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POVIDONE & EUDRAGIT
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POVIDONE
´ Povidone is a synthetic polymer consisting of
linear 1-Vinyl-2-pyrroldionone groups.
´
The degree of polymerization results inmaterials of various molecular weight range.
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POVIDONE
´ Povidone is usually available in four viscositygrades identified by their K values, whichapproximate K-15, K-30, K-60 and K-90.
´ The average molecular weight of these gradesare 10,000 40,000, 160,000 and 360,000
respectively.
´
The most common uses of Povidone inpharmaceuticals (frequently K-30) are as atablet binder and a tablet coating.
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ACRYLATE POLYMERS
´ A series of acrylate polymer is marketed under
Eudragit. Eudragit is trademark of Rohm GmbH
& Co. KG. Darmstadt in Germany, first
marketed in 1950s.
´ Eudragit is prepared by the polymerization of
acrylic and methacrylic acids or their esters,
e.g., butyl ester or dimethylaminoethyl ester.
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EUDRAGIT
´ Eudragit is prepared by the polymerization of acrylic and methacrylic acids or their esters, e.g.,butyl ester or dimethylaminoethyl ester.
´ Eudragit RL and RS are copolymer synthesizedfrom acrylic and methacrlic acid esters with a lowcontent of quaternary ammonium groups.
´ These polymers produce films for the delayed
action preparations.
´ Eudragit L and Eudragit S are the two forms of commercially available enteric acrylic resins.
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µK¶ IN POVIDONE-K 15 ETC
´ The K value is greatly influenced by the
molecular weight distribution of the polymersample used in the determination.
´ M= molecular weight
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µK¶ IN POVIDONE-K 15 ETC
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Substance T (K)
Acetylene 192.40
Ammonia 195.40
Argon 83.81Butane 134.60
Carbon (graphite) 4765.00
Carbon ioxi e 216.55
Carbon monoxi e 68.10
Neon 24.57
Nitric oxi e 109.50
Nitrogen 63.18
Nitrous oxi e 182.34
Oxygen 54.36
Palla ium 1825
Platinum 2045
Sulfur ioxi e 197.69
Titanium 1941.00
Uranium hexafluori e 337.17
Water 273.16
Xenon 161.30
Zinc 692.65