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Sample & Assay Technologies
Attention-grabber
Pathway Map Reference Guide
The most popular cell signaling pathways
Focus on Your Pathway
2 www.qiagen.com Pathway Map Reference Guide 07/2011
Table of contents
Molecular Mechanisms of Cancer 24
NFkB Family 25
Notch Signaling 26
p38 Signaling 27
p53 Signaling 28
PI3K Signaling 29
PPAR 30
Ras 31
Rho Family GTPases 32
SMAD Signaling Network 33
TCR Signaling 34
TGFb 35
TNF Superfamily 36
Toll-like Receptors 37
Transcriptional Network in
Embryonic Stem Cells 38
Ubiquitin-Proteasome–
dependent Proteolysis 39
VEGF 40
Wnt Signaling 41
Product listing 42
AKT Signaling 4
cAMP Signaling 5
Cellular Apoptosis 6
Chemokine Signaling 7
Cyclins and Cell Cycle Regulation 8
Cytokine Network 9
DNA Repair Mechanisms 10
EGF 11
Epithelial Tight Junctions 12
ErbB Family 13
ERK Signaling 14
Estrogen 15
Glucocorticoid Receptor Signaling 16
GPCR 17
HIF1a 18
IL-6 19
Insulin Receptor 20
JAK/STAT 21
LDL Oxidation in Atherogenesis 22
MAP Kinase Signaling 23
For up-to-date licensing information and product-specific disclaimers, see the respective QIAGEN kit handbook or user manual. QIAGEN kit handbooks and user manuals are available at www.qiagen.com or can be requested from QIAGEN Technical Services or your local distributor.
Trademarks: QIAGEN®, EpiTect® (QIAGEN Group); PowerPoint® (Microsoft Corporation).
Registered names, trademarks, etc. used in this document, even when not specifically marked as such, are not be considered unprotected by law.
The products featured in the guide are intended for molecular biology applications. These products are not intended for the diagnosis, prevention, or treatment of a disease.
© 2011 QIAGEN, all rights reserved
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 3
The Pathway Map Reference GuideThis guide illustrates important signaling pathways with their related RT2 Profiler PCR
Arrays and Cignal Reporter Assay Kits. To view the entire list of 500 pathway maps,
editable PowerPoint® slides, and related QIAGEN products, visit:
www.qiagen.com/pathway-centralDisclaimer: We acknowledge Protein Lounge, Inc. as the source of the Pathway Maps. Any questions or comments regarding the validity or accuracy of the pathway maps should be directed to Protein Lounge, Inc. directly.
Product informationRT2 Profiler PCR Arrays
RT2 Profiler PCR Arrays enable the analysis of key genes for a biological
pathway or disease state using real-time PCR in 2 hours. RT2 Profiler PCR Arrays
are available for all real-time PCR instruments. Associated pathway PCR arrays
related to the top 50 pathways are provided in this guide. An example of a
complete PCR array identifier catalog number is shown below:
To view the entire list of available RT2 Profiler PCR Arrays, visit:
www.qiagen.com/array-list
Cignal Reporter Assay Kits
Cignal Reporter Assay Kits provide a rapid, sensitive, and quantitative
assessment of over 45 signal transduction pathways by measuring the activities
of downstream transcription factors. GFP and luciferase reporter systems are
available. For a complete list of Cignal Reporter Assay Kits, visit:
www.qiagen.com/reporter-assays
PAXX-###Y-#
XX = species ### = unique pathway identifier Y = plate format # = pack size
4 www.qiagen.com Pathway Map Reference Guide 07/2011
Akt Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L
mTOR Signaling PAHS-098 MAPK/ERK CCS-010L
Oncogenes & Tumor Suppressor Genes PAHS-502 MAPK/JNK CCS-011L
MAP Kinase Signaling Pathway PAHS-61 NFkB CCS-013L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 5
cAMP Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
cAMP/Ca2+ Signaling PathwayFinder PAHS-066 cAMP/PKA CCS-002L
p53 Signaling Pathway PAHS-027 Amino Acid Deprivation CCS-5034L
Synaptic Plasticity PAHS-126 PKC/Ca2+ CCS-015L
MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L
6 www.qiagen.com Pathway Map Reference Guide 07/2011
Cellular Apoptosis
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Apoptosis PAHS-012 p53/DNA Damage CCS-004L
