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Your Autoimmunity Connection
Our Body’s Immune System Starts in the Mouth
Exploring the Link between the Oral Microbiome and Systemic Disease
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Bonnie Feldman, DDS, MBADrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients.
We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity
Bibliography for The Gateway to Health and Disease
[email protected]@DrBonnie360 www.facebook.com/YourAutoimmunityConnection Content and Visual Design by Tiffany Simms
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The mouth is home to hundreds of bacteria. Recent research shows that the ecosystem in your mouth – the oral microbiome – could be significantly connected to one’s health.
The following slides explore the overlooked roles the oral microbiome plays, the potential for personalization, and the connection to systemic diseases.
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Devine, Deirdre A., Philip D. Marsh, and Josephine Meade. "Modulation of host responses by oral commensal bacteria." Journal of oral microbiology 7 (2015). <http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941>.
The Overlooked Microbes in Your Mouth What is the Oral Microbiome?
Oral vs Gut Microbiome
Dewhirst, Floyd E., et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017. <http://jb.asm.org/content/192/19/5002.short>.
Krzyściak, Wirginia, Anna Jurczak, and Jakub Piątkowski. "The Role of Human Oral Microbiome in Dental Biofilm Formation." InTech. N.p., n.d. Web. <http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human-oral-microbiome-in-dental-biofilm-formation>.
Lloyd-Price, Jason, Galeb Abu-Ali, and Curtis Huttenhower. "The healthy human microbiome." Genome medicine 8.1 (2016): 1. <https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y>.
Nelson-Dooley, Cass. "The Mouth, the Oral Microbiome, and Systemic Inflammation." Institute for Functional Medicine. N.p., n.d. Web. 18 Jan. 2017. <https://www.functionalmedicine.org/home/focus_on/oral_microbiome/>.
What is the Oral Microbiome
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Nelson-Dooley, Cass, and Stephen F. Olmstead. "The Microbiome and Overall Health Part 5: The Oropharyngeal Microbiota's Far-Reaching Role in Immunity, Gut Health, and Cardiovascular Disease." Complementary Prescriptions. N.p., n.d. Web. 19 Jan. 2017. <http://www.cpmedical.net/newsletter/the-microbiome-and-overall-health-part-5-the-oropharyngeal>.
Zarco, Vess, and Ginsburg. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental Medicine.” Oral Diseases 18.2 (2012): 109–120. <http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full>.
The Hidden Gold Mine: Saliva’s ImportanceGlurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’” Journal of Oral Microbiology 7.0 (2015): 28223. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/>.
Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on Metagenomic Sequencing.” SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017. <http://link.springer.com/article/10.1186/s40064-016-3728-6>.
Zaura, Egija, et al. "On the ecosystemic network of saliva in healthy young adults." The ISME Journal (2017). <http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html>.
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Costalonga, Massimo, and Mark C. Herzberg. "The oral microbiome and the immunobiology of periodontal disease and caries." Immunology letters 162.2 (2014): 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>.Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the California Dental Association 44.7 (2016): 409–10. <https://www.ncbi.nlm.nih.gov/pubmed/27514152>. Kilian, M., et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal 221.10 (2016): 657-666. <http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html>. Liu, Bo, et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one 7.6 (2012): e37919. <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919>.
Our Disease Barometer: The Oral Microbiome in Caries & Periodontal Disease
Chicken or the Egg? The Oral Microbiome & Systemic Disease Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016). <http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full>. Scher, Jose U., et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis." Arthritis & Rheumatism 64.10 (2012): 3083-3094. <http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full>.Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly Normalized after Treatment.” Nature Medicine 21.8 (2015): 895–905. <http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html>.
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Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the New York Academy of Sciences 1372.1 (2016): 53–64. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full>. Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr. 2015. Web. 21 Jan. 2017. <http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-2015-_Pages-1-4.pdf>.Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism 22.2 (2015): 320–331. <http://www.sciencedirect.com/science/article/pii/S1550413115003307>. vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?." Clinical epigenetics 7.1 (2015): 33. <https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2>. Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372.1 (2016): 20–8. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full>. Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094. <http://www.sciencedirect.com/science/article/pii/S0092867415014816>. Zmora, Niv, et al. "Taking it personally: personalized utilization of the human microbiome in health and disease." Cell host & microbe 19.1 (2016): 12-20. <http://www.sciencedirect.com/science/article/pii/S1931312815005089>.
Dinnertime! The Personalized Nutrition Boom