294740316885000032961768492500000329761338161500004299049913980000043004864463449999930192297871303359511075304796043440000013062325758050000130766910817000002309105640535000023105421729000000331197870526500003313415237630000043148517699950000431628830235999999317724834725000053191613670932059789945532203443182000001323470964185000013249074965500000232634402891500002327780561280000033292170936450000333065362601000004332090158374999993335266907400000533496322310533639975547337836287835000013392728202000000134070935256500002342145884930000023435824172950000334501894966000003346455482025000043478920143899999934932854675500005350765079123522016114853536381438500000135507467621500001GDM 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Gestational age in days
Head circumference (mm)
HCAC 6 groups
Fetal growth profiles in diabetic pregnancies
IDDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631200577381119903700111974966211195956241119441586111928754811191335101118979472099999991188254340999999911867139609999999118517358099999991183633200999999911820928209999999118055244099999991179012060999999911774716809999999117593130099999991174390920999999911728505409999999117131016099999981169769780999999811682294009999998116668902099999981165148640999999811636082609999998116206788099999981160527500999999811589871211157446740999999811559063611154365981115282560111512852211149744841114820446111466640809999999114512370099999991143583320999999911420429409999999114050256099999991138962180999999911374218009999999113588142099999991134341040999999911328006609999999113126028099999991129719900999999911281795209999999112663914099999981125098760999999811235583809999998112201800099999981120477620999999811189372409999998111739686099999981115856480999999811143161011112775721111123534111096949611108154581110661420111050738211103533440999999911019930609999999110045268099999991098912300999999910973719209999999109583154099999991094291160999999910927507809999999109121040099999991089670020999999910881296409999999108658926099999991085048880999999910835085009999998108196812099999981080427740999999810788873609999998107734698099999981075806600999999810742662209999998107272584099999981071185460999999810696450811068104701106656432110650239411063483561106194318110604028011058862420999999910573220409999999105578166099999991054241280999999910527009009999999105116052099999991049620140999999910480797609999999104653938099999991044999000999999910434586209999999104191824099999991040377860999999810388374809999998103729710099999981035756720999999810342163409999998103267596099999981031135580999999810295952009999998102805482110265144409999998102497406110234336811021893301102035292110188125411017272161101573178099999991014191400999999910126510209999999101111064099999991009570260999999910080298809999999100648950099999991004949120999999910034087409999999100186836099999991000327980999999909987876009999998609972472209999998509957068409999998409941664609999998309926260809999999409910857009999999309895453209999999209880049409999999109864645609999999109849241809999999098338380099999989098184342099999988098030304099999988097876266099999987IDDM macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226312314344909999999122909766112267608309999998122442400099999981222087170999999912197503409999999121741351099999971215076680999999812127398509999998121040302099999991208066190999999912057293609999999120339253099999981201055700999999811987188709999999119638204099999991194045210999999711917083809999998118937155099999981187034720999999811846978909999999118236106099999991180024230999999811776874009999998117535057099999981173013740999999911706769109999999116834008099999981166003250999999811636664209999998116132959099999991158992760999999911566559309999997115431910099999981151982270999999811496454409999999114730861099999991144971780999999711426349509999998114029812099999981137961290999999911356244609999999113328763111309508009999998112861397099999981126277140999999911239403109999999112160348099999971119266650999999811169298209999998111459299099999991112256160999999911099193311107582500999999811052456709999998110290884099999991100572010999999910982351809999999109589835099999981093561520999999810912246909999999108888786099999991086551030999999910842142009999998108187737099999981079540540999999910772037109999999107486688099999991072530050999999810701932209999998106785639099999981065519560999999910631827309999999106084590099999981058509070999999810561722409999998105383541099999991051498580999999910491617509999998104682492099999981044488090999999810421512609999999103981443099999991037477600999999710351407709999998103280394099999981030467110999999910281302809999999102579345099999971023456620999999810211197909999998101878296099999991016446130999999910141093011011772470999999810094356409999998100709881099999991004761980999999910024251509999997100008832099999980997751490999999820995414660999999870993077830999999910990741000999999840988404170999999890986067340999999820983730510999999860981393680999999910979056850999999840976720020999999880974383190999999820972046360999999860969709530999999909673727009999998309650358709999998809626990409999998109603622109999998509580253809999999095568855099999983095335172099999987095101489099999981094867806099999985094634123099999989094400440099999983094166757099999987093933074099999980936993910999999850934657080999999890932320250999999820929983420999999870927646590999999809253097609999998409229729309999998909206361009999999309182992709999998609159624409999997909136256109999998409112887809999998809089519509999999209066151209999998609042782909999999090194146099999983089960463099999988089726780099999992089493097099999985DM2 non-macrosomia11912012112212312412512612712812913013113213313413513613713813914014114214314414514614714814915015115215315415515615715815916016116216316416516616716816917017117217317417517617717817918018118218318418518618718818919019119219319419519619719819920020120220320420520620720820921021121221321421521621721821922022122222322422522622722822923023123223323423523623723823924024124224324424524624724824925025125225325425525625725825926026126226311562740819999997115534842499999971154422767999999911534971109999999115257145399999981151645796999999811507201399999998114979448299999981148868825999999711479431689999997114701751199999971146091854999999911451661979999999114424054099999981143314883999999811423892269999998114146356999999981140537912999999711396122559999997113868659899999971137760941999999911368352849999999113590962799999981134983970999999811340583139999998113313265699999981132206999999999711312813429999997113035568599999971129430028999999911285043719999999112757871499999981126653057999999811257274009999998112480174399999981123876086999999711229504299999997112202477299999971121099115999999911201734589999999111924780199999981118322144999999811173964879999998111647083099999981115545173999999811146195169999997111369385999999971112768202999999911118425459999999111091688899999991109991231999999811090655749999998110813991799999981107214260999999811062886039999997110536294699999971104437289999999711035116329999999110258597599999991101660318999999811007346619999998109980900499999981098883347999999810979576909999997109703203399999971096106376999999710951807199999999109425506299999991093329405999999810924037489999998109147809199999981090552434999999810896267779999997108870112099999971087775463999999710868498069999999108592414999999991084998492999999810840728359999998108314717899999981082221521999999810812958649999997108037020799999971079444550999999710785188939999999107759323699999991076667579999999810757419229999998107481626599999981073890608999999810729649519999997107203929499999971071113637999999710701879809999997106926232399999991068336666999999910674110099999998106648535299999981065559695999999810646340389999998106370838199999971062782724999999710618570679999997106093141099999991060005753999999910590800969999998105815443999999981057228782999999810563031259999998105537746899999971054451811999999710535261549999997105260049799999991051674840999999910507491839999998104982352699999981048897869999999810479722129999998104704655599999971046120898999999710451952419999997104426958499999991043343927999999910424182709999998104149261399999981040566956999999810396412999999998103871564299999971037789985999999710368643289999997103593867199999991035013014999999910340873579999998103316170099999981032236043999999810313103869999998103038472999999971029459072999999710285334159999997102760775899999991026682101999999910257564449999999102483078799999981023905130999999810229794739999998DM2 macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631183880550999999911821121210000001118034369111785752611176806830999999911750384009999999117326997100000011171501541116973311111679646809999999116619625099999991164427821000000111626593911160890961115912253111573541009999999115558567100000011153817241115204881111502803811148511950999999911467435209999999114497509100000011143206661114143823111396698009999999113790137099999991136132941000000111343645111132596081113082765099999991129059220999999911272907910000001112552236111237539311121985500999999911202170709999999111844864100000011116680211111491178111131433509999999111137492099999991109606491000000111078380611106069631110430120111025327709999999110076434100000011098995911109722748110954590511093690620999999910919221910000001109015376100000011088385331108661690110848484709999999108308004099999991081311611000000110795431811077774751107600632099999991074237890999999910724694610000001107070103110689326011067164170999999910653957409999999106362731100000011061858881106009045110583220209999999105655359099999991054785161000000110530167311051248301104947987110477114409999999104594301100000011044174581104240615110406377211038869290999999910371008610000001103533243100000011033564001103179557110300271409999999102825871099999991026490281000000110247218511022953421102118499099999991019416560999999910176481310000001101587970110141112711012342840999999910105744109999999100880598100000011007037551100526912110035006909999999100173226099999990999963830999999970998195401000000040996426970999999990994658540999999950992890111000000020991121680999999980989353251000000040987584821098581639099999996098404796100000003098227953099999998098051110099999994097874267100000001097697424099999997097520581099999992097343738099999999097166895099999995096990052100000002096813209099999997096636366099999993096459523109628268009999999509610583710000000209592899409999999809575215109999999409557530810953984650999999960952216221000000030950447790999999990948679360999999940946910931000000010945142500999999970943374071000000040941605640999999990939837210999999950938068781000000020936300350999999980934531921000000040932763491093099506099999996092922663099999991GDM non-macrosomia1191201211221231241251261271281291301311321331341351361371381391401411421431441451461471481491501511521531541551561571581591601611621631641651661671681691701711721731741751761771781791801811821831841851861871881891901911921931941951961971981992002012022032042052062072082092102112122132142152162172182192202212222232242252262272282292302312322332342352362372382392402412422432442452462472482492502512522532542552562572582592602612622631171395040999999811701596669999998116892429299999991167688918999999711664535449999998116521817099999981163982796999999811627474229999999116151204899999971160276674999999811590413009999998115780592699999981156570552999999911553351789999997115409980499999981152864430999999811516290569999998115039368299999991149158308999999711479229349999998114668756099999981145452186999999811442168129999999114298143899999971141746064999999811405106909999998113927531699999981138039942999999911368045689999997113556919499999981134333820999999811330984469999998113186307299999991130627698999999711293923249999998112815695099999981126921576999999811256862029999999112445082899999971123215454999999811219800809999998112074470699999981119509332999999911182739589999997111703858499999981115803210999999811145678369999998111333246299999991112097088999999711108617149999997110962634099999981108390966999999811071555929999999110592021899999971104684844999999711034494709999998110221409699999981100978722999999910997433489999997109850797499999971097272600999999810960372269999998109480185299999991093566478999999710923311049999997109109573099999981089860356999999810886249829999999108738960899999971086154234999999710849188609999998108368348699999981082448112999999910812127389999997107997736499999971078741990999999810775066169999998107627124299999991075035868999999710738004949999997107256512099999981071329746999999810700943729999999106885899899999971067623624999999710663882509999998106515287699999981063917502999999910626821289999997106144675499999971060211380999999810589760069999998105774063299999991056505258999999710552698849999997105403451099999981052799136999999810515637629999999105032838899999971049093014999999710478576409999998104662226699999981045386892999999910441515189999997104291614499999971041680770999999810404453969999998103921002299999991037974648999999710367392749999997103550390099999981034268526999999810330331529999999103179777899999971030562404999999710293270309999998102809165699999981026856282999999910256209089999997102438553499999971023150160999999810219147869999998102067941299999991019444038999999710182086649999997101697329099999981015737916999999810145025429999999101326716899999971012031794999999710107964209999998100956104699999981008325672999999910070902989999997100585492499999971004619550999999810033841769999998100214880299999991000913428999999709996780549999997309984426809999997809972073069999998209959719329999997509947365589999998099350118499999973GDM macrosomia119120121122123124125126127128129130131132133134135136137138139140141142143144145146147148149150151152153154155156157158159160161162163164165166167168169170171172173174175176177178179180181182183184185186187188189190191192193194195196197198199200201202203204205206207208209210211212213214215216217218219220221222223224225226227228229230231232233234235236237238239240241242243244245246247248249250251252253254255256257258259260261262263120192611099999991200218000999999911985098911196801781119509367111933855609999999119167745099999991189969341000000111882612311186553121118484501099999991183136900999999911814287909999999117972068111780125711176304461117459635099999991172888240999999911711801310000001116947202111677639111166055800999999911643476909999999116263958099999991160931471115922336111575152511155807140999999911540990309999999115239092100000011150682811114897470111472665909999999114555848099999991143850370999999911421422611140434151113872604111370179309999999113530982099999991133601711000000111318936011130185491112847738099999991126769270999999911250611609999999112335305111216449411119936831111822872099999991116520610999999911148125010000001111310439111113962811109688170999999911079800609999999110627195099999991104563841110285573111011476211099439510999999910977314009999999109602329100000011094315181109260707110908989609999999108919085099999991087482740999999910857746311084066521108235841110806503009999999107894219099999991077234081000000110755259711073817861107210975099999991070401640999999910686935309999999106698542110652773111063569201106186109099999991060152980999999910584448710000001105673676110550286511053320540999999910516124309999999104990432099999991048196211104648810110447799911043071880999999910413637709999999103965566100000011037947551103623944110345313309999999103282322099999991031115110999999910294070011027698891102599078110242826709999999102257456099999991020866451000000110191583411017450231101574212099999991014034010999999910123259009999999101061779110089096811007201571100549346099999991003785350999999910020772410000001100036913109986610209999999809969529109999999409952448009999999099353669099999997099182858099999993099012047109884123609999999609867042509999999209849961409999999909832880309999999509815799209999999109798718109999999809781637009999999409764555909999999097474748099999997097303937099999993097133126109696231509999999609679150409999999209662069309999999909644988209999999509627907109999999109610826009999999809593744909999999409576663809999999095595827099999997
