Download - Pharma intro by yousaf shah
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INTRODUCTION TO
PHARMACOLOGY
Syed Yousaf Shah
Lecturer
Institute of Nursing
DUHS
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GRADE / GPA REQUIREMENT FOR EACH SEMESTER & GRADUATION
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Assessment
Pattern (formative and summative) Criteria for formative assessment : Attendance class participation quizzes,
Assignment and presentation. Internal evaluation 30%
Criteria for Summative : Midterm 30% weightage (Conducted by
Examination Department) End of semester 40 % weightage Overall assessment 100 % weightage
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TEACHING/LEARNINGSTRATEGIES
Lecture/tutorials/handouts, self-directed learning, drug cards and quiz.
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PHARMACOLOGY-Is.# Topic Date1 Introduction to Pharmacology 9-11-13
2 Introduction to Pharmacology 16-11-13
3 Introduction to Pharmacology 23-11-13
4 Introduction to Pharmacology Quiz I (5%) 30-11-13
5 Drugs Used to Treat and Prevent Infections 7-12-13
6 Drugs Used to Treat and Prevent Infections Assignment I(5%) 14-12-13
7 Drugs Used to Treat and Prevent Infections 21-12-13
8 Drugs Affecting the Gastrointestinal System 28-12-13
9 Drugs Affecting the Gastrointestinal System 04-12-13
10 Midterm 30%11 Drugs Affecting Haematology System 12 Drugs Affecting Haematology System 13 Drugs Affecting Haematology System Quiz II (5%)14 Anti-neoplastic-Drugs 15 Anti-neoplastic-Drugs Assignment II (5%)16 Anti-neoplastic-Drugs 17 Presentation & submission (10%)18 Final Exam 40%
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References:
1. Aucker, L. (2001). Pharmacology and the nursing process. (3rd ed.). London: Mosby.
2. Boyer, M. J. (2002). Math for nurses. (5th ed.). Philadelphia: Lippincott.
3. Bruegal, C. (2003). Staying a step ahead of migraines. Nursing 33, (11), pp.56-58.
4. Clayton, B. D. & Stock, Y. N. ((2001). Basic pharmacology for nurses. 12th ed London: Mosby.
5. Clayton, B. D. & Stock, Y. N. (2001). Drugs used to treat glaucoma and other eye disorders. In (12th ed.). Basic pharmacology for nurses. (pp. 430 - 468). London: Mosby.
6. Dosage calculations: Made incredibly easy (2001). (2nd ed). London: Saunders
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LEARNING OBJECTIVES
Define drug and pharmacology Discuss the terminologies related to
pharmacology Discuss the history of pharmacology briefly Briefly discuss routes of administration. Identify the purposes of medication Identify the source of medication Discuss the classification of drugs Describe the three type of drug supply system. Discuss the drugs standards and legislation. Identify resource to collect and utilize drug
information.
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PHARMACOLOGY
“A branch of medical sciences that study
drugs and their action on living
organisms”
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DRUG
“Any substance that brings about a change in biologic
function through its chemical actions
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DRUG
“chemical substance used in the treatment, cure,
prevention, or diagnosis of disease or used to
otherwise enhance physical or mental well-being."
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HISTORY OF PHARMACOLOGY
Chinese medicine – oldest Sumerian tablet – ointment and medicines
containing potassium nitrate, asafoetida. Eberspapyrus more than 700
pharmacopeal documents including beer,turpentine,berries,poppy,lead,salt & crushed precious stones etc.(Egyptian remedies).
Hippocrates – Father of medicine. Aristotle – separated Superstition from fact Paracelsus – mercurials in syphilis Francois megendiea – concept of scientific
methods in drug study.
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Ostwald schimiedorg , jacob abel – modern for experimental Pharmacology.
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WHY DO NURSES STUDY PHARMACOLOGY??
