An American HeartAssociation/American Stroke Association Journal
June 2017Volume 48Number 6
EDITORIALHave Stroke Neurologists Entered the Arena of Stroke-Related Cognitive Dysfunctions?: Not Yet, but They Should!
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Leonardo Pantoni, MD, PhD
Stroke : Highlights of Selected Articles 1443
ORIGINAL CONTRIBUTIONSClinical SciencesGenetic Drivers of von Willebrand Factor Levels in an Ischemic Stroke Population and Association With Risk for Recurrent Stroke
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Stephen R. Williams, PhD; Fang-Chi Hsu, PhD; Keith L. Keene, PhD; Wei-Min Chen, PhD; Godfrey Dzhivhuho, BS; Joe L. Rowles III, BS; Andrew M. Southerland, MD, MSc; Karen L. Furie, MD, MPH; Stephen S. Rich, PhD; Bradford B. Worrall, MD, MSc; Michèle M. Sale, PhD; GARNET (The Genomics and Randomized Trials Network) Collaborative Research Group
Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms 1451Steven A. Lubitz, MD, MPH; Owen E. Parsons, MSc; Christopher D. Anderson, MD, MMSc; Emelia J. Benjamin, MD, ScM; Rainer Malik, PhD; Lu-Chen Weng, PhD; Martin Dichgans, MD; Cathie L. Sudlow, MD, PhD; Peter M. Rothwell, MD, PhD; Jonathan Rosand, MD, MSc; Patrick T. Ellinor, MD, PhD; Hugh S. Markus, DM; Matthew Traylor, PhD; on behalf of the WTCCC2, International Stroke Genetics Consortium, and AFGen Consortia
Association Between Brain-Derived Neurotrophic Factor Genotype and Upper Extremity Motor Outcome After Stroke
1457
Won Hyuk Chang, MD, PhD; Eunhee Park, MD; Jungsoo Lee, PhD; Ahee Lee, MS; Yun-Hee Kim, MD, PhD
Haptoglobin Hp2 Variant Promotes Premature Cardiovascular Death in Stroke Survivors 1463Petra Ijäs, MD, PhD; Susanna Melkas, MD, PhD; Jani Saksi, PhD; Antti Jula, MD, PhD; Matti Jauhiainen, PhD; Niku Oksala, MD, PhD, DSc; Tarja Pohjasvaara, MD, PhD; Markku Kaste, MD, PhD; Pekka J. Karhunen, MD, PhD; Perttu Lindsberg, MD, PhD; Timo Erkinjuntti, MD, PhD
Clinical Correlates, Ethnic Differences, and Prognostic Implications of Perivascular Spaces in Transient Ischemic Attack and Ischemic Stroke
1470
Kui-Kai Lau, MRCP; Linxin Li, MD, DPhil; Caroline E. Lovelock, DPhil; Giovanna Zamboni, MD, DPhil; Tsz-Tai Chan, MBBS; Man-Fung Chiang, MBBS; Kin-Ting Lo, MBBS; Wilhelm Küker, MD, FRCR; Henry Ka-Fung Mak, MD, FRCR; Peter M. Rothwell, MD, PhD, FRCP, FMedSci
Dietary Protein Intake and Stroke Risk in a General Japanese Population: The Hisayama Study
1478
Mio Ozawa, PhD; Daigo Yoshida, PhD; Jun Hata, MD, PhD; Tomoyuki Ohara, MD, PhD; Naoko Mukai, MD, PhD; Mao Shibata, MD, PhD; Kazuhiro Uchida, PhD; Masashi Nagata, PhD; Takanari Kitazono, MD, PhD; Yutaka Kiyohara, MD, PhD; Toshiharu Ninomiya, MD, PhD
Ischemic Stroke in Nonvalvular Atrial Fibrillation at Warfarin Initiation: Assessment via a Large Insurance Database
1487
Ping G. Tepper, MD, PhD; Xianchen Liu, MD, PhD; Melissa Hamilton, MPH; Jack Mardekian, PhD; William Petkun, MD; Wilson Tan, MBBS; Daniel E. Singer, MD
Stroke
On the Cover: The image is taken from an article in this issue, “Cortical Venous Redness Represents Tissue Circulation Status in Patients With Moyamoya Disease” by Machida et al (Stroke. 2017;48:1665–1667. doi: 10.1161/STROKEAHA.116.015991). The image is Figure 1.