Gestational age in days
Head to abdominal circumference ratio (HCAC ratio)
Model
Conseguenze neonataliParalisi transitoria plesso brachiale (30-168)Frattura della clavicola (17-95)Frattura dellrsquo omero (01-42)Paralisi permanente del plesso brachiale(05-16)encefalopatia ipossico-ischemica (03)morte (0-035)
Hoffman MK Obstet Gynecol 2011117(6)1272Gherman RB Am J Obstet Gynecol 2006195(3)657
LA MACROSOMIA Egrave UN IMPORTANTE FATTORE DI RISCHIO PER DISTOCIA DI SPALLA
Iperglicemia e rischio di morte fetale a termine di gravidanza
Estimated rate of stillbirth in diabetic women 1920-2000
Diabetic-Associated Stillbirth Incidence Pathophysiology and PreventionDonald J Dudley Clin Perinatol 34 (2007)
4 of all stillbirths remain attributable to diabetes
Stillbirth rates are higher than in non diabetic pregnancies by 15 to 6-folds
bull spontaneous and therapeutic abortionbull stillbirthbull neonatal deathbull major congenital abnormalities
Adverse outcome
HbA1C gt7
1 increase in A1Ccorresponded to 55 increased
risk of adverse outcome
The risk of stillbirth appears to increase in diabetic pregnancies starting at 34 weeks
gestation particularly in the presence of fetal macrosomia
fetal and neonatal outcomes are directly correlated with the degree of maternal glycemic control
Langer O 1995
100 mgdLfor stillbirth
Diabetic patients n = 271691
Am J Obstet Gynecol 2002
The overall fetal death rates in diabetic women were increased when birth weight was 4000 g (adjusted rela- tive risk of 20 95 [CI] 18ndash22)
4873 diabetic women
pre-existing diabetes (n = 65) GDM lt12 weeks (n = 68)GDM 12ndash23 weeks of gestation (n = 1247)GDM ge24 weeks of gestation (n = 3493)
outcomes in GDM lt12 weeks are the worst of the GDM cohort and approximate those of women with pre-existing diabete
bull higher prepregnancy BMI bull greater insulin requirementsbull higher rates of hypertensive disorders of pregnancybull more insulin-resistant phenotype compared with later
GDMbull dysglycemia was more difficult to manage
2016
Differences in placental pathologyaccording to diabetes types
Type 1 Type 2 and Gestational Diabetes Mellitus Differentially Impact Placental Pathologic Characteristics of UteroplacentalMalperfusion Jennifer Huynh et al Placenta 2016
GDM is associated with a greater rate of villous immaturity
0102030405060708090
100GDMDMIDMII
o decreased tertiary villus formationo reduced vasculosyncytial membrane formationo increased large bullous villi
A retrospective study on 175 placentas with DVM vs 175 controls
Pregestational diabetes (8 vs 28 P lt 005 relative risk 28 Gestational diabetes (86 vs 34 P lt 005 relative risk 25 Prenatal or intrapartum intrauterine death (86 vs 0 P lt 005)
Delayed villous maturation (DVM)is associated with an increased risk of stillbirth in the late third trimester
Pathophysiology of fetal compromise in diabetic pregnancy
The growth factor-like effect of insulin producesplacental overgrowth as well as organomegalyand thus results in changes in vascular tone andhaemodynamic
Thickening of the basement membrane of the chorionic villi in diabetic pregnancies
Bjork 1984Nylund 1982Siddiqui 2003
A Lindam et al High maternal body mass index in early pregnancy and risks of stillbirth and infant mortality A population-based Sibling study in Sweden American Journal of Epidemiology 2016
STILLBIRTH RISK
BMI 25-299 OR 151 (95 CI 121-189)BMI 30-349 OR 177 (95 CI 124-25)BMI gt 35 OR 316 (95 CI 210-476)
OBESITArsquo E MORTE FETALE
6-7 per unit BMI for BMI gt 23
Tennant PWG Am J Obstet Gynecol 2007
HYPERINSULINISMHYPERANDROGENISM
IMPAIRED PLACENTATION
THE EFFECTS OF OBESITYMETABOLIC SYNDROME
Cakmak and Taylor Hum Reprod Update 2011
Makieva S Hum Reprod Update 2014
Piltonen TT Hum Reprod 2015 Crujeiras and Casanueva Hum Reprod Update 2015Denison FC Reproduction2010
Hotamisligil GS Nature 2006
LeptinCRH
Urocortin 3IL-6
INFLAMMATIONImpaired decidualizationImpaired trophoblast invasion
INSULIN RESISTANCEDYSLIPIDEMIALOW GRADE CHRONIC INFLAMMATION
Adiponectina Insulin LeptinTNFα IL-6
PLACENTAL ALTERATIONIN GENE EXPRESSION
PRETERM BIRTH PHIPREECLAMPSIASTILLBIRTH
CollagenaseCervical ripening
FFA
OXIDATIVE STRESS
PREVENZIONE STILLBIRTH
PREVENZIONE COMPLICANZE INTRAPARTUM DEL FETO MACROSOMA
MORBIDITAgrave NEONATALE
AUMENTO INCIDENZA TCCOMPLICANZE TRAVAGLIO INDOTTO
TIMING E MODALITArsquo DEL PARTO
Induzione o attesa
INDUZIONE DEL TRAVAGLIO
Quando fare un TC elettivo
gt 4000 grgt 4500 gr gt 5000 gr
ESISTONO RCT SUL TIMING E MODALITAgrave DEL PARTO NELLE GRAVIDANZE COMPLICATE DA DIABETE
425 donne con DMG escluse se PFS gt 4000Induzione tra 38+0 e 39+0 vs attesa fino a 41
No differenza in TC e outcome perinatale
200 donne diabete insulino trattato (13 diabete preesistente)Induzione a 38 vs attesa fino a 42
No differenza in TC gt di LGA e peso medio nel gruppo di attesa
RCT INDUZIONE VS ATTESA in GDM
RACCOMANDAZIONI DELLE LINEE GUIDA INTERNAZIONALI
2014
1 Diet controlled GDMrsquos may deliver post-dates if the fetal parameters are normal
2 Patients well controlled on insulin should probably be delivered by the due date
3 Poorly controlled GDMrsquos using insulin require individual judgment
Estimated weight at birth ge4500 g there is a significant increase in the risk ofshoulder dystocia so a primary section must be consideredWhen estimated weight at birth is 4000ndash4999g an informed consent aboutincreased shoulder dystocia risk
1 the timing of delivery in women with GDM that is controlled with only diet and exercise (A1GDM) should not be before 39 weeks of gestation unless otherwise indicatedExpectant management up to 40 67 weeks of gestation in the setting of indicated antepartum testing is generally appropriate
2 For women with GDM that is well controlled by medications (A2GDM) delivery is recommended from 39 07 weeks to 39 67 weeks of gestation
3 Earlier delivery for women with poorly controlled GDM delivery between 37 07 weeks and 38 67 weeks of gestation may be justified but delivery in the late preterm period from 34 07 weeks to 36 67 weeks of gestation should be reserved for those women who fail in-hospital attempts to improve glycemic control or who have abnormal antepartum fetal testing
cesarean delivery when the estimated fetal weight is ge 4500 g
MATERNAL DIABETES + ESTIMATED FETAL WEIGHT
MODALITAgrave E TIMING DEL PARTO nel GDM
GMD in terapia insulinicaBen controllato
+Condizioni fetali rassicuranti
MANAGEMENT DI ATTESANON OLTRE LA 40 SETTIMANAIN ASSENZA DI COMORBIDITAgrave
GDM in terapia nutrizionalecon profili glicemici ottimali
+Feto AGA
MANAGEMENT DI ATTESA FINO ALLA 41 SETTIMANA
Condotta di attesa uarr probabilitagrave di travaglio spontaneo minor rischio di parto cesareo per fallita induzione
EFW lt 4000g LGAControllo metabolico non
ottimale
4000g lt EFW gt 4500g EFW ge 4500g
Programmare TC elettivo
Parto vaginale indotto a 38-39 sett
Parto vaginale o TC Considerare-caratteristiche materne (statura BMI pregravidico pelvi bishop)-anamnesi ostetrica (pregressi parti macrosomici o con distocia)
MODALITAgrave E TIMING DEL PARTO nel GDM
IN BASE AL PESO FETALE STIMATO
- Patients with well-controlled diabetes may be allowed to progress to their expected date of delivery as long as antenatal testing remains reassuring - Expectant management beyond the estimated due date generally is not recommended
- Early delivery may be indicated in some patients with vasculopathy nephropathy poor glucose control or a prior stillbirth
- Cesarean delivery may be considered if the estimated fetal weight is greater than 4500 g
ANTENATAL CORTICOSTEROIDS FOR IMPROVING PRETERM BIRTH OUTCOMES WITH MATERNAL DIABETES MELLITUS
Antenatal Corticosteroids for Reducing Adverse Maternal and Child Outcomes in Special Populations of WomenatRisk of Imminent PretermBirth A Systematic Review and Meta-Analysis RachelMAmiya et al Plos One 2016
The presence of maternal diabetes in pregnancy is not a reason to withholdantenatal corticosteroids where there is an imminent RISK OF PRETERM BIRTH
A HYPERGLYCAEMIC EFFECT of corticosteroids in pregnant women closemonitoring and treatment for glycaemic control essential at all stage
If corticosteroids are administered to accelerate lung maturation an increased insulin requirement over the next 5 days should be anticipated (ACOG)
Betamethasone should be prescribed for inducing fetal lung maturity (beforeWeek34) only if strictly indicated because this will also cause the blood glucose levels to rise (GERMAN DIABETES ASSOCIATION)
GDM and the Use of Betamethasone
bull administration of betamethasone in the late preterm period should be limited to women with GDM only
bull ketoacidosis in the pregnant diabetic individual is a potential cause of fetal demise
bull it is recommended to closely monitor maternal glycaemia after betamethasone administration in women with poorly controlled diabetes particularly during the first 12 hours
Society of Obstetricians and Gynaecologists of Canada
The administration of betamethasone to pregnant women with GDM should be restricted to the routine obstetric indications related to the risk of preterm and
late preterm delivery between 24 to 36 weeksrsquo gestation
ASSISTENZA IN TRAVAGLIO
- MONITORAGGIO FETALE CONTINUO
- Monitoraggio glicemie plasmatiche materne nelle pz in terapia insulinica ogni ora
MANTENERE GLICEMIA gt70 E lt 126
(Endocrine Society Clinical Practice Guidelines 2013ACOG 2005)
GDM
- Intravenous infusion of regular insulin titrated and glucose
- Maintain hourly readings of BLOOD GLUCOSE LEVELS LESS THAN 110 MGDL
(ACOG 2005)
ASSISTENZA IN TRAVAGLIO DIABETE PREGESTAZIONALE
Venere di Willendorf
Thank you for your attention
Pathophysiology of fetal compromise in diabetic pregnancy
Islet cell hyperplasia common in stillborn IDMs
There is a significant association between fetalplasma insulin concentration and the degree of fetal acidemia
Hyperglycemia (chronic) when accompanied byminimal hypoxemia may result in lactic acidosis
Salvesen 1993Hay 1989Chukwuma 2001
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- Birth weight distribution in diabetic pregnancies
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- Fetal growth profiles in diabetic pregnanciesHead to abdomen circumf Ratio
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- Differences in placental pathology according to diabetes types
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- Pathophysiology of fetal compromise in diabetic pregnancy
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- GDM and the Use of Betamethasone
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- Pathophysiology of fetal compromise in diabetic pregnancy
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Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 1200577381 | 1231434491 | 1156274082 | 1183880551 | 1171395041 | 1201926111 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 1199037001 | 1229097661 | 1155348425 | 1182112121 | 1170159667 | 1200218001 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 1197496621 | 1226760831 | 1154422768 | 1180343691 | 1168924293 | 1198509891 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 1195956241 | 1224424001 | 1153497111 | 1178575261 | 1167688919 | 1196801781 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 1194415861 | 1222087171 | 1152571454 | 1176806831 | 1166453545 | 1195093671 | 1113788 | Intercept | 10927507815 | 00076442085 | 2483861646118 | 1429514624586 | 156360851038611E-240 | 10776950494 | 11078065136 | |||||||||||||||||||||
124 | -65 | 4225 | 1192875481 | 1219750341 | 1151645797 | 1175038401 | 1165218171 | 1193385561 | 1114767 | ctime | -000154038 | 00001873813 | 2361894509163 | -8220563736 | 0 | -00019095322 | -00011712279 | |||||||||||||||||||||
125 | -64 | 4096 | 1191335101 | 1217413511 | 115072014 | 1173269971 | 1163982797 | 1191677451 | 111572 | DM1M | -00248943874 | 00128608391 | 2384370237175 | -19356736562 | 00540899658 | -00502297654 | 00004409907 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 1189794721 | 1215076681 | 1149794483 | 1171501541 | 1162747423 | 1189969341 | 1116647 | DM2nM | -00012726893 | 00110006433 | 2439624938932 | -01156922599 | 09079916115 | -00229410469 | 00203956684 | ||||||||||||||||||||