“ To safely administer medications and to monitor patients who receive these
medications”
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GENERAL CLASSIFICATION OF DRUG
Prescription Drugs Official Drugs OTC Drugs Controlled Drugs High Alert Medications
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Therapeutic Classification
Analgesics Anxiolytics Anesthetics Anti- Asthmatics Antiinfectives Antibacterials Antivirals Antifungal AntiTuberculer Drug
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Antimalarials Antacids Antiacne Antihypertensives Antianginal Antiarrythmics Antiinflammatory Hypolipidemics Antiepileptics Antiemetics Antidiarrheal Antihistamines
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RELATED DEFINITION
Receptor “A specific protein in either the plasma membrane or interior of a target cell with which a chemical messenger/drug combines”
Mechanism of Action “The ways by which drugs can produce therapeutic effects”
Dose “The amount of a drug to be administered at one time”
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Indications “The reasons for administering amedication or performing a treatment”
Contra-indications “Factor that prevents the use of a
medication or treatment (e.g., Allergies)”
Pharmacology, Definitions
Effects (therapeutic effect) “The desired results of
administration of a medication” Side Effects (adverse
effects)“Effects that are harmful and undesired, and that occur in addition to the desired therapeutic effects”
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Duration“The time a drug concentration is sufficient to elicit a therapeutic response”
Onset“The time it takes for the drug to elicit a therapeutic response”
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FIVE R’s
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DRUG SOURCES
1.Plant Sources: Examples include digoxin from digitalis and
morphine from opium.2.Animal Sources: Glandular products from
animals are used, such as insulin and thyroid.3.From micro-organisms (fungi, bacteria)
Penicillin was discovered by Alexander Fleming in 1928 as a product of penicillium notatum (a mold growing in his lab)
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Mineral Sources: from minerals, for example, lithium carbonate (an antipsychotic), MgSO4 (a laxative)
Synthetic Sources:Examples include sulfonamides, and aspirin.
Recombinant proteins: such as interferons, antibodies
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SOURCES OF DRUG INFORMATION
Text books Materia medica Pharmacopea Formulary Journals Pharmacists
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Drug Nomenclature
the chemical name 2-methyl-5-nitroimidazole-l-ethanol is metronidazole. The word methylnitro is condensed to metro and ni-dazole is due to its imidazole ring
Chemical name - represents the exact description of the drug’s chemical composition
Generic name (non-proprietary)
- simpler than the chemical name and - derived from the chemical name itself - easier to remember
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Brand or trade name (proprietary) is developed by the company requesting approval for the drug and identifies it as the exclusive property of that company. Flagyl® is the trade name for metronidazole. Metoclon® is the trade name for Metoclopramide. Amoxil® is the trade name for amoxycillin. Panadol® is the trade name for Acetaminophene.
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Pregnancy Categories
Category A-studies in pregnant women failed to show risk to the fetus
Category B- animal studies have failed to show a risk to the fetus but there are no adequate studies in women
Category C-animal studies have shown an adverse effect on the fetus, no adequate human studies, benefits may outweigh risks
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Pregnancy Categories
Category D-positive evidence of human fetal risk.
Category X-animal or human studies have shown fetal abnormalities or toxicity
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DRUG BODY INTERACTION
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PHARMACOKINETICS
What the Body Does with the DRUG
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PHARMACODYNAMICS
What the Drug Does to the Body
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LOCK AND KEY MODEL
hormones or neurotransmitters (the"key") affect target cells by binding to specific receptors (the "lock”), which are often located in the cell membrane
"unlocks" the cell's response. Effect of hormone
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AGONIST
“A chemical messenger that binds to a receptor and triggers the cell’s response
often refers to a drug that mimics a normal messenger’s action”.
PILOCARPINE - muscarinic receptor agonist,
bind to and activate muscarinic receptors
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Drug Receptor Interactions
Agonist Receptor
Agonist-Receptor
Interaction
Lock and key mechanism
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ANTAGONIST
“A molecule that competes for a receptor with a chemical messenger normally present in the
body. The antagonist binds to the receptor but does not trigger the cell’s response”
Atropine - muscarinic receptor antagonist , can bind to muscarinic receptors but it does not trigger the cell’s response.
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Antagonist Receptor
Antagonist-Receptor
ComplexDENIED!
CompetitiveInhibition
Drug Receptor Interactions
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Definition
“A path by which a
drug, fluid, poison, or other substance is
brought into contact with the body.”
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Routes & Targetso Drug delivery intended to
local effect.• Eye, ear, nose
o Drug delivery intended to systemic effect• Circulatory system
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Routes of Administration
o2 classes of routes of administration.
1)Enteral2)Parenteral
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Factors Deciding Choice of Routeo Type of desired effect, systemic or local.
o Physiochemical properties, solid or insoluble.
o Rapidity of effect.o Dosage form available.o Patient’s age.o Patient’s condition.