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Clinical Significance of Isolated Atypical Transient Symptoms in a Cohort With Transient Ischemic Attack
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Philippa C. Lavallée, MD; Leila Sissani, BST; Julien Labreuche, BST; Elena Meseguer, MD; Lucie Cabrejo, MD; Céline Guidoux, MD; Isabelle F. Klein, MD, PhD; Pierre-Jean Touboul, MD; Pierre Amarenco, MD
Nonprocedural Symptomatic Infarction and In-Stent Restenosis After Intracranial Angioplasty and Stenting in the SAMMPRIS Trial (Stenting and Aggressive Medical Management for the Prevention of Recurrent Stroke in Intracranial Stenosis)
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Colin P. Derdeyn, MD; David Fiorella, MD, PhD; Michael J. Lynn, MS; Tanya N. Turan, MD; George A. Cotsonis, MA; Bethany F. Lane, RN; Jean Montgomery, RN; L. Scott Janis, PhD; Marc I. Chimowitz, MB, ChB; for the SAMMPRIS Investigators
Hemorrhage Risk of Brain Arteriovenous Malformations During Pregnancy and Puerperium in a North American Cohort
1507
Jose L. Porras, BS; Wuyang Yang, MD, MS; Eunice Philadelphia; Jody Law; Tomas Garzon-Muvdi, MD; Justin M. Caplan, MD; Geoffrey P. Colby, MD, PhD; Alexander L. Coon, MD; Rafael J. Tamargo, MD; Judy Huang, MD
Neurocognitive Performance After Cerebral Revascularization in Adult Moyamoya Disease 1514Penelope D. Zeifert, PhD; Peter Karzmark, PhD; Teresa E. Bell-Stephens, BSN, CNRN; Gary K. Steinberg, MD, PhD; Leslie J. Dorfman, MD
Socioeconomic Status and the Risk of Stroke Recurrence: Persisting Gaps Observed in a Nationwide Swedish Study 2001 to 2012
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Johanna Pennlert, MD, PhD; Kjell Asplund, MD, PhD; Eva-Lotta Glader, MD, PhD; Bo Norrving, MD, PhD; Marie Eriksson, PhD
CHA2DS2-VASc Score (Congestive Heart Failure, Hypertension, Age ≥75 [Doubled], Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack [Doubled], Vascular Disease, Age 65–74, Female) for Stroke in Asian Patients With Atrial Fibrillation: A Korean Nationwide Sample Cohort Study
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Tae-Hoon Kim, MD; Pil-Sung Yang, MD; Jae-Sun Uhm, MD; Jong-Youn Kim, MD; Hui-Nam Pak, MD; Moon-Hyoung Lee, MD; Boyoung Joung, MD; Gregory Y.H. Lip, MD
Circulating FABP4 (Fatty Acid–Binding Protein 4) Is a Novel Prognostic Biomarker in Patients With Acute Ischemic Stroke
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Wen-Jun Tu, PhD, MD; Xian-Wei Zeng, PhD, MD; Aijun Deng, PhD, MD; Sheng-Jie Zhao, PhD, MD; Ding-Zhen Luo, PhD, MD; Guo-Zhao Ma, MD; Hong Wang, PhD; Qiang Liu, PhD
White Matter Imaging Correlates of Early Cognitive Impairment Detected by the Montreal Cognitive Assessment After Transient Ischemic Attack and Minor Stroke
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Giovanna Zamboni, MD, DPhil; Ludovica Griffanti, PhD; Mark Jenkinson, DPhil; Sara Mazzucco, MD, PhD; Linxin Li, MD, DPhil; Wilhelm Küker, FRCR; Sarah T. Pendlebury, MD, DPhil, FRCP; Peter M. Rothwell, MD, PhD, FmedSci; on behalf of the Oxford Vascular Study
Use of Noncontrast Computed Tomography and Computed Tomographic Perfusion in Predicting Intracerebral Hemorrhage After Intravenous Alteplase Therapy