p53 Signaling Pathway PAHS-027 Cell Cycle CCS-003L
DNA Damage Signaling Pathway PAHS-029 ATF6 CCS-9031L
Autophagy PAHS-084 PI3K/Akt CCS-1022L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 7
Chemokine Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Chemokines & Receptors PAHS-022 NFkB CCS-013L
NFkB Signaling Pathway PAHS-025 MAPK/JNK CCS-011L
Toll-like Receptor Signaling Pathway PAHS-018 MAPK/ERK CCS-010L
MAP Kinase Signaling Pathway PAHS-061 Type I Interferon CCS-008L
8 www.qiagen.com Pathway Map Reference Guide 07/2011
Cyclins and Cell Cycle Regulation
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Cell Cycle PAHS-020 Cell Cycle CCS-003L
p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L
DNA Damage Signaling Pathway PAHS-029 PI3K/Akt CCS-1022L
Cellular Senescence PAHS-050 Wnt CCS-018L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 9
Cytokine Network
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Common Cytokines PAHS-021 Interferon g CCS-009L
Chemokines & Receptors PAHS-022 STAT3 CCS-9028L
Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L
Interferon a, b Response PAHS-016 Type I Interferon CCS-008L
10 www.qiagen.com Pathway Map Reference Guide 07/2011
DNA Repair Mechanisms
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
DNA Repair PAHS-042 Cell Cycle CCS-003L
DNA Damage Signaling Pathway PAHS-029 p53/DNA Damage CCS-004L
Telomeres and Telomerase PAHS-010 Hedgehog CCS-6030L
qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 11
EGF
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L
Growth Factors PAHS-041 MAPK/ERK CCS-010L
PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L
EGFR qBiomarker Somatic Mutation SMH-001 Estrogen Receptor CCS-005L
12 www.qiagen.com Pathway Map Reference Guide 07/2011
Epithelial Tight Junctions
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Epithelial to Mesenchymal Transition PAHS-090 PKC/Ca2+ CCS-015L
Endothelial Cell Biology PAHS-015 MAPK/ERK CCS-010L
Primary Cilia PAHS-127 SP1 CCS-6027L
Amino Acid Metabolism II PAHS-130 MAPK/JNK CCS-004L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 13
ErbB Family
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
EGF/PDGF Signaling Pathway PAHS-040 Estrogen Receptor CCS-005L
PI3K-Akt Signaling Pathway PAHS-058 Progesterone CCS-6043L
Breast Cancer PAHS-131 PI3K/Akt CCS-1022L
ErbB2 qBiomarker Somatic Mutation SMH-002 MAPK/ERK CCS-010L
14 www.qiagen.com Pathway Map Reference Guide 07/2011
ERK Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
MAP Kinase Signaling Pathway PAHS-061 MAPK/ERK CCS-010L
PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L
EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L
NFkB Signaling Pathway PAHS-025 NFkB CCS-013L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 15
Estrogen
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Breast Cancer and ER Signaling PAHS-005 Estrogen Receptor CCS-005L
Breast Cancer PAHS-131 Progesterone CCS-6043L
Nuclear Receptors and Coregulators PAHS-056 Androgen CCS-1019L
EGF/PDGF Signaling Pathway PAHS-040 C/EBP CCS-001L
16 www.qiagen.com Pathway Map Reference Guide 07/2011
Glucocorticoid Receptor Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Inflammatory Cytokines and Receptors PAHS-011 Glucocorticoid Receptor CCS-006L
Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L
Neutrophins & Receptors PAHS-031 VDRE CCS-2029L
Stress Response to Cellular Damage PAHS-019 Androgen CCS-1019L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 17
GPCR
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
GPCR Signaling PathwayFinder PAHS-071 cAMP/PKA CCS-002L
Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L
Primary Cilia PAHS-127 PKC/Ca2+ CCS-015L
Neurotransmitter Receptors & Regulators PAHS-060 Wnt CCS-018L
18 www.qiagen.com Pathway Map Reference Guide 07/2011
HIF1a
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Hypoxia Signaling Pathway PAHS-032 Hypoxia CCS-007L