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Enteral Routes“Drug placed directly in the GI tract”o Most common, economical, and safest.
o Most unreliable and slow.• Sublingual • Buccal • Oral• Rectal
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Oral Routeo p.o. or PO o Most conventionalo Economicalo safeo self administered o acceptable to patiento Patient’s Feasibilityo Painless
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AdvantagesOvercome by antidotes or emesis
unconscious patients via NG tube (nasogastric)
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Disadvantageso Stomach acid inactivation.o First Pass effecto Drug interactiono Food interactiono Absorption slow or irregularo Poorly or erratically absorbed drug
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o Esophageal ulcerationo Unconsciouso Precision o Very high doseo Rapid administration
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Factors affecting Drug Absorption Orally
o Form of drugo Foodo Digestive transito Drug interaction in digestive tract
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Form of drugo Drops or Tablets not have same kinetics
o Sustained-release delays and extends its absorption.
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Foodo When should a drug be taken: under
fasting conditions, before, during, after meals?
o consider Pharmacokinetic and Pharmacodynamic parameters.
o Bioavailability when taken during meals;o reduced: tetracyclines, isoniazid, penicillamine, captopril.
o unchanged or little modified: amoxicillin.o increased: propranolol
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Food
An hypoglycemic drug before meals.
A gastric protectant taken apart from meals and in the evening at bedtime.
NSAIDs during meals
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Digestive Transit
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Drug Interactions in the Digestive Tract
o Metals i.e. Fe++, Al ++ form organometallic complexes with antibiotics.
o Activated charcoal
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Sublingual / Buccal“held in the mouth or cheeks or under
the tongue.”o SLo SL - Rapid absorptiono Buccal – slower absorptiono Drug stabilityo Clinically useful drugs in sublingual :
• Nitroglycerine• Isosorbide dinitrate• GTN• Clonidine• Methyl testosterone
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Sublingual Route Of Administration
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BUCCAL DRUG ROUTE
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Advantageso Avoid first-pass effecto Low incidence of infectionDisadvantages
inconvenient small doses unpleasant taste of some drugs Erratic absorption.
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Rectal Routeo in recurrent vomiting or unconscious
o bypass livero Absorption incomplete, erratico glycerine, diclofenac o Enema & suppository
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Advantageso Bypass liver 50%o For childreno In emesis
Disadvantageso Inconvenient & embarrassingo Rectal inflammation occurs
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Parenteral Routeo For poorly absorbed drugso For unstable drugso Unconscious patientso Irreversible routeo Cause pain, fear, infection.o must be sterile and little irritant.
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Parenteral Routeo Intravenouso Intramuscularo Intradermalo Subcutaneous
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Intravenous Route “Placing a drug directly into the
blood stream”o IV o Precision of dose quickly.o Prompt effectso Absorption phase is bypassedo 100% bioavailabilityo precise, accurate and almost immediate
onset of action, o fairly pain free
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Intravenous routeo well-controlled throughout the body.
o for irritating solutionso single dose or by continuous infusion.
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Disadvantageso Greater risk of adverse effects a. high concentration attained rapidly b. Embolism
c. Hemolysiso Lack of sterilityo IV more difficult In obese person.o Oily solutions & insoluble substances
not suitableo Cant be withdrawn
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Intramuscular Route“injection of liquid into the area of
greatest mass of a large muscle”
o more rapid absorption than SC o only 5 IM sites
a. deltoid b. vastus lateralis c. rectus femorisd. ventrogluteal e. dorsogluteal
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Intramuscular Routeo IMo Aqueous Solution or specialized Depot
Preparationso contra-indicated anticoagulant therapy.o Rapid effect aqueous solutiono Slow, sustained effect depot preparationo Moderate volume, oily vehicles, irritant, o Absorption rate of blood flow to the
injection siteDisadvantageso Pain, Abscess
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Subcutaneous Route
“injection into the fatty layer of tissue just below the dermis of the skin but above the
muscle layer” o SQ, SC, subQ, s.c.o Absorption slow, sustainedo Rapid effect aqueous solutiono For insoluble suspension & solid pellet implantationso Only nonirritant drugs. o over weeks or months,e.g Testosterone , Insulino adrenaline, heparin, vaccines inj. SC
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Disadvantageso Not suitable for large volume
o Not for irritant drugso Pain, necrosis, tissue sloughing
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Subcutaneous Route
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Intradermal Route“Drug injects into layers of
skin”o Multiple puncture of epidermiso BCG, Small pox vaccinationo Testing drug sensitivity-
Penicillin's o Mantoux test for TB
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Intrathecal Route
“A needle is inserted between two vertebrae in the lower spine and into the space around the spinal cord.”
o Local routeo Rapid effectso local & Spinal anesthesia o BBB & Blood CSF Barrier o Drug entry into CNS o Acute CNS infections & brain tumors
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Disadvantageso infection at site.o Require skilled personel.
