Download - Pathology Visions 2007 - TECOTZKY
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Pathology Visions Conference
Oil Scanning
Amsterdam, Netherlands
Tuesday, December 4, 2007
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Pathology Visions: Solutions Gallery
SCAN
VIEWMANAGE
ANALYZE
START
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4INNOVATION
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Primary Oil Immersions Applications
• Hematopathology, Microbiology, Cytology Applications• Blood Smears, Bone Marrow Smears, Gram Stains, ...
• Oil Immersion Digital Slide Scanning
SCAN
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Oil Immersion ApplicationsBlood films:
• Representative areas in blood films can be scanned for full diagnostic workup.
• Resolution is sufficient to rule out abnormalities in:
• White blood cells
• Appreciate chromatin structure and identify nucleoli for accurate blast counts
• Distinguish all white cell precursors for an accurate differential count
• Red blood cells
• Spectrum of morphological changes including :
• Hypochromia / blisters, bites, acanthocytes, echinocytes, sickle cells and other schistocyte forms
• Inclusions down to the size of 1 to 2 microns such as Howell-Jolly, Pappenheimer bodies & malarial parasites
• Platelets
Oil ImmersionScanning
EXAMPLE: Hypochromia in red cells: http://www.objectivepathology.com/Public/CBC/Fe%20def.html
SCAN
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Oil Immersion ApplicationsMicrobiology
• Infectious organisms down to the one or two micron level for : • speciation of malarial parasites in red cells, • identifying Leishmania spp. in histocytes from tissue sections, fungal forms such as Aspergillosis and
Candida.
• EXAMPLE: Leishmania amastigotes in tissue sections:
• http://www.objectivepathology.com/Public/Leishmaniasis/TK%20B07-904%20Leish%20100x.html
Cytology:
• Powerful technique for capturing the fine cytological details in fine needle aspiration cytology.
• For example the fine nuclear features of papillary carcinoma of the thyroid such as the powdery chromatin, intranuclear pseudo-inclusions, micronucleoli and linear nuclear ridges ("grooves").
• EXAMPLE: Papillary carcinoma of the thyroid:
• http://www.objectivepathology.com/PublicClientImages/CAP/Aug-2007/PAP.html
SCAN
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Pathology ExamplesHypochromia in red cells Leishmania amastigotes in tissue sections:
•Papillary carcinoma of the thyroid:
SCAN
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Oil Immersion ScanningProduct Offerings
• Products & Features
• ScanScope OS• Dedicated Oil Immersions Digital Slide Scanner• Scans at 100x
• ScanScope® (CS, GL, GL-E) with Oil Immersion• Upgrade installed ScanScopes with Oil Immersion Option• Add Oil Immersion to New ScanScope Orders• Scans at 20x Dry, 40x Dry, 83x with Oil Immersion
SCAN
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Product OfferingsOil Scanner Product Portfolio
Product Offerings:
1. Scanning service (ScanScope OS)• http://aperio.com/productsservices/serv-scanning.asp
2. Dedicated oil scanner (ScanScope OS)
3. Oil upgrades to existing (ScanScope GL, GL-E, and CS)
4. Oil options for new (ScanScope GL, GL-E, and CS)
Note: No XT Oil Upgrades or Options
SCAN
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Product Specs ScanScope OS• 100x optical magnification realized
with 1.35 NA Plan Apo oil emersion objective
• Resolution 0.14 μm/pixel resolution
• Single-slide tray
• 5x5mm region in ~5 min (est.)
• 10x10mm region in ~20 min (est.) Maximum scan area recommended
• Height 12.5” x 19” x 20.5” (318 x 465 x502 mm)
• Weight 55 lbs (25 kg)
SCAN
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Integrated Color Management (ICM) “Aperio systems’ leading image quality is assured”
Glass Slide
ImageScopeColor
TransformNeutral Color Profile
Digital Slide Image Color Corrected for
ScanScope & Monitorcharacteristics
ScanScope
“HP2335.icc” file
sRGB (default)or
Monitor Color Profile(If available)
Default Color Profile(used if no Monitor Color Profile specified)
Digital Slide Image
ScanScope ICC Profile Digital Slide Image (.svs) file with embedded ScanScope Profile
ScanScope Color Profile
Digital Slide Image
• True Color For Lab Calibration Issues• Consistency Inter ScanScope & Inter Monitor• Image Analysis Advantages Eye / Algorithm Consistency
VIEW
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Integrated Color Management “OFF”
VIEW
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Integrated Color Management “ON”
VIEW
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Integrated Color Management “ON” on Left “OFF” on Right
Click to Toggle Integrated Color Management “ON” or “OFF”
VIEWDisplayed if Integrated Color Management is “ON”
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“BigTIFF” Support – Digital Slides Larger Than 4GB “Aperio delivers leading technology based on open standards”
“Aperio systems support the highest resolution
image infrastructure in the industry”
• Until today, we supported images up to 4GB in size
• Now, we will be able to support images up to 1EB (Exabyte)
Today
Now in 9.0
1,000 Times LargerThan Before
1,048,576 Terabytes
VIEW
Note: 1. See it for your self at http://www.bigtiff.org 2. Only Oil Scans are typically larger than 4GB
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Spectrum™ Plus with Reporting“Aperio systems deliver Workflow Solutions”
• IHC Report• Breast Panel• Standard Template Supports
• Stains: H&E, HER2, ER, PR• Specimens: Up to 3 per case/project• Slides: Up to 4 per specimen
• Standard Templates Included: IHC, Research Project, Slide List
• Professional Services Available: • Customization of Static & Dynamic (DB) Content & Format
• FAQs:• How can I use Aperio Reporting Today?• What’s Included? What’s Not Included?• Compatible with current dictation workflow?• How do customers get it?
• Who implements it & How? Time? Cost?
• Workflow: Scan, View, Manage, Analyze, & Report
MANAGE
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Marketing Collateral ScanScope® OS
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Marketing Collateral ScanScope® with Oil Immersion
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Marketing Collateral Spectrum™ Plus with Reporting
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Aperio Website Updates
• Affected Web Pages
• ScanScope Systems Web Page
• Data Sheets in Quick Links - Right Nav
• ScanScope® OS
• ScanScope® with Oil Immersion
• Spectrum Web Page
• Data Sheets in Quick Links - Right Nav
• Spectrum™ Plus with Reporting
• Image Analysis Web Page
• Colocalization Algorithm Image & Info
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Global Availability
U.S. & International Distributors and Dealers
• Launch Announced: October 24, 2007
• First Customer Shipment: December 10, 2007
U.S. & International Distributors and Dealers
• Launch Announced: October 24, 2007
• First Customer Shipment: December 10, 2007
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• The Aperio Release 9.0 is an
Exciting Opportunity for all of us!
• ScanScope OS & ScanScope with Oil Immersion• 1st Oil Immersion Scanning Solution
• Spectrum Plus with Reporting • Digital Slide Scanning, Viewing, Management, and Analysis Solution
• Integrated Color Management – True Color Quality throughout
• … And much, much, more…
• Release 9.0 Offers Significant Improvements and New Innovations !
Conclusion
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Thank You.
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Holland