Download - nutrizione e cancro/ firenze 2011

Cachessia neoplasticaInquadramento diagnostico e proposte terapeutiche

dr. Roberto Magarotto

responsabile unita’ di Cure di Supporto e Palliative dipartimento Oncologico Negrar/VR

[email protected]

Firenze , 18-19 marzo Cure palliative in Oncologia

Cachexia : a new dEfinition

Clin NUtr 2008 : 27, 793-799

• Cachexia is a complex metabolic syndrome associated with underlying illness and characterized by loss of muscle with or without loss of fat mass • The prominent clinical feature of cachexia is

weight loss in adults ( corrected for fluid retention) or growth failure in children ( excluding endocrine disorders)• Anorexia, inflammation, insulin resistance and

increased muscle protein breakdown are frequently associated with cachexia

Firenze 18 marzo 2011 Cure palliative in Oncologia

Cancer cachexia : international consensus

• Lancet Oncol. 2011 Feb 4. [Epub ahead of print]

• Definition and classification of cancer cachexia: an international consensus.

• Fearon K, Strasser F, Anker SD, Bosaeus I, Bruera E, Fainsinger RL, Jatoi A, Loprinzi C, Macdonald N, Mantovani G, Davis M, Muscaritoli M, Ottery F, Radbruch L, Ravasco P, Walsh D, Wilcock A, Kaasa S, Baracos VE.


http://www.ncbi.nlm.nih.gov/pubmed?term=%22Fearon%20K%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Strasser%20F%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Anker%20SD%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bosaeus%20I%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Bruera%20E%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Fainsinger%20RL%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Jatoi%20A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Loprinzi%20C%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/pubmed?term=%22Macdonald%20N%22%5BAuthor%5D

Lancet oncology febbraio 2011


Cancer anorexia cachexia syndrome linee guida aiom 2006 (lelli)


Cancer cachexia


Cancer cachexia :livelli sierici.1


Cancer cachexia :livelli sierici.2


Cancer cachexia : protein metabolism


Cancer cachexia: metabolismo del glucosio


Cancer cachexia : metabolismo lipidico


Cancer cachexia


Cachexia : prime conclusioni


Cancer cachexia


Screening nutritional status


39% pazienti con perdita di peso significativa ( >=10% )

Cancer cachexia


Cancer cachexia ( linee guida aiom)


Cancer cachexia ( Linee guida aiom)


Cancer cachexia ( linee guida Aiom)


Cancer cachexiauno studio italiano


Cancer cachexia :Mantovani e coll.


Cancer cachexiamantovani e coll.


Cancer cachexia


Cancer cachexiamantovani e coll.


Cancer cachexia mantovani e coll.


Dati definitivi


Cancer cachexia : Opportunita’ di ricerca


Malati terminali


Questo no!


Pero’…


Download - nutrizione e cancro/ firenze 2011

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