VEGF Signaling PAHS-091 ATF6 CCS-9031L
Angiogenic Growth Factors and Inhibitors PAHS-072 Amino Acid Deprivation CCS-5034L
Angiogenesis PAHS-024 PKC/Akt CCS-1022L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 19
IL-6
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L
Th17 for Autoimmunity and Inflammation PAHS-073 NFkB CCS-013L
Chemokines and Receptors PAHS-022 Interferon g CCS-009L
Common Cytokines PAHS-021 Interferon Regulation CCS-7040L
20 www.qiagen.com Pathway Map Reference Guide 07/2011
Insulin Receptor
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Insulin Signaling Pathway PAHS-030 PI3K/Akt CCS-1022L
Adipogenesis PAHS-049 PPAR CCS-3026L
Notch Signaling Pathway PAHS-059 MAPK/ERK CCS-010L
Alzheimer‘s Disease PAHS-056 MAPK/JNK CCS-011L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 21
JAK/STAT
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
JAK/STAT Signaling Pathway PAHS-039 Type I Interferon CCS-008L
Th17 for Autoimmunity and Inflammation PAHS-073 Interferon g CCS-009L
Interferon a, b Response PAHS-016 STAT3 CCS-9028L
Stem Cell Transcription Factors PAHS-501 Interferon Regulation CCS-7040L
22 www.qiagen.com Pathway Map Reference Guide 07/2011
LDL Oxidation in Atherogenesis
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Atherosclerosis PAHS-038 Liver X Receptor CCS-004L
Lipoprotein and Cholesterol Signaling PAHS-080 PPAR CCS-3026L
Endothelial Cell Biology PAHS-015 Hepatocyte NF CCS-3039L
Diabetes PAHS-023 NFkB CCS-013L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 23
MAP Kinase Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L
PI3K-Akt Signaling Pathway PAHS-058 MAPK/ERK CCS-010L
NFkB Signaling Pathway PAHS-025 PI3K/Akt CCS-1022L
Signal Transduction PathwayFinder PAHS-014 NFkB CCS-013L
24 www.qiagen.com Pathway Map Reference Guide 07/2011
Molecular Mechanisms of Cancer
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Cancer PathwayFinder PAHS-033 p53 CCS-004L
Epithelial to Mesenchymal Transition PAHS-090 Cell Cycle CCS-003L
EpiTect Methyl qPCR Arrays MeAH-### Wnt CCS-018L
qBiomarker Somatic Mutation SMH-### Notch CCS-014L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 25
NFkB Family
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
NFkB Signaling Pathway PAHS-025 NFkB CCS-013L
Toll-like Receptor Signaling Pathway PAHS-018 MAPK/JNK CCS-011L
TNF Ligands and Receptors PAHS-063 MAPK/ERK CCS-010L
MAP Kinase Signaling Pathway PAHS-061 SP1 CCS-6027L
26 www.qiagen.com Pathway Map Reference Guide 07/2011
Notch Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Notch Signaling Pathway PAHS-059 Notch CCS-014L
Stem Cell Signaling PAHS-047 Wnt CCS-018L
Hedgehog Signaling Pathway PAHS-078 Hedgehog CCS-6030L
WNT Signaling Pathway PAHS-043 EGR1 CCS-8021L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 27
p38 Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
MAP Kinase Signaling Pathway PAHS-061 MAPK/JNK CCS-011L
NFkB Signaling Pathway PAHS-025 MAPK/ERK CCS-010L
PI3K-Akt Signaling Pathway PAHS-058 Amino Acid Deprivation CCS-5034L
Toll-like Receptor Signaling Pathway PAHS-018 NFkB CCS-013L
28 www.qiagen.com Pathway Map Reference Guide 07/2011
p53 Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
p53 Signaling Pathway PAHS-027 p53/DNA Damage CCS-004L
Cell Cycle PAHS-020 Cell Cycle CCS-003L
DNA Damage Signaling Pathway PAHS-029 SP1 CCS-6027L
qBiomarker Somatic Mutation SMH-### Amino Acid Deprivation CCS-5034L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 29
PI3K Signaling in B-Lymphocyte
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
PI3K-Akt Signaling Pathway PAHS-058 PI3K/Akt CCS-1022L
T-Cell and B-Cell Activation PAHS-053 MAPK/ERK CCS-010L
mTOR Signaling PAHS-098 MAPK/JNK CCS-011L
Dendritic and Antigen Presenting Cell PAHS-406 NFkB CCS-013L
30 www.qiagen.com Pathway Map Reference Guide 07/2011
PPAR
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Adipogenesis PAHS-049 PPAR CCS-3026L
Nuclear Receptors and Coregulators PAHS-056 C/EBP CCS-001L