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Other Routes
o Topicalo Transdermalo Inhalation
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Topical Application.
o More conveniento Localized effect on skin lesionso Conjunctiva, nasopharynx, oropharynx, vagina,
urethra, urinary bladder, ear, nose, anal canal for local effects.
o Absorption rapid.
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Topical
Disadvantage & Toxicity
o Local irritationo Timolol eye drops contraindicated bronchial asthma and COPD
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Transdermal Route“Applied to the skin via physical delivery through a porous
membrane.”o More conveniento Sustained therapeutic blood levels via stratum corneumo Alcohol enhances penetration o Improved complianceo Patch delivers drug at constant rate o Single patch 7 dayso GTN, nictotine, fentanyl, hyoscine, clonidine
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Disadvantages
o Local irritation & erythema
o expensive
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Vaginal Route“Administered vaginally to women
as a solution, tablet, cream, gel, suppository, or ring. “
o Slow absorptiono Estrogen at menopauseo Prevent thinning of the vaginal wall.
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Intranasal Route“Administration of drugs directly
into nose”o either local or systemic effecto nasal decongestants
o Desmopressino Cocaineo Peptide hormone for osteoporosis
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Advantages
o Fast effect o Prevent drug degradation.
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Disadvantageso limited volume for administration.
o Drugs for continuous and frequent administration less suitable
o Nasal mucosa irritation.
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Inhalation Route“Inhaling of a drug in gas or liquid form; drug is
absorbed through alveoli of the lungs” o Atomized into smaller particles.o Smaller droplets go deeper drug absorption. o for systemic effects
o medical gases and general anesthetics by inhalation.
o Oxygen, nitric oxide and nitrous oxide.
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o for local treatmento bronchial indications o partial absorption and general effects.o Antibiotics, mucolytic, beta-adrenergic mimetic,
muscarinic receptor antagonists.
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Disadvantageo Oral thrush
o Sore throat
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American Drug Laws and Amendments
1938 Food, Drug and Cosmetic Act required proof of safety, authorized factory inspections, established penalties for fraudulent claims.
1952 Durham-Humphrey Amendment designated drugs that must be prescribed by a physician and dispensed by a pharmacist (e.g., controlled substances, etc.)
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American Drug Laws cont.
1970 Comprehensive Drug Abuse Prevention and Control Act; Title II, Controlled Substances Act.
Categorized according to potential for abuse.
Regulated distribution of narcotics and other drugs of abuse
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Categories of Controlled Substances
Schedule I—not approved for medical use and have high abuse potentials; LSD, heroin, peyote, ecstasy
Schedule II—used medically. High abuse potential (methadone, meperidine, cocaine)
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Categories of Controlled Substances
Schedule III - less potential for abuse than I and II but may lead to psychological or physical dependence (Tylenol with codeine)
Schedule IV - some potential for abuse (Valium)
Schedule V - contain moderate amounts of controlled substances.
(atropine and diphenoxylate)
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Drug administration cardinal rules Wash hands before giving meds Read MAR carefully. If ever in doubt,
check the original order Never give medications you are
uncertain of unless you have looked them up or have consulted with pharmacy
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Drug Administration Cardinal Rules
Never give more than 3cc per IM injection Wear gloves with all injections For sub q injections, use 25G, 5/8” needles Do not give oral meds if patient is
vomiting, sedated, NPO or is unconscious Follow narcotic protocol for signing out of
narcotics
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QUESTIONS???
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Referenceso Text book of pharmacology for nurses – J.K Grover – Monica malik
o Lippincott illustrated review of Pharmacology
o Katzung. B. G. Basic and clinical Pharmacology
o J.D tripathy, Essential of Medical Pharmacology
o www.Google.com
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THANK YOU