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Connor Batchelor, MSc; Pooneh Pordeli, PhD; Christopher D. d’Esterre, PhD; Mohamed Najm, BSc; Fahad S. Al-Ajlan, MD; Mari E. Boesen, MSc; Connor McDougall, BSc; Lisa Hur, BSc; Enrico Fainardi, MD; Jai Jai Shiva Shankar, MD; Marta Rubiera, MD; Alexander V. Khaw, MD; Michael D. Hill, MD, MSc; Andrew M. Demchuk, MD; Tolulope T. Sajobi, PhD; Mayank Goyal, MD; Ting-Yim Lee, PhD; Richard I. Aviv, MD; Bijoy K. Menon, MD, MSc
Prediction of Stroke Subtype and Recanalization Using Susceptibility Vessel Sign on Susceptibility-Weighted Magnetic Resonance Imaging
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Dong-Wan Kang, MD; Han-Gil Jeong, MD, MSc; Do Yeon Kim, MD; Wookjin Yang, MD; Seung-Hoon Lee, MD, PhD
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Efficacy of Stent-Retriever Thrombectomy in Magnetic Resonance Imaging Versus Computed Tomographic Perfusion–Selected Patients in SWIFT PRIME Trial (Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke)
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Nicolas Menjot de Champfleur, MD; Jeffrey L. Saver, MD; Mayank Goyal, MD; Reza Jahan, MD; Hans-Christoph Diener, MD, PhD; Alain Bonafe, MD; Elad I. Levy, MD, MBA; Vitor M. Pereira, MD; Christophe Cognard, MD; Dileep R. Yavagal, MD; Gregory W. Albers, MD
Aortic Stiffness, Increased White Matter Free Water, and Altered Microstructural Integrity: A Continuum of Injury
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Pauline Maillard, PhD; Gary F. Mitchell, MD; Jayandra J. Himali, PhD; Alexa Beiser, PhD; Evan Fletcher, PhD; Connie W. Tsao, MD, MPH; Matthew P. Pase, PhD; Claudia L. Satizabal, PhD; Ramachandran S. Vasan, MD; Sudha Seshadri, MD; Charles DeCarli, MD
ASPECTS (Alberta Stroke Program Early CT Score) Measurement Using Hounsfield Unit Values When Selecting Patients for Stroke Thrombectomy
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Maxim Mokin, MD, PhD; Christopher T. Primiani, BS; Adnan H. Siddiqui, MD, PhD; Aquilla S. Turk, DO
Early Endarterectomy Carries a Lower Procedural Risk Than Early Stenting in Patients With Symptomatic Stenosis of the Internal Carotid Artery: Results From 4 Randomized Controlled Trials
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Barbara Rantner, MD, PhD; Barbara Kollerits, PhD; Gary S. Roubin, MD; Peter A. Ringleb, MD; Olaf Jansen, MD; George Howard, PhD; Jeroen Hendrikse, MD; Alison Halliday, MD; John Gregson; Hans-Henning Eckstein, MD; David Calvet, MD; Richard Bulbulia, MD; Leo H. Bonati, MD; Jean-Pierre Becquemin, MD; Ale Algra, MD; Martin M. Brown, MD; Jean-Louis Mas, MD; Thomas G. Brott, MD; Gustav Fraedrich, MD; on behalf of the Carotid Stenosis Trialists’ Collaboration
Predictors of the Aspiration Component Success of a Direct Aspiration First Pass Technique (ADAPT) for the Endovascular Treatment of Stroke Reperfusion Strategy in Anterior Circulation Acute Stroke
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Raphaël Blanc, MD, MSc; Hocine Redjem, MD; Gabriele Ciccio, MD; Stanislas Smajda, MD; Jean-Philippe Desilles, MD; Eliane Orng, PharmD; Guillaume Taylor, MD; Elodie Drumez, BST; Robert Fahed, MD; Julien Labreuche, BST; Mikael Mazighi, MD, PhD; Bertrand Lapergue, MD, PhD; Michel Piotin, MD, PhD
Restarting Anticoagulant Therapy After Intracranial Hemorrhage: A Systematic Review and Meta-Analysis