Fatty Acid Metabolism PAHS-007 Liver X Receptor CCS-041L
Insulin Signaling Pathway PAHS-030 Antioxidant Response CCS-5020L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 31
Ras
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Oncogenes & Tumor Suppressor Genes PAHS-502 MAPK/ERK CCS-010L
PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L
EGF/PDGF Signaling Pathway PAHS-040 PI3K/Akt CCS-1022L
RTK Panel II qBiomarker Somatic Mutation SMH-009 p53/DNA Damage CCS-004L
32 www.qiagen.com Pathway Map Reference Guide 07/2011
Rho Family GTPases
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Cell Motility PAHS-128 PKC/Ca2+ CCS-015L
Cytoskeleton Regulators PAHS-088 PI3K/Akt CCS-1022L
Epithelial to Mesenchymal Transition PAHS-090 MAPK/ERK CCS-010L
PI3K-Akt Signaling Pathway PAHS-058 MAPK/JNK CCS-011L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 33
SMAD Signaling Network
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L
Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L
Stem Cell Signaling PAHS-047 Interferon g CCS-009L
Growth Factors PAHS-041 EGR1 CCS-8021L
34 www.qiagen.com Pathway Map Reference Guide 07/2011
TCR Signaling
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
T-Cell Anergy and Immune Tolerance PAHS-074 Interferon g CCS-009L
T-Cell and B-Cell Activation PAHS-053 STAT3 CCS-9028L
Th17 for Autoimmunity and Inflammation PAHS-073 Interferon Regulation CCS-7040L
Dendritic and Antigen Presenting Cell PAHS-406 Notch CCS-014L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 35
TGFb
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
TGFb/BMP Signaling Pathway PAHS-035 TGFb CCS-017L
Epithelial to Mesenchymal Transition PAHS-090 Wnt CCS-018L
Growth Factors PAHS-041 Interferon g CCS-009L
Th17 for Autoimmunity and Inflammation PAHS-073 EGR1 CCS-8021L
36 www.qiagen.com Pathway Map Reference Guide 07/2011
TNF Superfamily
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
TNF Ligands and Receptors PAHS-063 STAT3 CCS-9028L
NFkB Signaling Pathway PAHS-025 NFkB CCS-013L
Common Cytokines PAHS-021 Interferon g CCS-009L
Toll-like Receptor Signaling PAHS-018 Interferon Regulation CCS-7040L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 37
Toll-like Receptors
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Toll-like Receptor Signaling PAHS-018 NFkB CCS-013L
Inflammasomes PAHS-097 Type I Interferon CCS-008L
Innate and Adaptive Immune Response PAHS-052 Interferon Regulation CCS-7040L
Dendritic and Antigen Presenting Cell PAHS-406 STAT3 CCS-9028L
38 www.qiagen.com Pathway Map Reference Guide 07/2011
Transcriptional Network in Embryonic Stem Cells
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Embryonic Stem Cells PAHS-081 Nanog CCS-7037L
Stem Cell PAHS-405 Oct4 CCS-025L
Terminal Differentiation Markers PAHS-048 Sox2 CCS-038L
qBiomarker Screening and Validation IPHS-### KLF4 CCS-4036L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 39
Ubiquitin-Proteasome–dependent Proteolysis
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Ubiquitination (Ubiquitinylation) PAHS-079 ATF6 CCS-9031L
Autophagy PAHS-084 Cell Cycle CCS-003L
Unfolded Protein Response PAHS-089 ER Stress CCS-2032L
Chromatin Modification Enzymes PAHS-085 Antioxidant Response CCS-5020L
40 www.qiagen.com Pathway Map Reference Guide 07/2011
VEGF
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Angiogenic Growth Factors & Inhibitors PAHS-072 Hypoxia CCS-007L
VEGF Signaling PAHS-091 PI3K/Akt CCS-1022L
Angiogenesis PAHS-024 TGFb CCS-017L
Growth Factors PAHS-041 SP1 CCS-6027L
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 41
Wnt
Related products
RT2 Profiler PCR Arrays Cignal Reporter Assay Kits
Wnt Signaling Pathway PAHS-043 Wnt CCS-018L
Hedgehog Signaling Pathway PAHS-078 Notch CCS-014L
Stem Cell Signaling PAHS-047 Hedgehog CCS-6030L
Notch Signaling Pathway PAHS-059 TGFb CCS-017L
42 www.qiagen.com Pathway Map Reference Guide 07/2011
Top 60 RT2 Profiler PCR Arrays
RT2 Profiler PCR Arrays Cat. no. RT2 Profiler PCR Arrays Cat. no.