127 | -62 | 3844 | 1188254341 | 1212739851 | 1148868826 | 1169733111 | 1161512049 | 1188261231 | 1117548 | DM2M | -00326603281 | 00143197289 | 2333680597702 | -22807923425 | 00234630719 | -00608727913 | -00044478648 | |||||||||||||||||||||
128 | -61 | 3721 | 1186713961 | 1210403021 | 1147943169 | 1167964681 | 1160276675 | 1186553121 | 1118423 | DM3nM | -00078319191 | 00102230349 | 2661779271785 | -07661050855 | 04442926229 | -00279602193 | 00122963812 | |||||||||||||||||||||
129 | -60 | 3600 | 1185173581 | 1208066191 | 1147017512 | 1166196251 | 1159041301 | 1184845011 | 1119272 | DM3M | -00103923671 | 00168121354 | 4167163320542 | -06181467632 | 05368162888 | -00434395286 | 00226547944 | |||||||||||||||||||||
130 | -59 | 3481 | 1183633201 | 1205729361 | 1146091855 | 1164427821 | 1157805927 | 1183136901 | 1120095 | ctime DM1M | -00007964546 | 0000313309 | 2294715100798 | -2542073658 | 00116788476 | -00014137849 | -00001791244 | |||||||||||||||||||||
131 | -58 | 3364 | 1182092821 | 1203392531 | 1145166198 | 1162659391 | 1156570553 | 1181428791 | 1120892 | ctime DM2nM | 0000614723 | 00002699383 | 2384913816816 | 2277271851 | 00236562253 | 0000082955 | 0001146491 | |||||||||||||||||||||
132 | -57 | 3249 | 1180552441 | 1201055701 | 1144240541 | 1160890961 | 1155335179 | 1179720681 | 1121663 | ctime DM2M | -00002280464 | 000035415 | 2299388660551 | -06439259603 | 05202652078 | -00009258404 | 00004697476 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 1179012061 | 1198718871 | 1143314884 | 1159122531 | 1154099805 | 1178012571 | 1122408 | ctime DM3nM | 00003050062 | 00002515002 | 2587066853334 | 12127472744 | 02263327011 | -0000190242 | 00008002544 | ||||||||||||||||||||
134 | -55 | 3025 | 1177471681 | 1196382041 | 1142389227 | 1157354101 | 1152864431 | 1176304461 | 1123127 | ctime DM3M | -00001677324 | 00003926162 | 3843503141477 | -04272172818 | 06694603024 | -00009396769 | 0000604212 | |||||||||||||||||||||
135 | -54 | 2916 | 1175931301 | 1194045211 | 114146357 | 1155585671 | 1151629057 | 1174596351 | 112382 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 1174390921 | 1191708381 | 1140537913 | 1153817241 | 1150393683 | 1172888241 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 1172850541 | 1189371551 | 1139612256 | 1152048811 | 1149158309 | 1171180131 | 1125128 | |||||||||||||||||||||||||||||
138 | -51 | 2601 | 1171310161 | 1187034721 | 1138686599 | 1150280381 | 1147922935 | 1169472021 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 1169769781 | 1184697891 | 1137760942 | 1148511951 | 1146687561 | 1167763911 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 1168229401 | 1182361061 | 1136835285 | 1146743521 | 1145452187 | 1166055801 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 1166689021 | 1180024231 | 1135909628 | 1144975091 | 1144216813 | 1164347691 | 1127432 | Intercept | 1100131329 | 00097239735 | 5091201207314 | 1131359859981 | 0 | 10810272758 | 11192353823 | |||||||||||||||||||||
142 | -47 | 2209 | 1165148641 | 1177687401 | 1134983971 | 1143206661 | 1142981439 | 1162639581 | 1127943 | ctime | -00015055347 | 00001896264 | 2453458441236 | -79394796061 | 0 | -0001879038 | -00011320314 | |||||||||||||||||||||
143 | -46 | 2116 | 1163608261 | 1175350571 | 1134058314 | 1141438231 | 1141746065 | 1160931471 | 1128428 | ctimesq | -00000041757 | 00000034043 | 552737663669 | -12265704583 | 02205063137 | -00000108627 | 00000025114 | |||||||||||||||||||||
144 | -45 | 2025 | 1162067881 | 1173013741 | 1133132657 | 1139669801 | 1140510691 | 1159223361 | 1128887 | DM1M | -00337425008 | 00167371296 | 5123546308965 | -20160267375 | 00443186119 | -00666243475 | -00008606541 | |||||||||||||||||||||
145 | -44 | 1936 | 1160527501 | 1170676911 | 1132207 | 1137901371 | 1139275317 | 1157515251 | 112932 | DM2nM | -00143395763 | 00140808978 | 4950486711294 | -10183708815 | 03089991569 | -0042005267 | 00133261143 | |||||||||||||||||||||
146 | -43 | 1849 | 1158987121 | 1168340081 | 1131281343 | 1136132941 | 1138039943 | 1155807141 | 1129727 | DM2M | -00289134247 | 00183010824 | 4962153900811 | -15798751207 | 01147726649 | -00648705897 | 00070437403 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 1157446741 | 1166003251 | 1130355686 | 1134364511 | 1136804569 | 1154099031 | 1130108 | DM3nM | -00092688892 | 00131390588 | 5276671855448 | -0705445447 | 0480844366 | -0035080175 | 00165423965 | ||||||||||||||||||||
148 | -41 | 1681 | 1155906361 | 1163666421 | 1129430029 | 1132596081 | 1135569195 | 1152390921 | 1130463 | DM3M | -00041390353 | 00195639063 | 5795483919757 | -02115648675 | 08325208967 | -00425638329 | 00342857623 | |||||||||||||||||||||
149 | -40 | 1600 | 1154365981 | 1161329591 | 1128504372 | 1130827651 | 1134333821 | 1150682811 | 1130792 | ctime DM1M | -00008318378 | 00003148002 | 2321213468068 | -26424313041 | 00087914156 | -00014520686 | -0000211607 | |||||||||||||||||||||
150 | -39 | 1521 | 1152825601 | 1158992761 | 1127578715 | 1129059221 | 1133098447 | 1148974701 | 1131095 | ctime DM2nM | 0000549327 | 00002737601 | 2493756838497 | 20066000847 | 00458718509 | 00000101504 | 00010885037 | |||||||||||||||||||||
151 | -38 | 1444 | 1151285221 | 1156655931 | 1126653058 | 1127290791 | 1131863073 | 1147266591 | 1131372 | ctime DM2M | -00002165967 | 00003577736 | 2405317547939 | -06054015692 | 05454829861 | -00009213661 | 00004881728 | |||||||||||||||||||||
152 | -37 | 1369 | 1149744841 | 1154319101 | 1125727401 | 1125522361 | 1130627699 | 1145558481 | 1131623 | ctime DM3nM | 00003046641 | 00002553443 | 2697544368655 | 11931503388 | 02338588418 | -0000198057 | 00008073851 | |||||||||||||||||||||
153 | -36 | 1296 | 1148204461 | 1151982271 | 1124801744 | 1123753931 | 1129392325 | 1143850371 | 1131848 | ctime DM3M | 00002377602 | 00004715353 | 5115217222776 | 05042255855 | 06143199743 | -00006886239 | 00011641443 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 1146664081 | 1149645441 | 1123876087 | 1121985501 | 1128156951 | 1142142261 | 1132047 | ctimesq DM1M | 00000049385 | 00000057245 | 5269246547768 | 08626995541 | 0388695145 | -00000063071 | 00000161842 | ||||||||||||||||||||
155 | -34 | 1156 | 1145123701 | 1147308611 | 112295043 | 1120217071 | 1126921577 | 1140434151 | 113222 | ctimesq DM2nM | 00000075322 | 00000050896 | 5888156924564 | 14798997622 | 01394348201 | -00000024639 | 00000175282 | |||||||||||||||||||||
156 | -33 | 1089 | 1143583321 | 1144971781 | 1122024773 | 1118448641 | 1125686203 | 1138726041 | 1132367 | ctimesq DM2M | -00000022137 | 0000006526 | 55535916331 | -03392053768 | 07345832447 | -00000150323 | 0000010605 | |||||||||||||||||||||
157 | -32 | 1024 | 1142042941 | 1142634951 | 1121099116 | 1116680211 | 1124450829 | 1137017931 | 1132488 | ctimesq DM3nM | 00000005286 | 00000048671 | 5971385213096 | 01086008014 | 0913555607 | -00000090301 | 00000100872 | |||||||||||||||||||||
158 | -31 | 961 | 1140502561 | 1140298121 | 1120173459 | 1114911781 | 1123215455 | 1135309821 | 1132583 | ctimesq DM3M | -00000085347 | 0000008227 | 6863599279549 | -10373953144 | 02999169916 | -00000246879 | 00000076185 | |||||||||||||||||||||
159 | -30 | 900 | 1138962181 | 1137961291 | 1119247802 | 1113143351 | 1121980081 | 1133601711 | 1132652 | a Dependent Variable HCAC ratio echo 1 | ||||||||||||||||||||||||||||
160 | -29 | 841 | 1137421801 | 1135624461 | 1118322145 | 1111374921 | 1120744707 | 1131893601 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 1135881421 | 1133287631 | 1117396488 | 1109606491 | 1119509333 | 1130185491 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 1134341041 | 1130950801 | 1116470831 | 1107838061 | 1118273959 | 1128477381 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 1132800661 | 1128613971 | 1115545174 | 1106069631 | 1117038585 | 1126769271 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 1131260281 | 1126277141 | 1114619517 | 1104301201 | 1115803211 | 1125061161 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 1129719901 | 1123940311 | 111369386 | 1102532771 | 1114567837 | 1123353051 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 1128179521 | 1121603481 | 1112768203 | 1100764341 | 1113332463 | 1121644941 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 1126639141 | 1119266651 | 1111842546 | 1098995911 | 1112097089 | 1119936831 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 1125098761 | 1116929821 | 1110916889 | 1097227481 | 1110861715 | 1118228721 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 1123558381 | 1114592991 | 1109991232 | 1095459051 | 1109626341 | 1116520611 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 1122018001 | 1112256161 | 1109065575 | 1093690621 | 1108390967 | 1114812501 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 1120477621 | 1109919331 | 1108139918 | 1091922191 | 1107155593 | 1113104391 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 1118937241 | 1107582501 | 1107214261 | 1090153761 | 1105920219 | 1111396281 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 1117396861 | 1105245671 | 1106288604 | 1088385331 | 1104684845 | 1109688171 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 1115856481 | 1102908841 | 1105362947 | 1086616901 | 1103449471 | 1107980061 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 1114316101 | 1100572011 | 110443729 | 1084848471 | 1102214097 | 1106271951 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 1112775721 | 1098235181 | 1103511633 | 1083080041 | 1100978723 | 1104563841 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 1111235341 | 1095898351 | 1102585976 | 1081311611 | 1099743349 | 1102855731 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 1109694961 | 1093561521 | 1101660319 | 1079543181 | 1098507975 | 1101147621 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 1108154581 | 1091224691 | 1100734662 | 1077774751 | 1097272601 | 1099439511 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 1106614201 | 1088887861 | 1099809005 | 1076006321 | 1096037227 | 1097731401 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 1105073821 | 1086551031 | 1098883348 | 1074237891 | 1094801853 | 1096023291 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 1103533441 | 1084214201 | 1097957691 | 1072469461 | 1093566479 | 1094315181 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 1101993061 | 1081877371 | 1097032034 | 1070701031 | 1092331105 | 1092607071 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 1100452681 | 1079540541 | 1096106377 | 1068932601 | 1091095731 | 1090898961 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 1098912301 | 1077203711 | 109518072 | 1067164171 | 1089860357 | 1089190851 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 1097371921 | 1074866881 | 1094255063 | 1065395741 | 1088624983 | 1087482741 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 1095831541 | 1072530051 | 1093329406 | 1063627311 | 1087389609 | 1085774631 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 1094291161 | 1070193221 | 1092403749 | 1061858881 | 1086154235 | 1084066521 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 1092750781 | 1067856391 | 1091478092 | 1060090451 | 1084918861 | 1082358411 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 1091210401 | 1065519561 | 1090552435 | 1058322021 | 1083683487 | 1080650301 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 1089670021 | 1063182731 | 1089626778 | 1056553591 | 1082448113 | 1078942191 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 1088129641 | 1060845901 | 1088701121 | 1054785161 | 1081212739 | 1077234081 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 1086589261 | 1058509071 | 1087775464 | 1053016731 | 1079977365 | 1075525971 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 1085048881 | 1056172241 | 1086849807 | 1051248301 | 1078741991 | 1073817861 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 1083508501 | 1053835411 | 108592415 | 1049479871 | 1077506617 | 1072109751 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 1081968121 | 1051498581 | 1084998493 | 1047711441 | 1076271243 | 1070401641 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 1080427741 | 1049161751 | 1084072836 | 1045943011 | 1075035869 | 1068693531 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 1078887361 | 1046824921 | 1083147179 | 1044174581 | 1073800495 | 1066985421 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 1077346981 | 1044488091 | 1082221522 | 1042406151 | 1072565121 | 1065277311 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 1075806601 | 1042151261 | 1081295865 | 1040637721 | 1071329747 | 1063569201 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 1074266221 | 1039814431 | 1080370208 | 1038869291 | 1070094373 | 1061861091 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 1072725841 | 1037477601 | 1079444551 | 1037100861 | 1068858999 | 1060152981 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 1071185461 | 1035140771 | 1078518894 | 1035332431 | 1067623625 | 1058444871 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 1069645081 | 1032803941 | 1077593237 | 1033564001 | 1066388251 | 1056736761 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 1068104701 | 1030467111 | 107666758 | 1031795571 | 1065152877 | 1055028651 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 1066564321 | 1028130281 | 1075741923 | 1030027141 | 1063917503 | 1053320541 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 1065023941 | 1025793451 | 1074816266 | 1028258711 | 1062682129 | 1051612431 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 1063483561 | 1023456621 | 1073890609 | 1026490281 | 1061446755 | 1049904321 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 1061943181 | 1021119791 | 1072964952 | 1024721851 | 1060211381 | 1048196211 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 1060402801 | 1018782961 | 1072039295 | 1022953421 | 1058976007 | 1046488101 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 1058862421 | 1016446131 | 1071113638 | 1021184991 | 1057740633 | 1044779991 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 1057322041 | 1014109301 | 1070187981 | 1019416561 | 1056505259 | 1043071881 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 1055781661 | 1011772471 | 1069262324 | 1017648131 | 1055269885 | 1041363771 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 1054241281 | 1009435641 | 1068336667 | 1015879701 | 1054034511 | 1039655661 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 1052700901 | 1007098811 | 106741101 | 1014111271 | 1052799137 | 1037947551 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 1051160521 | 1004761981 | 1066485353 | 1012342841 | 1051563763 | 1036239441 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 1049620141 | 1002425151 | 1065559696 | 1010574411 | 1050328389 | 1034531331 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 1048079761 | 1000088321 | 1064634039 | 1008805981 | 1049093015 | 1032823221 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 1046539381 | 0997751491 | 1063708382 | 1007037551 | 1047857641 | 1031115111 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 1044999001 | 0995414661 | 1062782725 | 1005269121 | 1046622267 | 1029407001 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 1043458621 | 0993077831 | 1061857068 | 1003500691 | 1045386893 | 1027698891 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 1041918241 | 0990741001 | 1060931411 | 1001732261 | 1044151519 | 1025990781 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 1040377861 | 0988404171 | 1060005754 | 0999963831 | 1042916145 | 1024282671 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 1038837481 | 0986067341 | 1059080097 | 0998195401 | 1041680771 | 1022574561 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 1037297101 | 0983730511 | 105815444 | 0996426971 | 1040445397 | 1020866451 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 1035756721 | 0981393681 | 1057228783 | 0994658541 | 1039210023 | 1019158341 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 1034216341 | 0979056851 | 1056303126 | 0992890111 | 1037974649 | 1017450231 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 1032675961 | 0976720021 | 1055377469 | 0991121681 | 1036739275 | 1015742121 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 1031135581 | 0974383191 | 1054451812 | 0989353251 | 1035503901 | 1014034011 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 1029595201 | 0972046361 | 1053526155 | 0987584821 | 1034268527 | 1012325901 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 1028054821 | 0969709531 | 1052600498 | 0985816391 | 1033033153 | 1010617791 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 1026514441 | 0967372701 | 1051674841 | 0984047961 | 1031797779 | 1008909681 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 1024974061 | 0965035871 | 1050749184 | 0982279531 | 1030562405 | 1007201571 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 1023433681 | 0962699041 | 1049823527 | 0980511101 | 1029327031 | 1005493461 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 1021893301 | 0960362211 | 104889787 | 0978742671 | 1028091657 | 1003785351 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 1020352921 | 0958025381 | 1047972213 | 0976974241 | 1026856283 | 1002077241 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 1018812541 | 0955688551 | 1047046556 | 0975205811 | 1025620909 | 1000369131 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 1017272161 | 0953351721 | 1046120899 | 0973437381 | 1024385535 | 0998661021 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 1015731781 | 0951014891 | 1045195242 | 0971668951 | 1023150161 | 0996952911 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 1014191401 | 0948678061 | 1044269585 | 0969900521 | 1021914787 | 0995244801 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 1012651021 | 0946341231 | 1043343928 | 0968132091 | 1020679413 | 0993536691 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 1011110641 | 0944004401 | 1042418271 | 0966363661 | 1019444039 | 0991828581 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 1009570261 | 0941667571 | 1041492614 | 0964595231 | 1018208665 | 0990120471 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 1008029881 | 0939330741 | 1040566957 | 0962826801 | 1016973291 | 0988412361 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 1006489501 | 0936993911 | 10396413 | 0961058371 | 1015737917 | 0986704251 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 1004949121 | 0934657081 | 1038715643 | 0959289941 | 1014502543 | 0984996141 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 1003408741 | 0932320251 | 1037789986 | 0957521511 | 1013267169 | 0983288031 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 1001868361 | 0929983421 | 1036864329 | 0955753081 | 1012031795 | 0981579921 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 1000327981 | 0927646591 | 1035938672 | 0953984651 | 1010796421 | 0979871811 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 0998787601 | 0925309761 | 1035013015 | 0952216221 | 1009561047 | 0978163701 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 0997247221 | 0922972931 | 1034087358 | 0950447791 | 1008325673 | 0976455591 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 0995706841 | 0920636101 | 1033161701 | 0948679361 | 1007090299 | 0974747481 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 0994166461 | 0918299271 | 1032236044 | 0946910931 | 1005854925 | 0973039371 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 0992626081 | 0915962441 | 1031310387 | 0945142501 | 1004619551 | 0971331261 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 0991085701 | 0913625611 | 103038473 | 0943374071 | 1003384177 | 0969623151 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 0989545321 | 0911288781 | 1029459073 | 0941605641 | 1002148803 | 0967915041 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 0988004941 | 0908951951 | 1028533416 | 0939837211 | 1000913429 | 0966206931 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 0986464561 | 0906615121 | 1027607759 | 0938068781 | 0999678055 | 0964498821 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 0984924181 | 0904278291 | 1026682102 | 0936300351 | 0998442681 | 0962790711 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 0983383801 | 0901941461 | 1025756445 | 0934531921 | 0997207307 | 0961082601 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 0981843421 | 0899604631 | 1024830788 | 0932763491 | 0995971933 | 0959374491 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 0980303041 | 0897267801 | 1023905131 | 0930995061 | 0994736559 | 0957666381 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 0978762661 | 0894930971 | 1022979474 | 0929226631 | 0993501185 | 0955958271 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 14544665153 | 145370711215 | 141936936246 | 148214015655 | 151802867413 | 15951046706 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 146818513261 | 146806320467 | 143443250489 | 14965054802 | 153138453854 | 160833976231 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 148190374992 | 148241929719 | 144949564732 | 151087080385 | 154474040295 | 162157485402 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 149562236723 | 149677538971 | 146455878975 | 15252361275 | 155809626736 | 163480994573 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 150934098454 | 151113148223 | 147962193218 | 153960145115 | 157145213177 | 164804503744 | 1113788 | Intercept | 2414769727386 | 20910126541 | 2614067643015 | 1154832670487 | 245604019415608E-226 | 2373596005981 | 2455943448792 | |||||||||||||||||||||
124 | -65 | 4225 | 152305960185 | 152548757475 | 149468507461 | 15539667748 | 158480799618 | 166128012915 | 1114767 | ctime | 13718617315 | 00571400378 | 239396876075 | 240087648764 | 112260983751603E-65 | 12593002691 | 14844231939 | |||||||||||||||||||||
125 | -64 | 4096 | 153677821916 | 153984366727 | 150974821704 | 156833209845 | 159816386059 | 167451522086 | 111572 | DM1M | 43863861553 | 35074992723 | 247879000216 | 12505736466 | 02122692588 | -25219155524 | 112946878629 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 155049683647 | 155419975979 | 152481135947 | 15826974221 | 1611519725 | 168775031257 | 1116647 | DM2nM | 5901960556 | 29970254861 | 2551351047471 | 19692727284 | 00500037953 | -0000098509 | 118040196211 | ||||||||||||||||||||
127 | -62 | 3844 | 156421545378 | 156855585231 | 15398745019 | 159706274575 | 162487558941 | 170098540428 | 1117548 | DM2M | 72946085053 | 3886017583 | 2465909153986 | 18771424342 | 00616792034 | -03594115822 | 149486285928 | |||||||||||||||||||||
128 | -61 | 3721 | 157793407109 | 158291194483 | 155493764433 | 16114280694 | 163823145382 | 171422049599 | 1118423 | DM3nM | 38169455833 | 2797671658 | 2794039624019 | 13643293602 | 01735618163 | -16902451354 | 9324136302 | |||||||||||||||||||||
129 | -60 | 3600 | 15916526884 | 159726803735 | 157000078676 | 162579339305 | 165158731823 | 17274555877 | 1119272 | DM3M | 106791363334 | 46009359799 | 4361065178194 | 23210790978 | 00207427924 | 16363715676 | 197219010992 | |||||||||||||||||||||
130 | -59 | 3481 | 160537130571 | 161162412987 | 158506392919 | 16401587167 | 166494318264 | 174069067941 | 1120095 | ctime DM1M | 0063747521 | 00954499537 | 23168698318 | 06678632999 | 05048855867 | -01243133127 | 02518083548 | |||||||||||||||||||||
131 | -58 | 3364 | 161908992302 | 162598022239 | 160012707162 | 165452404035 | 167829904705 | 175392577112 | 1120892 | ctime DM2nM | 01344525116 | 00820224568 | 2396055602523 | 16392158554 | 01024806101 | -00271246799 | 02960297032 | |||||||||||||||||||||
132 | -57 | 3249 | 163280854033 | 164033631491 | 161519021405 | 1668889364 | 169165491146 | 176716086283 | 1121663 | ctime DM2M | 00646706337 | 01071763367 | 2349426497429 | 06034040315 | 05468220328 | -01464788125 | 02758200798 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 164652715764 | 165469240743 | 163025335648 | 168325468765 | 170501077587 | 178039595454 | 1122408 | ctime DM3nM | -00362752914 | 00761558388 | 2589784113082 | -04763297459 | 06342410886 | -01862388048 | 01136882221 | ||||||||||||||||||||
134 | -55 | 3025 | 166024577495 | 166904849995 | 164531649891 | 16976200113 | 171836664028 | 179363104625 | 1123127 | ctime DM3M | -00483525556 | 01165322709 | 3612630049027 | -04149284594 | 06784405727 | -02775193575 | 01808142462 | |||||||||||||||||||||
135 | -54 | 2916 | 167396439226 | 168340459247 | 166037964134 | 171198533495 | 173172250469 | 180686613796 | 112382 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 168768300957 | 169776068499 | 167544278377 | 17263506586 | 17450783691 | 182010122967 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 170140162688 | 171211677751 | 16905059262 | 174071598225 | 175843423351 | 183333632138 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 171512024419 | 172647287003 | 170556906863 | 17550813059 | 177179009792 | 184657141309 | 1125743 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
139 | -50 | 2500 | 17288388615 | 174082896255 | 172063221106 | 176944662955 | 178514596233 | 18598065048 | 1126332 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
20 | 140 | -49 | 2401 | 174255747881 | 175518505507 | 173569535349 | 17838119532 | 179850182674 | 187304159651 | 1126895 | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
141 | -48 | 2304 | 175627609612 | 176954114759 | 175075849592 | 179817727685 | 181185769115 | 188627668822 | 1127432 | Intercept | 2493205006423 | 26818036416 | 5445674623465 | 929674703907 | 0 | 244052553921 | 2545884473637 | |||||||||||||||||||||
142 | -47 | 2209 | 176999471343 | 178389724011 | 176582163835 | 18125426005 | 182521355556 | 189951177993 | 1127943 | ctime | 14061521215 | 00566931885 | 2517092044335 | 248028406738 | 152316286832415E-69 | 12944986657 | 15178055773 | |||||||||||||||||||||
143 | -46 | 2116 | 178371333074 | 179825333263 | 178088478078 | 182690792415 | 183856941997 | 191274687164 | 1128428 | ctimesq | -00043893444 | 00009648269 | 5486636325832 | -45493595563 | 0000006629 | -00062845511 | -00024941378 | |||||||||||||||||||||
144 | -45 | 2025 | 179743194805 | 181260942515 | 179594792321 | 18412732478 | 185192528438 | 192598196335 | 1128887 | DM1M | 43894056115 | 4616065213 | 5456102232991 | 09508976605 | 0342077354 | -46780300913 | 134568413143 | |||||||||||||||||||||
145 | -44 | 1936 | 181115056536 | 182696551767 | 181101106564 | 185563857145 | 186528114879 | 193921705506 | 112932 | DM2nM | 15590683451 | 38785326012 | 5275565255826 | 04019737631 | 06878661352 | -60601959221 | 91783326124 | |||||||||||||||||||||
146 | -43 | 1849 | 182486918267 | 184132161019 | 182607420807 | 18700038951 | 18786370132 | 195245214677 | 1129727 | DM2M | 8676546146 | 50408117368 | 5336958254148 | 17212597096 | 00857832245 | -12257196918 | 185788119839 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 183858779998 | 185567770271 | 18411373505 | 188436921875 | 189199287761 | 196568723848 | 1130108 | DM3nM | 2989076674 | 36263773904 | 5595101673168 | 08242596818 | 04101432535 | -4133900658 | 10112054006 | ||||||||||||||||||||
148 | -41 | 1681 | 185230641729 | 187003379523 | 185620049293 | 18987345424 | 190534874202 | 197892233019 | 1130463 | DM3M | 105484092442 | 54153335157 | 6097005984079 | 19478780418 | 00518881117 | -00865609965 | 211833794849 | |||||||||||||||||||||
149 | -40 | 1600 | 18660250346 | 188438988775 | 187126363536 | 191309986605 | 191870460643 | 19921574219 | 1130792 | ctime DM1M | 00294596956 | 00942274862 | 2385137605335 | 03126443967 | 0754824023 | -01561646683 | 02150840595 | |||||||||||||||||||||
150 | -39 | 1521 | 187974365191 | 189874598027 | 188632677779 | 19274651897 | 193206047084 | 200539251361 | 1131095 | ctime DM2nM | 011746192 | 00814521259 | 2525904242866 | 1442097659 | 01505135651 | -0042949909 | 02778737491 | |||||||||||||||||||||
151 | -38 | 1444 | 189346226922 | 191310207279 | 190138992022 | 194183051335 | 194541633525 | 201862760532 | 1131372 | ctime DM2M | 00627324914 | 01060902424 | 2467164426328 | 05913125468 | 05548523969 | -01462255978 | 02716905806 | |||||||||||||||||||||
152 | -37 | 1369 | 190718088653 | 192745816531 | 191645306265 | 1956195837 | 195877219966 | 203186269703 | 1131623 | ctime DM3nM | -00385302299 | 00755558747 | 270985031372 | -05099567717 | 06104968317 | -01872813721 | 01102209122 | |||||||||||||||||||||
153 | -36 | 1296 | 192089950384 | 194181425783 | 193151620508 | 197056116065 | 197212806407 | 204509778874 | 1131848 | ctime DM3M | 0104905579 | 01297608419 | 4609998204995 | 08084532857 | 04192466886 | -01500904642 | 03599016222 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 193461812115 | 195617035035 | 194657934751 | 19849264843 | 198548392848 | 205833288045 | 1132047 | ctimesq DM1M | 00003662169 | 00016182018 | 5261476667666 | 02263109881 | 08210474432 | -00028127131 | 00035451468 | ||||||||||||||||||||