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Santosh B. Murthy, MD, MPH; Ajay Gupta, MD; Alexander E. Merkler, MD; Babak B. Navi, MD, MS; Pitchaiah Mandava, MD, PhD, MSEE; Costantino Iadecola, MD; Kevin N. Sheth, MD; Daniel F. Hanley, MD; Wendy C. Ziai, MD, MPH; Hooman Kamel, MD
General Anesthesia Versus Conscious Sedation for Endovascular Treatment of Acute Ischemic Stroke: The AnStroke Trial (Anesthesia During Stroke)
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Pia Löwhagen Hendén, MD; Alexandros Rentzos, MD; Jan-Erik Karlsson, MD, PhD; Lars Rosengren, MD, PhD; Birgitta Leiram, MD; Henrik Sundeman, MD, PhD; Dennis Dunker, MD; Kunigunde Schnabel, MD; Gunnar Wikholm, MD, PhD; Mikael Hellström, MD, PhD; Sven-Erik Ricksten, MD, PhD
Randomized, Multicenter Trial of ARTSS-2 (Argatroban With Recombinant Tissue Plasminogen Activator for Acute Stroke)
1608
Andrew D. Barreto, MD, MS; Gary A. Ford, MD; Loren Shen, BSN; Claudia Pedroza, PhD; Jon Tyson, MD, MPH; Chunyan Cai, PhD; Mohammad H. Rahbar, PhD; James C. Grotta, MD; on behalf of the ARTSS-2 Investigators
To Treat or Not to Treat: Anticoagulants as Secondary Preventives to the Oldest Old With Atrial Fibrillation
1617
Peter Appelros, MD, PhD; Bahman Farahmand, PhD; Andreas Terént, MD, PhD; Signild Åsberg, MD, PhD
Resistant Atherosclerosis: The Need for Monitoring of Plaque Burden 1624J. David Spence, MD; Karla Solo, BMSc
Refining 3 Measures to Construct an Efficient Functional Assessment of Stroke 1630Yu-Lin Wang, MD; Gong-Hong Lin, BS; Yi-Jing Huang, BS; Mei-Hsiang Chen, PhD; Ching-Lin Hsieh, PhD
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Basic SciencesPoststroke Sonic Hedgehog Agonist Treatment Improves Functional Recovery by Enhancing Neurogenesis and Angiogenesis
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Yongming Jin, PhD; Austin Barnett, BS; Yifan Zhang, PhD; Xin Yu, ScD; Yu Luo, PhD
XBP1 (X-Box–Binding Protein-1)–Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G
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Meng Jiang, MD; Shu Yu, MD; Zhui Yu, MD; Huaxin Sheng, MD; Ying Li, MD; Shuai Liu, PhD; David S. Warner, MD; Wulf Paschen, PhD; Wei Yang, PhD
Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats
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Qin Hu, MD, PhD; Anatol Manaenko, PhD; Hetao Bian, MD, MS; Zongduo Guo, MD, PhD; Jun-Long Huang, MD; Zhen-Ni Guo, MD, MS; Peng Yang, MD, PhD; Jiping Tang, MD; John H. Zhang, MD, PhD
BRIEF REPORTSCortical Venous Redness Represents Tissue Circulation Status in Patients With Moyamoya Disease
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Toshio Machida, MD; Yoshinori Higuchi, MD; Shigeki Nakano, MD; Satoshi Ishige, MD; Atsushi Fujikawa, MD; Yuichi Akaogi, MD; Junichiro Shimada, MD; Yoichi Yoshida, MD; Sigenori Maru, RT; Junichi Ono, MD
Wake-Up Stroke Is Associated With Greater Nocturnal Mean Arterial Pressure Variability 1668Michelle D. Lundholm, BS; Melissa Rooney, MD; Matthew B. Maas, MD; Hrayr Attarian, MD; Shyam Prabhakaran, MD, MS
Oxygenation-Sensitive Magnetic Resonance Imaging in Acute Ischemic Stroke Using T2′/R2′ Mapping: Influence of Relative Cerebral Blood Volume
