β2tubulin>Ptf1a+β2tubulin>Meis embryos WT embryos

ATS9FCLKTAP2MATN2/3/4KH.C7.269CR2/CSMD2/3;SVEP1B4GT1/2/4CO7A1;FINCKLH20/3/5PMM1/2D19L1/2/3CO6A5CO4A1/2/6AGRB2;HMCN1;TSP1CAH14/6/9ODC/TXTP/UCP5SC6A5/7/9CORIN;FA11;TMPS2DESP;EPIPL;PLECKLH13/26/31/9KLK5;PRSS8;TMPS9GFAP;NFM;VIMECOCA1/MATN2/4DESM;GFAP;PERI;VIME

S61A1/2

-10

-5

0

5

10

-10 0 10 20tsne 1

tsne

2

OriginalTransformed 1Transformed 2Not transformed

OriginalTransformed 1 Transformed 2 Not transformed

−2 −1 0 1 2

Expression

PDE9AGCYA/BANKY2RUXG/LTRXR1/2/3ENPL;H90B3/A/BPPIA/E/FSC6A2/3/4TEBPARF5/L2/L3MeisFHL17;FRIH;FTMTSYT2/5/9ANPRB;GCYA/B

HS71B/L; HSP72/7C

GAPR1MTNBGMPR2;IMDH1;IMDH2LRP1BMOT13/2/3RUXEGCYA/BRPAP3;KCRM;KCRSPtf1aTDHHEM3

KCRB/M/S

S35G1RAB3A/B/CBCO/RPE65HMCN2GBB1/2/4PIPNA/B;PITC1KCC2A/C/GU119A/BERN1HGB1A;HMGB1/2/3NB5R1/3/4DCE2CD63;CD9/TSN8RGRNUCLCPBD/E/NSAC1/2; SYNJ1OPSB/D/G/RCLVS1;RLBP1;TTPALDKK3TBA1A;TBA1B;TBA1CLCLT1;PLCC/D/E

PDE6D

A B

Horie _Suppremental Figure S11