155 | -34 | 1156 | 194833673846 | 197052644287 | 196164248994 | 199929180795 | 199883979289 | 207156797216 | 113222 | ctimesq DM2nM | 00023659357 | 00014377496 | 586198451208 | 16455826512 | 01003857522 | -00004578318 | 00051897033 | |||||||||||||||||||||
156 | -33 | 1089 | 196205535577 | 198488253539 | 197670563237 | 20136571316 | 20121956573 | 208480306387 | 1132367 | ctimesq DM2M | -0000812769 | 00018523286 | 5638208329212 | -04387823077 | 06609873692 | -00044510765 | 00028255384 | |||||||||||||||||||||
157 | -32 | 1024 | 197577397308 | 199923862791 | 19917687748 | 202802245525 | 202555152171 | 209803815558 | 1132488 | ctimesq DM3nM | 00002363901 | 00013671209 | 5962454146829 | 01729109033 | 08627801407 | -00024485679 | 00029213481 | |||||||||||||||||||||
158 | -31 | 961 | 198949259039 | 201359472043 | 200683191723 | 20423877789 | 203890738612 | 211127324729 | 1132583 | ctimesq DM3M | -00017469554 | 00022279554 | 6974552491839 | -07841069586 | 04332435648 | -00061212587 | 0002627348 | |||||||||||||||||||||
159 | -30 | 900 | 20032112077 | 202795081295 | 202189505966 | 205675310255 | 205226325053 | 2124508339 | 1132652 | a Dependent Variable hoofdomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
160 | -29 | 841 | 201692982501 | 204230690547 | 203695820209 | 20711184262 | 206561911494 | 213774343071 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 203064844232 | 205666299799 | 205202134452 | 208548374985 | 207897497935 | 215097852242 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 204436705963 | 207101909051 | 206708448695 | 20998490735 | 209233084376 | 216421361413 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 205808567694 | 208537518303 | 208214762938 | 211421439715 | 210568670817 | 217744870584 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 207180429425 | 209973127555 | 209721077181 | 21285797208 | 211904257258 | 219068379755 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 208552291156 | 211408736807 | 211227391424 | 214294504445 | 213239843699 | 220391888926 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 209924152887 | 212844346059 | 212733705667 | 21573103681 | 21457543014 | 221715398097 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 211296014618 | 214279955311 | 21424001991 | 217167569175 | 215911016581 | 223038907268 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 212667876349 | 215715564563 | 215746334153 | 21860410154 | 217246603022 | 224362416439 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 21403973808 | 217151173815 | 217252648396 | 220040633905 | 218582189463 | 22568592561 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 215411599811 | 218586783067 | 218758962639 | 22147716627 | 219917775904 | 227009434781 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 216783461542 | 220022392319 | 220265276882 | 222913698635 | 221253362345 | 228332943952 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 218155323273 | 221458001571 | 221771591125 | 224350231 | 222588948786 | 229656453123 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 219527185004 | 222893610823 | 223277905368 | 225786763365 | 223924535227 | 230979962294 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 220899046735 | 224329220075 | 224784219611 | 22722329573 | 225260121668 | 232303471465 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 222270908466 | 225764829327 | 226290533854 | 228659828095 | 226595708109 | 233626980636 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 223642770197 | 227200438579 | 227796848097 | 23009636046 | 22793129455 | 234950489807 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 225014631928 | 228636047831 | 22930316234 | 231532892825 | 229266880991 | 236273998978 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 226386493659 | 230071657083 | 230809476583 | 23296942519 | 230602467432 | 237597508149 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 22775835539 | 231507266335 | 232315790826 | 234405957555 | 231938053873 | 23892101732 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 229130217121 | 232942875587 | 233822105069 | 23584248992 | 233273640314 | 240244526491 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 230502078852 | 234378484839 | 235328419312 | 237279022285 | 234609226755 | 241568035662 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 231873940583 | 235814094091 | 236834733555 | 23871555465 | 235944813196 | 242891544833 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 233245802314 | 237249703343 | 238341047798 | 240152087015 | 237280399637 | 244215054004 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 234617664045 | 238685312595 | 239847362041 | 24158861938 | 238615986078 | 245538563175 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 235989525776 | 240120921847 | 241353676284 | 243025151745 | 239951572519 | 246862072346 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 237361387507 | 241556531099 | 242859990527 | 24446168411 | 24128715896 | 248185581517 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 238733249238 | 242992140351 | 24436630477 | 245898216475 | 242622745401 | 249509090688 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 240105110969 | 244427749603 | 245872619013 | 24733474884 | 243958331842 | 250832599859 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2414769727 | 245863358855 | 247378933256 | 248771281205 | 245293918283 | 25215610903 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 242848834431 | 247298968107 | 248885247499 | 25020781357 | 246629504724 | 253479618201 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 244220696162 | 248734577359 | 250391561742 | 251644345935 | 247965091165 | 254803127372 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 245592557893 | 250170186611 | 251897875985 | 2530808783 | 249300677606 | 256126636543 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 246964419624 | 251605795863 | 253404190228 | 254517410665 | 250636264047 | 257450145714 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 248336281355 | 253041405115 | 254910504471 | 25595394303 | 251971850488 | 258773654885 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 249708143086 | 254477014367 | 256416818714 | 257390475395 | 253307436929 | 260097164056 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 251080004817 | 255912623619 | 257923132957 | 25882700776 | 25464302337 | 261420673227 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 252451866548 | 257348232871 | 2594294472 | 260263540125 | 255978609811 | 262744182398 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 253823728279 | 258783842123 | 260935761443 | 26170007249 | 257314196252 | 264067691569 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 25519559001 | 260219451375 | 262442075686 | 263136604855 | 258649782693 | 26539120074 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 256567451741 | 261655060627 | 263948389929 | 26457313722 | 259985369134 | 266714709911 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 257939313472 | 263090669879 | 265454704172 | 266009669585 | 261320955575 | 268038219082 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 259311175203 | 264526279131 | 266961018415 | 26744620195 | 262656542016 | 269361728253 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 260683036934 | 265961888383 | 268467332658 | 268882734315 | 263992128457 | 270685237424 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 262054898665 | 267397497635 | 269973646901 | 27031926668 | 265327714898 | 272008746595 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 263426760396 | 268833106887 | 271479961144 | 271755799045 | 266663301339 | 273332255766 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 264798622127 | 270268716139 | 272986275387 | 27319233141 | 26799888778 | 274655764937 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 266170483858 | 271704325391 | 27449258963 | 274628863775 | 269334474221 | 275979274108 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 267542345589 | 273139934643 | 275998903873 | 27606539614 | 270670060662 | 277302783279 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 26891420732 | 274575543895 | 277505218116 | 277501928505 | 272005647103 | 27862629245 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 270286069051 | 276011153147 | 279011532359 | 27893846087 | 273341233544 | 279949801621 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 271657930782 | 277446762399 | 280517846602 | 280374993235 | 274676819985 | 281273310792 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 273029792513 | 278882371651 | 282024160845 | 2818115256 | 276012406426 | 282596819963 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 274401654244 | 280317980903 | 283530475088 | 283248057965 | 277347992867 | 283920329134 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 275773515975 | 281753590155 | 285036789331 | 28468459033 | 278683579308 | 285243838305 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 277145377706 | 283189199407 | 286543103574 | 286121122695 | 280019165749 | 286567347476 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 278517239437 | 284624808659 | 288049417817 | 28755765506 | 28135475219 | 287890856647 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 279889101168 | 286060417911 | 28955573206 | 288994187425 | 282690338631 | 289214365818 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 281260962899 | 287496027163 | 291062046303 | 29043071979 | 284025925072 | 290537874989 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 28263282463 | 288931636415 | 292568360546 | 291867252155 | 285361511513 | 29186138416 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 284004686361 | 290367245667 | 294074674789 | 29330378452 | 286697097954 | 293184893331 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 285376548092 | 291802854919 | 295580989032 | 294740316885 | 288032684395 | 294508402502 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 286748409823 | 293238464171 | 297087303275 | 29617684925 | 289368270836 | 295831911673 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 288120271554 | 294674073423 | 298593617518 | 297613381615 | 290703857277 | 297155420844 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 289492133285 | 296109682675 | 300099931761 | 29904991398 | 292039443718 | 298478930015 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 290863995016 | 297545291927 | 301606246004 | 300486446345 | 293375030159 | 299802439186 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 292235856747 | 298980901179 | 303112560247 | 30192297871 | 2947106166 | 301125948357 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 293607718478 | 300416510431 | 30461887449 | 303359511075 | 296046203041 | 302449457528 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 294979580209 | 301852119683 | 306125188733 | 30479604344 | 297381789482 | 303772966699 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 29635144194 | 303287728935 | 307631502976 | 306232575805 | 298717375923 | 30509647587 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 297723303671 | 304723338187 | 309137817219 | 30766910817 | 300052962364 | 306419985041 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 299095165402 | 306158947439 | 310644131462 | 309105640535 | 301388548805 | 307743494212 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 300467027133 | 307594556691 | 312150445705 | 3105421729 | 302724135246 | 309067003383 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 301838888864 | 309030165943 | 313656759948 | 311978705265 | 304059721687 | 310390512554 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 303210750595 | 310465775195 | 315163074191 | 31341523763 | 305395308128 | 311714021725 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 304582612326 | 311901384447 | 316669388434 | 314851769995 | 306730894569 | 313037530896 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 305954474057 | 313336993699 | 318175702677 | 31628830236 | 30806648101 | 314361040067 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 307326335788 | 314772602951 | 31968201692 | 317724834725 | 309402067451 | 315684549238 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 308698197519 | 316208212203 | 321188331163 | 31916136709 | 310737653892 | 317008058409 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 31007005925 | 317643821455 | 322694645406 | 320597899455 | 312073240333 | 31833156758 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 311441920981 | 319079430707 | 324200959649 | 32203443182 | 313408826774 | 319655076751 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 312813782712 | 320515039959 | 325707273892 | 323470964185 | 314744413215 | 320978585922 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 314185644443 | 321950649211 | 327213588135 | 32490749655 | 316079999656 | 322302095093 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 315557506174 | 323386258463 | 328719902378 | 326344028915 | 317415586097 | 323625604264 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 316929367905 | 324821867715 | 330226216621 | 32778056128 | 318751172538 | 324949113435 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 318301229636 | 326257476967 | 331732530864 | 329217093645 | 320086758979 | 326272622606 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 319673091367 | 327693086219 | 333238845107 | 33065362601 | 32142234542 | 327596131777 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 321044953098 | 329128695471 | 33474515935 | 332090158375 | 322757931861 | 328919640948 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 322416814829 | 330564304723 | 336251473593 | 33352669074 | 324093518302 | 330243150119 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32378867656 | 331999913975 | 337757787836 | 334963223105 | 325429104743 | 33156665929 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 325160538291 | 333435523227 | 339264102079 | 33639975547 | 326764691184 | 332890168461 