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Responsible Conduct of Animal Research at UTHSCH
Chris S. Smith, DVMCenter for Laboratory Animal
Medicine and Care
Objectives
Federal laws Overview of the UTHSC Animal Care
and Use Program Ethical considerations in planning
an animal activity UTHSC resources for animal
activities
UTHSC ANIMAL PROGRAM METRICS
2.5 million dollar CLAMC budget 15% of all active and pending
UTHSC grants include animals 150 UTHSC scientists use animals 325 approved animal protocols 11,000 animals cared for daily
Federal Laws
UTHSC-Animal Care and Use Program
Federal Laws
AWCAWCOffice
Animal Care Program (CLAMC)
Animal Care ProgramCLAMC
Veterinarian Dr. Brad Goodwin
AWC Office
AWC
ChairDr. C. Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
Investigator
Federal LawsFederal Laws
AWCAWCOffice
Animal Care Program (CLAMC)
Veterinarian Dr. Brad Goodwin
ChairDr. C. Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
investigator
UTHSC-Animal Care and Use Program
Federal LawsFederal Regulations
And Policies
Animal Welfare Act
Health ResearchExtension Act
USDA
PHS
Animal Welfare Regulations
PHS Policy and Guide
Federal Agencies
Federal Laws RegulatingAnimal Research
Covered Animal Activities
All animal activities performed at UTHSC facilities.
All animal activities, even off site, where UTHSC funds are used to purchase the research animals.
Animal research activity performed offsite without UTHSC funds, but not approved by any other animal committee.
Federal Laws
UTHSC-Animal Care and Use Program
AWCAWCOffice
Animal Care Program (CLAMC)
Veterinarian Dr. Brad Goodwin
ChairDr. C. Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R.Isaguirre
Investigator
Federal Laws
UTHSC-Animal Care and Use Program
AWCAWCOffice
Animal Care Program (CLAMC)
Veterinarian Dr. Brad Goodwin
AWC OFFICEAWC
ChairDr. C. Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
Investigator
UTHSC Animal Welfare Committee
Mandated committee Appointed by the
President Composition of
membership Responsibilities
Protocols Inspections Concerns Authority
AWC Animal Protocol
Form available online Consult with AWC Coordinator if this is an
initial application Final document must be comprehensive
and well written Approval is for one year, and can be
renewed for two subsequent years, prior to expiring at the end of three years
Modifications of approved protocols can be done by memo
Animal Protocol Ethical Considerations:Justification
Research should be justified Purpose is sufficient to justify the use of
animals Model system is the best suited to
answer the scientific question Reasonable expectation that the
research methods employed will provide valid results
Animal Protocol Ethical Considerations:Personnel
Must be qualified through training or experience to accomplish experimental manipulations in a humane and scientifically acceptable manner
Animal Protocol Ethical Considerations:Species Selection and Quantity
The animals selected for a procedure should be of an appropriate species and quality and the minimum number required to obtain valid results.
Animal Protocol Ethical Considerations:Proper Use of Animals
• It is imperative to utilize methods that will avoid or minimize discomfort, distress and pain, when consistent with sound scientific practices.
Animal Protocol Ethical Considerations:Painful Procedures
Procedures that are known to cause more than momentary pain or distress, should be performed with appropriate sedation, analgesia, and/or anesthesia.
Animal Protocol Ethical Considerations:Unrelieved Pain or Distress
Animals that would otherwise suffer severe or chronic pain or distress that cannot be relieved, should be euthanized at the end of the procedure or if appropriate, during the procedure.
Animal Protocol Ethical Considerations:Environment and Well-being
The living conditions of animals should be appropriate for their species and contribute to their health and comfort.
Pertinent Laws, Policies, and Guidelines
The transportation, care and use of animals shall be in accordance with applicable federal laws, guidelines and policies.
Federal Laws
UTHSC-Animal Care and Use Program
AWCAWCOffice
Animal Care Program (CLAMC)
Animal Care ProgramCLAMC
Veterinarian Dr. Brad Goodwin
ChairDr. C. Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
Investigator
Center for Laboratory Animal Medicine and Care
Centralized program for animal housing, care, and use
40 staff members including 5 veterinarians and 7 veterinary health and surgery technicians
CLAMC managed resources located in 6 UTHSC buildings
Center for Laboratory Animal Medicine and Care
Present Locations- MSB/E
- IMM- DB
- Denton Cooley- MSI- UCT
Future Locations - BREF (2009/10)
Center for Laboratory Animal Medicine and Care
Services and resources Animal housing and husbandry Veterinary consultation & care Surgical resource & support Clinical laboratory Technical assistance Import and export Transportation Canine breeding program
Other UTHSC Animal Resources:Genetically Manipulated Rodent Models
IMM - Development of transgenic and knockout mouse strains
IMM –Cryopreservation of embryos
Dr. Rick WetselDr. Eva Zsigmond
Other UTHSC Animal Resources:FMR Imaging Research Resource
3.0 and 7.0 T dedicated for research
Dr. Ponnada Narayana – Radiology, MS
Federal Laws
UTHSC-Animal Care and Use Program
AWCAWCOffice
Animal Care Program (CLAMC)
Veterinarian Dr. Brad Goodwin
ChairDr. C Chappell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
Investigator
Institutional Training in Animal Care and Use
Coordinated by CLAMC
Institutional courses Introductory Species specific Offered monthly
One-on-one training
Occupational Health Environmental Health and Safety
Health and environmental risks are identified Personnel are aware of the risks Practices in place to minimize the risks Procedures in place to monitor exposure and to
provide medical intervention, if needed.
Federal Laws
AWCAWCOffice
Animal Care Program (CLAMC)
Veterinarian Dr. Brad Goodwin
ChairDr. C. Chapell
Research Staff
InstitutionalTrainingEnviron. SafetyOccup. Health
Federal RegulationsAnd Policies
Institutional OfficialDr. Peter Davies
R. Isaguirre
Investigator
UTHSC-Animal Care and Use Program
Good Animal Care = Good Science