Angiogenesis PAXX-024 Lipoprotein and Cholesterol Signaling PAXX-080
Apoptosis PAXX-012 MAP Kinase (MAPK) Signaling Pathway PAXX-061
Atherosclerosis PAXX-038 Mesenchymal Stem Cell PAXX-082
Autophagy PAXX-084 Mitochondria PAXX-087
Breast Cancer and ER Signaling PAXX-005 Mitochondrial Energy Metabolism PAXX-008
Cancer Drug Resistance & Metabolism PAXX-004 Neurogenesis and Neural Stem Cell PAXX-404
Cancer PathwayFinder PAXX-033 Neurotransmitter Receptors & Regulators PAXX-060
Cell Cycle PAXX-020 Neurotrophins and Receptors PAXX-031
Common Cytokines PAXX-022 NFkB Signaling Pathway PAXX-025
Cytoskeleton Regulators PAXX-021 Notch Signaling Pathway PAXX-059
Dendritic and Antigen Presenting Cell PAXX-088 Obesity PAXX-017
Diabetes PAXX-406 Oncogenes & Tumor Suppressor Genes PAXX-502
DNA Damage Signaling Pathway PAXX-029 Osteogenesis PAXX-026
DNA Repair PAXX-042 Oxidative Stress & Antioxidant Defense PAXX-065
Embryonic Stem Cell PAXX-047 p53 Signaling Pathway PAXX-027
Endothelial Cell Biology PAXX-015 PI3K-AKT Signaling Pathway PAXX-058
Epigenetic Chromatin Mod Enzymes PAXX-085 Signal Transduction PathwayFinder PAXX-014
Epithelial to Mesenchymal Transition PAXX-090 Stem Cell PAXX-405
ECM and Adhesion Molecules PAXX-013 Stress and Toxicity PathwayFinder PAXX-003
Fibrosis PAXX-020 T-Cell and B-Cell Activation PAXX-053
Glucose Metabolism PAXX-006 T-Cell Anergy and Immune Tolerance PAXX-074
Growth Factors PAXX-041 TGFb BMP Signaling Pathway PAXX-035
Hedgehog Signaling Pathway PAXX-078 Th17 for Autoimmunity & Inflammation PAXX-073
Hypoxia Signaling Pathway PAXX-032 Th1-Th2-Th3 PAXX-034
Inflammatory Cytokines and Receptors PAXX-011 Toll-like Receptor Signaling Pathway PAXX-018
Inflammatory Response & Autoimmunity PAXX-077 Transcription Factors PAXX-075
Innate & Adaptive Immune Responses PAXX-052 Tumor Metastasis PAXX-028
Insulin Signaling Pathway PAXX-030 Unfolded Protein Response PAXX-089
Interferon a, b Response PAXX-016 VEGF Signaling PAXX-091
JAK/STAT Signaling Pathway PAXX-039 Wnt Signaling Pathway PAXX-043
Pathway Map Reference Guide 07/2011 Sample & Assay Technologies 43
Cignal Reporter Assay Kits
* (#XXXXXX) = SAP Number. (Note: The catalog numbers shown are incomplete. See page 3 for instruction.)
Pathway Trxn. Factor Pathway Trxn. Factor
Amino Acid Deprivation ATF4/3/2 MAPK/ERK Elk-1/SRF
Androgen Androgen MAPK/JNK AP-1
Antioxidant Response Nrf2/1 MEF2 MEF2
ATF6 ATF6 c-Myc Myc/Max
C/EBP C/EBP Nanog Nanog
cAMP/PKA CREB NFkB NFkB
Cell Cycle E2F/DP1 Notch RBP-Jk
p53/DNA Damage p53 Oct4 Oct4
EGR1 EGR1 Pax6 Pax6
ER Stress CBF/NF-Y/YY1 PI3K/AKT FOXO
Estrogen Receptor ER PKC/Ca2+ NFAT
GATA GATA PPAR PPAR
Glucocorticoid Receptor GR Progesterone Receptor PR
Heat Shock Response HSF Retinoic Acid Receptor RAR
Heavy Metal Stress MTF1 Retinoid X Receptor RXR
Hedgehog GLI Sox2 Sox2
Hepatocyte Nuclear Factor 4 HNF4 SP1 SP1
Hypoxia HIF-1 STAT3 STAT3
Interferon Regulatory Factor IRF1 TGFb SMAD2/3/4
Type I Interferon a, b STAT1/2 Vitamin D Receptor VDR
Interferon g STAT1/1 Wnt TCF/LEF
KLF4 KLF4 Xenobiotic AhR
Liver X Receptor LXRa
Multi-Pathway Arrays Multi-Pathway Arrays
Signal Transduction 45-Pathway Nuclear Receptors 10-Pathway
Cancer 10-Pathway Stress & Toxicity 10-Pathway
Immune Signaling 10-Pathway Stem Cell & Differentiation 10-Pathway
Development 10-Pathway
Sample & Assay Technologies1069328 07/2011
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