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 326532400022 | 334871132479 | 340770416322 | 337836287835 | 328100277625 | 334213677632 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327904261753 | 336306741731 | 342276730565 | 3392728202 | 329435864066 | 335537186803 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 329276123484 | 337742350983 | 343783044808 | 340709352565 | 330771450507 | 336860695974 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330647985215 | 339177960235 | 345289359051 | 34214588493 | 332107036948 | 338184205145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 332019846946 | 340613569487 | 346795673294 | 343582417295 | 333442623389 | 339507714316 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333391708677 | 342049178739 | 348301987537 | 34501894966 | 33477820983 | 340831223487 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334763570408 | 343484787991 | 34980830178 | 346455482025 | 336113796271 | 342154732658 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336135432139 | 344920397243 | 351314616023 | 34789201439 | 337449382712 | 343478241829 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33750729387 | 346356006495 | 352820930266 | 349328546755 | 338784969153 | 344801751 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 338879155601 | 347791615747 | 354327244509 | 35076507912 | 340120555594 | 346125260171 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340251017332 | 349227224999 | 355833558752 | 352201611485 | 341456142035 | 347448769342 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 341622879063 | 350662834251 | 357339872995 | 35363814385 | 342791728476 | 348772278513 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 342994740794 | 352098443503 | 358846187238 | 355074676215 | 344127314917 | 350095787684 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 non macro | DM1 macro | DM2 non macro | DM2 macro | GDM non macro | GDM macro | controle | ||||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 11463706227 | 11313214135 | 117561169645 | 11494210651 | 119123845098 | 11836669555 | 1109612 | LINE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 116228381219 | 114928482685 | 119147661594 | 116723015527 | 120706214957 | 120053885147 | 1110695 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
121 | -68 | 4624 | 117819700168 | 11672482402 | 120734153543 | 118503924544 | 122288584816 | 121741074744 | 1111752 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
122 | -67 | 4489 | 119411019117 | 118521165355 | 122320645492 | 120284833561 | 123870954675 | 123428264341 | 1112783 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
123 | -66 | 4356 | 121002338066 | 12031750669 | 123907137441 | 122065742578 | 125453324534 | 125115453938 | 1113788 | Intercept | 2260293877445 | 15832942499 | 2075124501314 | 1427589266846 | 388446233098433E-209 | 2229079836699 | 2291507918191 | |||||||||||||||||||||
124 | -65 | 4225 | 122593657015 | 122113848025 | 12549362939 | 123846651595 | 127035694393 | 126802643535 | 1114767 | ctime | 15913189487 | 00257269757 | 1842828363543 | 618541008714 | 333232731447193E-125 | 1540561671 | 16420762263 | |||||||||||||||||||||
125 | -64 | 4096 | 124184975964 | 12391018936 | 127080121339 | 125627560612 | 128618064252 | 128489833132 | 111572 | DM1M | 128466647132 | 26637571167 | 2050371372228 | 48227612918 | 00000027571 | 75947975092 | 180985319172 | |||||||||||||||||||||
18 | 126 | -63 | 3969 | 125776294913 | 125706530695 | 128666613288 | 127408469629 | 130200434111 | 130177022729 | 1116647 | DM2nM | 25862183751 | 22924441061 | 2120345443705 | 11281489343 | 02605319151 | -19326822206 | 71051189709 | ||||||||||||||||||||
127 | -62 | 3844 | 127367613862 | 12750287203 | 130253105237 | 129189378646 | 13178280397 | 131864212326 | 1117548 | DM2M | 13576357083 | 30226756059 | 2068960521546 | 44915031756 | 00000117494 | 76171635627 | 195355506033 | |||||||||||||||||||||
128 | -61 | 3721 | 128958932811 | 129299213365 | 131839597186 | 130970287663 | 133365173829 | 133551401923 | 1118423 | DM3nM | 38603475284 | 20991973988 | 2240865618358 | 18389635632 | 00672437607 | -02763451957 | 79970402525 | |||||||||||||||||||||
129 | -60 | 3600 | 13055025176 | 1310955547 | 133426089135 | 13275119668 | 134947543688 | 13523859152 | 1119272 | DM3M | 104405796385 | 31656025476 | 3066137679353 | 32981334458 | 00010878058 | 42115250622 | 166696342147 | |||||||||||||||||||||
130 | -59 | 3481 | 132141570709 | 132891896035 | 135012581084 | 134532105697 | 136529913547 | 136925781117 | 1120095 | ctime DM1M | 0283151845 | 00432712225 | 1817500471523 | 65436525391 | 00000000006 | 0197773299 | 03685303911 | |||||||||||||||||||||
131 | -58 | 3364 | 133732889658 | 13468823737 | 136599073033 | 136313014714 | 138112283406 | 138612970714 | 1120892 | ctime DM2nM | -00048270024 | 00376596757 | 1948296000005 | -01281742952 | 0898143248 | -0079099973 | 00694459682 | |||||||||||||||||||||
132 | -57 | 3249 | 135324208607 | 136484578705 | 138185564982 | 138093923731 | 139694653265 | 140300160311 | 1121663 | ctime DM2M | 01895900684 | 00490866258 | 1769361289612 | 38623569074 | 00001573593 | 00927194724 | 02864606643 | |||||||||||||||||||||
19 | 133 | -56 | 3136 | 136915527556 | 13828092004 | 139772056931 | 139874832748 | 141277023124 | 141987349908 | 1122408 | ctime DM3nM | -00894909013 | 00351840743 | 2100120618088 | -2543505923 | 00116941229 | -01588501162 | -00201316865 | ||||||||||||||||||||
134 | -55 | 3025 | 138506846505 | 140077261375 | 14135854888 | 141655741765 | 142859392983 | 143674539505 | 1123127 | ctime DM3M | 00958706475 | 00550271082 | 3275705288599 | 17422439719 | 00824043069 | -00123804614 | 02041217564 | |||||||||||||||||||||
135 | -54 | 2916 | 140098165454 | 14187360271 | 142945040829 | 143436650782 | 144441762842 | 145361729102 | 112382 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
136 | -53 | 2809 | 141689484403 | 143669944045 | 144531532778 | 145217559799 | 146024132701 | 147048918699 | 1124487 | |||||||||||||||||||||||||||||
137 | -52 | 2704 | 143280803352 | 14546628538 | 146118024727 | 146998468816 | 14760650256 | 148736108296 | 1125128 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
138 | -51 | 2601 | 144872122301 | 147262626715 | 147704516676 | 148779377833 | 149188872419 | 150423297893 | 1125743 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
139 | -50 | 2500 | 14646344125 | 14905896805 | 149291008625 | 15056028685 | 150771242278 | 15211048749 | 1126332 | CURVE | Lower Bound | Upper Bound | ||||||||||||||||||||||||||
20 | 140 | -49 | 2401 | 148054760199 | 150855309385 | 150877500574 | 152341195867 | 152353612137 | 153797677087 | 1126895 | Intercept | 2279083606289 | 17563094035 | 2995277576238 | 1297654958632 | 282728501152131E-265 | 2244520919941 | 2313646292636 | ||||||||||||||||||||
141 | -48 | 2304 | 149646079148 | 15265165072 | 152463992523 | 154122104884 | 153935981996 | 155484866684 | 1127432 | ctime | 15999477276 | 00263569131 | 1888603928837 | 607031529296 | 763256315745845E-126 | 15479559629 | 16519394924 | |||||||||||||||||||||
142 | -47 | 2209 | 151237398097 | 154447992055 | 154050484472 | 155903013901 | 155518351855 | 157172056281 | 1127943 | ctimesq | -00010312178 | 00004063238 | 4962942680429 | -25379214479 | 00114560307 | -00018295447 | -0000232891 | |||||||||||||||||||||
143 | -46 | 2116 | 152828717046 | 15624433339 | 155636976421 | 157683922918 | 157100721714 | 158859245878 | 1128428 | DM1M | 103127687062 | 2964514122 | 2995736875962 | 34787382626 | 00005785175 | 44788588131 | 161466785993 | |||||||||||||||||||||
144 | -45 | 2025 | 154420035995 | 158040674725 | 15722346837 | 159464831935 | 158683091573 | 160546435475 | 1128887 | DM2nM | 34564457141 | 25599984087 | 309718791599 | 13501749463 | 01779456963 | -15807426566 | 84936340847 | |||||||||||||||||||||
145 | -44 | 1936 | 156011354944 | 15983701606 | 158809960319 | 161245740952 | 160265461432 | 162233625072 | 112932 | DM2M | 122005558 | 33556108055 | 3012230798113 | 36358673598 | 00003257347 | 55971477889 | 18803963811 | |||||||||||||||||||||
146 | -43 | 1849 | 157602673893 | 161633357395 | 160396452268 | 163026649969 | 161847831291 | 163920814669 | 1129727 | DM3nM | 42962102717 | 23463154496 | 326488482678 | 18310454685 | 00680049689 | -03195941768 | 89120147201 | |||||||||||||||||||||
21 | 147 | -42 | 1764 | 159193992842 | 16342969873 | 161982944217 | 164807558986 | 16343020115 | 165608004266 | 1130108 | DM3M | 89716998107 | 33847002499 | 3726004476445 | 26506630272 | 00083759649 | 23161905447 | 156272090768 | ||||||||||||||||||||
148 | -41 | 1681 | 160785311791 | 165226040065 | 163569436166 | 166588468003 | 165012571009 | 167295193863 | 1130463 | ctime DM1M | 02733356413 | 00441319342 | 1835739225022 | 61936021292 | 00000000038 | 01862646214 | 03604066613 | |||||||||||||||||||||
149 | -40 | 1600 | 16237663074 | 1670223814 | 165155928115 | 16836937702 | 166594940868 | 16898238346 | 1130792 | ctime DM2nM | -0001801609 | 00385275434 | 1993813052744 | -00467615844 | 09627500508 | -00777753614 | 00741721434 | |||||||||||||||||||||
150 | -39 | 1521 | 163967949689 | 168818722735 | 166742420064 | 170150286037 | 168177310727 | 170669573057 | 1131095 | ctime DM2M | 01835123355 | 00504002642 | 185279951151 | 36410986806 | 00003521385 | 00840801581 | 02829445129 | |||||||||||||||||||||
151 | -38 | 1444 | 165559268638 | 17061506407 | 168328912013 | 171931195054 | 169759680586 | 172356762654 | 1131372 | ctime DM3nM | -00828939084 | 00361345176 | 2154072117374 | -22940366688 | 00227523171 | -01541164168 | -00116713999 | |||||||||||||||||||||
152 | -37 | 1369 | 167150587587 | 172411405405 | 169915403962 | 173712104071 | 171342050445 | 174043952251 | 1131623 | ctime DM3M | 01043800754 | 00683335854 | 428970440431 | 15275076642 | 01273718042 | -00299302363 | 0238690387 | |||||||||||||||||||||
153 | -36 | 1296 | 168741906536 | 17420774674 | 171501895911 | 175493013088 | 172924420304 | 175731141848 | 1131848 | ctimesq DM1M | 00013868456 | 0000683559 | 4864834424972 | 20288601139 | 00430166221 | 00000437531 | 0002729938 | |||||||||||||||||||||
22 | 154 | -35 | 1225 | 170333225485 | 176004088075 | 17308838786 | 177273922105 | 174506790163 | 177418331445 | 1132047 | ctimesq DM2nM | -00005653252 | 00006296046 | 5273178841193 | -0897905202 | 03696458706 | -00018021664 | 00006715159 | ||||||||||||||||||||
155 | -34 | 1156 | 171924544434 | 17780042941 | 174674879809 | 179054831122 | 176089160022 | 179105521042 | 113222 | ctimesq DM2M | 00007500873 | 00007657059 | 4782889111002 | 09796023617 | 03277776707 | -0000754476 | 00022546507 | |||||||||||||||||||||
156 | -33 | 1089 | 173515863383 | 179596770745 | 176261371758 | 180835740139 | 177671529881 | 180792710639 | 1132367 | ctimesq DM3nM | -00004192175 | 00006038751 | 5431674664601 | -06942122545 | 04878459099 | -00016054342 | 00007669992 | |||||||||||||||||||||
157 | -32 | 1024 | 175107182332 | 18139311208 | 177847863707 | 182616649156 | 17925389974 | 182479900236 | 1132488 | ctimesq DM3M | 00005962862 | 00010887151 | 7036791456733 | 05476971909 | 05840735181 | -00015412327 | 0002733805 | |||||||||||||||||||||
158 | -31 | 961 | 176698501281 | 183189453415 | 179434355656 | 184397558173 | 180836269599 | 184167089833 | 1132583 | a Dependent Variable buikomtrek echo 1 (mm) | ||||||||||||||||||||||||||||
159 | -30 | 900 | 17828982023 | 18498579475 | 181020847605 | 18617846719 | 182418639458 | 18585427943 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 179881139179 | 186782136085 | 182607339554 | 187959376207 | 184001009317 | 187541469027 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 181472458128 | 18857847742 | 184193831503 | 189740285224 | 185583379176 | 189228658624 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 183063777077 | 190374818755 | 185780323452 | 191521194241 | 187165749035 | 190915848221 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 184655096026 | 19217116009 | 187366815401 | 193302103258 | 188748118894 | 192603037818 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 186246414975 | 193967501425 | 18895330735 | 195083012275 | 190330488753 | 194290227415 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 187837733924 | 19576384276 | 190539799299 | 196863921292 | 191912858612 | 195977417012 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 189429052873 | 197560184095 | 192126291248 | 198644830309 | 193495228471 | 197664606609 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 191020371822 | 19935652543 | 193712783197 | 200425739326 | 19507759833 | 199351796206 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 192611690771 | 201152866765 | 195299275146 | 202206648343 | 196659968189 | 201038985803 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 19420300972 | 2029492081 | 196885767095 | 20398755736 | 198242338048 | 2027261754 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 195794328669 | 204745549435 | 198472259044 | 205768466377 | 199824707907 | 204413364997 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 197385647618 | 20654189077 | 200058750993 | 207549375394 | 201407077766 | 206100554594 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 198976966567 | 208338232105 | 201645242942 | 209330284411 | 202989447625 | 207787744191 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 200568285516 | 21013457344 | 203231734891 | 211111193428 | 204571817484 | 209474933788 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 202159604465 | 211930914775 | 20481822684 | 212892102445 | 206154187343 | 211162123385 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 203750923414 | 21372725611 | 206404718789 | 214673011462 | 207736557202 | 212849312982 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 205342242363 | 215523597445 | 207991210738 | 216453920479 | 209318927061 | 214536502579 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 206933561312 | 21731993878 | 209577702687 | 218234829496 | 21090129692 | 216223692176 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 208524880261 | 219116280115 | 211164194636 | 220015738513 | 212483666779 | 217910881773 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 21011619921 | 22091262145 | 212750686585 | 22179664753 | 214066036638 | 21959807137 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 