OUTLINE:OUTLINE:

1. MATCH PROJECT

2. Health Implications of PAH in Indoor Environments

3. SPADE PROJECT

Dr Juana Maria Delgado-SaboritDivision of Environmental Health and Risk Management School of Geography, Earth and Environmental SciencesUniversity of Birmingham

OBJECTIVES: Quantify the magnitude and range of individual personal

exposures to a selected group of air toxics (VOC & PAH) Develop models for exposure prediction based on time/activity

diaries and micro-environmental concentrations

MATCH PROJECTMATCH PROJECT- Measurement and modelling of Air Toxic

Concentrations for Health effects and verification by biomarkers

METHODOLOGY: Personal Exposure Sampling Time-Activity Diary Microenvironment Monitoring Biomonitoring Model Development

RESULTS:

MATCH PROJECT

MATCH PROJECT

VOC PERSONAL EXPOSURE AND MICROENVIRONMENT CONCENTRATIONS

0.0

0.1

1.0

10.0

Concentrations (mg / m

3)

PE All Home All Work All Street All

Transport Vehicles All Transport Stations All Pubs and restaurants All Other Indoors All

-2.00 -1.00 0.00

Log 3-Ethenyl Pyridine

0.00

1.00

2.00

R-Square = 0.54

URINARY BIOMARKERS

Benzene Measured10.008.006.004.002.000.00

Ben

zen

e_P

red

icte

d

6.00

5.00

4.00

3.00

2.00

1.00

0.00

R Sq Linear = 0.469

R2=0.47

MODELLING

PERSONAL & MICROENVIRONMENT

PERCENTAGE CONTRIBUTION OF MICROENVIRONMENT TO PE

0

10

20

30

40

50

60

70

80

90

100

n-he

xane

Benze

ne

Tolue

ne

Ethylb

enze

ne

p-Xyle

ne

m-X

ylene

Pyridi

ne

o-Xyle

ne

1,3,5-Trim

ethylb

enze

ne

Styren

e

p-Iso

prop

yltolu

ene

1,2,4-Trim

ethylb

enze

ne

3-Ethe

nylpy

ridine

Naphtha

lene

1,3-Bu

tadie

ne

Per

centa

ge (%

)

OBJECTIVES: Assess typical range concentrations and profile of PAH indoor &

outdoors Assess carcinogenic potency of PAH indoors & outdoors Evaluate whether BaP can be used as a marker indoors

Health Implications of PAH in Indoor Environments

METHODOLOGY: Microenvironment Sampling – Indoors & Outdoors – MATCH Calculate carcinogenic potency (CP) and % contribution of BaP to CP

100)(

)().(%

1

xRCxRP

RCxRPPotencialCarc N

ii

ii

PAHs Abbrev. Potency Benzo[a]pyrene BAP 1.0 Benz[a]anthracene BAA 0.1 Benzo[b]fluoranthene BBF 0.1 Benzo[k]fluoranthene BKF 0.01 Chrysene CHY 0.001 Dibenz[a,h]anthracene DBA 1.0 Indeno[1,2,3-cd]pyrene IDP 0.1

CARCINOGENIC CONTRIBUTION

0.0

10.0

20.0

30.0

40.0

50.0

60.0

Benzo

(a)anthr

acen

e

Chrys

ene

Benzo

(b)flu

oran

then

e

Benzo

(k)fluo

ranthe

ne

Benzo

(a)pyren

e

Inde

no(1,2,3-cd)

pyre

ne

Diben

z(a,h)an

thrace

ne

Carc

inogenic

contrib

ution

Indoors ETS (Pub) Indoors No ETS Outdoors Trafficked Roadside Outdoors Park London 1991-1995 Aluminium Smelter

PAH CONCENTRATIONS

0.0

0.1

1.0

10.0

100.0

Acena

phthyle

ne

Acena

phthen

e

Fluo

rene

Phena

nthren

e

Anthrac

ene

Fluo

ranthe

ne

Pyren

e

Benzo

(a)anthr

acen

e

Chrys

ene

Benzo

(b)flu

oran

then

e

Benzo

(k)fluo

ranthe

ne

Benzo

(a)pyren

e

Inde

no(1,2,3-cd)

pyre

ne

Diben

z(a,h)an

thrace

ne

Benzo

(ghi)

peryl

ene

Coron

ene

Concentr

ations (ng / m

3)

Indoors ETS (Pub) Indoors No ETS Outdoors Trafficked Roadside Outdoors Park

Health Implications of PAH in Indoor Environments

OBJECTIVES: Source apportionment of PAH in ambient air Assess contribution of long-range transport & local sources Study the breakdown rates of PAH in the atmosphere Assess levels of PAH reaction products: quinones

SPADE PROJECTSPADE PROJECT – Sources and Processes determining polycyclic Aromatic hydrocarbons and their Degradation products in the Environment

METHODOLOGY: Gas and Particle phase sampling – PAH & Quinones Remote sampling – HYSPLIT back-trajectories Lagrangian experiment