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Alexander Seiler, MD; Ralf Deichmann, PhD; Ulrike Nöth, PhD; Waltraud Pfeilschifter, MD; Joachim Berkefeld, MD; Oliver C. Singer, MD; Johannes C. Klein, MD; Marlies Wagner, MD
Prevalence of Imaging Biomarkers to Guide the Planning of Acute Stroke Reperfusion Trials
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Bin Jiang, MD, PhD; Robyn L. Ball, PhD; Patrik Michel, MD; Tudor Jovin, MD; Manisha Desai, PhD; Ashraf Eskandari, RN; Zack Naqvi, BS; Max Wintermark, MD, MAS
Novel Screening Tool for Stroke Using Artificial Neural Network 1678Vida Abedi, PhD; Nitin Goyal, MD; Georgios Tsivgoulis, MD; Niyousha Hosseinichimeh, PhD; Raquel Hontecillas, PhD; Josep Bassaganya-Riera, PhD; Lucas Elijovich, MD; Jeffrey E. Metter, MD; Anne W. Alexandrov, PhD; David S. Liebeskind, MD; Andrei V. Alexandrov, MD; Ramin Zand, MD, MPH
Acupuncture Therapy and Incidence of Depression After Stroke 1682Chung-Yen Lu, MD, PhD; Hsin-Chia Huang, MD; Hen-Hong Chang, MD, PhD; Tsung-Hsien Yang, MD; Chee-Jen Chang, PhD; Su-Wei Chang, PhD; Pei-Chun Chen, PhD
Mexican Americans Receive Less Intensive Stroke Rehabilitation Than Non-Hispanic Whites
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Lewis B. Morgenstern, MD; Emma Sais, BA; Michael Fuentes, MD; Nneka L. Ifejika, MD, MPH; Xiaqing Jiang, MPH; Susan D. Horn, PhD; Erin Case, BA; Lynda D. Lisabeth, PhD
“Good Outcome” Isn’t Good Enough: Cognitive Impairment, Depressive Symptoms, and Social Restrictions in Physically Recovered Stroke Patients
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Arunima Kapoor, MSc; Krista L. Lanctôt, PhD; Mark Bayley, MD; Alex Kiss, PhD; Nathan Herrmann, MD; Brian J. Murray, MD; Richard H. Swartz, MD, PhD
Comparison of Associations of Reduced Estimated Glomerular Filtration Rate With Stroke Outcomes Between Hypertension and No Hypertension
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Xianwei Wang, MD, MHS; Yilong Wang, MD; Uptal D. Patel, MD; Huiman Xie Barnhart, PhD, MA; Zixiao Li, MD; Hao Li, PhD; Chunxue Wang, MD; Xingquan Zhao, MD; Liping Liu, MD; Yongjun Wang, MD; Daniel T. Laskowitz, MD, MHS
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Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke
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Alicia García-Culebras, MSc; Sara Palma-Tortosa, MSc; Ana Moraga, PhD; Isaac García-Yébenes, PhD; Violeta Durán-Laforet, MSc; Maria I. Cuartero, PhD; Juan de la Parra, MSc; Ana L. Barrios-Muñoz, MSc; Jaime Díaz-Guzmán, MD, PhD; Jesús M. Pradillo, PhD; María A. Moro, PhD; Ignacio Lizasoain, MD, PhD
TOPICAL REVIEWSCombining Neuroprotection With Endovascular Treatment of Acute Stroke: Is There Hope? 1700Michael Tymianski, MD, PhD
Behavioral Interventions for Stroke Prevention: The Need for a New Conceptual Model 1706Joel Salinas, MD, MBA, MSc; Lee H. Schwamm, MD
LETTERS TO THE EDITORLetter by Corea et al Regarding Article, “Telemedicine Quality and Outcomes in Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association”
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Francesco Corea, MD; Gordian Hubert, MD; Sònia Abilleira, MD
Letter by Ng et al Regarding Article, “Cervical Carotid Pseudo-Occlusions and False Dissections: Intracranial Occlusions Masquerading as Extracranial Occlusions”