211707518159 | 222708962785 | 214337178534 | 223577556547 | 215648406497 | 221285260967 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 213298837108 | 22450530412 | 215923670483 | 225358465564 | 217230776356 | 222972450564 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 214890156057 | 226301645455 | 217510162432 | 227139374581 | 218813146215 | 224659640161 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 216481475006 | 22809798679 | 219096654381 | 228920283598 | 220395516074 | 226346829758 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 218072793955 | 229894328125 | 22068314633 | 230701192615 | 221977885933 | 228034019355 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 219664112904 | 23169066946 | 222269638279 | 232482101632 | 223560255792 | 229721208952 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 221255431853 | 233487010795 | 223856130228 | 234263010649 | 225142625651 | 231408398549 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 222846750802 | 23528335213 | 225442622177 | 236043919666 | 22672499551 | 233095588146 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 224438069751 | 237079693465 | 227029114126 | 237824828683 | 228307365369 | 234782777743 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 2260293887 | 2388760348 | 228615606075 | 2396057377 | 229889735228 | 23646996734 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 227620707649 | 240672376135 | 230202098024 | 241386646717 | 231472105087 | 238157156937 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 229212026598 | 24246871747 | 231788589973 | 243167555734 | 233054474946 | 239844346534 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 230803345547 | 244265058805 | 233375081922 | 244948464751 | 234636844805 | 241531536131 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 232394664496 | 24606140014 | 234961573871 | 246729373768 | 236219214664 | 243218725728 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 233985983445 | 247857741475 | 23654806582 | 248510282785 | 237801584523 | 244905915325 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 235577302394 | 24965408281 | 238134557769 | 250291191802 | 239383954382 | 246593104922 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 237168621343 | 251450424145 | 239721049718 | 252072100819 | 240966324241 | 248280294519 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 238759940292 | 25324676548 | 241307541667 | 253853009836 | 2425486941 | 249967484116 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 240351259241 | 255043106815 | 242894033616 | 255633918853 | 244131063959 | 251654673713 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 24194257819 | 25683944815 | 244480525565 | 25741482787 | 245713433818 | 25334186331 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 243533897139 | 258635789485 | 246067017514 | 259195736887 | 247295803677 | 255029052907 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 245125216088 | 26043213082 | 247653509463 | 260976645904 | 248878173536 | 256716242504 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 246716535037 | 262228472155 | 249240001412 | 262757554921 | 250460543395 | 258403432101 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 248307853986 | 26402481349 | 250826493361 | 264538463938 | 252042913254 | 260090621698 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 249899172935 | 265821154825 | 25241298531 | 266319372955 | 253625283113 | 261777811295 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 251490491884 | 26761749616 | 253999477259 | 268100281972 | 255207652972 | 263465000892 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 253081810833 | 269413837495 | 255585969208 | 269881190989 | 256790022831 | 265152190489 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 254673129782 | 27121017883 | 257172461157 | 271662100006 | 25837239269 | 266839380086 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 256264448731 | 273006520165 | 258758953106 | 273443009023 | 259954762549 | 268526569683 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 25785576768 | 2748028615 | 260345445055 | 27522391804 | 261537132408 | 27021375928 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 259447086629 | 276599202835 | 261931937004 | 277004827057 | 263119502267 | 271900948877 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 261038405578 | 27839554417 | 263518428953 | 278785736074 | 264701872126 | 273588138474 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 262629724527 | 280191885505 | 265104920902 | 280566645091 | 266284241985 | 275275328071 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 264221043476 | 28198822684 | 266691412851 | 282347554108 | 267866611844 | 276962517668 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 265812362425 | 283784568175 | 2682779048 | 284128463125 | 269448981703 | 278649707265 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 267403681374 | 28558090951 | 269864396749 | 285909372142 | 271031351562 | 280336896862 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 268995000323 | 287377250845 | 271450888698 | 287690281159 | 272613721421 | 282024086459 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 270586319272 | 28917359218 | 273037380647 | 289471190176 | 27419609128 | 283711276056 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 272177638221 | 290969933515 | 274623872596 | 291252099193 | 275778461139 | 285398465653 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 27376895717 | 29276627485 | 276210364545 | 29303300821 | 277360830998 | 28708565525 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 275360276119 | 294562616185 | 277796856494 | 294813917227 | 278943200857 | 288772844847 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 276951595068 | 29635895752 | 279383348443 | 296594826244 | 280525570716 | 290460034444 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 278542914017 | 298155298855 | 280969840392 | 298375735261 | 282107940575 | 292147224041 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 280134232966 | 29995164019 | 282556332341 | 300156644278 | 283690310434 | 293834413638 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 281725551915 | 301747981525 | 28414282429 | 301937553295 | 285272680293 | 295521603235 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 283316870864 | 30354432286 | 285729316239 | 303718462312 | 286855050152 | 297208792832 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 284908189813 | 305340664195 | 287315808188 | 305499371329 | 288437420011 | 298895982429 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 286499508762 | 30713700553 | 288902300137 | 307280280346 | 29001978987 | 300583172026 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 288090827711 | 308933346865 | 290488792086 | 309061189363 | 291602159729 | 302270361623 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 28968214666 | 3107296882 | 292075284035 | 31084209838 | 293184529588 | 30395755122 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 291273465609 | 312526029535 | 293661775984 | 312623007397 | 294766899447 | 305644740817 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 292864784558 | 31432237087 | 295248267933 | 314403916414 | 296349269306 | 307331930414 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 294456103507 | 316118712205 | 296834759882 | 316184825431 | 297931639165 | 309019120011 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 296047422456 | 31791505354 | 298421251831 | 317965734448 | 299514009024 | 310706309608 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 297638741405 | 319711394875 | 30000774378 | 319746643465 | 301096378883 | 312393499205 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 299230060354 | 32150773621 | 301594235729 | 321527552482 | 302678748742 | 314080688802 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 300821379303 | 323304077545 | 303180727678 | 323308461499 | 304261118601 | 315767878399 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 302412698252 | 32510041888 | 304767219627 | 325089370516 | 30584348846 | 317455067996 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 304004017201 | 326896760215 | 306353711576 | 326870279533 | 307425858319 | 319142257593 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 30559533615 | 32869310155 | 307940203525 | 32865118855 | 309008228178 | 32082944719 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 307186655099 | 330489442885 | 309526695474 | 330432097567 | 310590598037 | 322516636787 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 308777974048 | 33228578422 | 311113187423 | 332213006584 | 312172967896 | 324203826384 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 310369292997 | 334082125555 | 312699679372 | 333993915601 | 313755337755 | 325891015981 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 311960611946 | 33587846689 | 314286171321 | 335774824618 | 315337707614 | 327578205578 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 313551930895 | 337674808225 | 31587266327 | 337555733635 | 316920077473 | 329265395175 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 315143249844 | 33947114956 | 317459155219 | 339336642652 | 318502447332 | 330952584772 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 316734568793 | 341267490895 | 319045647168 | 341117551669 | 320084817191 | 332639774369 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 318325887742 | 34306383223 | 320632139117 | 342898460686 | 32166718705 | 334326963966 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 319917206691 | 344860173565 | 322218631066 | 344679369703 | 323249556909 | 336014153563 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 32150852564 | 3466565149 | 323805123015 | 34646027872 | 324831926768 | 33770134316 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 323099844589 | 348452856235 | 325391614964 | 348241187737 | 326414296627 | 339388532757 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 324691163538 | 35024919757 | 326978106913 | 350022096754 | 327996666486 | 341075722354 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 326282482487 | 352045538905 | 328564598862 | 351803005771 | 329579036345 | 342762911951 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 327873801436 | 35384188024 | 330151090811 | 353583914788 | 331161406204 | 344450101548 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 329465120385 | 355638221575 | 33173758276 | 355364823805 | 332743776063 | 346137291145 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331056439334 | 35743456291 | 333324074709 | 357145732822 | 334326145922 | 347824480742 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 332647758283 | 359230904245 | 334910566658 | 358926641839 | 335908515781 | 349511670339 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334239077232 | 36102724558 | 336497058607 | 360707550856 | 33749088564 | 351198859936 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 335830396181 | 362823586915 | 338083550556 | 362488459873 | 339073255499 | 352886049533 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 33742171513 | 36461992825 | 339670042505 | 36426936889 | 340655625358 | 35457323913 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339013034079 | 366416269585 | 341256534454 | 366050277907 | 342237995217 | 356260428727 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340604353028 | 36821261092 | 342843026403 | 367831186924 | 343820365076 | 357947618324 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342195671977 | 370008952255 | 344429518352 | 369612095941 | 345402734935 | 359634807921 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343786990926 | 37180529359 | 346016010301 | 371393004958 | 346985104794 | 361321997518 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||||
GDM |
Intercepting Curves Random Effects are intercept and ctime (=slope) | ||||||||||||||||||||||||||||||||||||
AD week | AD dagen | ctime | ctimesq | DM1 lt977 | DM1 gt977 | DM2 | GDMlt977 | GDN gt977 | controle | |||||||||||||||||||||||||||
17 | 119 | -70 | 4900 | 110369658 | 109459854 | 118210372 | 120182679 | 1109612 | CURVE | |||||||||||||||||||||||||||
120 | -69 | 4761 | 112127016 | 111253055 | 119969023 | 121622973 | 1110695 | |||||||||||||||||||||||||||||
121 | -68 | 4624 | 113882472 | 113048962 | 121724538 | 123067511 | 1111752 | DM1 | ||||||||||||||||||||||||||||
122 | -67 | 4489 | 115636026 | 114847575 | 123476917 | 124516293 | 1112783 | |||||||||||||||||||||||||||||
123 | -66 | 4356 | 117387678 | 116648894 | 12522616 | 125969319 | 1113788 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
124 | -65 | 4225 | 119137428 | 118452919 | 126972267 | 127426589 | 1114767 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
125 | -64 | 4096 | 120885276 | 12025965 | 128715238 | 128888103 | 111572 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
18 | 126 | -63 | 3969 | 122631222 | 122069087 | 130455073 | 130353861 | 1116647 | Intercept | 228791388 | 1520384 | 108618 | 150483 | 000 | 225777917 | 231804859 | ||||||||||||||||||||
127 | -62 | 3844 | 124375266 | 12388123 | 132191772 | 131823863 | 1117548 | ctime | 1625169 | 022128 | 71096 | 73444 | 000 | 1581048 | 1669290 | |||||||||||||||||||||
128 | -61 | 3721 | 126117408 | 125696079 | 133925335 | 133298109 | 1118423 | ctimesq | -000951 | 000354 | 194196 | -2688 | 008 | -001648 | -000253 | |||||||||||||||||||||
129 | -60 | 3600 | 127857648 | 127513634 | 135655762 | 134776599 | 1119272 | macro977 | 12727526 | 3337854 | 108996 | 3813 | 000 | 6112005 | 19343047 | |||||||||||||||||||||
130 | -59 | 3481 | 129595986 | 129333895 | 137383053 | 136259333 | 1120095 | ctime macro977 | 356099 | 048599 | 71065 | 7327 | 000 | 259198 | 453001 | |||||||||||||||||||||
131 | -58 | 3364 | 131332422 | 131156862 | 139107208 | 137746311 | 1120892 | ctimesq macro977 | 002304 | 000793 | 188703 | 2906 | 004 | 000740 | 003867 | |||||||||||||||||||||
132 | -57 | 3249 | 133066956 | 132982535 | 140828227 | 139237533 | 1121663 | |||||||||||||||||||||||||||||
19 | 133 | -56 | 3136 | 134799588 | 134810914 | 14254611 | 140732999 | 1122408 | 109459854 | |||||||||||||||||||||||||||
134 | -55 | 3025 | 136530318 | 136641999 | 144260857 | 142232709 | 1123127 | GDM | ||||||||||||||||||||||||||||
135 | -54 | 2916 | 138259146 | 13847579 | 145972468 | 143736663 | 112382 | |||||||||||||||||||||||||||||
136 | -53 | 2809 | 139986072 | 140312287 | 147680943 | 145244861 | 1124487 | Estimates of Fixed Effectsa | ||||||||||||||||||||||||||||
137 | -52 | 2704 | 141711096 | 14215149 | 149386282 | 146757303 | 1125128 | Parameter | Estimate | Std Error | df | t | Sig | 95 Confidence Interval | ||||||||||||||||||||||
138 | -51 | 2601 | 143434218 | 143993399 | 151088485 | 148273989 | 1125743 | Lower Bound | Upper Bound | |||||||||||||||||||||||||||
139 | -50 | 2500 | 145155438 | 145838014 | 152787552 | 149794919 | 1126332 | Intercept | 233742502 | 1590949 | 123524 | 146920 | 000 | 230593448 | 236891556 | |||||||||||||||||||||
20 | 140 | -49 | 2401 | 146874756 | 147685335 | 154483483 | 151320093 | 1126895 | ctime | 1540699 | 026577 | 94983 | 57971 | 000 | 1487937 | 1593462 | ||||||||||||||||||||
141 | -48 | 2304 | 148592172 | 149535362 | 156176278 | 152849511 | 1127432 | ctimesq | -001568 | 000409 | 171203 | -3835 | 000 | -002376 | -000761 | |||||||||||||||||||||
142 | -47 | 2209 | 150307686 | 151388095 | 157865937 | 154383173 | 1127943 | macro977 | -2489983 | 5139890 | 126886 | -484 | 629 | -12660984 | 7681019 | |||||||||||||||||||||
143 | -46 | 2116 | 152021298 | 153243534 | 15955246 | 155921079 | 1128428 | ctime macro977 | 194553 | 123152 | 180726 | 1580 | 116 | -048449 | 437554 | |||||||||||||||||||||
144 | -45 | 2025 | 153733008 | 155101679 | 161235847 | 157463229 | 1128887 | ctimesq macro977 | 003690 | 001862 | 234405 | 1982 | 049 | 000022 | 007359 | |||||||||||||||||||||
145 | -44 | 1936 | 155442816 | 15696253 | 162916098 | 159009623 | 112932 | |||||||||||||||||||||||||||||
146 | -43 | 1849 | 157150722 | 158826087 | 164593213 | 160560261 | 1129727 | |||||||||||||||||||||||||||||
21 | 147 | -42 | 1764 | 158856726 | 16069235 | 166267192 | 162115143 | 1130108 | ||||||||||||||||||||||||||||
148 | -41 | 1681 | 160560828 | 162561319 | 167938035 | 163674269 | 1130463 | |||||||||||||||||||||||||||||
149 | -40 | 1600 | 162263028 | 164432994 | 169605742 | 165237639 | 1130792 | |||||||||||||||||||||||||||||
150 | -39 | 1521 | 163963326 | 166307375 | 171270313 | 166805253 | 1131095 | |||||||||||||||||||||||||||||
151 | -38 | 1444 | 165661722 | 168184462 | 172931748 | 168377111 | 1131372 | |||||||||||||||||||||||||||||
152 | -37 | 1369 | 167358216 | 170064255 | 174590047 | 169953213 | 1131623 | |||||||||||||||||||||||||||||
153 | -36 | 1296 | 169052808 | 171946754 | 17624521 | 171533559 | 1131848 | |||||||||||||||||||||||||||||
22 | 154 | -35 | 1225 | 170745498 | 173831959 | 177897237 | 173118149 | 1132047 | ||||||||||||||||||||||||||||
155 | -34 | 1156 | 172436286 | 17571987 | 179546128 | 174706983 | 113222 | |||||||||||||||||||||||||||||
156 | -33 | 1089 | 174125172 | 177610487 | 181191883 | 176300061 | 1132367 | |||||||||||||||||||||||||||||
157 | -32 | 1024 | 175812156 | 17950381 | 182834502 | 177897383 | 1132488 | |||||||||||||||||||||||||||||
158 | -31 | 961 | 177497238 | 181399839 | 184473985 | 179498949 | 1132583 | |||||||||||||||||||||||||||||
159 | -30 | 900 | 179180418 | 183298574 | 186110332 | 181104759 | 1132652 | |||||||||||||||||||||||||||||
160 | -29 | 841 | 180861696 | 185200015 | 187743543 | 182714813 | 1132695 | |||||||||||||||||||||||||||||
23 | 161 | -28 | 784 | 182541072 | 187104162 | 189373618 | 184329111 | 1132712 | ||||||||||||||||||||||||||||
162 | -27 | 729 | 184218546 | 189011015 | 191000557 | 185947653 | 1132703 | |||||||||||||||||||||||||||||
163 | -26 | 676 | 185894118 | 190920574 | 19262436 | 187570439 | 1132668 | |||||||||||||||||||||||||||||
164 | -25 | 625 | 187567788 | 192832839 | 194245027 | 189197469 | 1132607 | |||||||||||||||||||||||||||||
165 | -24 | 576 | 189239556 | 19474781 | 195862558 | 190828743 | 113252 | |||||||||||||||||||||||||||||
166 | -23 | 529 | 190909422 | 196665487 | 197476953 | 192464261 | 1132407 | |||||||||||||||||||||||||||||
167 | -22 | 484 | 192577386 | 19858587 | 199088212 | 194104023 | 1132268 | |||||||||||||||||||||||||||||
24 | 168 | -21 | 441 | 194243448 | 200508959 | 200696335 | 195748029 | 1132103 | ||||||||||||||||||||||||||||
169 | -20 | 400 | 195907608 | 202434754 | 202301322 | 197396279 | 1131912 | |||||||||||||||||||||||||||||
170 | -19 | 361 | 197569866 | 204363255 | 203903173 | 199048773 | 1131695 | |||||||||||||||||||||||||||||
171 | -18 | 324 | 199230222 | 206294462 | 205501888 | 200705511 | 1131452 | |||||||||||||||||||||||||||||
172 | -17 | 289 | 200888676 | 208228375 | 207097467 | 202366493 | 1131183 | |||||||||||||||||||||||||||||
173 | -16 | 256 | 202545228 | 210164994 | 20868991 | 204031719 | 1130888 | |||||||||||||||||||||||||||||
174 | -15 | 225 | 204199878 | 212104319 | 210279217 | 205701189 | 1130567 | |||||||||||||||||||||||||||||
25 | 175 | -14 | 196 | 205852626 | 21404635 | 211865388 | 207374903 | 113022 | ||||||||||||||||||||||||||||
176 | -13 | 169 | 207503472 | 215991087 | 213448423 | 209052861 | 1129847 | |||||||||||||||||||||||||||||
177 | -12 | 144 | 209152416 | 21793853 | 215028322 | 210735063 | 1129448 | |||||||||||||||||||||||||||||
178 | -11 | 121 | 210799458 | 219888679 | 216605085 | 212421509 | 1129023 | |||||||||||||||||||||||||||||
179 | -10 | 100 | 212444598 | 221841534 | 218178712 | 214112199 | 1128572 | |||||||||||||||||||||||||||||
180 | -9 | 81 | 214087836 | 223797095 | 219749203 | 215807133 | 1128095 | |||||||||||||||||||||||||||||
181 | -8 | 64 | 215729172 | 225755362 | 221316558 | 217506311 | 1127592 | |||||||||||||||||||||||||||||
26 | 182 | -7 | 49 | 217368606 | 227716335 | 222880777 | 219209733 | 1127063 | ||||||||||||||||||||||||||||
183 | -6 | 36 | 219006138 | 229680014 | 22444186 | 220917399 | 1126508 | |||||||||||||||||||||||||||||
184 | -5 | 25 | 220641768 | 231646399 | 225999807 | 222629309 | 1125927 | |||||||||||||||||||||||||||||
185 | -4 | 16 | 222275496 | 23361549 | 227554618 | 224345463 | 112532 | |||||||||||||||||||||||||||||
186 | -3 | 9 | 223907322 | 235587287 | 229106293 | 226065861 | 1124687 | |||||||||||||||||||||||||||||
187 | -2 | 4 | 225537246 | 23756179 | 230654832 | 227790503 | 1124028 | |||||||||||||||||||||||||||||
188 | -1 | 1 | 227165268 | 239538999 | 232200235 | 229519389 | 1123343 | |||||||||||||||||||||||||||||
27 | 189 | 0 | 0 | 228791388 | 241518914 | 233742502 | 231252519 | 1122632 | ||||||||||||||||||||||||||||
190 | 1 | 1 | 230415606 | 243501535 | 235281633 | 232989893 | 1121895 | |||||||||||||||||||||||||||||
191 | 2 | 4 | 232037922 | 245486862 | 236817628 | 234731511 | 1121132 | |||||||||||||||||||||||||||||
192 | 3 | 9 | 233658336 | 247474895 | 238350487 | 236477373 | 1120343 | |||||||||||||||||||||||||||||
193 | 4 | 16 | 235276848 | 249465634 | 23988021 | 238227479 | 1119528 | |||||||||||||||||||||||||||||
194 | 5 | 25 | 236893458 | 251459079 | 241406797 | 239981829 | 1118687 | |||||||||||||||||||||||||||||
195 | 6 | 36 | 238508166 | 25345523 | 242930248 | 241740423 | 111782 | |||||||||||||||||||||||||||||
28 | 196 | 7 | 49 | 240120972 | 255454087 | 244450563 | 243503261 | 1116927 | ||||||||||||||||||||||||||||
197 | 8 | 64 | 241731876 | 25745565 | 245967742 | 245270343 | 1116008 | |||||||||||||||||||||||||||||
198 | 9 | 81 | 243340878 | 259459919 | 247481785 | 247041669 | 1115063 | |||||||||||||||||||||||||||||
199 | 10 | 100 | 244947978 | 261466894 | 248992692 | 248817239 | 1114092 | |||||||||||||||||||||||||||||
200 | 11 | 121 | 246553176 | 263476575 | 250500463 | 250597053 | 1113095 | |||||||||||||||||||||||||||||
201 | 12 | 144 | 248156472 | 265488962 | 252005098 | 252381111 | 1112072 | |||||||||||||||||||||||||||||
202 | 13 | 169 | 249757866 | 267504055 | 253506597 | 254169413 | 1111023 | |||||||||||||||||||||||||||||
29 | 203 | 14 | 196 | 251357358 | 269521854 | 25500496 | 255961959 | 1109948 | ||||||||||||||||||||||||||||
204 | 15 | 225 | 252954948 | 271542359 | 256500187 | 257758749 | 1108847 | |||||||||||||||||||||||||||||
205 | 16 | 256 | 254550636 | 27356557 | 257992278 | 259559783 | 110772 | |||||||||||||||||||||||||||||
206 | 17 | 289 | 256144422 | 275591487 | 259481233 | 261365061 | 1106567 | |||||||||||||||||||||||||||||
207 | 18 | 324 | 257736306 | 27762011 | 260967052 | 263174583 | 1105388 | |||||||||||||||||||||||||||||
208 | 19 | 361 | 259326288 | 279651439 | 262449735 | 264988349 | 1104183 | |||||||||||||||||||||||||||||
209 | 20 | 400 | 260914368 | 281685474 | 263929282 | 266806359 | 1102952 | |||||||||||||||||||||||||||||
30 | 210 | 21 | 441 | 262500546 | 283722215 | 265405693 | 268628613 | 1101695 | ||||||||||||||||||||||||||||
211 | 22 | 484 | 264084822 | 285761662 | 266878968 | 270455111 | 1100412 | |||||||||||||||||||||||||||||
212 | 23 | 529 | 265667196 | 287803815 | 268349107 | 272285853 | 1099103 | |||||||||||||||||||||||||||||
213 | 24 | 576 | 267247668 | 289848674 | 26981611 | 274120839 | 1097768 | |||||||||||||||||||||||||||||
214 | 25 | 625 | 268826238 | 291896239 | 271279977 | 275960069 | 1096407 | |||||||||||||||||||||||||||||
215 | 26 | 676 | 270402906 | 29394651 | 272740708 | 277803543 | 109502 | |||||||||||||||||||||||||||||
216 | 27 | 729 | 271977672 | 295999487 | 274198303 | 279651261 | 1093607 | |||||||||||||||||||||||||||||
31 | 217 | 28 | 784 | 273550536 | 29805517 | 275652762 | 281503223 | 1092168 | ||||||||||||||||||||||||||||
218 | 29 | 841 | 275121498 | 300113559 | 277104085 | 283359429 | 1090703 | |||||||||||||||||||||||||||||
219 | 30 | 900 | 276690558 | 302174654 | 278552272 | 285219879 | 1089212 | |||||||||||||||||||||||||||||
220 | 31 | 961 | 278257716 | 304238455 | 279997323 | 287084573 | 1087695 | |||||||||||||||||||||||||||||
221 | 32 | 1024 | 279822972 | 306304962 | 281439238 | 288953511 | 1086152 | |||||||||||||||||||||||||||||
222 | 33 | 1089 | 281386326 | 308374175 | 282878017 | 290826693 | 1084583 | |||||||||||||||||||||||||||||
223 | 34 | 1156 | 282947778 | 310446094 | 28431366 | 292704119 | 1082988 | |||||||||||||||||||||||||||||
32 | 224 | 35 | 1225 | 284507328 | 312520719 | 285746167 | 294585789 | 1081367 | ||||||||||||||||||||||||||||
225 | 36 | 1296 | 286064976 | 31459805 | 287175538 | 296471703 | 107972 | |||||||||||||||||||||||||||||
226 | 37 | 1369 | 287620722 | 316678087 | 288601773 | 298361861 | 1078047 | |||||||||||||||||||||||||||||
227 | 38 | 1444 | 289174566 | 31876083 | 290024872 | 300256263 | 1076348 | |||||||||||||||||||||||||||||
228 | 39 | 1521 | 290726508 | 320846279 | 291444835 | 302154909 | 1074623 | |||||||||||||||||||||||||||||
229 | 40 | 1600 | 292276548 | 322934434 | 292861662 | 304057799 | 1072872 | |||||||||||||||||||||||||||||
230 | 41 | 1681 | 293824686 | 325025295 | 294275353 | 305964933 | 1071095 | |||||||||||||||||||||||||||||
33 | 231 | 42 | 1764 | 295370922 | 327118862 | 295685908 | 307876311 | 1069292 | ||||||||||||||||||||||||||||
232 | 43 | 1849 | 296915256 | 329215135 | 297093327 | 309791933 | 1067463 | |||||||||||||||||||||||||||||
233 | 44 | 1936 | 298457688 | 331314114 | 29849761 | 311711799 | 1065608 | |||||||||||||||||||||||||||||
234 | 45 | 2025 | 299998218 | 333415799 | 299898757 | 313635909 | 1063727 | |||||||||||||||||||||||||||||
235 | 46 | 2116 | 301536846 | 33552019 | 301296768 | 315564263 | 106182 | |||||||||||||||||||||||||||||
236 | 47 | 2209 | 303073572 | 337627287 | 302691643 | 317496861 | 1059887 | |||||||||||||||||||||||||||||
237 | 48 | 2304 | 304608396 | 33973709 | 304083382 | 319433703 | 1057928 | |||||||||||||||||||||||||||||
34 | 238 | 49 | 2401 | 306141318 | 341849599 | 305471985 | 321374789 | 1055943 | ||||||||||||||||||||||||||||
239 | 50 | 2500 | 307672338 | 343964814 | 306857452 | 323320119 | 1053932 | |||||||||||||||||||||||||||||
240 | 51 | 2601 | 309201456 | 346082735 | 308239783 | 325269693 | 1051895 | |||||||||||||||||||||||||||||
241 | 52 | 2704 | 310728672 | 348203362 | 309618978 | 327223511 | 1049832 | |||||||||||||||||||||||||||||
242 | 53 | 2809 | 312253986 | 350326695 | 310995037 | 329181573 | 1047743 | |||||||||||||||||||||||||||||
243 | 54 | 2916 | 313777398 | 352452734 | 31236796 | 331143879 | 1045628 | |||||||||||||||||||||||||||||
244 | 55 | 3025 | 315298908 | 354581479 | 313737747 | 333110429 | 1043487 | |||||||||||||||||||||||||||||
35 | 245 | 56 | 3136 | 316818516 | 35671293 | 315104398 | 335081223 | 104132 | ||||||||||||||||||||||||||||
246 | 57 | 3249 | 318336222 | 358847087 | 316467913 | 337056261 | 1039127 | |||||||||||||||||||||||||||||
247 | 58 | 3364 | 319852026 | 36098395 | 317828292 | 339035543 | 1036908 | |||||||||||||||||||||||||||||
248 | 59 | 3481 | 321365928 | 363123519 | 319185535 | 341019069 | 1034663 | |||||||||||||||||||||||||||||
249 | 60 | 3600 | 322877928 | 365265794 | 320539642 | 343006839 | 1032392 | |||||||||||||||||||||||||||||
250 | 61 | 3721 | 324388026 | 367410775 | 321890613 | 344998853 | 1030095 | |||||||||||||||||||||||||||||
251 | 62 | 3844 | 325896222 | 369558462 | 323238448 | 346995111 | 1027772 | |||||||||||||||||||||||||||||
36 | 252 | 63 | 3969 | 327402516 | 371708855 | 324583147 | 348995613 | 1025423 | ||||||||||||||||||||||||||||
253 | 64 | 4096 | 328906908 | 373861954 | 32592471 | 351000359 | 1023048 | |||||||||||||||||||||||||||||
254 | 65 | 4225 | 330409398 | 376017759 | 327263137 | 353009349 | 1020647 | |||||||||||||||||||||||||||||
255 | 66 | 4356 | 331909986 | 37817627 | 328598428 | 355022583 | 101822 | |||||||||||||||||||||||||||||
256 | 67 | 4489 | 333408672 | 380337487 | 329930583 | 357040061 | 1015767 | |||||||||||||||||||||||||||||
257 | 68 | 4624 | 334905456 | 38250141 | 331259602 | 359061783 | 1013288 | |||||||||||||||||||||||||||||
258 | 69 | 4761 | 336400338 | 384668039 | 332585485 | 361087749 | 1010783 | |||||||||||||||||||||||||||||
37 | 259 | 70 | 4900 | 337893318 | 386837374 | 333908232 | 363117959 | 1008252 | ||||||||||||||||||||||||||||
260 | 71 | 5041 | 339384396 | 389009415 | 335227843 | 365152413 | 1005695 | |||||||||||||||||||||||||||||
261 | 72 | 5184 | 340873572 | 391184162 | 336544318 | 367191111 | 1003112 | |||||||||||||||||||||||||||||
262 | 73 | 5329 | 342360846 | 393361615 | 337857657 | 369234053 | 1000503 | |||||||||||||||||||||||||||||
263 | 74 | 5476 | 343846218 | 395541774 | 33916786 | 371281239 | 0997868 | |||||||||||||||||||||||||||||
PDM1 | ||||||||||||||||||||||||||||||||||||
PDM 2 | ||||||||||||||||||||||||||||||||||||
GDM |