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Felix Ng, MBBS, MPH; Mineesh Datta, MBBS, FRANZCR; Philip M. Choi, MBChB, FRACP
Response by Grossberg et al to Letter Regarding Article, “Cervical Carotid Pseudo-Occlusions and False Dissections: Intracranial Occlusions Masquerading as Extracranial Occlusions”
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Jonathan A. Grossberg, MD; Diogo C. Haussen, MD; Raul G. Nogueira, MD
Letter by Sposato et al Regarding Article, “Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study”
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Luciano A. Sposato, MD, MBA; Sebastian Fridman, MD, MPH; Gustavo Saposnik, MD, MSc
Response by Lubitz et al to Letter Regarding Article, “Stroke as the Initial Manifestation of Atrial Fibrillation: The Framingham Heart Study”
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Steven A. Lubitz, MD, MPH; Sudha Seshadri, MD; Emelia J. Benjamin, MD, ScM
Letter by Murray and Barrow Regarding Article, “Trends in Recruitment Rates for Acute Stroke Trials, 1990–2014”
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Earnest L. Murray, MD; William C. Barrow, MD
Response by Feldman et al to Letter Regarding Article, “Trends in Recruitment Rates for Acute Stroke Trials, 1990–2014”
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William B. Feldman, MD, DPhil; Anthony S. Kim, MD, MAS; Winston Chiong, MD, PhD
Letter by Nighoghossian Regarding Article, “Risk of Pulmonary Embolism After Cerebral Venous Thrombosis”
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Norbert Nighoghossian, MD, PhD
Response by Merkler et al to Letter Regarding Article, “Risk of Pulmonary Embolism After Cerebral Venous Thrombosis”
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Alexander E. Merkler, MD; Ava L. Liberman, MD; Babak B. Navi, MD, MS
Letter by Machado-Alba et al Regarding Article, “Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation: Systematic Review and Meta-Analysis”
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Jorge Enrique Machado-Alba, MD, PhD; Daniel Ricardo Arias-Jaramillo, MD; Andrés Gaviria-Mendoza, MD
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Response by Bai et al to Letter Regarding Article, “Rivaroxaban Versus Dabigatran or Warfarin in Real-World Studies of Stroke Prevention in Atrial Fibrillation: Systematic Review and Meta-Analysis”
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Ying Bai, PhD; Alena Shantsila, PhD; Gregory Y.H. Lip, MD
Letter by McGowan Regarding Article, “Quality of Acute Care and Long-Term Quality of Life and Survival: The Australian Stroke Clinical Registry”
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Sharon McGowan, MBA
CORRECTIONSCorrection to: In-Hospital Risk Prediction for Post-stroke Depression: Development and Validation of the Post-stroke Depression Prediction Scale
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Correction to: Predictors of the Aspiration Component Success of a Direct Aspiration First Pass Technique (ADAPT) for the Endovascular Treatment of Stroke Reperfusion Strategy in Anterior Circulation Acute Stroke
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Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2017 American Heart Association, Inc. All rights reserved.
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